• YAKHAK HOEJI
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• v.55 no.5
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• pp.379-384
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• 2011

The aim of this study was to reduce the side effects and to develop effective drugs using bucillamine (B), lornoxicam (L), and its mixtures on the analgesic and anti-inflammatory effects. With this goal, we compared their effects on the four different mixtures with a sole treatment (B 40 mg/kg and L 1.60 mg/kg). The mixture 1, 2, 3, and 4 ratios of B to L (mg/kg) were 20 to 0.80, 40 to 1.60, 80 to 3.20, and 40 to 1.14, respectively. In terms of acetic acid-induced vascular permeability, B and L inhibited the amount of dye leakage approximately 37.8 and 66.5%, respectively. And mixture 1, 2 and 3 showed inhibition of 47.4%, 81.5%, and 84.3%. The mixture 4 inhibited approximately 49.4%. In carrageenan- induced paw edema model, mixtures of B and L effectively inhibited paw edema measured 1/2~3 hours after carrageenan injection. Especially, mixture 2 inhibited 50.7%, 52.7%, 50.9% of paw edema after 1, 2, and 3 hr, significantly. We also examined an analgesic effect using the writhing test. In terms of the acetic acid-induced writhing syndrome, the control group showed writhing syndrome 18.5 times. B and L showed 9 and 6.3 times, inhibiting 51.6% and 65.9% respectively. And aspirin, as a positive control drug, showed the 7.1 times writhing syndrome. The mixture 1, 2, 3, and 4 also significantly inhibited the writhing syndrome to 62.2%, 93.0%, 51.4%, and 77.8%, respectively. From these results, we could suggest that the range of B and L ratio of 25 : 1 to 35 : 1 may be applicable to developing analgesic and anti-inflammatory drugs.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.4
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• pp.636-644
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• 2009

This paper presents a compact, low insertion loss, sharp rejection and wide band microstrip band pass filter that is composed rectangular loop resonator and step-impedance-open-stub(SIOS) for wireless data communication. The SIOS can be reduce length about 30% more than general $0.25{\lambda}$ stub. And the stub can the advantage of tuning impedance magnitude. In order to demonstrate agrement of this paper prove, the optimized wide band pass filters are realized and experimented. A transmission line model used to calculate the frequency response of the new filters shows good agreement with measurements. The filter has 3dB fractional bandwith of 52.5%(3.267GHz), an insertion loss of better than 0.33dB from 4.587GHz to 7.854GHz, and two rejection of greater than 30dB within 221MHz$(4.366GHz{\sim}4.587GHz)$ at low frequency band, 181MHz$(7.854GHz{\sim}8.035GHz)$ at high frequency band. Maximum rejection characteristics of the filter are -54dB at low frequency and -60dB at high frequency.

• Proceedings of the KIEE Conference
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• 2001.05a
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• pp.123-125
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• 2001

In general, the PSS/E program is used for analyzing KEPCO System in terms of stability and the EMTDC Program is needed to analyze the transient characteristics of power system. The FSS/E provides various control models such as exciter. governor and PSS models whereas there ale few control of models in EMTDC. In this paper. we developed an EMTDC model for IEEET3 exciter which has been applied in KEPCO system. The EMTDC model is developed by examining PSS/E control block and using User Define Model in addition to default.lib provided by EMTDC we verify the correctness of developed IEEET3 model with PSS/E and EMTDC simulation results for the same test system.

• Corrosion Science and Technology
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• v.9 no.1
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• pp.29-33
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• 2010

Laser machining technique, which is used focusing pulse YAG laser beam irradiation was applied to form area ratio controlled model cut-edge on pre painted Zn coated steels. A corrosion behavior of formed model cut-edge was investigated by rest potential measurement in 1 mol $m^{-3}$ NaCl with and without 0.5 kmol $m^{-3}$ $H_3BO_4$/0.05kmol$m^{-3}$ $Na_2B_4O_7$. The rest potential showed almost constant value with fluctuations. The amplitude of fluctuations increased with exposed area of steel surface. White corrosion products of zinc oxide and simonkollite was formed after the experiments at the formed model cut-edge.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.11a
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• pp.213-216
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• 2005

This paper presents force feedback control performance of a 3DOF haptic device that can be used for minimally invasive surgery (MIS). As a first step, a 3DOF electrorheological (ER) joint is designed using a spherical mechanism. And it is optimized based on the mathematical torque modeling. Subsequently, the master haptic device is manufactured by the spherical joint. In order to achieve desired force trajectories, model based compensation strategy is adopted for the ER master. Therefore, Preisach model fur the PMA-based ER fluid is identified using experimental first order descending (FOD) curves. A compensation strategy is then formulated through the model inversion to achieve desired force at the ER master. Tracking control performances for sinusoidal force trajectory are presented, and their tracking errors are evaluated.

• Journal of Integrative Natural Science
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• v.10 no.2
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• pp.85-94
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• 2017

Fibroblast growth factor receptor (FGFR) belongs to the family of receptor tyrosine kinase. They play important roles in cell proliferation, differentiation, development, migration, survival, wound healing, haematopoiesis and tumorigenesis. FGFRs are reported to cause several types of cancers in humans which make it an important drug target. In the current study, HQSAR analysis was performed on a series of recently reported 1H-Pyrazolo [3,4-b]pyridine derivatives as FGFR antagonists. The model was developed with Atom (A) and bond (B) connection (C), chirality (Ch), hydrogen (H) and donor/acceptor (DA) parameters and with different set of atom counts to improve the model. A reasonable HQSAR model ($q^2=0.701$, SDEP=0.654, NOC=5, $r^2=0.926$, SEE=0.325, BHL=71) was generated which showed good predictive ability. The contribution map depicted the atom contribution in inhibitory effect. A contribution map for the most active compound (compound 24) indicated that hydrogen and nitrogen atoms in the side chains of ring B as well as hydrogen atoms in the side chain of ring C and the nitrogen atom in the ring D contributed positively to the activity in inhibitory effect whereas, the lowest active compound (compound 04) showed negative contribution to inhibitory effect. Thus results of our study can provide insights in the designing potent and selective FGFR kinase inhibitors.

• The Journal of the Acoustical Society of Korea
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• v.36 no.5
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• pp.338-344
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• 2017

In this paper, an interpolation method of HRTF (Head-Related Transfer Function) is proposed for small-sized measurement data set, especially. The proposed algorithm is based on acoustic modeling of HRTFs, and the algorithm tries to interpolate the HRTFs via estimation the model coefficients. However, the estimation of the model coefficients is hard if there is lack of measurement points, so the algorithm solves the problem by a data augmentation using the VBAP (Vector Based Amplitude Panning). Therefore, the proposed algorithm consists of two steps, which are data augmentation step based on VBAP and model coefficients estimation step by least squares method. The proposed algorithm was evaluated by a simulation with a measured data from CIPIC (Center for Image Processing and Integrated Computing) HRTF database, and the simulation results show that the proposed algorithm reduces mean-squared error by 1.5 dB ~ 4 dB than the conventional algorithms.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.6A
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• pp.697-704
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• 2004

This paper describes the design and fabrication of an MMIC variable gain LNA for 5GHz wireless LAN applications, using 0.5${\mu}{\textrm}{m}$ gate length GaAs MESFET transistors. The advantages of high gain and low noise performance of E-MESFETS and excellent linear performance of D-MESFETS are combined as a cascode topology in this design. Behavioral model equations are derived from the MESFET nonlinear current voltage characteristics by using Turlington's asymptote method in a cascode configuration. Using the behavioral model equations, a 4${\times}$50${\mu}{\textrm}{m}$ E-MESFET as a common source amplifier and a 2${\times}$50${\mu}{\textrm}{m}$ D-MESFET as a common gate amplifier are determined for the cascode amplifier. The fabricated variable gain LNA shows a noise figure of 2.4dB, variable gain range of more than 17dB, IIP3 of -4.8dBm at 4.9GHz, and power consumption of 12.8mW.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.51 no.3
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• pp.405-413
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• 2015

Acoustic target strength (TS) measurement and theoretical acoustic scattering models were applied to estimate the TS for assessing the fish biomass. TS measurement was made of ex situ sailfin sandfish Arctoscopus japonicus at 70 and 120 kHz, and then compared to backscatter model prediction. The live sandfish was tethered in seawater using monofilament lines. Measurements were made versus incidence angle, $-50^{\circ}$ to $50^{\circ}$ relative to dorsal aspect directions. Distorted wave Born approximation (DWBA) model was used to calculated TS pattern. The TS values of sandfish (body length: 16.2 cm) at 70 and 120 kHz were -66.94 dB and -64.45 dB, respectively, and were about 20 dB lower than TS of other fishes in Korea waters. These TS levels were distributed within the range of the theoretical TS. Ex situ measurement and theoretical TS may be applied to improve acoustical detection and biomass estimation of the sandfish, and is necessary to measure with various lengths.

• Wind and Structures
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• v.27 no.2
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• pp.101-109
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• 2018

Wall jet flow exists widely in engineering applications, including the simulation of thunderstorm downburst outflows, and has been investigated extensively by both experimental and numerical methods. Most previous studies focused on the scaling laws and self-similarity, while the effect of lip thickness and external stream height on mean velocity has not been examined in detail. The present work is a numerical study, using steady Reynolds-Averaged Navier Stokes (RANS) simulations at a Reynolds number of $3.5{\times}10^4$, of a turbulent plane wall jet with an external stream to investigate the influence of the wall jet domain on downstream development of the flow. The comparisons of flow characteristics simulated by the Reynolds stress turbulence model closure (Stress-omega, SWRSM) and experimental results indicate that this model may be considered reasonable for simulating the wall jet. The confined wall jet is further analyzed in a parametric study, with the results compared to the experimental data. The results indicate that the height and the width of the wind tunnel and the lip thickness of the jet nozzle have a great effect on the wall jet development. The top plate of the tunnel does not confine the development of the wall jet within 200b of the nozzle when the height of the tunnel is more than 40b (b is the height of jet nozzle). The features of the centerline flow in the mid plane of the 3D numerical model are close to those of the 2D simulated plane wall jet when the width of the tunnel is more than 20b.