• Biomolecules & Therapeutics
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• v.29 no.3
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• pp.295-302
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• 2021

Microglial priming is the process of microglial proliferation and activation in response to neurodegeneration and abnormal protein accumulation. Priming makes microglia susceptible to secondary inflammatory stimuli and causes exaggerated inflammatory responses. In the present study, we established a microglial priming model in mice by administering a single injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 20 mg/kg). MPTP induced microglial activation without dopaminergic degeneration; however, subsequent treatment with a sub-toxic dose of lipopolysaccharides (LPS) induced an amplified inflammatory response and caused nigrostriatal dopaminergic degeneration. These pathological and inflammatory changes, including microglial activation and dopaminergic cell loss in the substantia nigra (SN) area were reversed by papaverine (PAP) administration. In addition, MPTP/LPS enhanced interleukin-1β (IL-1β) expression and processing via nod-like receptor protein 3 (NLRP3) inflammasome activation in the SN region of mice. However, PAP treatment suppressed inflammasome activation and subsequent IL-1β maturation. Moreover, PAP inhibited nuclear factor-κB (NF-κB) and enhanced cAMP-response element binding protein (CREB) activity in the SN of MPTP/LPS mice. These results suggest that PAP inhibits the activation of NLRP3 inflammasome by modulating NF-κB and CREB signaling pathways, which results in reduced microglial activation and neuronal cell death. Thus, PAP may be a potential candidate for the treatment of Parkinsons's disease, which is aggravated by systemic inflammation.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2003.05a
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• pp.51-59
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• 2003

Marine Casualty Forecasting System (MCFS) is to broadcast the prediction number and risk level of marine casualties as like daily weather forecasting. The MCFS consists of marine casualty numerical D/B, prediction model and, three-dimensional statistics visualization system. The implementation procedure for the numerical D/B is described in the paper. The data relating to a total of 724 ship casualties in the west-southern sea area (latitude 33$^{\circ}$N∼35$^{\circ}$ and longitude 124$^{\circ}$E∼127$^{\circ}$E) of Korean peninsula for 11 years (1999∼2000) have been compiled. The analysis method of numerical D/B is proposed and discussed its usability.

• Journal of the Korean Chemical Society
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• v.47 no.3
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• pp.191-198
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• 2003

The pairwise energy model (PEM) assumes that the cross section for the reaction cross section for the reaction A+BC$\{leftrightarrow}$B+C, where B and C are isotopes of hydrogen, depends on only the pairwise relative energy Es between A and B. Until now, the PEM has been used to interpret theoretically the isotope effect for the reactions such as $O(^3P)+HD,\;Ar^++(H_2,\;D_2,and\;HD)$. In this paper we carry out extensive quasiclassical trajectory calculations for the three possible reactions $Cl+H_2$ and HD and show that the PEM works very well at high energy. In particular we are able to accurately predict the intramolecular isotope effect at high energy for the reaction of Cl+HD using only the cross section data for $Cl+H_2$. To understand that the PEM works so well at high energy, the internal energy distributions for the products are examined. The distributions for three reactions are different at a fixed relative collision energy E but are approximately same at a fixed pairwise energy Es. This suggests that the PEM works very well at high energy. We believe the conclusions reached here will apply to other A+BC systems.

• Journal of Biomedical Engineering Research
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• v.3 no.1
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• pp.9-16
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• 1982

Removal of urea and vitamin B12 was simulated using two pool models with closed loop dialysis, open loop dialysis, and hemodiafiltrations with predilution and postdilulion. It was found that urea removal was limited by dialyzer clearance, however B12 removal was limited both by the resistance between ECF and ICF and by dialyzer clearance. Open loop dialysis was better than closed loop dialysis in terms of dialysate requirement and removal efficiency. Residual renal function plays an important role in removing vitamin B12. Dialysis frequency more than twice/wide does not have great effect on removal efficiency, but has the effect of reducing the difference between maximum and minimum cancentrations during dialysis period.

• Journal of Ocean Engineering and Technology
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• v.12 no.3 s.29
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• pp.96-102
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• 1998

This paper presents to create a SAC(Sectional Area Curve) using an ANFIS(Adaptive-Network-based Fuzzy Inference System). First, it defines SACs of parent ships by using a B-spline approximation and a genetic algorithm and accumulates a database about SAC's control points. Second, it learns an ANFIS from parent ship data, which are related with principal dimensions and SAC's control points. This process is to model an ANFIS for SAC inferreice. When an ANFIS modeling is completed, we can determine a SAC through an ANFIS inferring.

• Journal of Animal Science and Technology
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• v.45 no.5
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• pp.711-724
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• 2003

Some growth curve models were used to fit individual growth of 1,083 Hanwoo cows born from 1970 to 2001 in Daekwanryeong branch, National Livestock Research Institute(NLRI). The effects of year-season of birth and age of dam were analyzed. In analysis of variance for growth curve parameters, the effects of birth year-season were significant for mature weight(A), growth ratio(b) and maturing rate(k)(P〈.01). The effects of age of dam were significant for growth ratio(b) but not significant for mature weight(A) and maturing rate(k). The linear term of the covariate of age at the final weights was significant for the A(P〈.01) and k(P〈.01) of Gompertz model, von Bertalanffy model and Logistic model. For the growth curve parameters fitted on individual data using Gompertz model, von Bertalanffy model and Logistic model, resulting the linear contrasts(fall-spring), Least square means of A in three nonlinear models were higher cows born at fall and A of Logistic model was significant(P〈.05) between the seasons. According to the results of the least square means of growth curve parameters by age of dam, least square means of mature weight(A) in Gompertz model was largest in 6 year and smallest estimating for 3 and 8 years of age of dam. The growth ratio(b) was largest in 2 year of age of dam and smallest estimating in 8 year. The A and k were not different by age of dam(p〉.05), On the other hand, the b was different by age of dam(p〈.01). The estimate of A in von Bertalanffy model was largest in 6 year and smallest in 8 and 9 years of age of dam. The b was largest in 2 year and tend to decline as age of dam increased. The A and k were not different by age of dam(p〉.05), On the other hand, the b was highly significant by age of dam(p〈.01).

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.167-174
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• 2014

Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore investigated the effects of barbigerone on all three in the B16F10 tumor model established in both zebrafish and mouse models, and explored underlying molecular mechanisms. In vitro, barbigerone inhibited B16F10 cell proliferation, survival, migration and invasion and suppressed human umbilical vascular endothelial cell migration, invasion and tube formation in concentration-dependent manners. In the transgenic zebrafish model, treatment with $10{\mu}M$ barbigerone remarkably inhibited angiogenesis and tumor-associated angiogenesis by reducing blood vessel development more than 90%. In vivo, barbigerone significantly suppressed angiogenesis as measured by H and E staining of matrigel plugs and CD31 staining of B16F10 melanoma tumors in C57BL/6 mice. Furthermore, it exhibited highly potent activity at inhibiting tumor growth and metastasis to the lung of B16F10 melanoma cells injected into C57BL/6 mice. Western blotting revealed that barbigerone inhibited phosphorylation of AKT, FAK and MAPK family members, including ERK, JNK, and p38 MAPKs, in B16F10 cells mainly through the MEK3/6/p38 MAPK signaling pathway. These findings suggested for the first time that barbigerone could inhibit tumor-angiogenesis, tumor growth and lung metastasis via downregulation of the MEK3/6/p38 MAPK signaling pathway. The findings support further investigation of barbigerone as a potential anti-cancer drug.

• The Korean Journal of Health Service Management
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• v.8 no.2
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• pp.197-208
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• 2014

This study examined the relationship between social support and depressive symptom among the middle and old-aged people, using dataset of the Korean Longitudinal Study of Ageing(KLoSA 3rd). The subjects were 7,874 persons aged 45 and over. Using this data, social support variables and its relation to depressions was observed based on social network model. A multiple regression model was used to study an association between social support and depressive symptom, controlling for socio-economic characteristics, health status and behavior. Also, this paper run two subgroup regression models based on gender of subjects (male, female), controlling for confounding variables. Authors found that there was lower the number of meetings with friends (1~3 times in a week: b=0.597, p<0.0001; 1~2 times in a month: b=0.609, p<0.0001; 1~6 times in a year or under: b=1.598, p<0.0001) and negative relationship between spouse satisfaction (b=-0.007, p=0.0237), children satisfaction (b=-0.019, p<0.0001) and depressive symptom. Also quantitative effect differences were compared according to gender and its effect on depression. Compared to the male group, female group showed significant difference in quantitative effect with number of meetings with friends and spouse satisfaction, but children satisfaction didn't show clear differences according to gender. This study suggested the importance of social support for promoting mental health among the middle and old-aged people.

• Journal of the Korean Society of Marine Environment & Safety
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• v.20 no.3
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• pp.323-333
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• 2014

In this paper, the wakes behind a square cylinder were simulated using two kinds of different turbulence models for the eddy viscosity concept such as the zero- and the one-equation model in which the former is the mixing length model and the latter is the k-equation model. For comparison between numerical and analytical solutions, we employed three skill assessments: the correlation coefficient(r) for the similarity of the wake shape, the error of maximum velocity difference(EMVD) for the accuracy of wake velocity and the ratio of drag coefficient(RDC) for the pressure distribution around the structure. On the basis of the numerical results, the feasibility of each model for wake simulation was discussed and a suitable value for the empirical constant was suggested in these turbulence models. The zero-equation model, known as the simplest turbulence model, overestimated the EMVD and its absolute mean error(AME) for r, EMVD and RDC was ranging from 20.3 % to 56.3 % for all test. But the AME by the one-equation model was ranging from 3.4 % to 19.9 %. The predicted values of the one-equation model substantially agreed with the analytical solutions at the empirical mixing length scale $L=0.6b_{1/2}$ with the AME of 3.4 %. Therefore it was concluded that the one-equation model was suitable for the wake simulation behind a square cylinder when the empirical constant for eddy viscosity would be properly chosen.

• Journal of the Korean Association of Geographic Information Studies
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• v.17 no.3
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• pp.160-174
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• 2014

The purpose of this paper is to develop a meso-scale grid-based continuous hydrological model and apply to assess the future watershed hydrology by climate change. The model divides the watershed into rectangular cells, and the cell profile is divided into three layered flow components: a surface layer, a subsurface unsaturated layer, and a saturated layer. Soil water balance is calculated for each grid cell of the watershed, and updated daily time step. Evapotranspiration(ET) is calculated by Penman-Monteith method and the surface and subsurface flow adopts lag coefficients for multiple days contribution and recession curve slope for stream discharge. The model was calibrated and verified using 9 years(2001-2009) dam inflow data of two watersheds(Chungju Dam and Soyanggang Dam) with 1km spatial resolution. The average Nash-Sutcliffe model efficiency was 0.57 and 0.71, and the average determination coefficient was 0.65 and 0.72 respectively. For the whole Han river basin, the model was applied to assess the future climate change impact on the river bsain. Five IPCC SRES A1B scenarios of CSIRO MK3, GFDL CM2_1, CONS ECHO-G, MRI CGCM2_3_2, UKMO HADGEMI) showed the results of 7.0%~27.1 increase of runoff and the increase of evapotranspiration with both integrated and distributed model outputs.