• The Journal of Internal Korean Medicine
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• v.43 no.6
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• pp.1162-1185
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• 2022

Purpose: We examined the effects of Dansam (Salvia miltiorrhiza Bunge, SM) and Dansam-eum (DSE) on gastroesophageal reflux disease (GERD) and reflux esophagitis by comparing the inhibitory effects of SM and DSE with the representative treatment of PPI Omeprazole to determine if the effects of the prescription DSE based on Korean medicine are better than those of a single-use of SM. Methods: We performed experiments using both animal models and cancer cells. Results: Comparison of SM and DSE with PPI in the animal model tests revealed that the effects were superior for SM and DSE than for PPI in all categories (8-OHdG, p-IκB, PAR2, COX-1, cathelicidin, p-JNK, Caspase 3, ATP6V1B1, GRPR, serotonin, and NPY). In three categories (COX-1, serotonin, and NPY), SM and DSE showed superior results over the Controls. In the animal model tests, DSE was superior to SM in all categories except for serotonin. The anti-cancer effects observed in cancer cell tests revealed that SM and DSE had meaningful results in terms of cytotoxicity and cell movement rate, as well as in cancer cell apoptosis. Conclusions: We confirmed that SM and DSE can have effects on reflux esophagitis through the regulation of oxidative stress, inflammation, mucosal protection, apoptosis, proton pumping, and the enteroendocrine system in the stomach and esophagus. We also confirmed that SM and DSE have superior effects to those of PPI on all aspects, especially gastric mucosa protection and enteroendocrine system control. We also confirmed that SM and DSE have anti-cancer effects. Above all, we confirmed that DSE has superior effects on almost all aspects compared to using SM alone.

• Journal of Microbiology and Biotechnology
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• v.33 no.3
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• pp.356-362
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• 2023

The 2'-fucosyllactose (2'-FL) is the richest components in a human milk oligosaccharide. Several studies have reported that 2'-FL has beneficial effects in infants. However, there are few studies on its immune-enhancing effects. This research aimed to examine the immune-enhancing effect of 2'-FL on immunosuppression by cyclophosphamide (CCP) in ICR mice. Mice were orally administered distilled water or 0.5 mg/kg B.W. 2'-FL for 14 days. An immunocompromised mouse model was induced using CCP 80 mg/kg B.W. at 12-14 days. Using the CCP had effects on reducing their body weight, organ weight, spleen index, natural killer (NK) cell activity, and cytokines concentration and expression. This study also used concanavalin A-mediated T-cell proliferation to verify the immune-enhancing effects in the sample. Body weight, spleen index, organ weight, and cytokine levels were measured to estimate the immune-enhancing effects. The body weight at 14 days tended to increase, and the spleen weight and index significantly increased in the 2'-FL group compared to the CCP group. The NK cell activity increased in the 2'-FL group compared to the CCP group, but there was no significant difference. The concentration of interleukin (IL)-2 tended to recover in the 2'-FL group compared to the CCP group. The 2'-FL group showed a significant increase of IL-10 and IFN-gamma concentration compared to the CCP group. In addition, there was a trend of increased IL-10 mRNA expression compared to the CCP group. These results revealed that 2'-FL improved CCP-induced immunosuppression, suggesting that 2'-FL may have the potential to enhance the immune system.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.57.3-58
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• 2021

We performed three-dimensional Monte Carlo dust scattering radiative transfer simulations for FUV light to obtain dust scattered FUV images and compared them with the observed FUV image obtained by FIMS/SPEAR and GALEX. From this, we find the scattering properties of interstellar dust in our Galaxy and suggest the intensity of extragalactic background light (EBL) at FUV wavelength. The best-fit values of the scattering properties of interstellar dust are albedo = 0.38^-0.04_+0.04, g-factor = 0.55^-0.15_+0.10, and EBL = 138^-23₊₂₁ CU for the allsky which are consistent well with the Milky Way dust model of Draine and direct measurements of Gardner et al., respectively. At the high Galactic latitude of |b|>10°, the observation is well fitted with the model of lower albedo = 0.35^-0.04_+0.06 and g-factor = 0.50^-0.20_+0.15. On the contrary, the scattering properties of interstellar dust show higher albedo = 0.43^-0.02_+0.02 and g-factor = 0.65^-0.15_+0.05 near the Galactic plane of |b|<10°. In the present simulation, recent three-dimensional distribution maps of interstellar dust in our Galaxy, stellar distances in the catalog of GAIA DR2, and FUV fluxes and/or spectral types in the TD-1 and Hipparcos star catalogs were used.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.55.2-56
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• 2021

The progenitor of Type Ia supernovae (SNe Ia) is mainly believed to be a close binary system of acarbon-oxygen white dwarf (CO WD) and non-degenerate companion (single degenerate) or another WD (double degenerate). However, it is unclear which system is more prevalent. Here, we present a high cadence optical/Near-IR light curve of normal but slightly faint type Ia SN 2019ein from IMSNG project. We fit the early light curve (t <+8.3 days from the first detection) with various models to find the shock-heated cooling emission from SN ejecta-companion interaction. No significant shock-heated cooling emission is found, from which we constrain the progenitor star size as the following. The upper limit (R_upper,*) of the companion size in R-band is ~0.2R_⊙ when forcing the first light time (t_fl) to have one value and ~0.9R_⊙ when using the mean value of tfl from the fitting in each band. Assuming the source of the I-band curve is almost powered from the radioactive decay, we obtained R_upper,*~1.2R_⊙. The early B-V color curve is in agreement with the model color curve of the 2M_⊙ main sequence companion. These results allow us to at least rule out large stars like red giants as a companion star of the binary progenitor system of this supernova. B-R and V-R color do not show any significant signs of a red bump, which shows a thin helium shell (MHe<0.1M_⊙) for the sub-Mch WD (double detonation model). In addition, we estimated the distance to NGC 5353 as 37.098±0.028Mpc.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.6B
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• pp.571-578
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• 2010

Manning's roughness coefficients were reevaluated for the computation of river flow of the Han River, the Nakdong River and the Geum River. The roughness coefficients were estimated by two methods. One is based on the assumption that roughness is primarily a function of grain diameter and the other is based on the findings that roughness may vary significantly with the flow discharge. The roughness coefficients adopted in each river improvement master plan have been compared with those obtained using the FLDWAV in this study, and their applicabilities have been reviewed, using the FLDWAV and HEC-RAS models. The design flood water levels computed by the abovementioned models with the roughness coefficients proposed in this study have shown good agreement with the measurements of time variation. The roughness coefficients computed using the FLDWAV model showed nearly no close correlation with the various hydraulic characteristic factors, such as grain size and river depth, etc.. Finally the design flood water levels and levee safety about the downstream part from the Paldang Dam of the Han River has been reviewed using HEC-2 model with roughness coefficients of this study and the results indicated that some parts of the existing levees were short of safety.

• Steel and Composite Structures
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• v.49 no.4
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• pp.441-456
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• 2023

Aiming at the development trend of light weight and high strength of engineering structures, this paper experimentally investigated the seismic performance of circular-in-square high-strength concrete-filled double skin steel tubular (HCFDST) stub columns with out-of-code width-to-thickness (B/t) ratios. Typical failure mode of HCFDST stub columns appeared with the infill material crushing, steel fracture and local buckling of outer tubes as well as the inner buckling of inner tubes. Subsequently, the detailed analysis on hysteretic curves, skeleton curves and ductility, energy dissipation, stiffness degradation and lateral force reduction was conducted to reflect the influences of hollow ratios, axial compression ratios and infill types, e.g., increasing hollow ratio from 0.54 to 0.68 and 0.82 made a slight effect on bearing capacity compared to the ductility coefficients; the higher axial compression ratio (e.g., 0.3 versus 0.1) significantly reduced the average bearing capacity and ductility; the HCFDST column SCFST-6 filled with concrete obviously displayed the larger initial secant stiffness with a percentage 34.20% than the column SCFST-2 using engineered cementitious composite (ECC); increasing hollow ratios, axial compression ratios could accelerate the drop speed of stiffness degradation. The out-of-code HCFDST stub columns with reasonable design could behave favorable hysteretic performance. A theoretical model considering the tensile strength effect of ECC was thereafter established and verified to predict the moment-resisting capacity of HCFDST columns using ECC. The reported research on circular-in-square HCFDST stub columns can provide significant references to the structural application and design.

• Journal of Animal Science and Technology
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• v.65 no.6
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• pp.1194-1204
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• 2023

Meat quality comprises a set of key traits such as pH, meat color, water-holding capacity, tenderness and marbling. These traits are complex because they are affected by multiple genetic and environmental factors. The aim of this study was to investigate the molecular genetic basis underlying nine meat quality-related traits in a Yorkshire pig population using a genome-wide association study (GWAS) and subsequent biological pathway analysis. In total, 45,926 single nucleotide polymorphism (SNP) markers from 543 pigs were selected for the GWAS after quality control. Data were analyzed using a genome-wide efficient mixed model association (GEMMA) method. This linear mixed model-based approach identified two quantitative trait loci (QTLs) for meat color (b^*) on chromosome 2 (SSC2) and one QTL for shear force on chromosome 8 (SSC8). These QTLs acted additively on the two phenotypes and explained 3.92%-4.57% of the phenotypic variance of the traits of interest. The genes encoding HAUS8 on SSC2 and an lncRNA on SSC8 were identified as positional candidate genes for these QTLs. The results of the biological pathway analysis revealed that positional candidate genes for meat color (b^*) were enriched in pathways related to muscle development, muscle growth, intramuscular adipocyte differentiation, and lipid accumulation in muscle, whereas positional candidate genes for shear force were overrepresented in pathways related to cell growth, cell differentiation, and fatty acids synthesis. Further verification of these identified SNPs and genes in other independent populations could provide valuable information for understanding the variations in pork quality-related traits.

• Korea Trade Review
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• v.45 no.5
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• pp.141-159
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• 2020

Container terminals at Gwangyang Port are operated by three container operators: A, B and C. Ultimately, there is consensus that a single operator should operate all terminals so that economies of scale can be achieved even in the operation of the container terminal. Integration between operators has a positive effect on both operators and shipping companies. From the operator's point of view, overlapping fixed costs between operators can be unified, reducing overall costs and utilizing spare facilities. On the other hand, from the viewpoint of the shipping company, it is possible to ensure stable use of the port facilities and always allow berthing, reduce days on demurrage and ship waiting, and provide one-stop service for work. However, existing cases of operators' integration or relocation of terminals remained to estimate the expected effects of alternatives, emphasizing only the financial point of view. The port terminal is a large system, and it is important to consider that it is an aggregate of major logistics facilities and equipment. Moreover, if the estimation can be made by quantifying the expected effect, the justification of the terminals' relocation can be further emphasized. Therefore, it is very important to estimate the expected effect from the viewpoint of systemic operation. Moreover, the need for operators' integration can be further emphasized if it can be estimated through quantification of expected effects. Currently, three alternatives are considered as alternatives to the terminals' relocation, and in this study, the optimal plan was derived for the 3 alternatives by the linear planning model of the minimum shuttle transportation cost in the terminal. The optimal plan is alternative 2, which shows the most advantageous integration effect in terms of expected effects. Alternative 2 integrates the B terminal into the C terminal, and the A terminal operates independently as it is.

• Nuclear Engineering and Technology
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• v.27 no.5
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• pp.701-709
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• 1995

The realistic discharge coefficient for the critical How model of RELAP5/AOD3/KAERI are determined for the subcooled and too-phase critical flow by assessments of nine MARVIKEN Critical flew Test(CFT). The selected test runs include a high initial subcooling and large nozzle aspect rat-io(L/D). The code assessment results show that RELAP5/MOD3/KAERI over-predicts the subcooled critical flow and under-predicts the two-phase critical flow. Using these result, the realistic discharge coefficients of critical flow models are quantified by an iterative method. The realistic discharge coefficients are determined to be 0.89 for the subcooled critical How and 1.07 for the two-phase critical flow, and the associated standard deviations are 0.0349 and 0.1189, respectively. The results obtained from this study can be applied to calculate the realistic system response of Large Break Loss of Coolant Accident and to evaluate the realistic Emergency Core Cooling System performance.

• Journal of agricultural medicine and community health
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• v.44 no.4
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• pp.209-219
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• 2019

Objectives: This study investigated musculoskeletal symptoms in upper limbs according to the working environment (job stress) of dental hygienists and examine their relationship with upper limb functions. Methods: The subjects include 198 dental hygienists in dental hospitals and dental clinics in Pusan and Gyeongnam. The questionnaire was consisted of general characteristics of the subjects, job stress, musculoskeletal symptoms in upper limbs and function (Disability Measurement Tool for Upper Extremity Disorders-11, DASH-11). Results: The study was analyzed their musculoskeletal symptoms in upper limbs according to their general characteristics and found that the symptoms occurred in the neck (39.4%), the shoulders (54.6%), elbows (14.7%), and the hands (50.0%). Job stress was associated with upper limb functions (DASH-11) (model 3, B=5.210, p=0.012) and repeated elbow bending and spreading posture was associated with DASH-11 (model 3, B=6.561, p=0.029). Elbow symptoms were associated with DASH-11 in the upper limbs (B=10.679, p=0.003). Conclusion: Dental hygienists are experiencing limitations of upper limb function due to job stress. In particular, even if the correction of their uncomfortable posture is significantly related to the job stress and upper limb function, in order to improve the upper limb function of the dental hygienist, efforts to reduce the job stress as well as the uncomfortable posture are necessary.