• 대한치과교정학회지
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• 제53권2호
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• pp.106-115
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• 2023

Objective: To evaluate the null hypothesis that there is no difference in a set of clinical predictors of potentially impacted canines between low-risk patients with and without displaced canines. Methods: The normal canine position group consisted of 30 patients with 60 normally erupting canines ranked in sector I (age, 9.30 ± 0.94 years). The displaced canine group comprised 30 patients with 41 potentially impacted canines ranked in sectors II to IV (age, 9.46 ± 0.78 years). Maxillary lateral incisor crown angulation, inclination, rotation, width, height, and shape, as well as palatal depth, arch length, width, and perimeter composed a set of clinical predictors, which were evaluated on digital dental casts. Statistical analyses consisted of group comparisons and variable correlations (p < 0.05). Results: There was a significant association between sex and mesially displaced canines. Unilateral canine displacement was more prevalent than bilateral displacement. The crown of the maxillary lateral incisors was significantly angulated more mesially and rotated mesiolabially in low-risk patients with displaced canines, who also had a shallower palate and shorter anterior dental arch length. Lateral incisor crown angulation and rotation, as well as palatal depth and arch length, were significantly correlated with the canine displacement severity. Conclusions: The null hypothesis was rejected. Maxillary lateral incisor angulation inconsistent with the "ugly duckling" stage as well as a shallow palate and short arch length are clinical predictors that can significantly contribute to the early screening of ectopic canines in low-risk patients.

• Animal Bioscience
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• 제35권9호
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• pp.1390-1399
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• 2022

Objective: The objective of this study was to evaluate the effects of dietary supplementation of Schizosaccharomyces pombe (S. pombe) -expressed phytase on growth performance, apparent ileal digestibility, organ indexes, meat quality, toe ash, and footpad lesions score in broiler chicks. Methods: A total of 390 one-day-old broiler chicks were randomly assigned to 5 groups based on the initial body weight (42.15±0.17 g), there were 6 replicate cages per treatment and 13 birds (mixed sex) per cage. The experimental period was 45 days, including 4 periods (starter, days 1 to 10; grower, days 11 to 24; finisher 1, days 25 to 38; finisher 2, days 39 to 45). Dietary treatments were based on a corn-soybean meal-basal diet and supplemented with 500, 750, 1,000, and 1,500 FTU/kg S. pombe-expressed phytase. One phytase unit (FTU) was defined as the amount of enzyme that catalyzes the release of one micromole phosphate from phytate per minute at 37℃ and pH 5.5. Results: The inclusion of increasing levels of phytase in the diet linearly increased the body weight gain during days 1 to 10 (p = 0.001), 25 to 38 (p = 0.016), 39 to 45 (p = 0.018), and 1 to 45 (p = 0.004), feed intake during days 25 to 38 (p = 0.032), feed conversion ratio during days 1 to 10 (p = 0.001), 39 to 45 (p = 0.038), and 1 to 45 (p = 0.012), carcass weight (p = 0.035), toe ash (p<0.001), and apparent ileal phosphorus digestibility (p = 0.049). However, the footpad lesions score (p = 0.040) decreased linearly with the increase in phytase levels in the diet. Conclusion: Dietary supplementation of S. pombe-expressed phytase was beneficial to the growth performance, toe ash, apparent ileal phosphorus digestibility, and footpad lesions of broiler chicks in a dose-dependent manner.

• 치위생과학회지
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• 제23권3호
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• pp.225-235
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• 2023

Background: This study aimed to analyze the effects of periodontal treatment and individual- and tooth-related factors on tooth extraction in people with disabilities. Methods: The Korea National Health Insurance claims data of individuals with disabilities aged 40~64 years with chronic periodontitis in 2008 were obtained. Of these, data on the disabled who underwent scaling/root plaining, subgingival curettage/periodontal surgery, or non-periodontal treatments, and data on their teeth were selected. The extraction of 716,688 teeth from 39,097 patients was tracked until 2018, and the patient- and tooth-level factors related to tooth loss were identified using a mixed-effect logistic regression analysis. Results: Data from approximately 17% of the teeth were extracted during a follow-up period of approximately 11 years. Among the tooth-level variables, scaling/root planing treatment at baseline and periodontal treatment during the follow-up period were associated with a lower risk of tooth loss (odds ratio=0.692 and 0.769, respectively, p<0.001). Non-vital teeth increased the risk of tooth loss by 3.159 times (p<0.001). Among the patient-level variables, females were less likely to have lost their teeth than males, and those with orthopedic impairment or brain lesions/mental disabilities, a higher age group, lower income level, or residents in medium/small cities or rural areas were more likely to have lost their teeth (p<0.001). Conclusion: Through approximately 11 years of follow-up, scaling or root planing, experience with periodontal treatment at least once, female sex, older age, lower income, smaller residential areas, type of disability, and pulp vitality were found to be associated with tooth loss in individuals with disabilities aged 40~64 years with chronic periodontitis. To prevent tooth loss in individuals with disabilities, it is necessary to establish a dental treatment plan that considers the timing of periodontal treatment and the characteristics of the patient and teeth.

• 한국환경과학회지
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• 제32권12호
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• pp.925-932
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• 2023

The objective of this study was to investigate the effects of microbial additive on the meat quality and fatty acid (FA) profiles of growing-finishing pigs. A total of 180 growing-finishing pigs (Landrace × Yorkshire × Duroc; mixed sex; 14 weeks of age; 58.0 ± 1.00 kg) were randomly distributed into three treatments with three pens consisting of 20 growing-finishing pigs per pen for 60 days. The experimental treatments were as follows: 0, 0.5, and 1.0% microbial additive. The crude protein, cooking loss, drip loss, water holding capacity, and shear force in loin muscle were no significant differences among treatments (p>0.05), except for the moisture and crude fat contents. The pH and TBARS of loin muscle shown no significant differences among treatments (p>0.05). However, the L^* and a^* values of loin muscle were the highest in the 1.0% supplementation group compared with the other treatments (p<0.05). The b^* value of loin muscle was the highest in the control group compared with the other treatments (p<0.05). Linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, and n-3 FAs contents of loin muscle were the highest in 1.0% supplementation group compared with the other treatments (p<0.05). In conclusion, using 1.0% microbial additive supplementation can improve meat quality by increasing polyunsaturated FA concentration and meat color in pig loins.

• The Korean Journal of Physiology and Pharmacology
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• 제28권2호
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• pp.121-127
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• 2024

Vancomycin is a frequently used antibiotic in intensive care units, and the patient's renal clearance affects the pharmacokinetic characteristics of vancomycin. Several advantages have been reported for vancomycin continuous intravenous infusion, but studies on continuous dosing regimens based on patients' renal clearance are insufficient. The aim of this study was to develop a vancomycin serum concentration prediction model by factoring in a patient's renal clearance. Children admitted to our institution between July 1, 2021, and July 31, 2022 with records of continuous infusion of vancomycin were included in the study. Sex, age, height, weight, vancomycin dose by weight, interval from the start of vancomycin administration to the time of therapeutic drug monitoring sampling, and vancomycin serum concentrations were analyzed with the linear regression analysis of the mixed effect model. Univariable regression analysis was performed using the vancomycin serum concentration as a dependent variable. It showed that vancomycin dose (p < 0.001) and serum creatinine (p = 0.007) were factors that had the most impact on vancomycin serum concentration. Vancomycin serum concentration was affected by vancomycin dose (p < 0.001) and serum creatinine (p = 0.001) with statistical significance, and a multivariable regression model was obtained as follows: Vancomycin serum concentration (mg/l) = -1.296 + 0.281 × vancomycin dose (mg/kg) + 20.458 × serum creatinine (mg/dl) (adjusted coefficient of determination, R² = 0.66). This prediction model is expected to contribute to establishing an optimal continuous infusion regimen for vancomycin.

• 한국환경보건학회지
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• 제50권3호
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• pp.201-211
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• 2024

Background: Organic ultraviolet (UV) filters are widely used in sunscreen products and have been identified as an emerging contaminant. Organic UV filters co-exist with multiple components, but their mixture toxicity remains largely unknown. Objectives: We investigated the toxicity of single and binary mixtures of commonly used UV-filters using the human adrenocarcinoma (H295R) cell line. Methods: After exposure to non-cytotoxic concentrations of avobenzone (AVO), homosalate (HS), octisalate (OS), octinoxate (OMC), and octocrylene (OC), the levels of testosterone (T) and 17β-estradiol (E2) were measured. The median effective concentration (EC₅₀) values for the E2 of the individual substances were used to determine the mixture effect of four binary combinations: OMC+AVB, OMC+HS, OMC+OS, and OMC+OC. The synergistic, additive, and antagonistic effects of the mixture were determined by calculating toxic units (TU). To examine the mechanism of mixture toxicity, eight genes involved in steroidogenesis were analyzed using the real-time polymerase chain reaction. Results: The significant increase in E2 in H295R cells exposed to AVO, HS, OS, OMC, and OC suggest an estrogenic effect of the tested UV-filters. A significant decrease in T was observed in cells exposed to HS and OS. EC₅₀ values for E2 increase were 105 nM for AVO, 110 nM for HS, 120 nM for OS, 55 nM for OMC, and 80 nM for OC. Both binary mixtures consisting of OMC+HS and OMC+OS have synergistic effects. Conclusions: Our results showed that five types of UV-filter substances increase E2 in H295R cells. We examined the mixture toxicity in terms of increased estrogenicity and confirmed that E2 significantly increased when OMC was mixed with a salicylate-based UV-filters. These findings highlight the importance of determining the impact of UV filter mixtures.

• 농업과학연구
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• 제51권2호
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• pp.123-132
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• 2024

Copper sulphate (CuSO₄) level was analyzed in this study to determine the effects on growth performance, nutrient digestibility, organ weight, and excreta score in Ross308-broilers. A total of 1,134 mixed sex, 1-d old Ross-308 chicks were randomly allocated to one of three treatment groups with 21 replication and 18 chicks / cage. For a period of 32 days, chicks were fed with the following treatment groups: CON: Basal diet, TRT1: 0.032% CuSO₄, TRT2: 0.047% CuSO₄ (Phase 1), 0.032% CuSO₄ (Phase 2), 0.025% CuSO₄ (Phase 3). The experiment was divided into three phases. Phase 1 (day 1 to 9), phase 2 (day 9 to 21), and phase 3 (day 21 to 32). During days 1 to 9, broilers receiving 0.032% or 0.047% of CuSO₄ in TRT1 and TRT2, respectively, had significantly higher body weight gain (BWG) (p = 0.042) than CON. Likewise, comparing TRT1 and TRT2 to CON during days 10 to 21, 0.032% of CuSO₄ significantly increased BWG (p = 0.013) and feed intake (FI), (p = 0.024) in the broiler. When compared to TRT1, the administration of 0.032% and 0.025% of CuSO₄ during days 22 to 32 reduced BWG and FI in CON and TRT2, respectively among the treatment groups. Throughout the experiment, the feed conversion ratio (FCR) did not change. However, the nutrient digestibility, weight of organs, and the score of excreta remained unchanged. The study found that CuSO₄ administration increased broiler BWG and FI without affecting FCR, nutrients digestibility, weight of organs, and excreta score.

• 대한지역사회영양학회지
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• 제19권6호
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• pp.527-536
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• 2014

본 연구는 중년 성인을 대상으로 식사 패턴을 파악하고, 식사 패턴에 따른 영양소 섭취실태와 대사증후군 위험요인의 관련성을 분석하고자 하였으며 연구결과는 다음과 같다. 1) 식품군별 평균 섭취량을 이용한 요인분석을 통해 육류, 주류, 난류, 유지류 등의 섭취가 두드러진 '육류와 술', 주식으로 잡곡류를 섭취하고 과일과 채소 등을 섭취하는 '잡곡과 채소 및 과일', 주식으로 백미를 위주로 하고 김치와 어패류를 섭취하는 '백미와 김치 및 어패류' 패턴이 분리되었다. 2) '육류와 술' 패턴의 요인점수가 높아질수록 신장, 체중, 허리둘레, 체질량지수가 증가하였고, 연령은 낮아지는 경향을 나타낸 반면 '잡곡과 채소 및 과일' 패턴은 반대의 경향을 나타내었다. '육류와 술' 패턴의 경우 남자, '잡곡과 채소 및 과일' 패턴의 경우 여자의 비율이 높았고, '백미와 김치 및 어패류' 패턴의 경우 교육수준이 높은 것으로 나타났다. 3) 식사 요인점수의 사분위에 따른 영양소 섭취량은 '육류와 술' 패턴의 식사를 할수록 에너지, 단백질, 나트륨의 섭취가 증가하였고, '잡곡과 채소 및 과일' 패턴의 식사를 할수록 탄수화물, 칼륨, 칼슘과 식이섬유의 섭취가 증가하였으며, '백미와 김치 및 어패류' 패턴의 식사를 할수록 에너지와 지질의 섭취가 증가하였고, 탄수화물, 칼륨과 식이섬유의 섭취가 감소하였다. 4) 식사 패턴과 영양소 섭취와의 상관관계에서 '육류와 술' 패턴의 경우 보정 후 단백질과 나트륨의 섭취가 양의 상관관계였으나, 탄수화물, 식이섬유, 칼슘, 칼륨 등의 섭취는 음의 상관관계였고, '잡곡과 채소 및 과일' 패턴의 경우 단백질, 지질, 나트륨과 티아민을 제외한 모든 영양소와 양의 상관관계를 나타내었다. 또한 '백미와 김치 및 어패류' 패턴과 지질의 섭취는 양의 상관관계였고, 탄수화물, 식이섬유, 칼륨 등의 무기질과 음의 상관관계를 나타내었다. 5) 식사 요인점수의 사분위에 따른 대사증후군의 위험도는 '육류와 술' 패턴의 식사를 할수록 복부비만과 대사증후군에 대한 위험도가 높아졌고, '잡곡과 채소 및 과일' 패턴의 식사를 할수록 고중성지방혈증에 대한 위험도가 낮아지는 것으로 나타났다. 본 연구의 결과로부터 식사 패턴과 대사증후군 위험요인간에 관련성이 있는 것으로 나타나 육류와 술의 섭취를 줄이고, 잡곡을 위주로 채소와 과일 등을 추가한 균형 잡힌 건강식을 섭취하는 것이 대사증후군의 예방 및 관리를 위해 권장될 수 있을 것으로 사료된다.

• Journal of Preventive Medicine and Public Health
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• 제15권1호
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• pp.167-177
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• 1982

This study was undertaken to observe relationships between patterns of feeding, supplementary-feeding and various maternal, family, and socioeconomic charactereistics in Hae Cheog Apartment area in Cheongdam-dong, Kangnamku, Seoul on July 2 to 12 in 1982. The results were based on a questionnaire from 179 mothers who have the last-born child under two years old. Results were as follows: 1) In socio-demographic characteristics, most of mothers were 25 to 30 years old and 52.0% of index children were under 6 months old. About 56.0% of families were the salaries and 47.0% of them earn over 500,000 won a month. 40.8% of mothers were college graduates and 81.6% of mothers had no occupation. 2) 89.4% of mothers received prenatal care in pregnancy of the index children and mothers who have delivered the child in medical institute were 88.3%. Mothers who recieved education of breast care and feeding technique through prenatal care were 22.4%, 31.8% respectively. 3) In the feeding method, 44.1% of mothers took the breast feeding, 24.0% of them chose the artificial feeding, and 20.7% of them chose the mixed feeding. Mothers who changed the-method from breast feeding to artificial feeding were 10.6% and only 0.6% of mothers changed from artificial feeding to breast feeding. 4) According to the questionnaire, 37 mothers have already finished lactation (no relation with. the beginning of weaning food). In breast feeding, one mother has lactated for $4{\sim}6$ months, one has lactated for $7{\sim}9$ months, four have lactated for $10{\sim}12$ months, and seven have. continued the lactation over 12 months. In artificial and mixed feeding, as the same phenomenon, most of mothers have lactated for more than 12 months. 5) The reasons for feeding method were as follows: In breast feeding, 64.6% of them took the method because they thought the breast milk nutrious, in artificial feeding, 34.9% of them chose it because they had occupation and in the mixed feeding, 67.6% of mothers took the method because of lack of their breast milk. In the case of changing the method from breast feeding to artificial feeding, 42.1% of them answered that they had to change the method because of lack of breast milk. 6) In most of cases, the 4th month was the proper period to begin the weaning food and 32.5% of breast feeding children and 27.6% of artificial feeding children began the weaning food in 4th month. After 4th month, there was no difference between breast feeding and artificial feeding in the beginning of weaning food. 7) In the matter of menstruation, 29.8% of mothers who had breast feeding started their menstruations in 3 months and the rest of them delayed until 12 months. 40% of mothers who had artificial feeding began to menstruate after 2 months and all the rest started within 5 months. 8) The birth interval between the index child and next new child (would-be-born): In breast feeding, the interval of $18{\sim}24$ months had a majority as 50.0%, and in the artificial feeding, the interval of over 24 months marked 66.7% of them. It was analyzed that the birth interval of artificial feeding was wider than that of breast feeding. 9) In the desirable number of children, the mothers who had breast feeding wanted two sons and two daughters as proper children. Those who want two children in disregard of the sex (son or daughter) were 89.3% of breast feeding, and 80.0% of artificial feeding respectively. Mothers who had breast feeding wanted two children rather than one child. 10) In the family planning practice, the rate of practice were 41.9% in breast feeding, and 58.1% in artificial feeding respectively. In the case of breast feeding, the using rate of family planning practice in men was higher than in women.

• Clinical and Experimental Pediatrics
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• 제50권9호
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• pp.848-854
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• 2007

목 적 : 최근 모유 수유에 대한 관심이 증가되고 있으나 모유 수유를 위한 충분한 교육과 여건이 성숙되지 못한 상황에서 이를 고집하여 조기 모유 황달이 증가하는 경향이 있다. 본 연구는 이러한 황달의 원인과 위험인자, 핵황달의 조기 예측도구로서 ABR 검사의 유용성을 알아보고자 시행하였다. 방 법 : 2005년 9월부터 2006년 5월까지 신생아 황달로 입원치료 받은 환아 중 임신과 분만 시 관련 합병증이 없었던 출생체중 2,500 g 이상, 재태 주령 37주에서 42주의 36명을 대상으로 하였다. 이 중 전적으로 모유 수유만을 시행한 환아 23명을 모유 수유군으로 하였고, 모유 수유를 우선으로 하였으나 부족분을 조제유로 보충한 13명을 혼합 수유군으로 하였다. 결 과 : 두 군간 임상적 특성은 통계학적 차이가 없었고 다만 외래 방문 시 일령은 모유 수유군($8.7{\pm}3.6$일)이 혼합 수유군($6.0{\pm}1.9$일)에 비해 유의하게 늦었으며(P=0.009), 1주 이후인 경우에서 혈청 빌리루빈이 높은 경향이 관찰되었다. 모유 수유군이 23명(63.9%), 혼합 수유군 13명(36.1%)으로 조사되었고, 혼합 수유의 경우 산모가 적극적으로 모유 수유를 원했으나 모유량의 부족으로 인한 선택이었으며, 모유 수유군에서 혼합 수유군에 비해 유의하게 체중 감소가 심하였다(P<0.05). 비정상 ABR은 혈청 빌리루빈 33.5 mg/dL(외래 방문 시 일령 9일), 32.1 mg/dL (외래 방문 시 일령 7일), 20.3 mg/dL(외래 방문 시 일령 13일) 의 3례에서 V 파형의 소실이 관찰되었고 추적검사가 이루어진 경우 회복을 보였다. ABR 검사 상 70 dB 자극에서 III 파형이 혈청 빌리루빈 값의 증가에 따른 잠복기 연장이 유의한 상관관계를 보였고(P=0.002), 연령을 포함한 다중회귀분석에서도 혈청 빌리루빈 값과 유의한 결과를 확인할 수 있었다(P<0.01). 결 론 : 신생아 황달에서 핵황달의 조기 예측도구로서 ABR 검사를 이용하기 위해서는 향후 지속적인 연구를 통해 파형의 소실 외에도 유의한 잠복기의 연장이나 파형의 변형에 따르는 분석을 위해 검사방법과 정상치를 표준화함으로써 도움이 될 수 있을 것으로 생각된다. 또한 모유 수유의 경우 조기 모유 황달을 예방하려면 산모에 대한 충분한 교육 및 생후 1주 이내의 외래 방문을 권할 필요가 있으며, 혈청 빌리루빈 및 ABR 검사를 시행하면 교환 수혈의 시행 여부에도 도움이 될 수 있을 것으로 생각된다.