• The Korean Journal of Pain
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• v.29 no.3
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• pp.153-157
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• 2016

Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the ${\mu}$-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys. The most common adverse reactions are nausea, dizziness, vomiting, and somnolence. Constipation is more common in use of the ER formulation. Precautions against concomitant use of central nervous system depressants, including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and alcohol, or use of tapentadol within 14 days of the cessation of monoamine oxidase inhibitors, are advised. The safety and efficacy have not been established for use during pregnancy, labor, and delivery, or for nursing mothers, pediatric patients less than 18 years of age, and cases of severe renal impairment and severe hepatic impairment. The major concerns for tapentadol are abuse, addiction, seeking behavior, withdrawal, and physical dependence. The presumed problem for use of tapentadol is to control the ratio of MOR agonist and NRI. In conclusion, tapentadol produces both nociceptive and neuropathic pain relief, but with worries about abuse and dependence.

• Computers and Concrete
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• v.8 no.5
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• pp.563-581
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• 2011

The signal-based acoustic emission (AE) characterization of concrete fracture process utilizing home-programmed AE monitoring system was performed for three kinds of static loading tests (Cubic-splitting, Direct-shear and Pull-out). Each test was carried out to induce a distinct fracture mode of concrete. Apart from monitoring and recording the corresponding fracture process of concrete, various methods were utilized to distinguish the characteristics of detected AE waveform to interpret the information of fracture behavior of AE sources (i.e. micro-cracks of concrete). Further, more signal-based characters of AE in different stages were analyzed and compared in this study. This research focused on the relationship between AE signal characteristics and fracture processes of concrete. Thereafter, the mode of concrete fracture could be represented in terms of AE signal characteristics. By using cement-based piezoelectric composite sensors, the AE signals could be detected and collected with better sensitivity and minimized waveform distortion, which made the characterization of AE during concrete fracture process feasible. The continuous wavelet analysis technique was employed to analyze the wave-front of AE and figure out the frequency region of the P-wave & S-wave. Defined RA (rising amplitude), AF (average frequency) and P-wave & S-wave importance index were also introduced to study the characters of AE from concrete fracture. It was found that the characters of AE signals detected during monitoring could be used as an indication of the cracking behavior of concrete.

• Transactions of the Korean Society of Automotive Engineers
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• v.19 no.2
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• pp.1-11
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• 2011

The skid-steering method that applied a number of mobile robot currently is extremely effective in narrow area. But it contains several problems such as its natural properties, slip, occurred by different direction between vehicle's driving and wheel's rotary. Through this paper, suitable control algorithm of $6{\times}6$ skid steering wheeled vehicle and its driving methods are proposed by analyzing the behavior $6{\times}6$ skid-steered wheeled vehicle model designed by engineering analysis strategy. To do this, based on a behavior of designed driving system, required torque and other performance of in-wheel type motor system are considered, and finally control algorithm for each wheel is proposed and simulated using this model. To test the proposed vehicle system, driver model is designed using PID closed loop system and included in the total driving control algorithm. The Performance of designed vehicle model is verified by using DYC (Direct Yaw Control) cornering mode and slip mode control to follow the steering input which are essential to evaluate the driving performance of $6{\times}6$ vehicle. Proposed modeling strategy and control method will be implemented to the real $6{\times}6$ in-wheel drive type vehicle.

• Proceedings of the KSAR Conference
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• 2001.03a
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• pp.48-48
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• 2001

A new neurological mutant has been found in the ICR outbred strain mouse. Affected mice display profound deafness and a head-tossing and bidirectional circling behavior, showing an autosomal recessive mode of inheritance. It was, therefore, named cir/Kr with the gene symbol cir. The auditory tests identified clearly the hearing loss of the cir mice when compared to wild type mice. Pathological studies confirmed the developmental defects in the middle ear, cochlea, cochlear nerve, and semicircular canal areas, which were correlated to the abnormal behavior observed in the cir mice. Thus, cir mice may be useful as a model for studying inner ear abnormalities and deafness. We have constructed a genetic linkage map by positioning 14 microsatellite markers across the (cir) region and intraspecific backcross between cir and C57BL/6J mice. The cir mouse harbors an autosomal recessive mutation on mouse chromosome 9. The cir gene was mapped to a region between D9Mit116 and D9Mit38 Estimated distances between cir and D9Mit116, and between cir and D9Mit38 are 0.7 and 0.2 cM, respectively. The gene in order was defines : centromere-D9Mit182-D9Mit51/D9Mit79/D9Mit310-D9Mit212/D9Mit184-D9Mit116-cir-D9Mit38-D9Mit20-D9Mit243-D9Mit16-D9Mit55/D9Mit125-D9Mit281. The mouse map location of the cir locus appears to be in a region homologous to human 3q21. Our present date suggest that the nearest flanking marker D9Mit38 provides a useful anchor for the isolation of the cir gene in a yeast artificial chromosome contig.

• Proceedings of the KWS Conference
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• 2002.10a
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• pp.720-725
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• 2002

In recent years, techniques for micro-assembly with high repeatability under a scanning electron microscope (SEM) are required to construct highly functional micro-devices. Adhesion phenomenon is more significant for smaller objects, becanse adhesional force is proportional to size of the objects while gravitational force is proportional to the third power of it. It is also known that adhesional force between micro-objects exposed to Electron Beam irradiation of SEM increases with the elapsed time. Therefore, mechanical manipulation techniques using a needle-shaped tool by adhesional force are often adopted in basic researches where micro-objects are studied. These techniques, however, have not yet achieved the desired repeatability because many of these could not have been supported theoretically. Some techniques even need the process of trial-and-error. Thus, in this paper, mechanical and adhesional micro-manipulation are analyzed theoretically by introducing new physical factors, such as adhesional force and rolling-resistance, into the kinematic system consisting of a sphere, a needle-shaped tool, and a substrate. Through this analysis, they are revealed that how the micro-sphere behavior depends on the given conditions, and that it is possible to cause the fracture of the desired contact interfaces selectively by controlling the force direction in which the tool-tip loads to the sphere. Based on the acquired knowledge, a mode diagram, which indicates the micro-sphere behavior for the given conditions, is designed. By refening to this mode diagram, the practical technique of the pick and place manipulation of a micro-sphere under an SEM by the selective interface fracture is proposed.

• Journal of the Korean Vacuum Society
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• v.21 no.5
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• pp.249-257
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• 2012

Nonlinear dynamical behaviors of plasma in the Pierce diode are investigated by a numerical code developed using a one dimensional fluid model. The plasma in Pierce diode is alternately stable and unstable as Pierce parameter is changed. The dynamical characteristics of neutral and non-neutral Pierce system is examined analytically and numerically. It alternately has growing and oscillatory mode as Pierce parameter varies. As Pierce parameter is decreased, each oscillatory mode undergoes a sequence of subharmonic period-doubling bifurcation and then culminate in a chaotic strange attractor. The analysis for this nonlinear behavior can be used as a model for understanding of beam-plasma interaction in more complex geometries and a data for chaos control.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.2 s.48
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• pp.1-10
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• 2006

Reinforced concrete bridge columns with relatively small aspect ratio show flexure-shear behavior, which is flexural behavior at initial and medium displacement stages and shear failure at final stage. Since the columns with flexure-shear failure have lower ductility than those with flexural failure, shear capacity curve models shall be applied as well as flexural capacity curve in order to determine ultimate displacement for seismic design or performance evaluation. In this paper, a modified shear capacity curve model is proposed and compared with the other models such as the CALTRANS model, Aschheim et al.'s model, and Priestley et al.'s model. Four shear capacity curve models are applied to the 4 full scale circular bridge column test results and the accuracy of each model is discussed. It may not be fully adequate to drive a final decision from the application to the limited number of test results, however the proposed model provides the better prediction of failure mode and ultimate displacement than the other models for the selected column test results.

• Journal of Korean Society of Steel Construction
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• v.21 no.4
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• pp.375-384
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• 2009

The application of the diagrid structural system has increased of late, but cyclic loadings such as winds and earthquakes cannot be fully understood through only an analytical study due to the difficulty of considering its welding property. In this study, diagrid nodes that had been scaled down to 1/5 of their full sizes were tested to find out their structural behavior under seismic or wind loads. Four specimens were used with five parameters, including the welding method and the design details. Cyclic loading tests were carried out, where a tensile load was applied to one brace member and a compression load to the other. The major failure modes in the tests were only failure of bending with tensile stress and tension failure. The welding method and the design details had no effect on the initial stiffness and yielding stress but play a significant role in the failure mode and energy dissipation, respectively.

• Journal of the Korea Concrete Institute
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• v.21 no.6
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• pp.781-788
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• 2009

Mechanical properties of steel-concrete interface were evaluated on the basis of experimental observations. The properties included bond strength, unbounded and bonded friction angles, residual level of friction angle, mode I fracture energy, mode II bonded fracture energy and unbonded slip-friction energy under different levels of normal stress, and shape parameters to define geometrical shape of failure envelope. For this purpose, a typical type of constitutive model of describing steel-concrete interface behavior was presented based on a hyperbolic three-parameter Mohr-Coulomb type failure criterion. The constitutive model depicts the strong dependency of interface behavior on bonding condition of interface, bonded or unbounded. Values of the interface parameters were determined through interpretation of experimental results, geometry of failure envelope and sensitivity analysis. Nonlinear finite element analysis that incorporates steel-concrete interface as well as material nonlinearities of concrete and steel were performed to predict the experimental results.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.35 no.9
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• pp.799-804
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• 2007

The behavior of spray emanating from an injector to be employed in a liquid-propellant thrust chamber is investigated by optical measurement techniques. The injector has eight holes, each of which has 30 cant angle from the center-axis with the diameter of 0.406 mm. In order to examine an atomization process according to the spray-generation conditions and the evolution along spray downstream, variational features in the velocity and size of droplets obtained through Dual-mode Phase Doppler An 799emometry (DPDA) are delineated and discussed together with instantaneous plane images captured by using Nd:Yag laser sheet beam. A categorization of spray-flow regime representing the atomization and turbulent nature is made through evaluating the non-dimensional parameters, i.e., Reynolds number and Weber number based upon the theoretical injection velocity. These qualitative and quantitative data of spray breakup will be a firm basis for the design of brand-new thruster