• Food Science of Animal Resources
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• v.37 no.3
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• pp.368-375
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• 2017

Clostridium difficile infection (CDI) is the main cause of hospital-acquired diarrhea that can cause colitis or even death. The medical-treatment cost and deaths caused by CDI are increasing annually worldwide. New approaches for prevention and treatment of these infections are needed, such as the use of probiotics. Probiotics, including Bifidobacterium spp. and Lactobacillus, are microorganisms that confer a health benefit to the host when administered in adequate amounts. The effect of Bifidobacterium longum ATCC 15707 on infectious disease caused by C. difficile 027 was investigated in a mouse model. The survival rates for mice given the pathogen alone, and with live cells, or dead cells of B. longum were 40, 70, and 60%, respectively. In addition, the intestinal tissues of the B. longum-treated group maintained structural integrity with some degree of damage. These findings suggested that B. longum ATCC 15707 has a function in repressing the infectious disease caused by C. difficile 027.

• Korean journal of food and cookery science
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• v.32 no.3
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• pp.363-369
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• 2016

Purpose: The purpose of this study was to understand the interrelationships among diversity management, employees' job engagement, and organizational commitment in a deluxe hotel. Methods: In a total of 344 F & B employees obtained from empirical research, this study reviewed the reliability and fitness of the research model and verified a total of 4 hypotheses using the Amos program. Results: The proposed model provided an adequate fit to the data, $x^2$=316.722 (df=112), CMIN/df=2.828, GFI=0.899, NFI=0.941, IFI=0.961, TLI=0.953, CFI=0.961, RMSEA=0.073. SEM results showed that diversity management (building cultural awareness: ${\beta}$=0.206; pragmatic management policy; ${\beta}$=0.315) had a positive and significant influence on job engagement. Also, employees' job engagement (${\beta}$=0.623) had significant positive effects on organizational commitment. Conclusion: This study shows diversity management of hotel employees and its effectiveness as well as which diversity management is needed positive attitude.

• Journal of the Korean Magnetic Resonance Society
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• v.6 no.2
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• pp.94-102
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• 2002

An interesting recent application of intermolecular NOE experiment is the saturation transfer difference NMR(STD-NMR) method that is useful in screening compound libraries to identify bio-active ligands. This technique also identifies the group epitopes of the bound ligand in a reversibly forming protein-ligand complex. We present here a complete relaxation and conformational exchange matrix (CORCEMA) theory (Moseley et al., J. Magn. Reson. B, 108, 243-261 (1995)) applicable for the STD-NMR experiment. Using some ideal model systems we have analyzed the factors that influence the STD intensity changes in the ligand proton NMR spectrum when the resonances from some protons on the receptor protein are saturated. These factors will be discussed and some examples of its application in some model systems will be presented. This CORCEMA theory for STD-NMR and the associated algorithm are useful in a quantitative interpretation of the STD-NMR effects, and are likely to be useful in structure-based drug design efforts. They are also useful in a quantitative characterization of protein-protein (or protein-nucleic acid) contact surfaces from an intermolecular cross-saturation NMR experiment.

• Journal of Integrative Natural Science
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• v.11 no.2
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• pp.93-100
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• 2018

Caspases, a family of cysteinyl aspartate-specific proteases plays a central role in the regulation and the execution of apoptotic cell death. Caspase-3 has been proven to be an effective target for reducing the amount of cellular and tissue damage because the activation of caspases-3 stimulates a signalling pathway that ultimately leads to the death of the cell. In this study, Hologram based Quantitative Structure Activity Relationship (HQSAR) models was generated on a series of Caspase-3 inhibitors named 3, 4-dihydropyrimidoindolones derivatives. The best HQSAR model was obtained using atoms, bonds, and hydrogen atoms (A/B/H) as fragment distinction parameter using hologram length 61 and 3 components with fragment size of minimum 5 and maximum 8. Significant cross-validated correlation coefficient ($q^2=0.684$) and non cross-validated correlation coefficients ($r^2=0.754$) were obtained. The model was then used to evaluate the eight external test compounds and its $r^2_{pred}$ was found to be 0.559. Contribution map show that presence of pyrrolidine sulfonamide ring and its bulkier substituent's makes big contributions for improving the biological activities of the compounds.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2001.11a
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• pp.257-261
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• 2001

This paper presents the implementation of wide-band RFIC amplifier operating from near 50MHz to 3GHz using Tachyonics SiGe HBT foundry. Voltage shunt feedback is used for the flat gain and the broad band impedance matching. Initial design parameters are calculated using the low frequency small signal analysis. Since the HBT model was not available at the design time, discrete tuning board was made for fine tuning in the low frequency range. Fabricated amplifier shows 12dB gain with 1dB fluctuation and PldB reaches 15dBm at 850MHz.

• Journal of the Korean Society of Food Science and Nutrition
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• v.23 no.2
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• pp.298-302
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• 1994

This study is carried out in order to investigate to the physical property of Castella. The material is 19 kinds of Castella on the market in Kyushu area.As an result of the sensory evaluation for Castella, it could be classified into 3 types ; a) high grade, C) low grade, and B) midium grade.The results are summarized as follow. The water content of 3 type Castella was most 26-30% but Korea's was more lower . ΔE of A an dB type Castella was similiar , but A and C types was very different. in the Creep test, 3 types are all the 6-element Voigt model, consisting of Hookean body , Newtonian body and two sets of Voigt body. Eo of A type is 13-36% higher than other types. The parts of retardation strain of A type are 21-41% lower than B type, 8-13% higher than C type, respectively.

• The Journal of the Acoustical Society of Korea
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• v.8 no.1
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• pp.81-87
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• 1989

This paper discribes the method associated with modeling of Korean phonemes. Hidden Markov models(HMM's) may be viewed as an effective technique for modeling the inherent nonstationarity of speech signal. We propose a 3-state phoneme model to represent the sequentially changing characteristics of phonemes, i.e., transition-to-stationary-to-transition. Also we clarify that the duration of a phoneme is an important factor to have an effect in recognition accuracy and show that improvement in recognition rate can be obtained by using duration-dependent 3-state hidden Markov models.

• Korean Journal of Food Science and Technology
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• v.37 no.6
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• pp.1012-1017
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• 2005

Predictive growth model of putrefactive bacteria of surimi-based imitation crab in the modified surimi-based imitation crab (MIC) broth was investigated. The growth curves of putrefactive bacteria were obtained by measuring cell number in MIC broth under different conditions (Initial cell number, $1.0{\times}10^2,\;1.0{\times}10^3$ and $1.0{\times}10^4$ colony forming unit (CFU)/mL; temperature, $15^{\circ}C,\;20^{\circ}C\;and\;25^{\circ}C$) and applied them to Gompertz model. The microbial growth indicators, maximum specific growth rate constant (k), lag time (LT) and generation time (GT), were calculated from Gompertz model. Maximum specific growth rate (k) of putrefactive bacteria was become fast with rising temperature and fastest at $25^{\circ}C$. LT and GT were become short with rising temperature and shortest at $25^{\circ}C$. There were not significant differences in k, LT and GT by initial cell number (p>0.05). Polynomial model, $k=-0.2160+0.0241T-0.0199A_0$, and square root model, $\sqrt{k}=0.02669$ (T-3.5689), were developed to express the combination effects of temperature and initial cell number, The relative coefficient of experimental k and predicted k of polynomial model was 0.87 from response surface model. The relative coefficient of experimental k and predicted k of square root model was 0.88. From above results, we found that the growth of putrefactive bacteria was mainly affected by temperature and the square root model was more credible than the polynomial model for the prediction of the growth of putrefactive bacteria.

• Journal of applied mathematics & informatics
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• v.17 no.1_2_3
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• pp.361-377
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• 2005

A mathematical model dealing with a prey-predator system with disease in the prey is considered. The functional response of the predator is governed by a Hoilling type-2 function. Mathematical analysis of the model regarding stability and persistence has been performed. The effect of delay and diffusion on the above system is studied. The role of diffusivity on stability and persistence criteria of the system has also been discussed.

• The Pure and Applied Mathematics
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• v.12 no.3 s.29
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• pp.169-178
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• 2005

In this paper we study the existence and local asymptotic limit of the topological Chern-Simons vortices of the CP(1) model in $\mathbb{R}^2$. After reducing to semilinear elliptic partial differential equations, we show the existence of topological solutions using iteration and variational arguments & prove that there is a sequence of topological solutions which converges locally uniformly to a constant as the Chern­Simons coupling constant goes to zero and the convergence is exponentially fast.