• Journal of Microbiology and Biotechnology
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• 제10권3호
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• pp.399-404
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• 2000

The adjuvant effect of a muramyl dipeptide (MDP) derivative, MDP-Lys(L18), on enhancing of antitumor immunity induced by X-irradiated tumor cells against highly metastatic B16-BL6 melanoma cells was examined in mice. Mice immunized intradermally (i.d.) with a mixture of X-irradiated B16-BL6 cells and MDP-Lys (L18) [Vac+MDP-Lys (L18)] followed by an intravenous (i.v.)inoculation of $10^4$ viable tumor cells 7 days after immunization, showed a significant inhibition of experimental lung metastasis of B16-BL6 melanoma cells. The most effective immunization for the prophylactic inhibition of tumor metastasis was obtained from the mixture of $100{\;}\mu\textrm{g}$ of MDP-Lys (L18) and $10^4$ X-irradiatied tumor vaccine. Furthermore, immunization of mice with Vac+MDP-Lys(L18), 3 days after tumor challenge, resulted in a significant inhibition of lung metastasis of B16-BL6 melanoma cells in an experimental lung metastasis model. Similarly, the administration of Vac+MDP-Lys(L18), 1 or 7 days after tumor removal, markedly inhibited tumor metastasis of B16-BL6 in a spontaneous lung metastasis model. When Vac+MDP-Lys (L18) was i.d. administered 3 days after subcutaneous (s.c.) inoculation of tumor cells ($5{\times}10^5/site$) on the back, mice treated with Vac+MDP-Lys(L18) showed inhibition of significantly tumor growth on day 20. These results suggest that MDP-Lys (L18) is able to enhance antitumor activity induced by X-irradiated tumor vaccine to reduce lung metastasis of tumor cells, and is a potent immunomodulating agent which may be applied prophylactically as well as therapeutically to treatment of cancer metastasis.

• The Journal of Korean Institute of Communications and Information Sciences
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• 제36권5B호
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• pp.573-581
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• 2011

The underwater channel is known to offer poor communications channel. The channel medium is highly absorptive and the transmission bandwidth is limited. In addition, the channel is highly frequency selective; the degree of selectiveness depends on a detailed geometry of the channel. Furthermore, the response changes over time as the channel conditions affecting the response such as water temperature, sea surface wind and salinity are time-varying. The transceiver design to deal with the frequency and time selective channel, therefore, becomes very challenging. It has been known that deep fading at certain specific sub-carriers are detrimental to OFDM systems. To mitigate this negative effect, the proposed coded OFDM system employs an LDPC code based modulation. In this paper, we aim 1) to provide a detailed underwater channel model; 2) to design a robust LDPC coded OFDM system; 3) to test the proposed system under a variety of channel conditions enabled by the channel model.

• East Asian mathematical journal
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• 제33권2호
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• pp.235-255
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• 2017

This study focuses on the teaching of fraction related to curriculum, introducing time of fraction, the meaning of fractions in textbook, material of teaching of fraction concept, teaching model of introducing time of fraction concept, special cases of teaching fraction and common points of representation of fraction among Korea, New Zealand and Singapore. For this study, Korea's mathematics textbooks(3-1, 3-2, 4-1, 5-1, 6-1) and New National Curriculum Mathematics(3, 4, 5. 6. 7)of New Zealand and New Syllabus Primary Mathematics(2B, 3B, 4A, 4B, 5A, 6A)of Singapore were selected for comparison and analysis. As a results we will suggest a reference to the development of mathematical curriculum, teaching fraction and improving the quality of the textbook through a method of comparative analysis of Korea, New Zealand and Singapore.

• Rapid Communication in Photoscience
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• 제3권3호
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• pp.53-55
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• 2014

The shade avoidance syndrome is a morphological and physiological response when plants are exposed to shade. Recent work in Arabidopsis had begun to define the molecular components of the shade avoidance syndrome in dicotyledonous model plant. However, little is known about the shade avoidance response networks in agriculturally important monocotyledon crops such as rice. Here, we found that the degree of bending at the lamina joint is inversely proportional to the R:FR ratio. To elucidate which phytochrome is involved in this response, we did lamina joint inclination assay with the rice phytochrome-deficient mutants (osphyA, osphyB, and osphyC) and the wild type plants. Whereas the osphyA and osphyC knockout mutants bent at the lamina joint in the far-red rich condition as the wild type plants, the osphyB knockout mutants no longer bent at the lamina joint in the far-red rich condition. These results suggest that PHYB acts as a sole photoreceptor in the lamina joint inclination response in rice.

• Journal of Physiology & Pathology in Korean Medicine
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• 제32권6호
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• pp.384-395
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• 2018

The aim of this study was to investigate whether a novel formulation of an herbal extracts has an inhibitory effect on obesity. To determine its anti-obesity effects, we performed anti-obesity-related experiments in vitro and in vivo. Thus, our present study was carried out to evaluate the anti-obesity effect of herbal extracts using a high fat diet (HFD)-induced obese mouse model and 3T3-L1 adipose cells. The effects of each herbal extracts on lipid accumulation in 3T3-L1 cells were examined using Oil Red O staining. Results showed that treatment with each herbal extracts at $10{\sim}100{\mu}g/ml$ had no effect on cell morphology and viability. Without evidence of toxicity, herbal extracts treatment decreased lipid accumulation compared with the untreated adipocytes controls as shown by the lower absorbance of Oil Red O stain. Futhermore, compared with control-differentiated mature adipocytes, each herbal extracts significantly inhibited lipid accumulation in mature 3T3-L1 adipocytes. In the HFD-fed obese mice, body weight, liver weight and white adipose tissue weights were significantly reduced by mixture of herbal extracts administration in mouse skin. Futhermore, we found that mixture of herbal extracts administration suppressed serum triglyceride (TG), and total cholesterol (TCHO) in HFD-induced obese mouse model. The mixture of herbal extracts of permeability was estimated by measuring the transepithelial electrical resistance (TEER) value in pig skin. The optimized formulations of herbal extracts (Test 3 formulation) showed skin permeation. However, test 1 formulation containing essential oil as enhancer showed maximum skin permeation. After confirming the enhanced skin permeability, in vivo studies were performed to assess whether skin irritation potential on the basis of a primary irritation index (PII) in rabbit skin. Reactions were scored for erythema/edema reactions at 24 h, 48 h and 72 h post-application. It was concluded that the test 1 formulation was not irritation (PII = 0). The present study suggests that the test 1 formulation might be of therapeutic interest with respect to the treatment of obesity.

• The Journal of Korean Institute of Communications and Information Sciences
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• 제29권1A호
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• pp.93-98
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• 2004

Serial ATA interface Is inexpensive comparatively and performance is superior. So it is suitable technology in demand that now require data transmission and throughput of high speed. This paper describes a design and implementation of Serial ATA Link layer about error detection and 8b/10b encoder/decoder for DC balance in frequency 150MHz. The 8b/10b Encoder is partitioned into a 5b/6b plus a 3b/4b coder. The logical model of the block is described by using Verilog HDL at register transistor level and the verified HDL is synthesized using standard cell libraries. And it is fabricated with $0.35{\mu}m$ Standard CMOS Cell library and the chip size is about $1500{\mu}m\;*\;1500{\mu}m$. The function of this chip has been verified and tested using testboard with FPGA equipment and IDEC ATS2 test equipment. It is used to frequency of 100MHz in verification processes and supply voltage 3.3V. The result of testing is well on the system clock 100MHz. The designed and verified each blocks may be used IP in the field of high speed serial data communication.

• Proceedings of the Korea Concrete Institute Conference
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• 한국콘크리트학회 2008년도 추계 학술발표회 제20권2호
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• pp.709-712
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• 2008

RC super tall buildings are planned and constructed recently in domestic area. Concrete is characterized by time dependant material such as creep and shrinkage. For this properties of concrete, differential shortening is one of the main issues on super tall buildings construction. This study includes material research, which is performing as a pre design stage to solve differential shortening on Lotte Super Tower Jamsil core structure(50, 60, & 70 MPa). The major part of this study is composed with comparison and analysis between experimental data and predicted data on total shrinkage and total compliance which were used on design stage. Four models, ACI209R Model, Ba${\check{z}}$ant-Baweja B3 Model, CEB MC99 Model, & GL2000 Model, were employed to predict them. It also tries to seek a proper model for high strength and high performance concrete in the case of no concrete test.

• Transactions of the Korean Society of Mechanical Engineers B
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• 제28권1호
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• pp.24-30
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• 2004

Analysis model for the two-phase catalytic reactor is presented. With the progress in development of micro thermofluidic devices, needs fur understanding of the phenomena in two phase reaction in cm scale has been arisen. To investigate thermal and reactive performance of down scaled two phase reactor simple analysis model that is a kind of lumped flow model is proposed. Analysis model presented is based on the experiment on mm scale model reactor. Target experiment is catalytic decomposition of 70wt％ hydrogen peroxide with existence of perovskite L $a_{0.8}$S $r_{0.2}$Co $O_3$ catalyst. It is composed of balance equations of mass and energy. Each phase is considered to be a species fur the simplicity. Axial diffusion and transversal distribution of properties are neglected. Two phase catalytic reaction is modeled as successive gasification of liquid lump around catalyst and reaction in gas phase. Heat transfer is modeled by model function ofNu number. Modeled Nu is expressed as Nu=N $u_{0}$ (1＋ $a_1$( $a_2$ $T^{-}$ $a_3$)exp( $a_4$ $T^{-1}$)exp( $a_{5}$ z). Transfer coefficients are determined by the comparison of experimental results. With the model, heat transfer characteristics are investigated. Also by the mass transfer coefficient, characteristics in mass transfer is investigated. With the result basic understanding on design and analysis of mm scale two-phase reactive device is obtained. Also it can be further applied to micro scale reactive device fabricated by micromachining.ing..

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• 제19권8호
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• pp.837-843
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• 2008

This paper proposes a power divider based on meta-material structure with dual-band operation. The meta-material structures of left-hand characteristic are constituted of series capacitors and shunt inductors, but they have parasitic series inductance and shunt capacitance effects. There is represented the composite right/ left-handed transmission line (CRLH-TL) model. When the power divider is implemented by using the CRLH-TL, the power divider can operate dual band. To verify the power divider with dual band, we are implemented to operate dual-band that is 0.88 GHz and 1.67 GHz. The characteristics of divider have the return loss less than each 21.0 dB and 15.8 dB and the insertion loss better than 3.83 dB and 3.64 dB at each frequency. Also, the output phase difference is $3{\sim}6^{\circ}$.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• 제13권8호
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• pp.811-818
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• 2002

In this paper, a shorting pin and slot-loaded microstrip patch antenna is designed and fabricated. A shorting pin and slots are used for harmonic suppression on an inset fed antenna. A shorting pin and slot properties are analyzed by cavity model of the rectangular patch and the characteristics of the designed antenna are described. The designed antenna provides a gain of 7 dBi at the fundamental frequency, 5.8 GHz. In the second and third harmonic frequencies, the proposed antenna has gain suppression properties of -3.3 dB and -14.3 dB at each harmonic frequency, respectively.