• Nutrition Research and Practice
• /
• v.15 no.6
• /
• pp.715-731
• /
• 2021

BACKGROUND/OBJECTIVES: Premenstrual syndrome (PMS) is a disorder characterized by repeated emotional, behavioral, and physical symptoms before menstruation, and the exact cause and mechanism are uncertain. Hyperprolactinemia interferes with the normal production of estrogen and progesterone, leading to PMS symptoms. Thus, we judged that the inhibition of prolactin hypersecretion could mitigate PMS symptoms. MATERIALS/METHODS: Hordeum vulgare L. extract (HVE), Chrysanthemum zawadskii var. latilobum extract (CZE), and Lomens-P0 the mixture of these extracts were tested in subsequent experiments. The effect of extracts on prolactin secretion at the in vitro level was measured in GH3 cells. Nitric oxide and pro-inflammatory mediator expression were measured in RAW 264.7 cells to confirm the anti-inflammatory effect. Also, the hyperprolactinemic Institute for Cancer Research (ICR) mice model was used to measure extract effects on prolactin and hormone secretion and uterine inflammation. RESULTS: Anti-inflammatory effects of and prolactin secretion suppress by HVE and CZE were confirmed through in vitro experiments (P < 0.05). Treatment with Lomens-P0 inhibited prolactin secretion (P < 0.05) and restored normal sex hormone secretion in the hyperprolactinemia mice model. In addition, extracts significantly inhibited the expression of pro-inflammatory biomarkers, including interleukin-1𝛽, and -6, tumor necrosis factor-𝛼, inducible nitric oxide synthase, and cyclooxygenase-2 (P < 0.01). We used high-performance liquid chromatography analyses to identify tricin and chlorogenic acid as the respective components of HVE and CZE that inhibit prolactin secretion. The Lomens-P0, which includes tricin and chlorogenic acid, is expected to be effective in improving PMS symptoms in the human body. CONCLUSIONS: The Lomens-P0 suppressed the prolactin secretion in hyperprolactinemia mice, normalized the sex hormone imbalance, and significantly suppressed the expression of inflammatory markers in uterine tissue. This study suggests that Lomens-P0 may have the potential to prevent or remedy materials to PMS symptoms.

• The Journal of the Korea Contents Association
• /
• v.21 no.9
• /
• pp.632-643
• /
• 2021

The purpose of this study was to examine how the level of self-compassion of correctional workers influenced depression and the simple and double mediating effects of job stress and job autonomy. Although correctional officers experience high levels of stress and depression, there are limited strategies to protect their job performance. The total of 210 correctional workers in S. Korea were included in the final analysis using SPSS PROCESS Macro model 6. For the analysis, Korean Self-Compassion Scale (K-SCS), Korean occupational stress scale (KOSS), and Center for Epidemiological Studies Depression Scale (CESDS) were used. The results of the study were as follows. First, the correlation analysis showed statistically significant relationships between the variables(p<.01). Second, the simple mediating effect of job autonomy was found in the relationship between the self-compassion and depression as well as the double mediating effect of job stress and job autonomy. The influences of low level of self-compassion on mental health (depression) could be modified by improving the level of work related empowerment (job autonomy) as a protective factor. Based on the results of the study, the further study suggestions and limitations were discussed.

• Journal of the Society of Disaster Information
• /
• v.17 no.2
• /
• pp.254-265
• /
• 2021

Purpose: Inspection and diagnosis on the performance and safety through domestic port facilities have been conducted for over 20 years. However, the long-term development strategies and directions for facility renewal and performance improvement using the diagnosis history and results are not working in realistically. In particular, in the case of port structures with a long service life, there are many problems in terms of safety and functionality due to increasing of the large-sized ships, of port use frequency, and the effects of natural disasters due to climate change. Method: In this study, the maintenance history data of the gravity type quay in element level were collected, defined as big data, and a predictive approximation model was derived to estimate the pattern of deterioration and aging of the facility of project level based on the data. In particular, we compared and proposed models suitable for the use of big data by examining the validity of the state-based deterioration pattern and deterioration approximation model generated through machine learning algorithms of GP and SGP techniques. Result: As a result of reviewing the suitability of the proposed technique, it was considered that the RMSE and R² in GP technique were 0.9854 and 0.0721, and the SGP technique was 0.7246 and 0.2518. Conclusion: This research through machine learning techniques is expected to play an important role in decision-making on investment in port facilities in the future if port facility data collection is continuously performed in the future.

• 한국노년학
• /
• v.38 no.4
• /
• pp.905-922
• /
• 2018

The purpose of this study was to examine the mediating effects of generativity and ego-integration on the relationship between leisure activity experience and life satisfaction after retirement, and to clarify the structural relationship between variables. In this study, SPSS for window 21.0 program r and AMOS 18.0 were used. First, correlation analysis was performed among the main variables to investigate the relationship between variables. Next, confirmatory factor analysis and fit of hypothesis model were confirmed. Finally, the bootstrapping procedure was conducted to verify the significance of the indirect effect. The main results of this study are as follows. First, leisure activity experience, life satisfaction, generativity and ego-integration were statistically correlated. Second, in the research model, there was a double-mediated effect of the generativity and ego-integration in the married couple's leisure experience and life satisfaction after retirement. The indirect effect that affects life satisfaction was found to be greater through mediation. This study has limitations in collecting data on retirees who have retirement experience or retired husbands who have. The reason for this is that there is a difference in the sense of life satisfaction between the couple and their spouse, and the significance of the path between the variables may also differ. Therefore, the follow-up study suggests the necessity of analyzing only the couple.

• 교육공학연구
• /
• v.33 no.4
• /
• pp.1001-1024
• /
• 2017

Flipped classroom has used widely in university in that its unique structure can facilitate learners' higher-thinking skills and promote competencies. Learners are expected to extend knowledge through performing online and offline, but they have difficulty in understanding their roles and specific behaviors to achieve the learning goals in the flipped learning. Therefore, a guidance for students has been required to support learners' mastery learning. The purpose of this study is to identify successful learners' characteristics in terms of "competency". For this, three-phased competency modeling was employed. In Phase I, Behavioral Event Interviews were conducted with eight learners of the flipped classroom. In Phase II for identifying competencies and developing a competency model, the data was coded, followed by testing reliability of the coding. Based on the meaning codes, competencies and behavioral indexes were developed. The final competencies consist of learning orientation, learning management, feedback seeking, peer interaction, and knowledge extension. In Phase III, validation of the competency model was conducted by explanatory factor analysis. As last, competencies were aligned by the two-phase of the flipped classroom. The finding will be used as the guidance for the learners and instructors in the flipped classroom.

• Journal of the Korea Convergence Society
• /
• v.9 no.12
• /
• pp.175-180
• /
• 2018

In this study, CFRP was manufactured with the laminate angle of $45^{\circ}$. The specimen of TDCB bonded with the adhesive for structure was designed by CATIA and the analysis was progressed by using the finite element analysis program of ANSYS. This study model was designed on the basis of British industry and ISO standard and the configuration factor(m) was established with variable according to the angle of model configuration. As the study result of this paper, the maximum deformations at the specimens with the tapered angles of $4^{\circ}$ and $8^{\circ}$ become most as 12.628 mm and least as 12.352mm respectively. Also, the maximum equivalent stresses at the specimens with the tapered angles of $6^{\circ}$ and $8^{\circ}$ become most as 9210.3 MPa and least as 4800.5 MPa respectively. The damage data of TDCB structure with the laminate angle which was manufactured with CFRP could be secured through this study result. As the damage data of TDCB structure bonded with CFRP obtained on the basis of this study result are utilized, the esthetic sense can be shown by being grafted onto the machine or structure at real life.

• Clean Technology
• /
• v.25 no.1
• /
• pp.56-62
• /
• 2019

The equilibrium, kinetic and thermodynamic parameters of adsorption of murexide by granular activated carbon were investigated. The experiment was carried out by batch experiment with the variables of the amount of the adsorbent, the initial concentration of the dye, the contact time and the temperature. The isothermal adsorption equilibrium was best applied to the Freundlich equation in the range of 293 ~ 313 K. From the separation factor (${\beta}$) of Freundlich equation, it was found that adsorption of murexide by granular activated carbon could be the appropriate treatment method. The adsorption energy (E) obtained from the Dubinin- Radushkevich equation shows that the adsorption process is a physical adsorption process. From the kinetic analysis of the adsorption process, pseudo second order model is more consistent than pseudo first order model. It was found that the adsorption process proceeded to a spontaneous process and an endothermic process through Gibbs free energy change ($-0.1096{\sim}-10.5348kJ\;mol^{-1}$) and enthalpy change ($+151.29kJ\;mol^{-1}$). In addition, since the Gibbs free energy change decreased with increasing temperature, adsorption reaction of murexide by granular activated carbon increased spontaneously with increasing temperature. The entropy change ($147.62J\;mol^{-1}\;K^{-1}$) represented the increasing of randomness at the solid-solution interface during the adsorption reaction of murexide by activated carbon.

• 한국노년학
• /
• v.36 no.3
• /
• pp.581-594
• /
• 2016

This study aims to observe the effect of age friendliness of cities on life satisfaction and to suggest ways to improve quality of life of older people. The secondary data sets were used in this study, which were '2014 Survey of Living Conditions and Welfare Needs of Korean Older People.' It's a nationwide data collected by the Korean Institute of Health and Social Affairs. A multilevel analysis model was used to analyze the data because the level of age friendliness has a hierarchical data structure. Results showed as follows: First, life satisfaction of older adults is affected by the level of age-friendliness of cities in which they live. Second, on the personal level, older people showed low life satisfaction when they are more older and have more chronic diseases and more depressed. On the contrary, life satisfaction of older adults increased when they have higher education and income. Third, on the city level, older people showed higher life satisfaction when they live in high employment rate area and participation rate of lifelong education. Cautions should be placed when interpret the result because the variables that represent the characteristics of age friendless of cities were constituted arbitrary. Based on the results, suggestions for improving the city environment age-friendly and implications for social welfare practice were provided.

• Journal of the Korean Society of International Agriculture
• /
• v.30 no.4
• /
• pp.320-327
• /
• 2018

The purpose of this study is to suggest the policy direction for promoting Korean grape, Shine Muscat, export to China. For this, the data were collected from 102 Chinese who live in Guangzhou province. The survey was conducted from Oct 10th to 13th 2017. PLS-SEM model is used to investigate the main factors that cause the Chinese consumers to purchase Korean grape, Shine Muscat. This study finds that the post-evaluation factor is more important to obtain final evaluation and to purchase Korean grape in the future. Thus farmers and research institutes should investigate how to improve the quality for the sweetness and the texture of the grape, reflecting the Chinese consumers' preference.

• Journal of the Korean Data Analysis Society
• /
• v.20 no.6
• /
• pp.3155-3167
• /
• 2018

The purpose of this study was to investigate factor of principals' trust in teachers which principals of secondary school recognized and to explore their needs on building trust in teachers. For this purpose, this study used survey question of which investigated conception of principals' trust in teachers and performed with 296 secondary school principals. First, gap of two statuses was proven by t-test. Second, the order of priority was presented by Borich model. Third, the result of the locus for focus model was presented in the form of coordinate plane. Lastly, top priority and the second priority were determined. The result of this study was as following. 'Class management, instruction, and caring for students' category is highest in needs of secondary school principals on trust in teachers. Next, second priority category is 'partnership with parents'. It means secondary school principals recognize that students and parents are most important on education and their trust in teachers. Based on the review, finding and implications are discussed.