• Title/Summary/Keyword: mitigate

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Xylitol Mitigate Neutrophil Inflammatory Response Against Porphyromonas gingivalis Infection

  • Na, Hee Sam;Song, YuRi;Choi, Yoon Hee;Chung, Jin
    • International Journal of Oral Biology
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    • v.43 no.3
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    • pp.141-146
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    • 2018
  • Periodontitis is generally a chronic disorder characterized by breakdown of tooth-supporting tissues, producing dentition loss. Porphyromonas gingivalis (P. gingivalis), a Gramnegative anaerobic rod, is one of the major pathogens associated with periodontitis. Neutrophils are first line defense cells in the oral cavity that play a significant role in inflammatory response. Xylitol is a known anti-caries agent and has anti-inflammatory effects. In this study, we conducted experiments to evaluate anti-inflammatory effects of xylitol on P. gingivalis infected neutrophils for possible usage in prevention and treatment of periodontal infections. P. gingivalis was intraperitoneally injected and peritoneal lavage was collected for cytokine determination. For in vitro study, neutrophils were collected from mouse peritoneal cells after zymosan injection or bone marrow cells. Neutrophils were stimulated with live P. gingivalis and ELISA was used to determine the effect of xylitol on P. gingivalis induced cytokine production. $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ concentration and neutrophil population in the peritoneal lavage was increased in P. gingivalis-infected mouse. Peritoneal cells infected with live P. gingivalis revealed significantly increased production of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ at multiplicity of infection of 10. Neutrophils from bone marrow and peritoneal lavage revealed increased production of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$. Xylitol significantly mitigated P. gingivalis induced cytokine production in neutrophils. Findings indicate that xylitol is an anti-inflammatory agent in neutrophils infected with live P. gingivalis, that suggests its use in periodontitis management.

An Efficient Method to Update Character Moving Directions for Massively Multi-player Online FPS Games (대규모 온라인 FPS 게임을 위한 효율적인 캐릭터 방향 갱신 기법)

  • Lim, Jong-Min;Lee, Dong-Woo;Kim, Youngsik
    • Journal of Korea Game Society
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    • v.14 no.5
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    • pp.35-42
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    • 2014
  • In the market of First Person Shooter (FPS) games, Massively Multi-player Online FPS games (MMOFPS) like 'PlanetSide 2' have been popular recently. Dead reckoning has been widely used in order to mitigate the network traffic overload for the game server with hundreds or thousands of people. This paper proposes the efficient analytical method to calculate the tolerable threshold angle of moving direction, which is one of the most important factors for character status updating when dead reckoning is used in MMOFPS games. The experimental results with game testers shows that the proposed method minimizes the position error for character moving and provides natural direction updates of characters.

A Study on Usability Evaluation for Human Care Contents based Rehabilitation Training Equipment (휴먼 케어 콘텐츠 기반의 재활 훈련 장비의 사용성 평가 연구)

  • Kim, Hansang;Choi, Byung-Jae
    • Journal of the Korean Institute of Intelligent Systems
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    • v.27 no.2
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    • pp.157-163
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    • 2017
  • Due to economic development and advancement of medical science, an aging society where the proportion of the elderly population increases is coming. Korea's aging speed is growing rapidly compared to that of other developed countries. The physical and mental abilities of elderly people with aging are getting worse more and more. They want a kind of auxiliary system in order to mitigate and prevent their weakness. The supplementary system can greatly contribute to improving the quality of life for elderly people. In particular, some devices that include muscle strengthening and cognitive and balance ability enhancement are useful for the most older people. In this paper, we introduce a development of human care contents based rehabilitation equipment to enhance these functions, and present its usability evaluation. The evaluation is conducted for rehabilitation specialists as well as expected users and their results are analyzed.

Cathodic Protection of Reinforced Concrete Slab with Zn-Mesh in Marine Environment (해양환경 중 Zn-mesh를 적용한 콘크리트 슬랩의 음극방식 특성)

  • Kim, Ki-Joon;Jeong, Jin-A;Lee, Woo-Chul
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.04a
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    • pp.1065-1068
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    • 2008
  • Marine bridges are readily deteriorated due to the exposure to marine environment. The concrete deterioration occurred by corrosion of steel in concrete is mainly relevant to chloride in seawater. Chloride ions penetrate through porous concrete, and then reach to the reinforcing steel, and finally corroded them. The corrosion by-products(rusts) increase the volume as much as 6 to 10 times of origin steel. this creates expanding pressure and tensile stress, which cause the structures cracking and spalling. Sometimes the rebar corrosion is accelerated, and then collapsed catastrophically. In order to prevent corrosion damage, it is important to understand well regarding the reason of concrete corrosion, the quantification of its damage, and protection method/system to stop or to mitigate the corrosion. In this study, slab specimens were fabricated to evaluate the effect of cathodic protection which was simulated to marine bridges, and/or port structures. Zn-mesh sacrificial anode has been applied as a chathodic protection system and accelerated test conditions, i.e. temperature and salt concentration have been used in this study.

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Recommender Systems using SVD with Social Network Information (사회연결망정보를 고려하는 SVD 기반 추천시스템)

  • Kim, Min-Gun;Kim, Kyoung-jae
    • Journal of Intelligence and Information Systems
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    • v.22 no.4
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    • pp.1-18
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    • 2016
  • Collaborative Filtering (CF) predicts the focal user's preference for particular item based on user's preference rating data and recommends items for the similar users by using them. It is a popular technique for the personalization in e-commerce to reduce information overload. However, it has some limitations including sparsity and scalability problems. In this paper, we use a method to integrate social network information into collaborative filtering in order to mitigate the sparsity and scalability problems which are major limitations of typical collaborative filtering and reflect the user's qualitative and emotional information in recommendation process. In this paper, we use a novel recommendation algorithm which is integrated with collaborative filtering by using Social SVD++ algorithm which considers social network information in SVD++, an extension algorithm that can reflect implicit information in singular value decomposition (SVD). In particular, this study will evaluate the performance of the model by reflecting the real-world user's social network information in the recommendation process.

An Empirical Study on Berth-Length Calculation of Container Terminal (컨테이너 터미널 선석길이 산정에 관한 실증 연구)

  • Song, Yong-Seok;Nam, Ki-Chan;Yeon, Jeong-Hum;Kim, Jeong-Eun
    • Journal of Navigation and Port Research
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    • v.27 no.2
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    • pp.179-184
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    • 2003
  • In order to mitigate the overcapacity of Busan port, Busan new port has been developed as transshipment port which is capable of handling 8,000 TEU containership. Generally, design of transshipment port has to reflect the capacity of feeder because both mother vessels and feeders enter the planned port at the same time. However, the existing plan of Busan new port capacity needs to be reexamined since the adopted capacity of each berth at new port, 300,000 TEU, does not seem to be enough to handle both mother vessels and feeders. Therefore, in this study we calculated the required number of berth and berth length by considering cargo handling capacity in terms of the ship size and this study makes some implications in relation with the terminal development plan.

Design and Implementation of a Alarm-Cause Tracking System for Nuclear Power Plant (원자력발전소용 경보원인추적시스템 설계 및 구현)

  • Kim, Jung-Taek;Lee, Jung-Woon;Park, Jae-Chang;Kwon, Kee-Choon;Lyu, Sung-Pil
    • The Journal of Information Technology
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    • v.5 no.2
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    • pp.81-94
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    • 2002
  • When a alarm is happened in nuclear power plant, operator tries to identify the direct and specific causes of the alarm and to do proper actions to mitigate the effect of it. To recognize the specific causes of it, the operator uses his experiences, alarm procedures, logic diagrams and so on. But, if the alarm procedure described many causes of the alarm unfortunately, it is very difficult for the operator who has no experience on the alarm to search the causes of it in hundreds of logic diagrams when emergency. In this study, a system is proposed, which tracks and displays the causes of alarms on-line from computerized logic diagrams.

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Analysis of Phase Noise Effects in a Short Range Weather Radar (단거리 기상 레이다에서의 위상 잡음 영향 분석)

  • Lee, Jonggil
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.22 no.8
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    • pp.1090-1098
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    • 2018
  • Many short range weather radars with the low elevation search capability are needed for analysis and prediction of unusual weather changes or rainfall phenomena which occurs regionally. However, due to the characteristics of low elevation electromagnetic wave beam, it is highly probable that the received weather signals of these radars are seriously contaminated by the ground clutter. Therefore, the filter removing low Doppler frequency band is generally used to mitigate this problem. However, the phase noise in a radar system may limit the removal of the strong clutter and this may cause serious problems in estimating weather parameters because of the remaining clutter. Therefore, in this paper, the characteristics of phase noise in a radar system are investigated and the effects of the system phase noise are analyzed in the improvement of signal to clutter ratio for the strong clutter environment such as a short and low-elevated weather radar.

Novel Active Voltage Quality Regulator with Adaptive DC-Link Voltage Control

  • Xiao, Guochun;Zeng, Zhong;Liu, Kai;Hu, Zhiliang;Wang, Zhaoan
    • Journal of Power Electronics
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    • v.11 no.6
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    • pp.880-889
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    • 2011
  • In this paper, a novel Active Voltage Quality Regulator (AVQR) topology with a thyristor rectifier and an adaptive dclink voltage control strategy are proposed. The proposed AVQR can efficiently mitigate the long duration variations (e.g. undervoltages/overvoltages), voltage imbalances and voltage harmonics. Compared with conventional AVQRs, it can regulate the load voltage very well with a much lower dc-link voltage. This is accomplished by replacing the diode rectifier with a thyristor rectifier. Moreover, its dc-link voltage can vary with the deviations of the supply voltage through the proposed adaptive dc-link voltage control strategy. All of these contribute to its significantly higher efficiency for online operating, which is very important and attractive for many applications. The proposed topology and control strategy are theoretically analyzed in detail. Simulation results are also provided in the paper. Finally, the feasibility and effectiveness of the proposed method are verified by means of experimental results from a 2kVA prototype. Both of the simulation and experimental results show that the proposed AVQR can achieve a much higher efficiency and similar regulation performance when compared with the conventional ones.

A New Resource Allocation Technique to Mitigate Co-Channel Interference in Cellular OFDMA Systems (OFDMA 시스템에서 셀 외곽지역의 동일 채널간섭 최소화를 위한 자원할당 기법)

  • Kim Dai-Kwan;Kim Jong-Kyung;Seo Jong-Soo
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.6A
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    • pp.603-610
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    • 2006
  • This paper considers the problem of mitigating CCI(Co-channel Interference) in cellular OFDMA downlink systems. The users in the cell-edge area suffer from large CCIs, and their SINR requirements are hard to be maintained. To guarantee their QoS, we propose a new exclusive sub-carrier allocation and power control algorithm. The performance of the proposed two-step algorithm is simulated in SUI-A path-loss model, and it is compared with that of the conventional algorithm. The simulation results show that the data transmission rate in the cell-edge area was increased by 600Kbps within the same power constraint. The results indicate that with proposed algorithm, the data rate stability can be achieved independently of the user location in the cell.