• Journal of Korean Neurosurgical Society
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• 제54권5호
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• pp.390-398
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• 2013

Objective : We determined whether the relationship between the neuropsychological performance of patients with mild traumatic brain injury (TBI) and their psychopathological characteristics measured by disability evaluation are interrelated. In addition, we assessed which psychopathological variable was most influential on neuropsychological performance via statistical clustering of the same characteristics of mild TBI. Methods : A total of 219 disability evaluation participants with mild brain injury were selected. All participants were classified into three groups, based on their psychopathological characteristics, via a two-step cluster analysis using validity and clinical scales from the Minnesota Multiphasic Personality Inventory (MMPI) and Symptom Checklist-90-revised (SCL-90-R). The Korean Wechsler Adult Intelligence Scale (K-WAIS), Korean Memory Assessment Scale (K-MAS) and the Korean Boston Naming Test (K-BNT) were used to evaluate the neurocognitive functions of mild TBI patients. Results : Over a quarter (26.9%) experienced severe psychopathological symptoms and 43.4% experienced mild or moderate psychopathological symptoms, and all of the mild TBI patients showed a significant relationship between neurocognitive functions and subjective and/or objective psychopathic symptoms, but the degree of this relationship was moderate. Variances of neurocognitive function were explained by neurotic and psychotic symptoms, but the role of these factors were different to each other and participants did not show intelligence and other cognitive domain decrement except for global memory abilities compared to the non-psychopathology group. Conclusion : Certain patients with mild TBI showed psychopathological symptoms, but these were not directly related to cognitive decrement. Psychopathology and cognitive decrement are discrete aspects in patients with mild TBI. Furthermore, the neurotic symptoms of mild TBI patients made positive complements to decrements or impairments of neurocognitive functions, but the psychotic symptoms had a negative effect on neurocognitive functions.

• Investigative and Clinical Urology
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• 제59권6호
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• pp.399-409
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• 2018

Purpose: To analyze data from an observational, prospective, cumulative registry study in 805 hypogonadal men stratified by mild or moderate-to-severe lower urinary tract symptoms (LUTS) according to International Prostate Symptom Score. Materials and Methods: A total of 412 men underwent testosterone therapy (TTh) with injectable testosterone undecanoate, 393 men served as untreated controls. Measures of urinary function, anthropometric and metabolic parameters were performed at least twice per year. Results: Data from 615 men with mild LUTS (253 treated, 362 untreated) and 190 with moderate-to-severe LUTS (159 treated, 31 untreated) were available. During a follow-up period of 8 years a significant improvement of LUTS was noted for all TTh-patients whereas the control-groups showed deterioration or fluctuation around initial values. Despite advancing age, TTh fully prevented worsening of symptoms. In parallel, a considerable improvement of anthropometric parameters, lipids and glycemic control, blood pressure, C-reactive protein, and quality of life was found. Moderate-to-severe LUTS was associated with worse cardiometabolic risk profile at baseline as well as worse cardiovascular outcomes during follow-up in comparison to mild LUTS. Effect size of TTh was more pronounced in men with moderate-to-severe than with mild LUTS. Conclusions: Correcting hypogonadism by TTh is highly effective and safe for improving LUTS in hypogonadal men. TTh may also improve cardiometabolic risk and major adverse cardiovascular events.

• 정신신체의학
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• 제20권2호
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• pp.105-111
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• 2012

연구목적 : 본 연구는 경도인지장애(Mild cognitive impairment, 이하 MCI)와 알쯔하이머형 치매(Dementia of Alzheimer's type, 이하 AD)의 신경정신증상 빈도와 점수를 조사하고 비교 분석한 뒤, 인지기능과 Korean Neuropsychiatric Inventory(K-NPI) 결과와의 상관관계를 알아보고자 하였다. 방 법 : MCI 또는 AD를 진단받은 163명의 환자들을 세 군으로 분류하였다. K-NPI를 이용하여 MCI 환자 55명, 경도의 AD 환자 56명, 중등도 이상의 AD 환자 52명을 대상으로 신경정신증상을 조사하였고, 세 군간의 K-NPI의 부척도별 빈도와 composite score를 비교하였다. 결 과 : MCI군에서 가장 흔한 증상은 우울/불쾌감, 수면/야간행동, 불안, 과민/불안정 순이었다. 경도 AD군에서의 증상은 초조/공격, 우울/불쾌감, 불안, 무감동/무관심, 수면/야간행동 순으로 빈번하게 나타났다. 중등도 이상 AD 군에서는 무감동/무관심, 우울/불쾌감, 초조/공격, 망상 순이었다. 이 중 망상, 환각, 초조/공격, 무감동/무관심, 이상행동증상, 식욕/식습관의 변화의 빈도는 세 군 간에 통계적으로 유의한 차이를 나타내었다. 총 NPI 점수는 MMSE-KC 점수와는 음의 상관관계를, GDS와는 양의 상관관계를 보였고, 모두 통계적으로 유의하였다. 결 론 : 신경정신증상은 MCI, AD에서 흔히 보이는데, 본 연구에서는 MCI와 경도의 AD에서 이들 증상들이 유사한 양상을 나타내었다. 정신증은 중등도 이상 AD에서 가장 흔하게 나타났고, 이로 인해 더욱 빠른 인지기능의 저하를 초래할 수 있다. 따라서 MCI와 AD의 각 진행 단계에 따른 적절한 치료가 필요하다.

• 한국콘텐츠학회논문지
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• 제19권4호
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• pp.651-662
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• 2019

본 연구는 경증치매노인의 행동심리증상과 가족의 부양스트레스 및 자기효능감의 관계를 파악함으로써 치매노인 가족의 부양스트레스를 감소시키는데 기초자료를 제공하기 위함이다. 이에 따른 관계를 규명하기 위한 분석은 기술통계, t-test, ANOVA를 이용하였다. 경증치매노인의 행동심리증상에 대한 가족의 부양스트레스와 자기효능감에 대해 알아본 결과, 치매노인의 행동심리증상과 가족의 부양스트레스는 양의 상관관계 (r=.655, p<.001), 치매노인 가족의 부양스트레스와 자기효능감은 음의 상관관계(r=-.334, p<.001)가 있었다. 본 연구결과를 토대로 경증치매노인의 행동심리증상에 대한 적절한 대처법 개발을 통해 지역사회 경증치매노인 가족의 부양스트레스를 감소시키고 자기효능감을 향상시키기 위한 방안이 필요할 것으로 사료된다.

• 대한방사선기술학회지:방사선기술과학
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• 제26권4호
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• pp.33-38
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• 2003

본 연구에서는 범 반구성 뇌경색(panhemisheric infarction)등 다른 종류의 뇌혈관 질환에 대한 관심에 비해서 비교적 소홀하기 쉬우며 임상적 증상이 뚜렷하게 나타나지 않아 조기 진단과 치료가 잘 이루어지지 않는 열공성 뇌경색 (lacunar infarction)의 자기공명상 소견을 알아보고자 하였다. 전체 대상자 196명에 대한 자기공명영상 검사 소견에서 정상이 116명 이였으며 very mild lacunar infarction 13명, mild lacunar infarction 41명, lacunar infarction 26명 등 80명이 열공성 뇌경색을 가지고 있었다. 그러나 very mild lacunar infarction과 mild lacunar infaction은 임상적으로 큰 의미가 없으므로 lacunar infaction으로 진단된 26명(13%)이 실질적인 임상적 의미를 갖는 열공성 뇌경색으로 해석되고 있다.

• 생물정신의학
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• 제15권3호
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• pp.194-203
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• 2008

Objectives : This study was aimed at evaluating the relationship between somatic symptoms, depression, anxiety and cognitive function in the patients with Mild Traumatic Brain Injury(MTBI). Methods : Thirty seven patients with MTBI were selected from those patients who had visited the Department of Neuropsychiatry of Wonkwang University Hospital from 2003 to 2007. To assess and quantify the somatic symptoms, depression and anxiety, Personality Assessment Inventory(PAI) was used. Assessment of cognitive function was carried out by using Korean Wechsler Adult Intelligence Scale(K-WAIS), Rey-Kim Memory Test, and Kims Executive Function Test. The effects of somatic symptoms, depression, and anxiety on the cognitive function were evaluated by Pearson correlation test. Results : Somatic symptoms, depression, and anxiety, all showed inverse correlation to cognitive function. Specifically, 1) an increase in somatic symptoms was associated with a decrease in attention, verbal short term memory, verbal recall and recognition, and visual memory. 2) An increase in anxiety was associated with a decrease in verbal recall and recognition. 3) An increase in depression was associated with a decrease in cognitive function that requires high attention and verbal memory. Conclusion : The patients with MTBI displayed diverse symptoms ranging from cognitive impairment to somatic symptoms, depression, and anxiety. Somatic and emotional symptoms were correlated with cognitive function(especially executive function). Importantly, this study raises the possibility of treating the cognitive impairment associated with MTBI by treating somatic symptoms, depression, and anxiety.

• 대한약침학회지
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• 제10권2호통권23호
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• pp.107-117
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• 2007

Objectives : This study is desinged in order to evaluate the Poison extraction method for the Atopic dermatitis. Methods : The authors observed the two cases of Atopic dermatitis patients who previously used steroid-based ointment. for treating the Poison Extraction Method. Conclusions : 1. In case 1, the patient with mild case of Atopic dermatitis in face is treated with the Poison extraction method. Rash symptoms intensed for first few days. As sweating appeared in the local area from the seventh day, all the symptoms was disappeared rapidly. No recurrence was found. 2. In case 2, the patient with severe case of Atopic dermatitis in whole body is treated with the Poison extraction method. The symptoms intensed after two months and all the symptoms of itchiness, rash, scaly letter dissapeared in the third and fourth months. No recurrence was found. 3. In both cases of mild and severe cases of Atopic dermatitis. all the symptoms were disappeared and no recurrence was found with the Poison Extraction Method.

• Clinical and Experimental Pediatrics
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• 제54권1호
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• pp.40-44
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• 2011

We present a case of tacrolimus-induced encephalopathy after successful kidney transplantation. An 11-year-old girl presented with sudden onset of neurologic symptoms, hypertension, and psychiatric symptoms, with normal kidney function, after kidney transplantation. The symptoms improved after cessation of tacrolimus. Magnetic resonance imaging (MRI) showed acute infarction of the middle cerebral artery (MCA) territory in the right frontal lobe. Three days later, she had normal mental function and maintained normal blood pressure with left hemiparesis. Follow-up MRI was performed on D19, showing new infarct lesions at both cerebral hemispheres. Ten days later, MRI showed further improvement, but brain single photon emission computed tomography (SPECT) showed mild reduction of uptake in both the anterior cingulate gyrus and the left thalamus. One month after onset of symptoms, angiography showed complete resolution of stenosis. However, presenting as a mild fine motor disability of both hands and mild dysarthria, what had been atrophy at both centrum semiovale at 4 months now showed progression to encephalomalacia. There are two points of interest in this case. First, encephalopathy occurred after administration of tacrolimus and improved after discontinuation of the drug. Second, the development of right-side hemiplegia could not be explained by conventional MRI; but through diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) of white matter tract, visualization was possible.

• 생물정신의학
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• 제24권4호
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• pp.212-218
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• 2017

Objectives We aimed to examine whether mindfulness skills are mediating the improvements of depressive symptoms in patients with mood disorders who practiced Mindfulness-Based Cognitive Therapy (MBCT). Methods A total of 19 patients with mood disorder were included in this study. The participants were divided into two subgroups: a normal to mild depression group and a moderate depression group. The participants completed questionnaires to assess depressive symptoms, anxiety, quality of life, suicidal idea, and mindfulness skills which were measured by the Five Facets of Mindfulness Questionnaire (FFMQ) before and after MBCT course. Results The moderate depression group showed improvements through MBCT in depressive symptoms and suicidal idea, but not in anxiety and quality of life. The normal to mild depression group showed no significant change through MBCT. The improvement of depressive symptoms in the moderate depression group was predictable by improvements of the five facets of mindfulness, especially by 'observe' and 'non-react' components. Conclusions This study showed that currently depressive patients with moderate severity but not with normal to mild severity benefit from MBCT in reducing depressive symptoms and suicidal idea. The improvement of depressive symptoms was mediated by improved mindfulness skills through MBCT.

• 대한지역사회영양학회지
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• 제13권3호
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• pp.426-438
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• 2008

The purpose of this study was to examine bowel habits, dietary habits, and nutrient intake of constipated adults, and the effects of prune products on relieving constipation symptoms. Fifty one adults with self-reported constipation (mean age 23 years, range 19-41 years, 10 males and 41 females) participated in this study. After a baseline survey on bowel habits and dietuy habits, participants were asked to consume at least 50 g of prune and 200 ml of prune juice per day during a 4-week period in addition to usual diet. Nutrient intake was estimated by a 24 hour recall at the baseline and once every week by diet records during the intervention. Data were analyzed after classifying the subjects into mild constipation group and severe constipation group by the severity of the symptoms. During the intervention, the subjects with mild constipation consumed 56 g of prunes (about 5.6 fruits) and 200 ml of prune juice, and the subjects with severe constipation consumed 59 g of prunes (about 5.9 fruits) and 207 ml of prune juice. Average intakes of energy, dietary fiber and water of the subjects in the mild constipation and severe constipation group increased during the intervention compared to the baseline. Average dietary fiber intake of the mild constipation and severe constipation groups significantly increased from 12.5 g and 11.6 g at the baseline to 18.5 g and 16.8 g after consuming prune products, respectively. These changes were accompanied by an increase in the number of bowel movements, a decrease of defecation time, a change to a softer stool consistency, and a decrease of abdominal pain during defecation. Seventy two subjects answered that prune products were effective to improve their overall constipation symptoms. Our data show that supplementation of prune products is effective to provide energy, dietary fiber and water, and to relieve constipation symptoms for constipated adults.