• The Journal of Internal Korean Medicine
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• v.30 no.3
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• pp.594-603
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• 2009

Objectives : ICH breaks down blood vessels within the brain parenchyma, which finally leads to neuronal loss, drugs to treat ICH have not yet been established. In this experiment, we measured the effect of Woowhangchongshim-won (WWCSW) on intracerebral hemorrhage (ICH) in rat using microarray technology. Methods : We measured the effect of WWCSW on ICH in rat using microarray technology. ICH was induced by injection of collagenase type IV, and total RNA was isolated. Image files of microarray were measured using a ScanArray scanner, and the criteria of the threshold for up- and down-regulation was 2 fold. Hierarchical clustering was implemented using CLUSTER and TREEVIEW program, and for Ontology analysis. GOSTAT program was applied in which p-value was calculated by Chi square or Fisher's exact test based on the total array element. Results : WWCSW-treatment restored the gene expression altered by ICH-induction in brain to the levels of 76.0% and 70.1% for up- and down-regulated genes, respectively. Conclusion : Co-regulated genes by ICH model of rat could be used as molecular targets for therapeutic effects of drug including WWCSW. That is, the presence of co-regulated genes may represent the importance of these genes in ICH in the brain and the change of expression level of these co-regulated genes would also indicate the functional change of brain tissue.

• Proceedings of the Korean Society of Toxicology Conference
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• 1998.10a
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• pp.8-13
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• 1998

Polyoma Virus Enhancer core Binding Protein (PEBP2)는 유전자의 전사를 조절하는 hetero-dimeric transcription factor로서 $\alpha$와 $\beta$ subunit으로 구성되어 있다. $\alpha$ subunit을 coding 하는 유전자중 하나인 PEBP2aB는 급성백혈병과 관련되어있는 t(8;21) 또는 t(12;21)에 의하여 변형됨으로서 백혈병 발병의 원인이 되고 있다 (Miyoshi et al., 1993; .Romana et al., 1995). $\beta$ subunit을 coding 하는 PEBP2$\beta$도 inv(16)에 의하여 변형됨으로서 백혈병을 유도하는 주요 원인이 되고 있다 (Liu et al., 1993). 이 유전자들의 생물학적 활성을 밝히기 위한 연구가 gene targeting에 의한 knockout mouse 생산 방법으로 수행되었다. 그 결과 PEBP2$\alpha$B와 PEBP2$\beta$ 유전자가 definitive hematopoiesis에 있어서 결정적으로 중요한 역할을 하고 있음이 관찰되었다 (Okuda et al., 1996, Wang et al., 1996a, 1996b), 이는 이들 유전자가 bematopoietic master switch 유전자임을 밝힌 중요한 결과로서 이로부터 혈액학 연구 분야의 새로운 장이 열리게 되었다. 또한 이러한 연구 결과들은 PEBP2 family에 속하는 다른 유전자의 생물학적 활성의 연구를 촉진하는 계기가 되었다. 최근 PEBP2$\alpha$A 유전자가 결손된 마우스가 생산되었는데 이 유전자의 경우에는 모든 종류의 뼈의 생성이 완전히 결손됨이 관찰되었다 (Komori et al., 1997). 이는 PEBP2$\alpha$A 유전자가 뼈의 생성을 지배하는 master switch 유전자임을 보여주는 중요한 관찰로서 bone biologist 들의 큰 관심을 모으고 있다. 본 연구팀은 PEBP2 family 유전자 중 유일하게 아직 생물학적 활성이 규명되지 않은 PEBP2$\alpha$C 유전자의 활성을 knockout 마우스를 생산하는 방법에 의하여 분석하였으며 소화기관의 형성에 중요한 역할을 하고 있음을 확인하였다.

• Journal of Korean Society for Quality Management
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• v.42 no.2
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• pp.253-264
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• 2014

Purpose: The aim of this study is to gain a competitive advantage in the global marketplace by examining the current situation of three domestic Food Dehydrator companies' products. Food Dehydrators are sort of small domestic appliances(SDA), first introduced by Korean companies. Furthermore, this study suggests the improvement plans in the rapidly changing world situation. Methods: Evaluate through comparing three domestic Food Dehydrator companies' products based on the PQI(Premium Quality Index) model, developed by product quality evaluation experts group. Results: At first, we classified evaluation factors into three parts - usability quality, emotional quality - and each of the factors includes sub factors. Under this condition, the results of this study are as follows; the brand quality is remaining at a high satisfaction level compare to other two factors but emotional quality is assessed to be low. This study has shown at customers consider brand and usability quality factors as the most important factor due to the nature of the product. Conclusion: As the possibility of increasing customer needs such as product design and sensitive quality besides usability quality has risen in a competitive global market, the manufacturing companies in Korea are recommended to put forth the necessary effort to improve their product quality, especially in terms of emotional quality.

• Biomolecules & Therapeutics
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• v.26 no.6
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• pp.576-583
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• 2018

Human rhinoviruses (HRV) are one of the major causes of common cold in humans and are also associated with acute asthma and bronchial illness. Heat-shock protein 90 (Hsp90), a molecular chaperone, is an important host factor for the replication of single-strand RNA viruses. In the current study, we examined the effect of the Hsp90 inhibitor pochonin D, in vitro and in vivo, using a murine model of human rhinovirus type 1B (HRV1B) infection. Our data suggested that Hsp90 inhibition significantly reduced the inflammatory cytokine production and lung damage caused by HRV1B infection. The viral titer was significantly lowered in HRV1B-infected lungs and in Hela cells upon treatment with pochonin D. Infiltration of innate immune cells including granulocytes and monocytes was also reduced in the bronchoalveolar lavage (BAL) by pochonin D treatment after HRV1B infection. Histological analysis of the lung and respiratory tract showed that pochonin D protected the mice from HRV1B infection. Collectively, our results suggest that the Hsp90 inhibitor, pochonin D, could be an attractive antiviral therapeutic for treating HRV infection.

• Journal of Preventive Medicine and Public Health
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• v.31 no.3 s.62
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• pp.384-394
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• 1998

In order to investigate the effect of the urinary excretion of sodium and potassium on the change on blood pressure over 3 years, 668 adolescents aged 13 years living in Kangwha area were investigated in a longitudinal follow-up study. Two measurements were taken on each blood pressure (diastolic, systolic) and the average of the two readings was used in the analysis. Sodium and potassium intake were estimated by the determination of those electrolytes in 24hr urine. The mixed model regression analysis was used to identify the effect of urinary sodium and potassium on the change of blood pressure after controlling for BMI of each age. On simple bivariate analysis no relationship was found between urinary sodium excretion and systolic or diastolic blood pressure among both male and female, however, a significant positive association between urinary potassium excretion and systolic blood pressure among male. The results of mixed regression analysis showed that the body mass index (BMI) were more influential that urinary electrolytes among this study subjects. It suggested that risk factors observed from the adults, may not be identical with that of the growing aged population. After control of the BMI and age, significant association between sodium and diastolic BP among male, and association between potassium and systolic BP among female, were found. In summary, the results indicate that growth has been more influential than dietary factor on blood pressure for growing aged population.

• Journal of Korean Society of Steel Construction
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• v.14 no.6
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• pp.803-811
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• 2002

Current composite steel and concrete bridges are designed using full-interaction theory assuming there is no relative slip, between the steel and concrete components along their interface, because of the complexities of partial-interaction analysis techniques. However, in the assessment of existing composite bridges this simplification may not be warranted as it is often necesary to extract the correct capacity and endurance from the structure. This may only be achieved using partial-interaction theory which tuly reflects the behaviour of the structure. In this paper, Parametric analyses have been carried out in order to confirm the partial-interaction curvatures with deflection effect using the finite element method. Therefore, the model is considered for simply supported steel and concrete composite bridges with a uniform distribution of connectors subjected to a single concentrated load. For the case studies, this study applicate a parameters such as the number and space of stud shear connector and elastic modulus of concrete slabs. From this study, it is known that partial-interaction effect was in the increase to the increasing the deflection of composite bridges, and stiffness and strength of slab concrete considering the occurrence of crack effect seriously to the partial-interaction behavior.

• Journal of Soil and Groundwater Environment
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• v.17 no.2
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• pp.47-53
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• 2012

In this study, the adsorption of $Cu^{2+}$ and $Cd^{2+}$ from aqueous solution on the biochar derived from used coffee grounds at different pyrolysis temperatures has been investigated as a potential low-cost treatment method for heavy metal-containing waters. Three biochar samples prepared by heating coffee sludge at temperature of $300^{\circ}C$ (B300), $500^{\circ}C$ (B500), and $700^{\circ}C$ (B700) were tested for the adsorption capacity and kinetics of Cd and Cu. Also the influencing factor of heavy metal removal by ion exchange in terms of cation exchange capacity (CEC) of each biochar was measured. Adsorption of Ca and Cu by biochar produced at higher pyrolysis temperature showed higher adsorption capacity but the optimal pyrolysis temperature based on performance and economy was known as $500^{\circ}C$. Sorption of Cu and Cd by biochar followed a Langmuir model at pH 6~6.5, attributing mainly to surface sorption. The biochar was more effective in Cu and Cd sorption than activated carbon (AC), with BC 500 being the most effective, which indicates that sorption of Cd and Cu by coffee sludge biochar is partly influenced by chemical sorption on surface functional group as well as physical sorption.

• Journal of Korean Society of Water and Wastewater
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• v.22 no.1
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• pp.105-112
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• 2008

Disinfection is a basic and effective microorganism inactivation method and historically contributed a decrease in waterborne diseases. To guarantee the disinfection ability, improving T in CT value is important. Many indexes are used to estimate the hydraulic efficiency, however, these are black-box analysis. Therefore it is need to develope new estimation method. In this study, internal short-circuiting estimation method (ISEM) is developed using CFD and we inquire into the factor which causes increase of $T_{10}/T$ value as LW ratio increases. And the effect of shape on the relation of LW ratio and $T_{10}/T$ is analyzed. As LW ratio increases, internal short-circuiting index (ISI) of influent and effluent zone is rapidly reduced and recirculation and dead zone are reduced in channel zone. Therefore, as the $T_{10}/T$ value converges maximum value, ISI curve is changed from "V" shape to "U" shape and hydraulic efficiency is improved especially in downstream portion of clearwell. The less the shape ratio(width/length of clearwell) is the less the $T_{10}/T$ value is at a same LW ratio because the portion of turning zone increases as shape ration decreases, therefore more boundary separation is generated.

• Journal of Wetlands Research
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• v.14 no.3
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• pp.317-328
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• 2012

The objects of this study are to perform appropriateness analysis of USLE(universal soil loss equation) model and to accumulate the data measured in field. The basin area of Bongdong station is $342.27km^2$. This study simulated sediment outflows in the basin and performed a comparative analysis of simulated outputs with actual measurement values. Also annual rainfall was used to calculate rainfall-runoff erosivity factor which can influence soil erosion. The calculation of annual average soil erosion was made by soil erosion maps. The maps with a resolution of ($30m{\times}30m$) were created by multiplication of factors(R, LS, K, C, P) from ArcView Map Calculator. In this paper, it was shown that soil erosion was not occur in the most of basin.

• Journal of Wetlands Research
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• v.13 no.3
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• pp.471-479
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• 2011

Evapotranspiration (ET) including evaporation from a land surface and transpiration from photosynthesis of vegetation is a hydrological factor that has an important role in water cycle. However, there is a limitation to understand it due to heterogeneity of land cover and vegetation. In this study, Mapping EvapoTRanspiration with Internalized Calibration (METRIC) model, one of the energy balance models, and MODerate resolution Imaging Spectroradiometer (MODIS) satellite based well-known Penman-Monteith algorithm were compared. Two ET maps were categorized and compared by land cover classification. The results represented overall applicability of the two models with the highest correlation coefficients in needleleaf and broadleaf forests. This study will be useful to estimate remote sensing based ET maps with high resolution and to figure out spatio-temporal variability and seasonal changes.