• Structural Engineering and Mechanics
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• 제27권4호
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• pp.457-475
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• 2007

Analysis of transverse stresses at layer interfaces in a composite laminate has always been a challenging task. Composite structures possess highly irregular material properties at layer interfaces, which cause high shear stresses. Classical Plate Theory and First Order Shear Deformation Theory (FSDT) use post computing to calculate transverse stresses. This paper presents Reissner Mixed Variational Theorem (RMVT) based finite element model to carry out layer-wise analysis of composite laminates. Selective integration scheme has been used. The formulation has been validated by solving numerical examples and comparing the results with those published in the literature.

• Journal of applied mathematics & informatics
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• 제5권1호
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• pp.73-90
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• 1998

In this paper we introduce and study a number of new classes of quasi variational inequalities. using essentially the projection technique and its variant forms we prove that the gen-eralized set-valued mixed quasivariational inequalities are equivalent to the fixed point problem and the Wiener-Hopf equations(normal maps). This equivalence enables us to suggest a number of iterative algorithms solving the generalized variational inequalities. As a special case of the generalized set-valued mixed quasi variational in-equalities we obtain a class of quasi variational inequalities studied by Siddiqi Husain and Kazmi [35] but there are several inaccuracies in their formulation of the problem the statement and the proofs of the problem the statement and the proofs of their results. We have removed these inaccuracies. The correct formulation of thir results can be obtained as special cases from our main results.

• Structural Engineering and Mechanics
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• 제69권4호
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• pp.427-437
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• 2019

In this study, an alternative solution procedure presented by using variational methods for analysis of shear deformable functionally graded material (FGM) beams with mixed formulation. By using the advantages of $G{\hat{a}}teaux$ differential approaches, a refined complex general functional and boundary conditions which comprises seven independent variables such as displacement, rotation, bending moment and higher-order bending moment, shear force and higher-order shear force, is derived for general thick-thin FGM beams via shear deformation beam theories. The mixed-finite element method (FEM) is employed to obtain a beam element which have a 2-nodes and total fourteen degrees-of-freedoms. A computer program is written to execute the analyses for the present study. The numerical results of analyses obtained for different boundary conditions are presented and compared with results available in the literature.

• 한국전산구조공학회논문집
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• 제25권6호
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• pp.469-476
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• 2012

본 논문에서는 대규모 구조해석을 위하여 국부(local) 및 전역-국부 혼합(mixed) Lagrange 승수(Lagrange multiplier)를 이용한 새로운 유한요소 영역분할 기법을 제시한다. 제시되는 FETI 알고리즘은 계산 효율성을 향상시키기 위하여 기존의 FETI 기법들에서 사용되어 온 전통적인 Lagrange 승수법과는 달리, 국부 및 전역-국부 혼합 Lagrange 승수를 도입하고 ALF(Augmented Lagrangian Formulation)과의 결합을 유도하여 공유면 문제(interface problem)의 해의 수렴성을 향상 시켰다. 추가적으로, 몇 가지 수치예제 계산을 통해 기존의 FETI-DP 기법과 비교하여 유연도 행렬의 조건수, 계산 시간 그리고 메모리 사용량에 대한 계산결과를 제시하였다.

• Structural Engineering and Mechanics
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• 제26권6호
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• pp.725-739
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• 2007

In recent years there are many plate bending elements that emerged for solving both thin and thick plates. The main features of these elements are that they are based on mix formulation interpolation with discrete collocation constraints. These elements passed the patch test for mix formulation and performed well for linear analysis of thin and thick plates. In this paper a member of this family of elements, namely, the Discrete Reissner-Mindlin (DRM) is further extended and developed to analyze both thin and thick plates with geometric nonlinearity. The Von K$\acute{a}$rm$\acute{a}$n's large displacement plate theory based on Lagrangian coordinate system is used. The Hu-Washizu variational principle is employed to formulate the stiffness matrix of the geometrically Nonlinear Discrete Reissner-Mindlin (NDRM). An iterative-incremental procedure is implemented to solve the nonlinear equations. The element is then tested for plates with simply supported and clamped edges under uniformly distributed transverse loads. The results obtained using the geometrically NDRM element is then compared with the results of available analytical solutions. It has been observed that the NDRM results agreed well with the analytical solutions results. Therefore, it is concluded that the NDRM element is both reliable and efficient in analyzing thin and thick plates with geometric non-linearity.

• 대한약침학회지
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• 제24권3호
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• pp.142-151
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• 2021

Objectives: Although Korean Medicine (KM) subsidized by the National Health Insurance (NHI) has been used for a long time, there has been no active analysis using claims data. Therefore, the purpose of this study was to examine the NHI KM utilization trend using NHI statistics and to measure the level of market concentration by year. Methods: By restructuring the contents of NHI Statistics for Pharmaceuticals for 2010-2019, the claim cases, costs, and annual growth rates of KM were demonstrated by year, sex, age group, region, therapeutic group, and KM treatment. The proportion of highly used k treatments in cost was calculated as the concentration ratio (CR) k and its trend by year was investigated. Results: In 2019, the NHI cost on KM amounted to ₩38.2 billion KRW, increasing by 11.6% per year on average in 2010-2019. Notably, KM was used more frequently among women and patients aged ≥ 65 years, and the mixed formulation accounted for 95% of the total cost of KM. The CR of the simple formulation increased rapidly, whereas that of the mixed formulation remained constant. In 2019, three simple formulation treatments- peony, licorice, and ginseng- accounted for 93.8% of the total cost for KM (CR3 = 93.8%). Conclusion: NHI KM is rapidly increasing. Investigating the CR of KM confirmed that KM prescriptions have been concentrated in small numbers over the past 10 years.

• Structural Engineering and Mechanics
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• 제8권5호
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• pp.505-512
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• 1999

Based on the concept of the parameter-mixed synthesis, this paper presents a mixed formulation of the substructure synthesis method in terms of the physics-impedance-modal parameter. An example is given to show the validity of this method.

• Kyungpook Mathematical Journal
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• 제58권3호
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• pp.453-462
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• 2018

In this paper, we present a symbolic formulation of the error obtained due to an approximation of a given function by the mixed-interpolating function. Using the proposed symbolic method, we compute the error evaluation operator as well as the error estimation at any arbitrary point. We also present an algorithm to compute an approximation of a function by the mixed interpolation technique in terms of projector operator. Certain examples are presented to illustrate the proposed algorithm. Maple implementation of the proposed algorithm is discussed with sample computations.

• Journal of Microbiology and Biotechnology
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• 제24권10호
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• pp.1438-1444
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• 2014

Lactic acid bacteria (LAB) are probiotics that provide numerous beneficial effects on the host body, especially on the intestine. Combining several strains of LAB, we prepared a formulation containing four different LAB and studied its anti-inflammatory activity both in vitro and in vivo. The formulation significantly reduced NO production from RAW 264.7 cells treated with bacterial lipopolysaccharide, indicating that the formulation might include anti-inflammatory activity. The formulation also suppressed inflammatory change induced by trinitrobenzene sulfonic acid (TNBS) in mice, where oral or rectal administration of the formulation protected the colon tissue from the damage by TNBS. Expressions of the IL-6 and FasL genes appeared to be down-regulated by the formulation in TNBS-treated colon tissues, suggesting that the suppression of those genes may be involved in the anti-inflammatory activity of the formulation.

• Journal of Pharmaceutical Investigation
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• 제26권1호
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• pp.1-11
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• 1996

Biphenyldimethyldicarboxylate (PMC), which has been used to treat hepatitis, is insoluble in water, therefore it has low bioavailability after oral administration. For the purpose of increasing the dissolution rate of PMC, the physical mixtures and inclusion complexes of PMC and $dimethyl-{\beta}-cyclodextrin\;(DM\;{\beta}CD)\;or\;hydroxypropyl-{\beta}-cyclodextrin\;(HP{\beta}CD)$ in molar ratio of 1 : 1 and 1 : 2 were prepared by solvent evaporation method. Mixed micelles of PMC were prepared by reacting PMC with bile salts [sodium cholate(NaC), sodium glycocholate (NaGC)] and oleic acid (OA) or palmitoylcarnitine chloride(PCC). Chloroform/water partition coefficient (PC) of PMC was 36.14 in artificial gastric juice (AGJ) and 33.47 in artificial intestinal juice (AIJ), respectively, on the other hand octanol/water PC was 63.36. PMC formulation was prepared by reacting PMC with PEG400-glycerin system(95 : 5, 90 : 10, respectively) and PEG400-PEG4000-glycerin system (70 : 25 : 5, 65 : 25 : 10, respectively). Dissolution test was performed in AGJ and AIJ by paddle method at $37{\pm}0.5^{\circ}C$. The dissolution rates of PMC tablets on the market were 5.74% and 8.26% at AGJ and AIJ, respectively and marketed PMC capsules were 22.14% and 28.64% at AGJ and AIJ, respectively. The dissolution rates of inclusion complexes of PMC with $DM{\beta}CD$ and $HP{\beta}CD$ in a molar ratio of 1 : 1 were more fast than those of corresponding physical mixtures. The decreasing order of dissolution rates was as follows; PMC-PEG400-PEG4000-glycerin formulation > PMC-PEG400-glycerin formulation > mixed micelles > CD inclusion complexes. The dissolution rates of PMC-PEG400-glycerin and PMC-PEG400-PEG4000-glycerin formulation were most fast and the percentage of dissolution was almost 100% within 20 minutes. And their dissolution rates after 120 minutes were markedly increased as compared with capsules on the market (4.0-fold and 3.2-fold in PMC-PEG400-glycerin formulation at AGJ and AIJ, respectively, and 4.8-fold and 3.7-fold in PMC-PEG400-PEG4000-glycerin formulation at AGJ and AIJ, respectively).