• IMMUNE NETWORK
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• v.21 no.5
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• pp.34.1-34.16
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• 2021

Sjögren's syndrome (SS) is an autoimmune disease characterized by dryness of the mouth and eyes. The glandular dysfunction in SS involves not only T cell-mediated destruction of the glands but also autoantibodies against the type 3 muscarinic acetylcholine receptor or aquaporin 5 (AQP5) that interfere with the secretion process. Studies on the breakage of tolerance and induction of autoantibodies to these autoantigens could benefit SS patients. To break tolerance, we utilized a PmE-L peptide derived from the AQP5-homologous aquaporin of Prevotella melaninogenica (PmAqp) that contained both a B cell "E" epitope and a T cell epitope. Repeated subcutaneous immunization of C57BL/6 mice with the PmE-L peptide efficiently induced the production of Abs against the "E" epitope of mouse/human AQP5 (AQP5E), and we aimed to characterize the antigen specificity, the sequences of AQP5E-specific B cell receptors, and salivary gland phenotypes of these mice. Sera containing anti-AQP5E IgG not only stained mouse Aqp5 expressed in the submandibular glands but also detected PmApq and PmE-L by immunoblotting, suggesting molecular mimicry. Characterization of the AQP5E-specific autoantibodies selected from the screening of phage display Ab libraries and mapping of the B cell receptor repertoires revealed that the AQP5E-specific B cells acquired the ability to bind to the Ag through cumulative somatic hypermutation. Importantly, animals with anti-AQP5E Abs had decreased salivary flow rates without immune cell infiltration into the salivary glands. This model will be useful for investigating the role of anti-AQP5 autoantibodies in glandular dysfunction in SS and testing new therapeutics targeting autoantibody production.

• The Journal of Korean Society for Radiation Therapy
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• v.31 no.1
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• pp.75-81
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• 2019

Purpose: Helmet type bolus for 3D printer is being manufactured because of the disadvantages of Bolus materials when photon beam is used for the treatment of scalp malignancy. However, PLA, which is a used material, has a higher density than a tissue equivalent material and inconveniences occur when the patient wears PLA. In this study, we try to treat malignant scalp tumors by using M3 wax helmet with 3D printer. Methods and materials: For the modeling of the helmet type M3 wax, the head phantom was photographed by CT, which was acquired with a DICOM file. The part for helmet on the scalp was made with Helmet contour. The M3 Wax helmet was made by dissolving paraffin wax, mixing magnesium oxide and calcium carbonate, solidifying it in a PLA 3D helmet, and then eliminated PLA 3D Helmet of the surface. The treatment plan was based on Intensity-Modulated Radiation Therapy (IMRT) of 10 Portals, and the therapeutic dose was 200 cGy, using Analytical Anisotropic Algorithm (AAA) of Eclipse. Then, the dose was verified by using EBT3 film and Mosfet (Metal Oxide Semiconductor Field Effect Transistor: USA), and the IMRT plan was measured 3 times in 3 parts by reproducing the phantom of the head human model under the same condition with the CT simulation room. Results: The Hounsfield unit (HU) of the bolus measured by CT was $52{\pm}37.1$. The dose of TPS was 186.6 cGy, 193.2 cGy and 190.6 cGy at the M3 Wax bolus measurement points of A, B and C, and the dose measured three times at Mostet was $179.66{\pm}2.62cGy$, $184.33{\pm}1.24cGy$ and $195.33{\pm}1.69cGy$. And the error rates were -3.71 %, -4.59 %, and 2.48 %. The dose measured with EBT3 film was $182.00{\pm}1.63cGy$, $193.66{\pm}2.05cGy$ and $196{\pm}2.16cGy$. The error rates were -2.46 %, 0.23 % and 2.83 %. Conclusions: The thickness of the M3 wax bolus was 2 cm, which could help the treatment plan to be established by easily lowering the dose of the brain part. The maximum error rate of the scalp surface dose was measured within 5 % and generally within 3 %, even in the A, B, C measurements of dosimeters of EBT3 film and Mosfet in the treatment dose verification. The making period of M3 wax bolus is shorter, cheaper than that of 3D printer, can be reused and is very useful for the treatment of scalp malignancies as human tissue equivalent material. Therefore, we think that the use of casting type M3 wax bolus, which will complement the making period and cost of high capacity Bolus and Compensator in 3D printer, will increase later.

• Journal of Wetlands Research
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• v.17 no.3
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• pp.237-244
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• 2015

This study is estimated the flood damage probability of the flood discharge, the flood stage estimation and Economic Analysis for Flood Control about considering of uncertainty. Sum River Basin has chosen and the probability precipitation is estimated by using the concept of critical rainfall duration depending on the frequency of each flood stage estimation point. For calculating the expected annual damage, the functions of long term hazard, discharge-frequency, stage-discharge and depth-damage are established for 8 areas in Sum River Basin. The expected annual damaged is obtained which is based on the sampling informations through more than 500,000 simulation from the functions of considered uncertainty. The result about the optimum frequency and Investment Priorities are estimated by conducting the evaluation about planning the levee of various of Design Frequency. In analysis result, 12% of B/C value has increased if the uncertainty has concerned. Also the optimum frequency or Investment Priorities are possible to be changed. If the political and social analysis perform together it would be helpful to have a reasonable decision other than only the economical analysis as actual Flood damaged reduction planning.

• Korean Journal of Acupuncture
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• v.25 no.2
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• pp.159-177
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• 2008

Objectives : Crohn's disease is a severe chronic inflammation that is treated mainly by immunosuppression, which often has serious side effects. There is need to develop new therapeutic methods or drugs that have few side effects in order to treat this disease. Acupuncture with Moxi-tar at Cheonchu (ST25) has anti-inflammatory properties, but the mechanism of its anti-inflammatory actions is unclear. We investigated the protective effects and speculated the mechanisms of acupuncture with Moxi-tar at ST25 on trinitrobenzene sulfonic acid (TNBS) induced colitis in mice which is a well known Crohn's disease animal model. Methods : 5 % TNBS was treated at day 1 and day 7 into rectum of mice. To investigate therapeutic effects of acupuncture with Moxi-tar at ST25, acupuncture was carried out on day 3, and day 6. For the data analysis, we observed macroscopic and microscopic findings of the colon. Weight and width of the colon, degree of damage, changes of body weight, and myeloperoxygenase (MPO) activity were checked. For analysing protein expression, we carried out immunohistochemical staining and Western blot. For analysing mRNA expression, RT-PCR was carried out. Results : TNBS induced damages on the colon of mice, while acupuncture of Moxi-tar at ST25 suppressed TNBS mediated damages similar to those on the colons of mice in the control (not treated with TNBS) group. The average body weight of TNBS treated mice (77.4%) was decreased compared with that of the control mice (105%), and acupuncture with Moxi-tar at ST25 suppressed the loss of body weight caused by TNBS (from 77.4% to 95.3%). TNBS induced infiltration of immune cells in all layers of the colon while acupuncture with Moxi-tar at ST25 suppressed infiltration of immune cells caused by TNBS. Furthermore, acupunctured with Moxi-tar at ST25 suppressed macro-, micro- colonic damages caused by TNBS. Acupunctured with Moxi-tar at ST25 dramatically improved the clinical and histopathological symptoms such as the increase in weight of the distal colon and the MPO activity in TNBS-induced colitis. Acupuncture with Moxi-tar at ST25 down-regulated the nuclear transcription factor kappa B ($NF-{\kappa}B$) activity and suppressed tumor necrosis factor-a (TNF-${\alpha}$), interleukin-$1{\beta}$ (IL-1${\beta}$), and intracellular adhesion molecule-1 (ICAM-1) expressions caused by TNBS. Conclusions : Acupuncture with Moxi-tar at ST25 helps recovery from the TNBS-induced colonic damage by down-regulation of $NF-{\kappa}B$ activity and suppressing of TNF-${\alpha}$, IL-1${\beta}$, and ICAM-1 expressions. This may be an important method for the treatment of Crohn's disease.

• The Journal of Korean Academy of Prosthodontics
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• v.43 no.6
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• pp.707-716
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• 2005

Statement of problem. Collarless metal ceramic fixed partial dentures(FPDs) had an esthetic problem such as opaque reflection in cervical region. To overcome this, modified coping which removed its facial cervical metal could be used. The marginal quality could be worsen according to the amount of its facial metal reduction. Purpose. The purpose of this study was to evaluate marginal fits of collarless metal ceramic FPDs with retainers of modified copings. Material and method. Dentoform maxillary left central incisor and right lateral incisor were prepared for 3-unit collarless metal ceramic FPD and fixed in yellow stone. This model was duplicated to PBT resin dies via CAD/CAM and injection molding. Four different facial margin design groups were investigated. Group A was a coping with a thin facial metal collar, group B was a collarless coping with its facial metal to the shoulder, group C was a collarless coping with its facial metal 1 mm short of the shoulder, and group D was a collarless coping with its facial metal 2 mm short of the shoulder. Seven collarless metal ceramic FPDs per group were fabricated. They were cemented to PBT resin dies with resin cement. After removal of pontics, each retainers were separated and observed under Accura 2000 optical microscope. Then, retainers were embeded in orthodontic resin and cross sectioned faciopalatally. Internal marginal fits of midfacial porcelain margins were observed under FE-SEM. Result and conclusion. Within the limitations of this in vitro study. The following conclusions were drawn. 1. Mean marginal gaps of collarless FPDs were in the $50-60{\mu}m$ range. 2. In midfacial margin, marginal discrepancies were greater in group A than in the experimental groups(p<0.05). 3. In midpalatal margin, marginal gaps were greater in group C and D than in group A and B(p<0.05). 4. Marginal fits of porcelain margins were better than those of metal margins in collarless metal ceramic FPDs. 5. In both teeth, internal marginal gaps of group C and D were greater than those of group A and B(p<0.05).

• The KIPS Transactions:PartB
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• v.10B no.4
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• pp.373-380
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• 2003

Most of low cost digital cameras reveal relatively high lens distortion. The purpose of this research is to compensate the degradation of image quality due to the geometrical distortion of a lens system. The proposed method consists of two stages : calculation of a lens distortion coefficient by a simplified version of Tsai´s camera calibration and subsequent image warping of the original distorted image to remove geometrical distortion based on the calculated lens distortion coefficient. In the lens distortion coefficient calculation stage, a practical method for handling scale factor ratio and image center is proposed, after which its feasibility is shown by measuring the performance of distortion correction using a quantitative image quality measure. On the other hand, in order to apply image warping via inverse spatial mapping using the result of the lens distortion coefficient calculation stage, a cubic polynomial derived from an adopted radial distortion lens model must be solved. In this paper, for the purpose of real-time operation, which is essential for embedding into an information device, an approximated solution to the cubic polynomial is proposed in the form of a solution to a quadratic equation. In the experiment, potential for real-time implementation and equivalence in performance as compared with that from cubic polynomial solution are shown.

• The KIPS Transactions:PartB
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• v.19B no.3
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• pp.189-194
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• 2012

In this paper, we propose a query expansion method based on word graphs using pseudo-relevant and pseudo non-relevant documents to achieve performance improvement in information retrieval. The initially retrieved documents are classified into a core cluster when a document includes core query terms extracted by query term combinations and the degree of query term proximity. Otherwise, documents are classified into a non-core cluster. The documents that belong to a core query cluster can be seen as pseudo-relevant documents, and the documents that belong to a non-core cluster can be seen as pseudo non-relevant documents. Each cluster is represented as a graph which has nodes and edges. Each node represents a term and each edge represents proximity between the term and a query term. The term weight is calculated by subtracting the term weight in the non-core cluster graph from the term weight in the core cluster graph. It means that a term with a high weight in a non-core cluster graph should not be considered as an expanded term. Expansion terms are selected according to the term weights. Experimental results on TREC WT10g test collection show that the proposed method achieves 9.4% improvement over the language model in mean average precision.

• Journal of Korean Society of Rural Planning
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• v.13 no.3
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• pp.123-133
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• 2007

The purpose of this study is to develop the landscape resource assessment system(LRAS) to help evaluate the value of landscape resources(Jeju Island's Stonewall fencing farming land) for the introduction of direct payment system of the landscape preservation objectively and to applicate the model in the fields. Delphi survey on Jeju's stonewall experts shows that the order of priority among value evaluation elements on Jeju's stonewall is its harmony with surroundings(34%), the preservation of its original state(34%) and its density and scale(32%). Evaluation system development of landscape resources(Jeju's stonewall fencing filming land) and field observation survey utilizing it consists of the following five steps. Step 1 includes the first Delphi survey on Jeju's stonewall experts to decide its value evaluation elements and their priority. Step 2 is the second Delphi survey on Jeju's stonewall experts to grade pictures of landscape resources(Jeju's stonewall fencing farming land) on the basis of expert-proposed value evaluation standards. Step 3 consists of analysis work using the result of Delphi survey on experts. Step 4 is to select five grade standard pictures according to each of three grading elements of A, B, C belonging to each of the three standards. Then, it is necessary to make panels including five A-grade pictures, five B-grade pictures and five C-grade pictures according to each of the three elements of density, harmony, and original state preservation. Step 5 consists of field observation survey. According to the result of few experts' value evaluation of stonewall fencing farming land with the aid of NRAS developed in this research, the area of Pyeongdae-ri is ranked first, and then the area of Bukcheon-ri, Chocheon-up, the area of Gwakgi-ri, Ewol-up, the area of Shinum-ri, Ewol-up and the area of Yongsu-ri, hankyung-Myun are ranked in the order named. When those areas are graded, A Grade Areas includes the areas of Pyeongdae-ri, the area of Bukcheon-ri, the area of Gwakgi-ri, B Grade Areas consist of the area of Shinum-ri and the area of Yongsu-ri, and the areas of Onpyeong, wimi and youngrak belong to C Grade Area.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.7
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• pp.192-203
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• 2016

The purpose of this study is to investigate the effects of task conflict on job attitudes (organizational commitment & job satisfaction), focusing on the mediating effects of supervisory communication & co-worker communication. Recently, the importance of communication as a research topic has been increasing. According to prior research, communication satisfaction has a positive effect on job performance. However, studies which take into account the different types of communication are lacking. Therefore, this study considered two types of communication (supervisory communication and coworker communication). A research model and hypotheses were developed in order to examine the theoretical research issues and questions. The sample consisted of 280 survey data drawn from employees in firms located in Korea. The data was analyzed by the statistical packages, SPSS 21.0 & AMOS 21.0 for Windows. The findings of the analysis are as follows. Firstly, it was found that task conflict had a negative (-) effect on organizational commitment & job satisfaction. Therefore, H1a & H1b are supported. Secondly, it was found that task conflict had a negative (-) effect on supervisory communication. Therefore, H2a is supported. However, it did not have a significant effect on co-worker communication. Hence, H2b is not supported. Thirdly, as regards the mediating effect of supervisory communication, it was found that supervisory communication mediated the effect of task conflict on job attitudes (organizational commitment & job satisfaction). Therefore, H3a & H3b are supported. Finally, the mediating effect of co-worker communication was not significant. Therefore, none of the sub-hypotheses of H4 are supported. Based on these findings, this study suggested directions for future research.

• The KIPS Transactions:PartB
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• v.12B no.1 s.97
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• pp.47-56
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• 2005

A moving object has a various features that its spatial location, shape, and size are changed as time goes. In addition, the moving object has both temporal feature and spatial feature. It is one of the highly interested feature information in video data. In this paper, we propose an efficient content-based multimedia information retrieval system, so tailed ECoMOT which enables user to retrieve video data by using a trajectory information of moving objects in video data. The ECoMOT includes several novel techniques to achieve content-based retrieval using moving objects' trajectories : (1) Muitiple trajectory modeling technique to model the multiple trajectories composed of several moving objects; (2) Multiple similar trajectory retrieval technique to retrieve more similar trajectories by measuring similarity between a given two trajectories composed of several moving objects; (3) Superimposed signature-based trajectory indexing technique to effectively search corresponding trajectories from a large trajectory databases; (4) convenient trajectory extraction, query generation, and retrieval interface based on graphic user interface