• The Journal of Internal Korean Medicine
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• v.35 no.2
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• pp.195-207
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• 2014

Objectives : The purpose of this study was to investigate how Rhei Radix et Rhizoma affects on insulin resistance and adipose tissue inflammatory response in high fat diet induced obese C57BL/6 mice. Methods : Obesity was induced in C57BL/6 mice by high fat diet for 12 weeks. Models were divided into 3 groups (n=6) of normal diet, high fat diet (HFD), and high fat diet with Rhei Radix et Rhizoma and investigated for 12 weeks. We measured body weight, FBS and oral glucose tolerance test (OGTT), serum insulin, homeostatic model assessment-insulin resistance (HOMA-IR), weight of liver and epididymal fat pad. Inflammatory markers such as adipose tissue macrophage (ATM), tumor necrosis factor-${\alpha}$ and interlukin-10 and CD68 of epididymal adipocyte were determined to evaluate the effect of Rhei Radix et Rhizoma on adipose tissue inflammation. Results : Compared with the HFD group, we observed loss of body weight and epididymal fat pad weight, improvement of glucose level and HOMA-IR, reduction of ATM and gene expression of TNF-${\alpha}$, CD68 in the high fat diet with Rhei Radix et Rhizoma group. Conclusions : This study suggests that Rhei Radix et Rhizoma has effects on insulin resistance and adipose tissue inflammatory response in high fat diet induced obese mice.

• Journal of Society of Preventive Korean Medicine
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• v.16 no.1
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• pp.57-70
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• 2012

The apoptotic process of gastric mucosa triggered by induction of proapoptotic gene expression, such as Bax. Stress-inducing factors may affect Bcl-2/Bax ratio and thus the rate of apoptosis through modulation of the expression of both proteins depending upon the experimental model. TGF-${\beta}$ is believed to be essential in wound healing for regulation of cell growth and differentiation and is known to be involved in tissue repair and remodeling. The polypeptide growth factors, such as vascular endothelial growth factor(VEGF), regulate essential cell functions involved in tissue healing including cell proliferation, migration, and differentiation. The purpose of this study was to investigate whether the oral administration of $Hwangyeon-tang$ (HYT) would have protect effects on gastric ulcer in rat. Sprague-Dawley rats (n=40) were randomly divided into 4 groups ; Normal, Saline, Cimetidine and HYT group. The saline, cimetidine and HYT extract were orally administrated to each group and gastric ulcer was induced with HCl/EtOH solution. After 1 hour, the stomachs were collected for histological observation and immunohistochemistry. In Results, the wound healing of gastric ulcer was promoted by HYT and the significant alterations of BAX/Bcl-2, TGF-${\beta}1$ and VEGF proteins in gastric mucosa were observed. These results suggest that Fritillaria ussuriensis extract promotes wound healing and has protective effects on gastric ulcer in rats.

• Journal of Korean Society of Transportation
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• v.22 no.4 s.75
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• pp.7-18
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• 2004

There have been various research in analyzing airport productivity such as measuring total factor productivity using the models of translog cost function. DEA(Data Envelopment Analysis) model is very useful in measuring productivity with linear programming when the output is not clearly identified and measured quantitatively in such complex facilities as airport. This study is to measure airport productivity using DEA approach for Northeast Asia. Seven international airports were analyzed including Incheon International Airport in Korea, Cheklapkok Airport in Hongkong, Narita Airport in Japan, and Changi Airport in Singapore. With the productivity measured, we can identify one of the important aspects of comparative advantage in hub competition in Asia.

• Journal of Technology Innovation
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• v.23 no.3
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• pp.43-65
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• 2015

Technology standard continues to exist as an social agreement throughout all industry. With development of Information and Communication, it is recently considered as a strategic factor for enhancing interoperability and increasing market dominance. Hence, technology standard research(standardization research) have a significance in analyzing the process of standard adoption and its economic effect and deriving theoretical and policy implications. However, as existing relative researches are lack in consideration on indigenous value of technology and its interoperability, there exists limitation in drawing the result of technology centered analysis. The goal of this study is to suggest new technology centered standard method by implying function of technology differentiation rate and technology preference that are deduced by technology network analysis into two stage game theory. As an example of empirical case, we selected wireless pan technology of Internet of Things, and derive its technological structure and implications related to standard.

• Toxicological Research
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• v.17
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• pp.305-307
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• 2001

Toluene diisocyanate (TDI) is widely used in the manufacture of polyurethanes and is a recognized cause of occupational asthma. Although extensive investigations have been undertaken, the molecular mechanism(s) of the disease is still unclear. We hypothesized that inflammatory cytokines are required during both the sensitization and elicitation phases of the disease and have utilized TNF-R knock-out (KO) mice to address the hypothesis. Black C57 TNFR knock-out mice were exposed to TDI by sc injection and challenged by inhalation of 100 ppb TDI vapor. Control animals included: wild type C57 animals, sham-exposed animals that were challenged with TDI, and animals that were injected with anti-TNF antibodies prior to sensitization and again prior to challenge. Total IgE was increased in the knock-out animals compared with the wild type sensitized and challenged animals whereas TDI-specific IgG antibodies did not differ significantly in KO and wild type animals. There was less inflammation in the nares and trachea in KO animals compared with the wild type animals exposed to TD1 as well as less goblet cell hyperplasia and epithelial damage. Airway reactivity was assessed in animals treated with anti-TNF$\alpha$ antibody and found to be substantially reduced compared with that in sensitized and challenged animals. These results indicate that TNF$\alpha$ plays a role in the immunologic and physiologic responses and in airways inflammation in this animal model and suggests a role for TNF in occupational asthma due to TDI.

• Journal of Korean society of Dental Hygiene
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• v.12 no.5
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• pp.973-985
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• 2012

Objectives : The aim of this study is to investigate the possible impact factors on adults' self-reports of dry mouth and to develop strategies to improve oral health education policy. Methods : This study was conducted on a total of 622 self-administered questionnaires adult above 20 and under 65 years of age living in Seoul and Gyeonggi provinces. The final participants consisted of 443 adults without chronic illness, taking medications and wearing dentures. The Hierarchical Multiple Regression model with three stages was used to assess the association for exposure of interest, such as socio-demographics, health-related behavior, mental health and self-reported of dry mouth. Results : The participants reported mean score of dry mouth($6.32{\pm}4.47$), of which 191 were male($6.81{\pm}4.56$) and 252 were female($5.94{\pm}4.37$). Hierarchical Multiple Regression revealed that the score of dry mouth was shown to be significantly higher for the following people: Males, who were employed, unemployed, negative self-perceived general health, perceived stress, and participants who had no experience awareness of distress in two weeks. The explanatory power was 21.9%. The most powerful impact factor regarding to employment was shown to be negatively associated to dry mouth, and self-perceived general health, experiencing awareness of distressful in two weeks was also important factors. Conclusions : Based on these results in order to develop oral health education policy strategies for the prevention and management of dry mouth, there need to be considered for the employee.

• The Journal of the Korea Contents Association
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• v.14 no.3
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• pp.203-214
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• 2014

In this study, a meta-analysis was conducted to investigate the effect of community-based rehabilitation on patients with brain injury by ICF factor in previous studies and examine the application of recent community-based rehabilitation program. Total 15 articles that satisfied the selection criteria were divided by ICF factors to obtain the effect size. Homogeneity and publication bias were tested for those selected papers. As a result, the overall effect size of community-based rehabilitation was 0.22; the effect size by physical function and structure among the ICF factors came to be 0.21; and the effect size of activity and participation was 0.20, indicating a small effect size. The studies involved in a meta-analysis were considered as the absence of heterogeneity and publication bias, which indicates that the results of this study are subjectively reliable. These results well explained the level of change on ICF factors, especially physical function and structure, activity and participation, in other words, the intervention effect of community-based rehabilitation on patients with brain injury.

• Journal of Microbiology and Biotechnology
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• v.7 no.4
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• pp.267-271
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• 1997

We developed a dermal equivalent (DE) which was engineered using human dermal fibroblasts and a matrix of collagen gel. The in vitro construction of the DE was accomplished by casting a porcine collagen type I solution plus concentrated medium with isolated and cultured fibroblasts. These constructs were attached to culture dishes or left floating in culture medium. Contraction of attached gels results in decreased gel thickness without a change in gel diameter, and contraction of floating gels results in decreased gel thickness and diameter. After contraction, there was no increase in cell number in floating gels, but cells in attached gels began to increase after about 4 days of the lag phase in cell growth curve. At this lag phase, addition of fibroblast growth factor (FGF) at a concentration of $0.1{\mu}$/ml promoted cell proliferation in the attached collagen gels, but no effect in floating gels. These results indicate that the method of contraction had an influence on the extracellular matrix (ECM) organization, and this influenced not only cell growth but also fibroblast responsiveness to FGF. This suggests that attached collagen gel is more suitable as a dermal equivalent than the floating gel. And the final contracted area of attached gel is much larger than that of the floating gel since floating gel is contracted in all directions but attached gel is contracted only vertically.

• Asian Journal of Atmospheric Environment
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• v.11 no.2
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• pp.79-95
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• 2017

A number of field studies have provided evidence that biomass burning is one of the major global sources of atmospheric particles. In this study, we have collected $PM_{2.5}$ emitted from biomass burning combusted at open burning and laboratory chamber situations. The open burning experiment was conducted with the cooperation of 9 farmers in Chiba Prefecture, Japan, while the chamber experiment was designed to evaluate the characteristics of chemical components among 14 different plant species. The analyzed categories were $PM_{2.5}$ mass concentration, organic carbon (OC), elemental carbon (EC), ionic components ($Na^+$, ${NH_4}^+$, $Ca^{2+}$, $Mg^{2+}$, $K^+$, $Cl^-$, ${NO_3}^-$ and ${SO_4}^{2-}$), water-soluble organic carbon (WSOC), water-insoluble inorganic carbon (WIOC), char-EC and soot-EC. OC was the dominant chemical component, accounting for the major fraction of primary $PM_{2.5}$ derived from biomass burning, followed by EC. Ionic components contributed a small portion of $PM_{2.5}$, as well as that of $K^+$. In some cases, $K^+$ is used as biomass burning tracer; however, the observations obtained in this study suggest that $K^+$ may not always be suitable as a tracer for biomass burning emissions. Also, the results of all the samples tested indicate relatively low values of char-EC compared to soot-EC. From our results, careful consideration should be given to the usage of $K^+$ and char-EC as indicators of biomass burning. The calculated ratios of WSOC/OC and WIOC/OC were 55.7% and 44.3% on average for all samples, which showed no large difference between them. The organic materials to OC ratio, which is often used for chemical mass closure model, was roughly estimated by two independent methods, resulting in a factor of 1.7 for biomass burning emissions.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.6
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• pp.73-80
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• 2010

Conventional slope stability analysis is focused on calculating minimum factor of safety or maximum probability of failure. To minimize inherent uncertainty of soil properties and analytical model and to reflect various analytical models and its failure shape in slope stability analysis, slope stability analysis method considering simultaneous failure probability for multi failure mode was proposed. Linear programming recently introduced in system reliability analysis was used for calculation of simultaneous failure probability. System reliability analysis for various analytical models could be executed by this method. Optimum design to determine angle of a simple slope is executed for multi failure mode using linear programming. Because of complex consideration for various failure shapes and modes, it is possible to secure advanced safety by using simultaneous failure probability.