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Pharmacological Treatment of Major Depressive Episodes with Mixed Features: A Systematic Review

  • Shim, In Hee;Bahk, Won-Myong;Woo, Young Sup;Yoon, Bo-Hyun
    • Clinical Psychopharmacology and Neuroscience
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    • v.16 no.4
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    • pp.376-382
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    • 2018
  • We reviewed clinical studies investigating the pharmacological treatment of major depressive episodes (MDEs) with mixed features diagnosed according to the dimensional criteria (more than two or three [hypo]manic symptoms+principle depressive symptoms). We systematically reviewed published randomized controlled trials on the pharmacological treatment of MDEs with mixed features associated with mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). We searched the PubMed, Cochrane Library, and ClinicalTrials.gov databases through December 2017 with the following key word combinations linked with the word OR: (a) mixed or mixed state, mixed features, DMX, mixed depression; (b) depressive, major depressive, MDE, MDD, bipolar, bipolar depression; and (c) antidepressant, antipsychotic, mood stabilizer, anticonvulsant, treatment, medication, algorithm, guideline, pharmacological. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We found few randomized trials on pharmacological treatments for MDEs with mixed features. Of the 36 articles assessed for eligibility, 11 investigated MDEs with mixed features in mood disorders: six assessed the efficacy of antipsychotic drugs (lurasidone and ziprasidone) in the acute phase of MDD with mixed features, although four of these were post hoc analyses based on large randomized controlled trials. Four studies compared antipsychotic drugs (olanzapine, lurasidone, and ziprasidone) with placebo, and one study assessed the efficacy of combination therapy (olanzapine+fluoxetine) in the acute phase of BD with mixed features. Pharmacological treatments for MDEs with mixed features have focused on antipsychotics, although evidence of their efficacy is lacking. Additional well-designed clinical trials are needed.

Functional Improvement of the Clothing Material for Patients by Chitosan/Nanosilver Mixed Solution - The Assessment of Mechanical Properties and Hand Value - (키토산/은나노 혼합용액처리에 의한 환자복 소재의 기능성 향상 - 역학적 특성과 태 평가 -)

  • Jeong, Kyoung-Mi;Kang, In-Sook;Bae, Hyun-Sook
    • Textile Coloration and Finishing
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    • v.21 no.1
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    • pp.21-29
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    • 2009
  • In order to enhance the functionality of a cotton fabric actually used as a clothing material for patients, the fabrics were treated with a chitosan/nanosilver mixed solution. The nanosilver had excellent biocompatibility, provided expectation of an additional performance, did not harm human beings, and supplements chitosan, which was disadvantaged if used alone for fabric treatment. The nanosilver was mixed thereto and a treatment effect due to a mixing ratio was considered. This study was observed through mechanical properties and hand value which were the important function. The treatment of chitosan/nanosilver mixed solution gave a smoother surface than the treatment of chitosan alone. As a result of evaluation of the forms according to KES-FB system, Koshi was deduced, and both Numeri and Fukurami were increased. Thereby, the cotton fabric was a little smooth to provide elasticity, due to the treatment of chitosan/nanosilver mixed solution. THV of the treated fabrics calculated from this basis increased at all mixing ratio as compared with the untreated fabric. The fabrics treated with chitosan/nanosilver mixed solution were shown a better THV than the fabric treated with chitosan alone.

Sensory and Physical Characteristics of Consomme Prepared with Different Ratios of Beef and Chicken (쇠고기와 닭고시의 배합비에 따른 Consomme의 관능적 및 물리적 특성)

  • Kim Young-Sik;Jang Myung-Sook
    • Journal of the East Asian Society of Dietary Life
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    • v.15 no.5
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    • pp.582-590
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    • 2005
  • The application of consomme prepared with different ratios of ground beef and ground chicken to improve taste preferences and the cost of foodstuffs was attempted by reviewing fundamental data and the effect on the sensory and physical characteristics of treatment These treatments were prepared with different ratios(9:1(A), 7:3(B), 5:5(C), 3:7(D), 1:9(E) w/w) of ground beef and ground chicken, respectively. Sensory properties were evaluated in the aspects of both acceptability and intensity. From the acceptability aspect, A treatment showed the highest scores in smell, B in mouthfeel and taste, A and B in color and overall acceptability, respectively. In terms of acceptability, B treatment was favored most for color, mouthfeel, taste and overall acceptability except smell. The more the ground chicken, the higher the intensity aspect E treatment showed higher values than A in all the intensity aspects. Moisture contents and crude proteins increased by increasing the mixed ratio of ground beef, whereas crude ash, solid matter and pH increased by increasing the mixed ratio of ground chicken. Tumidity values were the highest in E treatment, whereas the lowest in A. Tumidity values were increased significantly by increasing the mixed ratio of ground chicken. Viscosity increased by increasing the mixed ratio of ground chicken. The highest viscosity was shown in E treatment The colorimetric lightness values(L) decreased and redness(a), yellowness(b) and total color difference values(AE) increased significantly by increasing the mixed ratio of ground chicken. This experimental study showed that A and B treatment had the highest values in overall acceptability. The results of analysis in crude protein, solid matter, tumidity and viscosity were increased by increasing the mixed ratio of ground chicken. B treatment prepared with a ratio of 7:3 of ground beef and chicken had the most favorable sensory quality. These results suggested the basic information to improve acceptability and to save the costs of Consomme recipes for foodservice institutions.

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A case of patient who have depressive episode mixed with organic depressive disorder (기질성 우울장애가 혼재된 우울증 환자 1례)

  • Seo, Won-Hee;Moon, Ik-Ryol;Kim, Jeong-Keun;Bae, Kyeong-Yeon;Heo, Yoon-Kyoung;Park, Hyeong-Seon
    • Journal of Oriental Neuropsychiatry
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    • v.14 no.2
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    • pp.199-206
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    • 2003
  • Objective : This is a case report of the patient diagnosed as the depressive episode mixed with organic depressive disorder. Method : We treat the patient with herbal medication and gave acupuncture treatment about 5 weeks, the symptom of the patient improved. The herbal medication and acupuncture treatment which we gave patient was based on Oriental medical diagnosis. Results : The patient had been taken the western medical treatment for 2 months, the symptom of the patient was not improved. But after the Oriental medical treatment, the patient is on the improving state. Conclusion : In the treatment of the depressive disorder which is mixed with organic depressive disorder, we found that the Herbal medication and Acupuncture based on correct 'Byonjung(辦證)' help the care of depressive episode which is mixed with organic depressive disorder.

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The effect of heat treatment mass flow on superconducting property of Bi-2223/Ag Tapes. (열처리 가스유량에 따른 Bi-2223/Ag 초전도 테이프의 특성에 미치는 영향)

  • 양주생;하동우;이동훈;최정규;황선역;오상수;김상철;김명호
    • Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
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    • 2003.10a
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    • pp.96-98
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    • 2003
  • Many of research efforts have been focused on the improvement of critical current density Jc of silver-sheathed Bi-2223 tapes for practical applications of material. Bi-2223 superconducting wires with 55 filaments were fabricated by stacking, drawing process with different heat-treatment histories. After rolling process, Bi-2223 tapes were heat-treatment at 780~826$^{\circ}C$ with variable mass flow rate of mixed gas. In this study, the effect of changes in the variable mass flow rate of mixed gas during the heat treatment of Bi-2223/Ag tapes has been investigated. Distinct differences were observed in the Bi-2223 phase and critical current as flow rate of mixed gas. We could achieve proper conditions of mass flow rate of mixed gas for Ag-alloy clad Bi-2223 superconducting tapes.

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Effect of Continuous Treatment of Mixed Organic Fertilizer With Food Waste on the Growth and Yield of Solarium lycopersicum

  • Ho-Jun Gam;Yosep Kang;Eun-Jung Park;Seong-Heon Kim;Sang-Mo Kang;In-Jung Lee
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2022.10a
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    • pp.110-110
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    • 2022
  • According to the statistics of the Ministry of Environment, the amount of food waste generated in Korea is 15,903 tons, which accounts for about 30% of the daily household waste. Food waste in Korea is on the rise, and various odors, greenhouse gases, and leachate generated in the process of discharging, transporting, and processing are emerging as social problems. Accordingly, there is a need for a method for recycling food waste. Therefore, this study was carried out to establish an appropriate limiting dose by manufacturing fertilizer mixed with food waste powder and treating it on tomatoes to investigate the growth and yield of crops. The experiment was carried out with continuous cultivation in 2021 (1st year) and 2022 (2nd year), and the treatment groups were set to No Treatment (NT), Chemical Fertilizer (CF), Mixed Fertilizer (MF), and Mixed Fertilizer×2 (MF×2). As a result of the 1st year growth survey, shoot and root length did not show a significant difference between the treatment groups, and the fresh weight showed a significant difference between the MF and MF×2. As a result of the 2nd year growth survey, there was no significant difference in shoot length, root length, and dry weight between the treatment groups, and the fresh weight of the CF was significantly greater than that of the MF×2. The yield of 1st year, MF×2 increased significantly compared to other treatment groups. In the case of 2nd year, CF, and MF×2 show significantly high values compared to NT. Judging from these results, continuous cultivation using food waste powder mixed fertilizer did not have a significant effect on crop growth and yield. However, it is considered that several studies including continuous cultivation experiments are needed to accurately set the appropriate application amount and limit the application amount of the mixed fertilizer for food waste.

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Evaluation of Physical Shear Pre-treatment and Biogas Characteristics using Mixed Sludge (물리적 파쇄 가용화를 이용한 혼합슬러지의 가용화 효율 및 바이오가스 특성 평가)

  • Choi, Jae-Hoon;Jeong, Seong-Yeob;Kim, Ji-Tae
    • Journal of Korean Society on Water Environment
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    • v.35 no.4
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    • pp.362-369
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    • 2019
  • In this study, biodegradation efficiency improvement of mixed sludge for the anaerobic digestion process in wastewater treatment plant was investigated. In order to release the organic material contained in the sludge cell and promote the hydrolysis step, mixed sludge of 7% TS (Total Solids) was physically shear-treated at a shear strength of 1,000 ~ 4,000 rpm and a maximum of 120 mins. As a result of the comparison between mixed sludge before and after the treatment, the concentration of $SCOD_{Cr}$(Soluble Chemical Oxygen Demand-chromium method) was increased through the conversion of granular organic matter into dissolved organic matter as shear strength and treatment time increases. The solubilization efficiency increased rapidly after 30 min of solubilization application time, and they were 11.23 %, 20.10 %, 22.52 % and 25.43% at 120 min for each shear strength conditions, respectively. Additionally, the BMP(Biochemical Methane Potential) test was conducted with the optimized samples to determine the increase of methane production by the shear pre-treatment. Consequently, methane production of each samples were 0.275, 0.310, 0.323 and $0.335m^3/kg\;VS_{add}$, which indicates that methane production was increased to a maximum of 21.28% compared to the control without the solubilization process ($0.262m^3/kg\;VS_{add}$). As a result, the physical shear-treatment is a promising process for sewage sludge pre-treatment to reduce the organic waste and increase the energy production.

Preparation of the Applicable Regulatory Guideline on Mixed Waste in Korea Based on the Analysis of US Laws and Regulations

  • Sim, Eun-Jin;Lee, Sun-Kee;Kim, Chang-Lak;Kim, Tae-Man
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.19 no.1
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    • pp.141-160
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    • 2021
  • Unit 1 of the Kori Nuclear Power Plant (NPP) and Unit 1 of the Wolsong NPP are being prepared for decommissioning; their decommissioning is expected to generate large amounts of intermediate-level, low-level, and very low level Waste. Mixed waste containing both radioactive and hazardous substances is expected to be produced. Nevertheless, laws and regulations, such as the Korean Nuclear Safety Act and Waste Management Act, do not define clear regulatory guidelines for mixed waste. However, the United States has strictly enforced regulations on mixed waste, focusing on the human health and environmental effects of its hazardous components. The U.S. Nuclear Regulatory Commission and the U.S. Department of Energy regulate the radioactive components of mixed waste under the Atomic Energy Act. The U.S. Environmental Protection Agency regulates the hazardous waste component of mixed waste under the Resource Conservation and Recovery Act. In this study, the laws, regulations, and authorities pertaining to mixed waste in the United States are reviewed. Through comparison and analysis with waste management laws and regulations in Korea, a treatment direction for mixed waste is suggested. Such a treatment for mixed waste will increase the efficiency of managing mixed waste when decommissioning NPPs in the near future.

A Case Report of A Mixed Hemorrhoid Patient Treated by Herbal medicine Treatment (한약 치료로 개선된 혼합 치핵 환자에 관한 증례 보고)

  • Jo, Yoon-Sang;Jin, Hyeun-Gyu;Lee, Seok-Min;Kim, Seok-Hee;Seo, Hyung-Sik;Choi, Yoo-Min
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.34 no.4
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    • pp.171-180
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    • 2021
  • Objectives: The purpose of this study is to report the clinical course of a patient with mixed hemorrhoids treated with Korean medicine alone. Methods: A patient visited for an mixed hemorrhoids was treated with Korean herbal medicine. The effects of the treatment were evaluated via photography of hemorrhoids and symptoms of pain, bleeding, prolapse, itching, discharge and Total Symptom Score(TSS). Results: After treatment, in photography before and after, the size of hemorrhoids was reduced and lost. Scores of Pain (4→0), bleeding (3→0), prolapse (3→2), itching (0→0), discharge (1→0) and TSS (11.5->3) were observed. Conclusion: In light of the reduced size of hemorrhoids and scores of symptoms, herbal medicine might be a possible treatment method on mixed hemorrhoids.

Effects of Mixed Activators on Enzymatic Activation for Wool.polyester Blend Fabrics (양모.폴리에스터 혼방직물의 효소가공 시 활성제 복합사용의 효과)

  • Song, Hyun-Joo;Song, Wha-Soon
    • Journal of the Korean Society of Clothing and Textiles
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    • v.32 no.9
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    • pp.1461-1466
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    • 2008
  • This study provides effects of mixed activators on enzymatic activation and determines optimum mixture ratio for enzymatic treatment. Wool 80% and polyester 20% blend fabric and papain from carica papaya are used in this experiment. L-cysteine and sodium sulfite are used as activators for papain treatment process. The treatment condition is pH 7.5, $70^{\circ}$, papain concentration 10%(o.w.f), 60 minutes. L-cysteine and sodium sulfite are added in enzyme solution with various concentrations($0{\sim}50mM$). The optimum treatment condition is determined by measuring weight loss, tensile strength, whiteness, water contact angle(WCA), dyeability and surface micrographs. The results are as follow; The optimum mixture ratio of activators is L-cysteine 2mM and sodium sulfite 10mM. Mixed activators assists in improving the activation of papain. WCA of papain treated fabrics is decreased since papain treatment with activator mixture makes wool polyester blend fabrics more hydrophilic. Dyeing property of papain-treated fabrics more improves by the treatment with mixed activators than with single activator. It means that this method can save time and lower cost. After papain treatment in the presence of mixed activator, the surface of fabrics is modified. The surface of wool fiber shows to be descaled and hydrolyzed, and that of polyester fiber shows to be cracked.