• Journal of Korean society of Dental Hygiene
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• v.18 no.1
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• pp.77-92
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• 2018

Objectives: The purpose of this study was to review depression and anxiety associated with pain during scaling procedures, and to establish measures for reducing scaling pain encompassing not only physical factors but also psychological aspects of patients. This study also attempts to reduce anxiety through proper patient education prior to scaling procedures. Methods: In Seoul, and Gyeonggi area from July 26, 2017 to August 19, 2017, there were 327 copies of questionnaire data collected, excluding 23 questionnaires with insufficient information such as missing entries. The following inductions were made based on data collected. Results: There are positive correlations between pain and depression, dental anxiety, trait anxiety, and state anxiety. Especially, stronger correlation is present between pain and dental anxiety. Depression (${\beta}=0.439$, p<0.001) is the most influential factor associated with pain. Next is dental anxiety (${\beta}=0.292$, p<0.001). Higher the depression and dental anxiety tend to increase pain over scaling procedure. This model is with adjusted explanatory power of 28.2%. Conclusions: The result demonstrates that there is a correlation between scaling pain and depression, dental anxiety, trait anxiety, and state anxiety. Especially, depression and dental anxiety were prominent factors in affecting scaling pain. Therefore, considering aforementioned-findings, a dental hygienist's positive attitude may help in reducing the pain of the patient during scaling procedures, by affecting the psychological state of the patient and reduce the anxiety through proper education prior to scaling procedures.

• Journal of Microbiology and Biotechnology
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• v.28 no.1
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• pp.122-135
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• 2018

Listeriolysin O (LLO), one of the most immunogenic proteins of Listeria monocytogenes and its main virulence factor, mediates bacterial escape from the phagosome of the infected cell. Thus, its expression in a nonpathogenic bacterial host may enable effective delivery of heterologous antigens to the host cell cytosol and lead to their processing predominantly through the cytosolic MHC class I presentation pathway. The aim of this project was to characterize the delivery of a model antigen, chicken egg ovalbumin (OVA), to the cytosol of dendritic cells by recombinant Bacillus subtilis vegetative cells expressing LLO. Our work indicated that LLO produced by non-sporulating vegetative bacteria was able to support OVA epitope presentation by MHC I molecules on the surface of antigen presenting cells and consequently influence OVA-specific cytotoxic T cell activation. Additionally, it was proven that the genetic context of the epitope sequence is of great importance, as only the native full-sequence OVA fused to the N-terminal fragment of LLO was sufficient for effective epitope delivery and activation of $CD8^+$ lymphocytes. These results demonstrate the necessity for further verification of the fusion antigen potency of enhancing the MHC I presentation, and they prove that LLO-producing B. subtilis may represent a novel and attractive candidate for a vaccine vector.

• Journal of Computational Design and Engineering
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• v.3 no.4
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• pp.337-348
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• 2016

An experimental approach is presented for the measurement of wear that is common in the threading of cold-forged steel. In this work, the first objective is to measure wear on various types of roll taps manufactured to tapping holes in microalloyed HR45 steel. Different geometries and levels of wear are tested and measured. Taking their geometry as the critical factor, the types of forming tap with the least wear and the best performance are identified. Abrasive wear was observed on the forming lobes. A higher number of lobes in the chamber zone and around the nominal diameter meant a more uniform load distribution and a more gradual forming process. A second objective is to identify the most accurate data-mining technique for the prediction of form-tap wear. Different data-mining techniques are tested to select the most accurate one: from standard versions such as Multilayer Perceptrons, Support Vector Machines and Regression Trees to the most recent ones such as Rotation Forest ensembles and Iterated Bagging ensembles. The best results were obtained with ensembles of Rotation Forest with unpruned Regression Trees as base regressors that reduced the RMS error of the best-tested baseline technique for the lower length output by 33%, and Additive Regression with unpruned M5P as base regressors that reduced the RMS errors of the linear fit for the upper and total lengths by 25% and 39%, respectively. However, the lower length was statistically more difficult to model in Additive Regression than in Rotation Forest. Rotation Forest with unpruned Regression Trees as base regressors therefore appeared to be the most suitable regressor for the modeling of this industrial problem.

• Journal of the Economic Geographical Society of Korea
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• v.20 no.3
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• pp.405-418
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• 2017

SHIFT is public rental housing policy introduced by Seoul Metropolitan in 2007, which works as Chonsei(korean unique deposit rental system). This paper examines the effect of SHIFT on Chonsei prices of neighborhood apartments. To estimate the change in prices of Chonsei after the provision of SHIFT, I collect data on Chonsei prices of apartments within a 5km radius from the SHIFT housings. Summary of main results are following. Chonsei prices of the apartments within a 2-3km radius decreased by 4.4% after the provision of SHIFT housings. In contrast, when it comes to apartments within a 1-2km radius, I can't find the stochastic relationship between the provision of SHIFT hosing and price changes. This results can be explained by "Offset effects" caused by real estate development. Provision of SHIFT can sequentially induce nearby area's development, which plays a factor in the effect of price increases. And this offset effects varies in each apartment complex depending on demand for Chonsei and supply of the SHIFT.

• Journal of the Korean Society for Railway
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• v.19 no.3
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• pp.351-362
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• 2016

The purpose of this study is to investigate service factors and relationships affecting customer satisfaction by measuring indexes of the entire set of high-speed railway station facilities and train services. In this study, we collected data from 202 KTX passengers and analyzed the data using the structural equation model (SEM) method. Through exploratory factor analysis (EFA), we found five major service factors, including parking related service (PRS), station convenient facilities related service (SCS), ticketing services (TIS), service within the train (SWT), and inner environments (INE). As result of a hypothesis test, it was found that PRS does not influence SWT, whereas SCS and TIS positively affect train related service. Also, SWT and INE significantly affect the overall service satisfaction of customers. Thus, our findings provide that station facilities and train service experience are important factors that can enhance customer satisfaction.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.15 no.3
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• pp.118-128
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• 2016

As the rural areas have experienced the population reduction and the aging, the service level of public transit decreases. This study analyzes the effecting factor to user satisfaction of demand response transport(DRT) as alternative to rural public transit by the quantile regression that aims at estimating either the conditional median or other quantiles of the response variable. Jeonbuk Province tested DRT operations in Dongsang of Wanju County and Sannae of Jeongup City each in 2015. The user DRT satisfaction of Wanju was higher than one of Jeongup in basic statistics analysis. The difference in satisfaction between higher quantile and lower quntile of Wanju is smaller than one of Jeongupy as a result of quantile regression analysis. Also, Wanju DRT continues the second test operation of DRT as satisfaction from Ordinary Least Squares(OLS) close to higher satisfaction quantile.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.2
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• pp.183-189
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• 2015

Foeniculum vulgare Mill. (fennel) is used to flavor food, in cosmetics, as an antioxidant, and to treat microbial, diabetic and common inflammation. No study to date, however, has assessed the anti-inflammatory effects of fennel in experimental models of inflammation. The aims of this study were to investigate the anti-inflammatory effects of fennel in model of lipopolysaccharide (LPS)-induced acute lung injury. Mice were randomly assigned to seven groups (n=7~10). In five groups, the mice were intraperitoneally injected with 1% Tween 80-saline (vehicle), fennel (125, 250, $500{\mu}l/kg$), or dexamethasone (1 mg/kg), followed 1 h later by intratracheal instillation of LPS (1.5 mg/kg). In two groups, the mice were intraperitoneally injected with vehicle or fennel ($250{\mu}l/kg$), followed 1 h later by intratracheal instillation of sterile saline. Mice were sacrificed 4 h later, and bronchoalveolar lavage fluid (BALF) and lung tissues were obtained. Fennel significantly and dose-dependently reduced LDH activity and immune cell numbers in LPS treated mice. In addition fennel effectively suppressed the LPS-induced increases in the production of the inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, with $500{\mu}l/kg$ fennel showing maximal reduction. Fennel also significantly and dose-dependently reduced the activity of the proinflammatory mediator matrix metalloproteinase 9 and the immune modulator nitric oxide (NO). Assessments of the involvement of the MAPK signaling pathway showed that fennel significantly decreased the LPS-induced phosphorylation of ERK. Fennel effectively blocked the inflammatory processes induced by LPS, by regulating pro-inflammatory cytokine production, transcription factors, and NO.

• The Journal of Internal Korean Medicine
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• v.35 no.4
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• pp.428-438
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• 2014

Objectives: Obesity is an important cause of insulin resistance that leads to obese type 2 diabetes. Recently it has been found that obesity is associated with adipose tissue accumulation which causes systemic inflammation. In this study, we investigated effects of Inula helenium on the inflammation in high fat diet-induced insulin resistance mouse. Methods: Insulin resistance was induced in C57BL/6 male mice (19~21 g) on a 60% fat diet. Mice were divided into 3 groups (n=6) of normal, control and Inula helenium. After 12 weeks, body weight, FBS, oral glucose tolerance test (OGTT), serum level of insulin, epididymal fat pad, liver weight and the gene expression of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-6, interleukin (IL)-10 and cluster of differentiation (CD) 68 were measured. Also, adipose tissue macrophage was analyzed by fluorescence activated cell sorting. Results: Inula helenium significantly reduces oral glucose tolerance levels, insulin serum level and adipose tissue macrophage. Also Inula helenium increased IL-10 gene expression and decreased CD68 gene expression. Conclusions: These results show that Inula helenium has anti-insulin resistance and anti-inflammatory effects on a high fat diet-induced insulin resistance mouse model.

• The Journal of Internal Korean Medicine
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• v.35 no.4
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• pp.519-531
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• 2014

Objectives: Diabetic nephropathy is the most common cause of end stage renal disease. Transforming growth factor (TGF)-${\beta}1$, type IV collagen, advanced glycation end-products (AGEs), and angiotensin II type 1 receptor (AT1) are the main factors of diabetic nephropathy. We investigated the effects of Prunus on renal function and histopathological changes of diabetic nephropathy rat model induced by unilateral nephrectomy and streptozotocin. Methods: Diabetes was induced in male Sprague-Dawley rats ($290{\pm}10g$) by injecting streptozotocin (55 mg/kg) into the tail vein after unilateral nephrectomy. Rats were divided into 3 groups (n=6): normal, control, and Prunus. After 8 weeks of oral administration of Prunus extract on the Prunus group from 3 days after streptozotocin injection, we checked weight, 24 hrs urine, blood biochemistry and renal tissue to evaluate renal function and histopathological changes by examining parameters including albuminuria, BUN, creatinine, cholesterol, low density lipoprotein (LDL), triglyceride, TGF-${\beta}1$, type IV collagen, AGEs, and AT1. We also measured mRNA expression of TGF-${\beta}1$, type IV collagen, AGEs, and AT1 by Real Time polymerase chain reaction (RT-PCR). Results: Prunus decreased the amount of 24 hrs proteinuria, and inhibited histopathological changes of diabetic nephropathy including the expression and accumulation of TGF-${\beta}1$, type IV collagen and AGEs which could promote development of diabetic nephropathy. Prunus also inhibited mRNA expression of TGF-${\beta}1$, type IV collagen. Conclusions: These findings suggest that Prunus might protect the renal function and inhibit the development of renal injury by regulating factors including TGF-${\beta}1$, type IV collagen, AGEs, except AT1, so Prunus can be used for diabetic patients to prevent the progression of diabetic nephropathy.

• Korean Journal of Child Studies
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• v.11 no.1
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• pp.58-71
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• 1990

The purpose of the study was to investigate the mother-child interactions in terms of maternal child- rearing behavior, maternal self-esteem, and their school-age children's self-esteem. The subjects were, all living in the Seoul area. A pre-test was conducted twice on 98 subjects. Each time the values of Chronbach's ${\alpha}$ were obtained on maternal behavior, maternal self-esteem and children's self-esteem. Data analysis was by ANOVA, Pearson's product-moment correlation. multiple regression analysis. Chronbach's ${\alpha}$, and factor analysis. Children's self-esteem was positively related (1) to family background factors:educational level, employment status of mothers, social economic status, and number of siblings (2) to maternal self-esteem and (3) to maternal child-rearing behavior in the dimensions of affection, acceptance, and encouragement of independency. Children's self-esteem was negatively related to maternal child-rearing behavior in the dimensions of hostility, rejection and encouragement of dependency. The relative importance of independent variables on children's self-esteem was found to be in the following order:mother's educational level. social economic status, and number of siblings (${\beta}=0.5935$, p< .001), maternal child-rearing behavior in the affection-hostility dimension (${\beta}=0.0849$, p< .001), and in the acceptance-rejection dimension(${\beta}=0.0365$, p< .05). The regression model showed that 25 percent of the children's self-esteem could be accounted for by family background factors. and maternal child-rearing behavior in the affection-hostility dimension and the acceptance-rejection dimension ($R^2=0.25$).