• Biomedical Science Letters
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• v.11 no.2
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• pp.175-183
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• 2005

The two major isoflavones in soy, genistein and daidzein, are well known to prevent hormone-dependent cancers by their anti estrogenic activity. The exact molecular mechanisms for the protective action are, however, not provided yet. It has been reported that genistein and daidzein have a potential anticancer activity through their antiproliferative effect in many hormone-dependent cancer cell lines. Transforming growth $factor-\beta1(TGF-\beta1)$ has also been found to have cell growth inhibitory effect, especially in mammary epithelial cells. This knowledge led to a hypothetical mechanism that the soy isoflavones-induced growth inhibitory effect can be derived from the regulation of $TGF-\beta1$ and $TGF-\beta$ receptors. In order to test this hypothesis, the effects of the soy isoflavones at various concentrations and periods on the expression of $TGF-\beta1$and $TGF-\beta$ receptors were investigated by using Northern blot analysis in human breast carcinoma epithelial cell lines, an estrogen receptor positive cell line (MCF-7) and an estrogen receptor negative cell line (MDA-MB-231). As a result, only genistein has shown a profound dose-dependent effect on $TGF-\beta1$ expression in the $ER^+$ cell line within the range of doses tested, and the expression levels are correspondent to their inhibitory activities of cell growth. Moreover, daidzein showed down-regulated $TGF-\beta1$ expression at a low dose, the cell growth proliferation was promoted at the same condition. Therefore, antiproliferative activity of the soy isoflavones can be mediated by $TGF-\beta1$ expression, and the effects are mainly, if not all, occurred by ER dependent pathway. The expression of $TGF-\beta$ receptors was induced at a lower dose than the one for $TGF-{\beta}1$ induction regardless of the presence of ER, and the expression patterns are similar to those of the cell growth inhibition. These results indicated that the regulation of $TGF-\beta$ receptor expression as well, prior to $TGF-\beta1$ expression, may be involved in the antiproliferative activity of soy isoflavones. Little or no expression of $TGF-\beta$ receptors was found in the MCF-7 and MDA-MB-231 cells, suggesting refractory properties of the cells to growth inhibitory effect of the $TGF-\beta$. The soy isoflavones can seemingly restore the sensitivity of growth inhibitory responses to $TGF-\beta1$ by re-inducing $TGF-\beta$ receptors expression. In conclusions, our findings presented in this study show that the antitumorigenic activity of the soy isoflavones could be mediated by not only $TGF-\beta1$induction but $TGF-\beta$ receptor restoration. Thus, soy isoflavones could be good model molecules to develop new nonsteroidal antiestrogenic chemopreventive agents, associated with, regulation of $TGF-\beta$ and its receptors.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.13 no.4
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• pp.73-82
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• 2018

This research was implemented to check what effects entrepreneurship have on the entrepreneurial intention verify the emotional factor 'Fear on Business' in terms of the relationship between entrepreneurship and the entrepreneurial intention. Above all, in the study Health Belief Model was applied to research into emotional factors, such as 'Fear on Business'. Specifically, it was performed to check what effects 'Fear on Business' has on the entrepreneurial intention and to see if there are any mediating effects between entrepreneurship and the entrepreneurial intention. To achieve the research purposes above, the students who took a business start-up and entrepreneurship related course were surveyed (all 356); and research findings were produced. To summarize the findings, entrepreneurship did influence the entrepreneurial intention significantly. In addition, entrepreneurship significantly influenced 'Fear on Business'. And 'Fear on Business' significantly influenced the EI; it turned out that 'Fear on Business' plays a mediating role between entrepreneurship and the entrepreneurial intention. From these result, it is thought that programs or policies for reducing 'Fear on Business' are needed. Finally, because entrepreneurship can affect the entrepreneurial intention through the medium of 'Fear on Business', it is thought that the government's effort to create a social atmosphere is needed to overcome 'Fear on Business'.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.4
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• pp.201-212
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• 2016

A Wind resource assessment and optimal micrositing of wind turbines were implemented for the development of an onshore wind farm of 30 MW capacity on Gadeok Island in Busan, Republic of Korea. The wind data measured by the automatic weather system (AWS) that was installed and operated in the candidate area were used, and a reliability investigation was conducted through a data quality check. The AWS data were measured for one year, and were corrected for the long term of 30 years by using the modern era retrospective analysis for research and application (MERRA) reanalysis data and a measure- correlate-predict (MCP) technique; the corrected data were used for the optimal micrositing of the wind turbines. The micrositing of the 3 MW wind turbines was conducted under 25 conditions, then the best-optimized layout was analyzed with a various wake model. When the optimization was complete, the estimated park efficiency and capacity factor were from 97.6 to 98.7 and from 37.9 to 38.3, respectively. Furthermore, the annual energy production (AEP), including wake losses, was estimated to be from 99,598.4 MWh to 100,732.9 MWh, and the area was confirmed as a highly economical location for development of a wind farm.

• Journal of Wetlands Research
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• v.19 no.2
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• pp.202-210
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• 2017

Shear stress is one of the most important mechanical factors used in various fields and is important for the design of artificial channels. Current shear stresses have been used in the past, but there are factors that are difficult to actually measure or calculate, such as bed shear stress and energy slope in the equation used. In particular, the energy slope is a very difficult factor to estimate, and it is difficult to estimate the slope and flow velocity of the boundary layer although the energy slope can be used to obtain the shear stress distribution. In addition, the bed shear stress among the shear stress distribution is very difficult to measure directly, and the research is somewhat slower than the velocity. In this study, we have studied the simple calculation of the average flow velocity and the shear stress distribution using entropy M without reflecting the energy gradient, and we used existing laboratory data to demonstrate the utility of the applied equation. The stress distribution in the graphs was comparatively analyzed. In the case of the uniform flow and the non-uniform flow, the correlation coefficient was almost identical to 0.930-0.998.

• Journal of Korea Water Resources Association
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• v.40 no.12
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• pp.985-994
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• 2007

Small hydropower is the one of the cleanest one among new and renewable energy with less green house gas emissions. Recently, the necessity of developing small hydropower is emerging since its remaining potential resources in this country are abundant. However, a survey or research on the small hydropower development has been hardly performed since the 1990#s. These circumstances encourages a systematic approach for the small hydropower development. The purpose of this study is to propose a methodology of the location analysis for developing small hydropower. To this end, constraint and location criteria with weights are established and quantification method of each factor is presented. Especially, the analysis procedure is established on the basis of GSIS. Also the study focus on raising the objectivity and precision of analysis by developing system model with automatic search. The proposed methodology is applied to Bochung stream in Keum Riverbasin. The result selects the four and two locations of dam type and run-of-river type respectively. This study will be beneficial to the future activation of small hydropower development as a fundamental work.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.28 no.1
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• pp.59-65
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• 2010

The purpose of this study is to analyze the risk of the forest fire, considering the topography and the forest, for establishing disaster prevention measures of cultural heritage, Uireung, over in Cheonjang-mountain. To do that, we estimate the occurrence and spread of the forest fire over in Cheonjang-mountain through a forest fire probability model(logistic regression), using the space characteristic data($100m{\times}100m$). The factor, occurrence of the forest fire, are diameter class, southeast, southwest, south, coniferous, deciduous, and mixed forest. We assume the probability of the fire forest in each point as follow : [1+exp{-(-4.8081-(0.02453*diameter class)+(0.6608*southeast)+(0.507*southwest)+(0.7943*south)+(0.29498*coniferous forest)+(0.28897*deciduous forest)+(0.17788*mixed forest))}]$^{-1}$. To divide dangerous zone of the big forest fire, we make the basic materials for disaster prevention measures, through the map of coniferous forests, deciduous forests, and mixed forest. The damage of cultural heritage caused by a forest fire will be reduced through the effective preventive measures, by forecast a forest fire to using this study.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.8
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• pp.62-68
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• 2016

The feeder cable assembly is an automotive part used for telecommunication. If it malfunctions, the control and safety of the automobile can be put at risk. ALT (Accelerated Life Testing) is a testing process for products in which they are subjected to conditions (stress, strain, temperatures, etc.) in excess of their normal service parameters in an attempt to uncover faults and potential modes of failure in a short amount of time. Failure is caused by defects in the design, process, quality, or application of the part, and these defects are the underlying causes of failure or which initiate a process leading to failure. Thermal shock occurs when a thermal gradient causes different parts of an object to expand by different amounts. Thermal shock testing is performed to determine the ability of parts and components to withstand sudden changes in temperature. In this research, the main causes of failure of the feeder cable assembly were snapping, shorting and electro-pressure resistance failure. Using the Coffin-Manson model for ALT, the normal conditions were from Tmax = $80^{\circ}C$ to Tmin = $-40^{\circ}C$, the accelerated testing conditions were from Tmax = $120^{\circ}C$ to Tmin = $-60^{\circ}C$, the AF (Acceleration Factor) was 2.25 and the testing time was reduced from 1,000 cycles to 444 cycles. Using the Bxlife test, the number of samples was 5, the required life was B0.04%.10years, in the acceleration condition, 747 cycles were obtained. After the thermal shock test under different conditions, the feeder cable assembly was examined by a network analyzer and compared with the Weibull distribution modulus parameter. The results obtained showed good results in acceleration life test mode. For the same reliability rate, the testing time was decreased by a quarter using ALT.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.10
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• pp.7078-7088
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• 2015

This study examined effects of health behaviors and sleep related factor on cognitive function in the elderly hypertensive patients. Data were collected through a face to face interview survey with structured questionnaire form 140 elderly with hypertension ($age{\geq}65years$) from February 5 to May 1, 2013. Research instruments included Pittsburgh Sleep Quality Index(PSQI), Epworth Sleepiness Scale(ESS) and Korean version the Mini-Mental State Examination(MMSE-K). Cognitive function was negatively related to degradation in quality of sleep(r=-.29, p<.001). Sleep duration were negatively related to body mass index(r=-.18, p=.032) and degradation in quality of sleep(r=-.59, p<.001). Sleep duration was positively related to daytime sleepiness(r=.22, p=.008). Hierarchical multiple regression showed that age, education levels and living arrangement were associated with cognitive function(F=8.56, p<.001, Adjusted $R^2=.14$). After controlling for demographic characteristics and health behaviors, degradation in quality of sleep(${\beta}=-.27$, p=.008) was identified as significant predictors of cognitive function. This final model explained 17.0% of the cognitive function in the elderly hypertensive patients(F=4.09, p<.001). Therefore, as a strategy improving cognitive function of the elderly with hypertension, therapeutic intervention should be developed to improve quality of sleep considering age, education levels and living arrangement.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.11
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• pp.5476-5487
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• 2013

From foreign and/or domestic investors' perspectives, it may be interesting to find any financial attributes or profile of the firms headquartered in 'Chungcheong' province concerning profitability, given that this subject so far drew less attention in the previous literature. This study performed three hypothesis tests on the profitability indicator by utilizing the models such as the 'panel data' one and the 'logistic' regression one, applying a modified 'Dupont' system. With respect to the major findings, the results identified that the proxies measuring leverage across the book-value(BVLEV1) and the market-value(MVLEV1) bases, were statistically significant constituents determining profitability. Another explanatory variable, SIZE, with its positive and statistically significant relationship to the indicator, represented that the firms in the province were smaller than their counterparts in the other regional areas in Korea. DRELY applying a modified 'Dupont' system, found to be the only statistically significant discriminating factor between these comparison groups. As one of the primary contributions of this study, the outcomes may be used by the financial institutions operated across the regions including Seoul Metropolitan area, when implementing their lending practices to provide funds for potential borrowers such as the firms belonging to 'Chungcheong' province.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.772-779
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• 2019

This study identified the relationship between leisure attitudes, leisure promotion, leisure drugs, leisure satisfaction, and the intention to rejoin maritime sports by the participants of this study. The researchers selected 542 adult men and women who live in Seoul and the Incheon, Gyeonggi and Chungcheong provinces, and who were currently engaged in marine sports activities. Data processing was performed using SPSS 21.0 and AMOS 18.0 for the frequency analysis, reliability analysis, confirmatory factor analysis, correlation analysis and structural equation model analysis. The results of this study were as follows. First, the leisure attitudes of marine sports participants did not affect the promotion of leisure (p>.05). Second, the attitude towards leisure of the marine sports participants had a negative effect on using leisure pharmaceuticals (p<.05). Third, the leisure attitudes of marine sports participants affected their leisure satisfaction (p<.05). Fourth, the promotion of leisure activities of the marine sports participants did not affect their leisure satisfaction (p>.05). Fifth, the leisure restrictions of marine sports participants did not affect their leisure satisfaction (p>.05). Sixth, the leisure activities of marine sports participants affected the intention of rejoining (p<.05).