• Biomedical Science Letters
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• v.24 no.1
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• pp.1-8
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• 2018

${\mu}MT$ knockout mice are genetically deficient in the transmembrane domain of mu chain of the immunoglobulin M (IgM) heavy chain, resulting in the absence of mature B cells. ${\mu}MT$ knockout mice is an in vivo model system used to clarify the role of B cells in various diseases. Enteropathogenic Escherichia coli (EPEC) induces acute and chronic diarrheal disease, especially in children of developing countries. The formation of attaching and effacing (A/E) lesion is a prominent pathogenic factor in the intestinal epithelium of EPEC infection. The A/E lesion is modulated by genes located on the pathogenic island locus of enterocyte effacement (LEE) which encode a type III secretion system (T3SS) and A/E lesion-related effector proteins. Citrobacter rodentium is a murine pathogen utilized in studying the pathogenic mechanisms of EPEC in human infections. Citrobacter rodentium produce A/E lesion to attach to intestinal epithelium, thus providing a murine model pathogen to study EPEC. Several studies have investigated the pathogenesis of Citrobacter rodentium in the ${\mu}MT$ knockout mice. In this review, we introduce the ${\mu}MT$ murine model in the context of C. rodentium pathogenesis and describe in detail the role of B cells and antibodies in this disease.

• Korean Journal of Computational Design and Engineering
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• v.12 no.3
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• pp.220-232
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• 2007

Current geometric modeling and analysis are commonly based on B-Rep modeling and a finite elements method respectively. Furthermore, it is difficult to represent an object whose material property is heterogeneous using the B-Rep method because the B-Rep is basically used for homogeneous models. In addition, meshes are required to analyze a property of a model when the finite elements method is applied. However, the process of generating meshes from B-Rep is cumbersome and sometimes difficult especially when the model is deformed as time goes by because the topology of deforming meshes are changed. To overcome those problems in modeling and analysis including homogeneous and heterogeneous materials, we suggest a unified modeling and analysis method based on implicit representation of the model using R-function which is suggested by Rvachev. For implicit modeling of an object a distance field is approximated and blended for a complex object. Using the implicit function mesh-free analysis is possible where meshes are not necessary. Generally mesh-free analysis requires heavy computational cost compared to a finite elements method. To improve the computing time of function evaluation, we utilize GPU programming. Finally, we give an example of a simple pipe design problem and show modeling and analysis process using our unified modeling and analysis method.

• The korean journal of orthodontics
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• v.24 no.3 s.46
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• pp.709-719
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• 1994

The aim of this investigation was to identify which suing is more suitable for uprighting of the 30 degree inclined lower second molar in different situations. Between four different molar uprighting springs which were A, B, C type and T-loop spring, the author tested T-loop suing as a control material and the other springs were experimental group. Each spring was fabricated from .017' $\times$ .025' TMA wire and preactivated with 40 degree tip-back bend. Stabilizing unit included from the lower right central incisor to the lower right second premolar which were made by acrylic resin. The photoelastic overview of the lower right quadrant showed that stress concentrations were observed in its photoelastic model. The obtained results were as follows. 1. Higher concentration of compression can be seen clearly at the distal curvature than the mesial of the lower second molar when A type uprighting spring was applied, which can be used as a space regainer. 2. Higher level compression was presented at the mesial root apex area than the distal of the lower second molar in B type uprighting spring, which can be used as a space closer. 3. Areas of higher compression and tension were observed about the mesial and distal root of the lower second moalr than A and B type in C type uprighting spring, which can be used as a partial space regainer.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2009.06a
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• pp.639-640
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• 2009

• The Korean Journal of Physiology and Pharmacology
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• v.7 no.2
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• pp.65-71
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• 2003

Increasing evidences suggest that ischemia-induced vascular damage is an integral step in the cascade of the cellular and molecular events initiated by cerebral ischemia. In the present study, employing a mouse brain endothelioma-derived cell line, bEnd.3, and oxygen-glucose deprivation (OGD) as an in vitro stroke model, the role of nuclear factor kappa B (NF-${\kappa}B$) activation during ischemic injury was investigated. OGD was found to activate NF-${\kappa}B$ and to induce bEnd.3 cell death in a time-dependent manner. OGD phosphorylated neither 32 Ser nor 42 Tyr of $I{\kappa}B{\alpha}$. OGD did not change the amount of $I{\kappa}B{\alpha}$. The extents of OGD-induced cell death after 8 h, 10 h, 12 h and 14 h of OGD were 10%, 35%, 60% and 85%, respectively. Reperfusion following OGD did not cause additional cell death, indicating no reperfusion injury after ischemic insult in cerebral endothelial cells. Three known as NF-${\kappa}B$ inhibitors, including pyrrolidine dithiocarbamate (PDTC) plus zinc, aspirin and caffeic acid phenethyl ester (CAPE), inhibited OGD-induced NF-${\kappa}B$ activation and increased OGD-induced bEnd.3 cell death in a dose dependent manner. There were no changes in the protein levels of bcl-2, bax and p53 which are modulated by NF-${\kappa}B$ activity. These results suggest that NF-${\kappa}B$ activation might be a protective mechanism for OGD-induced cell death in bEnd.3.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.8 no.3
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• pp.221-230
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• 1996

The Suh and Park's analytical model. originally developed to calculate wave reflection from a conventional fully perforated caisson breakwater, is applied to a partially perforated caisson breakwater by approximating the vertical wall of the lower part of the front face of the caisson as a very steep sloping wall. Also, in the model, the inertial resistance term at the perforated wall is modified by using the blockage coefficient proposed by Kakuno and Liu. The model is compared against the hydraulic experimental data reported by Park et al. in 1993. Both the experimental data and the analytical model results show that the influence of inertial resistance is important so that wave reflection becomes minimum when B/L. is approximately 0.2 (in which R : wave chamber width, and 1, : wave length inside the wave chamber), which is somewhat smaller than the theoretical value B/L, : 0.25 obtained by assuming that the influence of inertial resistance is negligible. It is also shown that the analytical model based on a linear wave theory tends to overpredict the reflection coefficient as the wave nonlinearity increases, thus the model is preferably to be used for ordinary waves of small steepness.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.32 no.1
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• pp.52-59
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• 2006

Purpose: The purpose of this study was to evaluate the influence of apical-coronal implant position on the stress distribution after occlusal and oblique loading. Materials and Methods: The cortical and cancellous bone was assumed to be isotropic, homogeneous, and linearly elastic. The implant was apposed to cortical bone in the crestal region and to cancellous bone for the remainder of the implant-bone interface. The cancellous core was surrounded by 2-mm-thick cortical bone. An axial load of 200 N was assumed and a 200-N oblique load was applied at a buccal inclination of 30 degrees to the center of the pontic and buccal cusps. The 3-D geometry modeled in Iron CAD was interfaced with ANSYS. Results: When only the stress in the bone was compared, the minimal principal stress at load Points A and B, with a axial load applied at 90 degrees or an oblique load applied at 30 degrees, for model 5. The von Mises stress in the screw of model 5 was minimal at Points A and B, for 90- and 30-degree loads. When the von Mises stress of the abutment screw was compared at Points A and B, and a 30-degree oblique load, the maximum principal stress was seen with model 2, while the minimum principal stress was with model 5. In the case of implant, the model that received maximum von Mises stress was model 1 with the load Point A and Point B, axial load applied in 90-degree, and oblique load applied in 30-degree. Discussion and Conclusions: These results suggests that implantation should be done at the supracrestal level only when necessary, since it results in higher stress than when implantation is done at or below the alveolar bone level. Within the limited this study, we recommend the use of supracrestal apical-coronal positioning in the case of clinical indications.

• The KIPS Transactions:PartB
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• v.11B no.3
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• pp.345-352
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• 2004

This paper deals a method to deliver more realistic sound by cancelling the cross-talk which is inherent to the 5.1 channel speaker system. The acoustical model for cross-talk cancellation is the free field model. This model minimizes distortion of sound. 1 used the bark scale sound quality compensation which based on psycho-acoustic. For the surround channels, band-limited sound quality compensation is performed in the frequency domain. I also performed the sound qualify assessment test on the traditional 2 channel stereo and 5.1 channel system. This test is performed in the tort chamber which satisfies the ITU-R specifications. 1 uses the IACC(Inter-Aural Cross-Correlation) to determine the preferences of the amateur and the golden ear experts to asses the trans-aural filter. According to the result from the proposed method, I got more the 38dB separation rates with the Dolby standard speaker array. The results on the diffusion by the subjective test with the experts shows 0.4∼0.5 point Increased then before.

• Journal of the Korean Operations Research and Management Science Society
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• v.40 no.3
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• pp.97-117
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• 2015

There has been a lack of research that has addressed firm performance associated with the mechanism among dependence, conflict and cooperation in the context of B2B relationships. Building on current knowledge regarding key constructs of dependence, conflict, and cooperation, the authors examine the primary assumption underlying firm performance and presents a process model of key constructs on firm performance using two moderators (relationship length and firm type). In so doing, a professional online research firm conducts panel survey and a total of 200 responses are used to test our proposed model. The results show that both conflict-cooperation and cooperation-firm performance linkages are significant, but other proposed links are insignificant. While the moderating effect of firm type is not significant, the dependence-performance link is moderated by relationship length, particularly in the stage of the initial relationships. These results has implications for a better understanding of B2B relationships from the initial stage to the sustainable stage.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.13 no.10
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• pp.1017-1024
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• 2002

In this paper, we present the analysis of radio wave propagation characteristics in curved tunnels. Tunnel propagation models are performed in two cases which are using ray-tracing method for straight tunnels and geometrical optics extension to the standard hybrid waveguide model for curved ones. By regression analysis for measured power based on distance between the transmitter and the received antenna in tunnels that have 3.5 m $\times$ 6 m cross section and limited wall depth path loss are 0.19 dB/m for straight section and 0.68 dB/m for curved ones. By comparing model analysis with measurement in tunnels, it has been shown that the simulated results of tunnel propagation models are similar to the measured values.