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Short Bowel Syndrome as the Leading Cause of Intestinal Failure in Early Life: Some Insights into the Management

  • Goulet, Olivier;Nader, Elie Abi;Pigneur, Benedicte;Lambe, Cecile
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.22 no.4
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    • pp.303-329
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    • 2019
  • Intestinal failure (IF) is the critical reduction of the gut mass or its function below the minimum needed to absorb nutrients and fluids required for adequate growth in children. Severe IF requires parenteral nutrition (PN). Pediatric IF is most commonly due to congenital or neonatal intestinal diseases or malformations divided into 3 groups: 1) reduced intestinal length and consequently reduced absorptive surface, such as in short bowel syndrome (SBS) or extensive aganglionosis; 2) abnormal development of the intestinal mucosa such as congenital diseases of enterocyte development; 3) extensive motility dysfunction such as chronic intestinal pseudo-obstruction syndromes. The leading cause of IF in childhood is the SBS. In clinical practice the degree of IF may be indirectly measured by the level of PN required for normal or catch up growth. Other indicators such as serum citrulline have not proven to be highly reliable prognostic factors in children. The last decades have allowed the development of highly sophisticated nutrient solutions consisting of optimal combinations of macronutrients and micronutrients as well as guidelines, promoting PN as a safe and efficient feeding technique. However, IF that requires long-term PN may be associated with various complications including infections, growth failure, metabolic disorders, and bone disease. IF Associated Liver Disease may be a limiting factor. However, changes in the global management of IF pediatric patients, especially since the setup of intestinal rehabilitation centres did change the prognosis thus limiting "nutritional failure" which is considered as a major indication for intestinal transplantation (ITx) or combined liver-ITx.

Relationship Analysis of Reference Evapotranspiration and Heating Load for Water-Energy-Food Nexus in Greenhouse (물-에너지-식량 넥서스 분석을 위한 시설재배지의 기준작물증발산량과 난방 에너지 부하 관계 분석)

  • Kim, Kwihoon;Yoon, Pureun;Lee, Yoonhee;Lee, Sang-Hyun;Hur, Seung-Oh;Choi, Jin-Yong
    • Journal of The Korean Society of Agricultural Engineers
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    • v.61 no.4
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    • pp.23-32
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    • 2019
  • Increasing crop production with the same amount of resources is essential for enhancing the economy in agriculture. The first prerequisite is to understand relationships between the resources. The concept of WEF (Water-Energy-Food) nexus analysis was first introduced in 2011, which helps to interpret inter-linkages among the resources and stakeholders. The objective of this study was to analyze energy-water nexus in greenhouse cultivation by estimating reference evapotranspiration and heating load. For the estimation, this study used the physical model to simulate the inside temperature of the agricultural greenhouse using heating, solar radiation, ventilated and transferred heat losses as input variables. For estimating reference evapotranspiration and heating load, Penman-Monteith equation and seasonal heating load equation with HDH (Heating Degree-Hour) was applied. For calibration and validation of simulated inside temperature, used were hourly data observed from 2011 to 2012 in multi-span greenhouse. Results of the simulation were evaluated using $R^2$, MAE and RMSE, which showed 0.75, 2.22, 3.08 for calibration and 0.71, 2.39, 3.35 for validation respectively. When minimum setting temperature was $12^{\circ}C$ from 2013 to 2017, mean values of evapotranspiration and heating load were 687 mm/year and 2,147 GJ/year. For $18^{\circ}C$, Mean values of evapotranspiration and heating load were 707 mm/year and 5,616 GJ/year. From the estimation, the relationship between water and heat energy was estimated as 1.0~2.6 GJ/ton. Though additional calibrations with different types of greenhouses are necessary, the results of this study imply that they are applicable when evaluating resource relationship in the greenhouse cultivation complex.

Assessment of Photochemical Reflectance Index Measured at Different Spatial Scales Utilizing Leaf Reflectometer, Field Hyper-Spectrometer, and Multi-spectral Camera with UAV (드론 장착 다중분광 카메라, 소형 필드 초분광계, 휴대용 잎 반사계로부터 관측된 서로 다른 공간규모의 광화학반사지수 평가)

  • Ryu, Jae-Hyun;Oh, Dohyeok;Jang, Seon Woong;Jeong, Hoejeong;Moon, Kyung Hwan;Cho, Jaeil
    • Korean Journal of Remote Sensing
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    • v.34 no.6_1
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    • pp.1055-1066
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    • 2018
  • Vegetation indices on the basis of optical characteristics of vegetation can represent various conditions such as canopy biomass and physiological activity. Those have been mostly developed with the large-scaled applications of multi-band optical sensors on-board satellites. However, the sensitivity of vegetation indices for detecting vegetation features will be different depending on the spatial scales. Therefore, in this study, the investigation of photochemical reflectance index (PRI), known as one of useful vegetation indices for detecting photosynthetic ability and vegetation stress, under the three spatial scales was conducted using multi-spectral camera installed in unmanned aerial vehicle (UAV),field spectrometer, and leaf reflectometer. In the leaf scale, diurnal PRI had minimum values at different local-time according to the compass direction of leaf face. It meant that each leaf in some moment had the different degree of light use efficiency (LUE). In early growth stage of crop, $PRI_{leaf}$ was higher than $PRI_{stands}$ and $PRI_{canopy}$ because the leaf scale is completely not governed by the vegetation cover fraction.In the stands and canopy scales, PRI showed a large spatial variability unlike normalized difference vegetation index (NDVI). However, the bias for the relationship between $PRI_{stands}$ and $PRI_{canopy}$ is lower than that in $NDVI_{stands}$ and $NDVI_{canopy}$. Our results will help to understand and utilize PRIs observed at different spatial scales.

Self-Healing Properties in Cracking of Blast Furnace Slag Cement Paste (고로 슬래그 시멘트 페이스트 균열에서의 자기치유 특성)

  • Lee, Seung-Heun;Kang, Kook-Hee;Lim, Young-Jin;Lee, Se-Jin;Park, Byeong-Seon
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.7 no.1
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    • pp.29-36
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    • 2019
  • This study investigated the self-healing properties of blast furnace slag cement paste sample with $Na_2SO_4$ as a blast furnace slag activator after conducting the permeability test. Self-healing properties were examined by crack filling ratio and quantification of self-healing products. The degree of self-healing was evaluated by the crack filling ratio, and the crack filling ratio was analyzed by panoramic analysis using BSE-DIP for objectivity. The average crack filling ratio showed a tendency of decreasing from the upper part of the specimen to the lower part as the average of the top part was 18%, the middle part was 7% and the bottom part was 5% on average. The maximum crack filling ratio was 44% and the minimum crack filling ratio was 3%. The residual self-healing product after the permeability test contained a large amount of Ca element and Al element derived from the blast furnace slag, and the Si element was mainly present near the crack surface. The most abundant minerals in self-healing products were about 68% C-A-H. $CaCO_3$ was about 13% and C-A-S-H was about 8%. Three minerals accounted for 90% of self-healing products. C-A-H was mainly present at a part slightly distant from the crack surface and showed an angular or acicular shape. The C-A-S-H was generated on the surface naturally connected to the existing specimen, and the $CaCO_3$ was generally observed on the surface of the specimen or the inside of the crack.

Basic Research for the Development of Collision Risk Model of Passing Vessels at an Anchorage (Safety Domain) (정박지 통항선박의 충돌위험 모델 개발을 위한 기초연구 - 정박지 통항선박의 안전 -)

  • Lee, Jin-Suk;Kwon, Yumin;Choi, Jung-Suk
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.27 no.1
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    • pp.67-73
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    • 2021
  • The purpose of this study is to obtain a safe area for a passing vessel between anchored vessels by developing a model to predict the collision risk, frequent collisions occur between the anchored vessel and the passing vessel through the anchorage. For this, this study selected the southern anchorage of Busan port, which is the largest harbor in Korea, as the target area and extracted and analyzed VTS (Vessel Traffic Service) data during the period in which anchored vessels were the most waited. The ratio of D/L for each bearing was obtained to determine the safe distance (D) passes based on the length (L) of the passing vessel between anchored vessels. Based on the average domain of the D/L ratio distribution, the percentage of anchored vessels within the scope of the pre-studied ship's domain was analyzed to obtain a domain reflecting the degree of risk of VTSOs. Further research will evaluate and analyze the collision risk of a passing vessel using Domain-watch, the minimum safe distance between anchored vessels, and the safe domain of a passing vessel through anchorage, to develop a model for VTS to manage anchorages more efficiently and safely.

Effect of Demand for Labor On Investment in Education (노동에 대한 수요가 교육에 대한 투자에 미치는 영향)

  • Ahn, Sukwhan
    • Journal of Industrial Convergence
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    • v.19 no.6
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    • pp.21-35
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    • 2021
  • The purpose of this paper is to examine how demand for labor affects the job seeker's decision on the level of investment in education. In the current paradigm of economic growth in which innovations and technological developments generally weaken the strength demand for labor and increases the uncertainty related to employment, this paper provides a theoretical framework that can be used as a basic framework in understanding the decision of investment in education in varying conditions of demand for labor. The following are the findings of this paper. First, the level of investment in education can generally be regarded to be higher as the demand for labor exacerbates but for the job seekers with a certain characteristic. Second, the Arrow-Pratt absolute risk-aversion measure is the characteristic of the job seeker that determines in what direction the job seeker changes in the level of investment in education, For an arbitrary level of demand for labor there exists a certain threshold which determines the minimum degree of risk-aversion required for the job seeker's Arrow-Pratt should go over to increase the level of education as demand for labor weakens. Third, the job seekers lower the level of education even though the demand condition in labor markets weakens if the compensation function does not depend on the level of education. This is surprising because it turns out that one of the reasons why job seekers invest in education is that they want to be recognized in their compensation for their level of education even when more education still raises the probability of employment.

Optimal Combination of Acupoints Based on Network Analysis for Chemotherapy-Induced Peripheral Neuropathy (네트워크 분석에 기반한 항암화학요법으로 유발된 말초신경병증의 최적 경혈 조합)

  • Kim, Min-Woo;Kim, Joong-Il;Lee, Jin-Hyun;Jo, Dong-Chan;Kang, Su-Bin;Lee, Ji-Won;Park, Tae-Yong;Ko, Youn-Seok
    • Journal of Korean Medicine Rehabilitation
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    • v.32 no.1
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    • pp.107-124
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    • 2022
  • Objectives This study aimed to identify optimal combinations of acupoints used to treat chemotherapy-induced peripheral neuropathy (CIPN). Methods We searched four international databases (MEDLINE, EMBASE, the Allied and Complementary Medicine Databases [AMED], and China National Knowledge Infrastructure [CNKI]) and five Korean databases (DBpia, Research Information Sharing Service [RISS], Korean Studies Information Service System [KISS], Oriental Medicine Advanced Searching Integrated System [OASIS], and KoreaMed) to identify randomized controlled trials (RCTs) that used acupuncture to treat CIPN. Network analysis was performed on the acupoints used in more than three included articles. We constructed a network by calculating the Jaccard similarity coefficient between acupoints and applied minimum spanning tree. Then, modularity analysis, degree centrality (Cd), and betweenness centrality (Cb) were used to analyze properties of the acupoints. Results A total of 25 articles were included. 24 acupoints were extracted from 25 articles. The combinations of acupoints having the highest Jaccard similarity coefficient were {EX-UE9, EX-LE10} and {ST36, SP6}. In the modularity analysis, acupoints were classified to six modules. ST40, EX-UE11, and KI6 had the highest Cd value while ST40, GB34 had the highest Cb value. Conclusions This study found the systematic framework of acupoint combinations used in CIPN studies. This study is expected to provide new perspectives of CIPN treatment to therapists. A RCT is in progress of using the network of this study as a guideline. If significant results are derived from the RCT, it will be possible to lay the groundwork to consider acupuncture for CIPN treatment.

A Case of a Soyangin Patient with Aggravated Voiding Dysfunction after Pontine Infarction (교뇌경색 이후 배뇨장애가 악화된 소양인 환자의 한의 치료 1례 보고)

  • Hye-Jin, Lee;Ye-Chae, Hwang;Tae-Bin, Yim;Kyung-Hwa, Lee;Seung-Yeon, Cho;Seong-Uk, Park;Jung-Mi, Park;Chang-Nam, Ko
    • The Journal of the Society of Stroke on Korean Medicine
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    • v.23 no.1
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    • pp.73-84
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    • 2022
  • ■Objective The purpose of this case report is to report the effect of Korean medicine treatment on a patient with pontine infarction complaining of discomfort due to aggravated voiding dysfunction after the onset of the stroke. ■Methods The patient was hospitalized for 44 days and treated with herbal medicine, acupuncture, electroacupuncture, moxibustion, and interferential current therapy(ICT). We checked the amount of self-voided volume and postvoid residual urine volume(PVR), and asked the patient to subjectively evaluate the degree of discomfort due to voiding dysfunction. ■Results After 44 days of hospitalization, the patient responded that the subjective discomfort due to residual urine remained 30% and delayed urine remained 50% compared to the day of admission. The maximum amount of PVR was 234 ml on the 3rd day, and the minimum amount of PVR was checked on 25th and 35th day as 0 ml. ■Conclusions This study suggests that Korean medicine treatment may be effective in the treatment of voiding dysfunction after stroke.

Adult Physical Activity and Health Related Quality of Life : National Big Data Utilization (7th National Health and Nutrition Survey) (성인의 신체활동과 건강관련 삶의 질 : 국가빅데이터를 중심으로)

  • Kim, Seung-Ju;Jeon, Min-Ju
    • Journal of Korea Entertainment Industry Association
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    • v.14 no.8
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    • pp.455-465
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    • 2020
  • The purpose of this study was to investigate the relationship between physical activity and health-related quality of life of adults using the 7th National Health and Nutrition Survey. The study was conducted with 11,211 adults, and the health-related quality of life was defined using the EuroQol group's EQ-5D and physical activity using GPAQ. Data analysis was performed using the SAS 9.4 program, the general characteristics and degree of physical activity of the subject, Chi-square for KEQ-5D index, and Logistic Regression Analysis for the relationship between physical activity and quality of life. As a result of the study, the general characteristics of the subjects were marital status, educational status, occupation, smoking, alcohol consumption, economic status, stress, chronic disease, chronic disease treatment, physical activity due to leisure and physical activity due to occupation, depending on gender. There was a difference (p<0.05). As for the quality of life related to physical activity and health, the quality of life was significantly lower by 37% in the 'minimum physical activity group' of occupational physical activity (p<0.05). The results of this study are expected to be provided as basic data for physical activity-related health policy establishment and physical activity programs.

Changes in Physicochemical Properties of Rice Grain during Long-Term Storage (장기저장한 벼 종실의 이화학적 특성 변화)

  • Lee, In-Keun;Kim, Kwang-Ho;Choi, Hae-Chune
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.38 no.6
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    • pp.524-530
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    • 1993
  • The experiment was carried out to investigate the changes in physicochemical properties of milled rice harvested in different year and stored for four to sixty four months. The fat acidity of milled rice increased sharply from four to sixteen months storage, and after then it was increased slowly to sixty four months. Amylose, magnesium, potassium content, and K/Mg ratio of milled rice were not changed by storage duration. Water absorption rates of milled rice at 21$^{\circ}C$ and 77$^{\circ}C$, and alkali digestion value were increased by longer storage duration. Difference of water absorption rate between rice samples was greater during initial forty minutes after soaking at 21$^{\circ}C$ and with longer the soaking time at 77$^{\circ}C$. Shorter gel length of rice flour was found with prolonged storage duration, while peak, minimum, cool, breakdown and setback viscosity of gelatinized rice flour on amylograph were increased along with increasing the storage duration. The volume expansion rate during cooking and degree of iodine coloration of cooking water were higher in the longer stored rice compared with shorter one, and the amount of soluble solid in cooking water was significantly decreased in rice stored longer period.

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