• Geomechanics and Engineering
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• v.27 no.6
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• pp.583-594
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• 2021

The gas permeability behavior of unsaturated bentonite-based materials is of major importance for ensuring effective sealing of high-level radwaste repositories. This study investigated this by taking a sample of Granular Bentonite Material (GBM) at the end of the Engineered Barrier Emplacement (EB) experiment in the Opalinus Clay, placing it under different humidity conditions until it achieved equilibration, and testing the change in the gas permeability under loading and unloading. Environmental humidity is shown to have a significant effect on the water content, saturation, porosity and dry density of GBM and to affect its gas permeability. Higher sensitivity to confining pressure is exhibited by samples equilibrated at higher relative humidity (RH). It should be noted that for the sample at RH=98%, when the confining pressure is raised from 1 MPa to 6 MPa, gas permeability can be reduced from 10^-16 m² to 10^-19 m², which is close to the requirements of gas tightness. Due to higher water content and easier compressibility, samples equilibrated under higher RH show greater irreversibility during the loading and unloading process. The effective gas permeability of highly saturated samples can be increased by 2-3 orders of magnitude after 105℃ drying. In addition, cracks possibly occurred during the dehydration and drying process will become the main channel for gas migration, which will greatly affect the sealing performance of GBM.

• Smart Media Journal
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• v.11 no.11
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• pp.25-31
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• 2022

Deep learning-based image processing is essential for autonomous vehicles. To process road images in real-time in a System-on-Chip (SoC) environment, we need to execute deep learning models on a NPU (Neural Procesing Units) specialized for deep learning operations. In this study, we imported seven open-source image processing deep learning models, that were developed on GPU servers, to Texas Instrument Deep Learning (TIDL) NPU environment. We confirmed that the models imported in this study operate normally in the SoC virtual environment through performance evaluation and visualization. This paper introduces the problems that occurred during the migration process due to the limitations of NPU environment and how to solve them, and thereby, presents a reference case worth referring to for developers and researchers who want to port deep learning models to SoC environments.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.10
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• pp.2359-2368
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• 2013

In this paper, an IRD (internal read data) circuit preventing the reentry into the read mode while keeping the read-out DOUT datum at power-up even if noise such as glitches occurs at signal ports such as an input signal port RD (read) when a power IC is on, is proposed. Also, a pulsed WL (word line) driving method is used to prevent a DC current of several tens of micro amperes from flowing into the read transistor of a differential paired eFuse OTP cell. Thus, reliability is secured by preventing non-blown eFuse links from being blown by the EM (electro-migration). Furthermore, a compared output between a programmed datum and a read-out datum is outputted to the PFb (pass fail bar) pin while performing a sensing margin test with a variable pull-up load in consideration of resistance variation of a programmed eFuse in the program-verify-read mode. The layout size of the 8-bit eFuse OTP IP with a $0.18{\mu}m$ process is $189.625{\mu}m{\times}138.850{\mu}m(=0.0263mm^2)$.

• Journal of Ginseng Research
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• v.35 no.3
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• pp.360-367
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• 2011

In this study, we investigated the effects of total ginseng saponin (TGS) on the cutaneous wound healing process using histological analysis. A total of 24 ICR mice, 5-weeks-old, were used for all in vivo experiments. Mice were divided into control and TGS-treated groups and four equidistant 1-cm full-thickness dorsal incisional wounds were created. The wounds were extracted at days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area and contracture measurements, keratinocyte migration rate, and calculation of infiltrating inflammatory cells. The results showed that the wound area was smaller and keratinocyte migration rate was higher in the TGS-treated group than that of the control group from days 3 to 7. Inflammatory cells in the TGS-treated group at days 1 and 3 were reduced compared to the control group. Wound contraction in the TGS-treated group was greater than in the control group on days 3 to 5, and collagen deposition in the TGS-treated group was higher than in the control group during wound healing. The results indicate a beneficial effect of TGS when used to treat skin wounds.

• Microbiology and Biotechnology Letters
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• v.44 no.3
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• pp.285-292
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• 2016

In the present study, we evaluated the in vitro wound-healing properties of two types of rice cell extracts (RCEs; prepared using ethanol and pressurized hot water extraction methods), using human dermal fibroblasts and keratinocytes. The effects of the RCEs (at 25–100 μg/ml) on cytotoxicity and cell migration were assessed. Both RCEs were not cytotoxic to the two cell types, instead increasing their proliferation by up to 25% in a dose-dependent manner compared with the controls. Furthermore, both RCEs significantly enhanced the migratory ability of the two cell types (fibroblast, 230–450%; keratinocyte, 170–350%). Additionally, we examined the effect of the RCEs on type I collagen synthesis, which is important in the wound reconstruction process. The RCEs significantly increased collagen type I mRNA and protein levels to a degree comparable to that induced by vitamin C. These results suggest the RCEs to be candidate materials for use in promoting wound healing, through their actions of increasing cell migration and accelerating wound re-epithelialization.

• Journal of the Korean Institute of Intelligent Systems
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• v.23 no.5
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• pp.385-391
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• 2013

Big Data is data of big size which is not processed, collected, stored, searched, analyzed by the existing database management system. The parallel genetic algorithm using the Hadoop for BigData technology is easily realized by implementing GA(Genetic Algorithm) using MapReduce in the Hadoop Distribution System. The previous study that the genetic algorithm using MapReduce is proposed suitable transforming for the GA by MapReduce. However, they did not show good performance because of frequently occurring data input and output. In this paper, we proposed the MRPGA(MapReduce Parallel Genetic Algorithm) using improvement Map and Reduce process and the parallel processing characteristic of MapReduce. The optimal solution can be found by using the topology, migration of parallel genetic algorithm and local search algorithm. The convergence speed of the proposal method is 1.5 times faster than that of the existing MapReduce SGA, and is the optimal solution can be found quickly by the number of sub-generation iteration. In addition, the MRPGA is able to improve the processing and analysis performance of Big Data technology.

• The KIPS Transactions:PartD
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• v.17D no.1
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• pp.25-40
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• 2010

Service-Oriented Architecture (SOA) is a development paradigm for reusing services as an independent reuse unit. A service delivers a cohesive functionality through its external interface. Since services have unique characteristics which are not typically presented in conventional development approaches, there is a demand for effective approaches to developing services. Most of the current SOA methodologies presenta process where services are designed and developed from the requirements rather than reusing existing assets, which demands high cost and effort. Hence, a desirable approach is to be able to develop services by migrating from their existing legacy systems such as object-oriented system. A difficulty in this migration is that objects in object-oriented systems reveal characteristics which differ considerably from those of services. That is, objects are designed without considering commonalities among several consumers. In this paper, we first define mapping relationships between key artifacts in object-oriented system and those in SOA services. By these relationships and considering commonalities among several applications in a domain, we propose three systematic methods to migrate from object-oriented system to SOA services. Each method consists of a list of input and output artifacts and detailed guidelines which are performed in order. Through these methods, service developers can easily develop services with less effort.

• Nuclear Engineering and Technology
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• v.26 no.4
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• pp.461-470
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• 1994

Sorption experiments of $^{60}$ Co, $^{85}$ Sr. and $^{137}$ Cs onto sandstone particles in a batch were carried out to investigate the migration mobility. Sorption kinetics and reversibility as well as sorption mechanisms were examined. Sorption reaction occurred mostly within 10 hours on the outer surface of the sandstone particle but diffusion into the inner surface of the mineral has still occurred after that time. In order to distinguish sorption types of radionuclides, a sequential chemical extraction was introduced. The sorbed radionuclides were then extracted by applying different solutions of synthetic groundwater, CaCl$_2$, KCl and KOX-HA Especially KCl is adopted to extract the ion-exchanged cesium. Sorption types considered are reversible sorption under groundwater condition, ion exchange, association with ferro-manganese oxides or oxyhydroxides, and irreversible fixation. Strontium sorbs onto the sandstone surface mainly by fast and reversible ion exchange reaction. However, cobalt and cesium do not sorb by simple process. The main sorptive binding of cobalt was the association with ferro-manganese oxides and the secondary one was irreversible fixation. Diffusion into the lattice of minerals controlled the sorption rate of cobalt The main sorptin type of cesium was irreversible fixation, while ion exchange reaction was the secondary importance. Hence the oreder of migration mobility for the three radionuclides was Sr$^{2＋}$ ＞ Co$^{2＋}$ ＞ Cs$^{＋}$ in the sandstones.

• The Korean Journal of Archival Studies
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• no.14
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• pp.91-117
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• 2006

Electronic Records need to be appraised the authenticity as well as the value itself. There has been various kinds of discussion about how records to be appraised the value of themselves, but there's little argument about how electronic records to be appraised the authenticity of themselves. Therefore this article is modeling some specific authenticity appraisal methods and showing each stages those methods should or may be applied. At the Ingest stage, integrity verification right after records creation in the organization which produced the records, quality and integrity verification about the transferred in the organization which received the records and integrity check between SIP and AIP in the organization which received and preserved the records are essential. At the Preservation stage, integrity check between same AIPs stored in different medium separately and validation of records where or not damaged and recovery damaged records are needed. At the various Processing stages, suitability evaluation after changing the record's management control meta data and changing the record's classification, integrity check after records migration and periodical validation and integrity verification about DIPs are required. For those activities, the appraisal methods including integrity verification, content consistency check, suitability evaluation about record's meta data, feasibility check of unauthorized update and physical status validation should be applied to the electronic records management process.

• Biomolecules & Therapeutics
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• v.30 no.4
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• pp.340-347
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• 2022

Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis is associated with epithelial-mesenchymal metastasis (EMT). However, the specific signals that induce and regulate EMT in carcinoma cells remain unclear. PRR16/Largen is a cell size regulator that is independent of mTOR and Hippo signalling pathways. However, little is known about the role PRR16 plays in the EMT process. We found that the expression of PRR16 was increased in mesenchymal breast cancer cell lines. PRR16 overexpression induced EMT in MCF7 breast cancer cells and enhances migration and invasion. To determine how PRR16 induces EMT, the binding proteins for PRR16 were screened, revealing that PRR16 binds to Abl interactor 2 (ABI2). We then investigated whether ABI2 is involved in EMT. Gene silencing of ABI2 induces EMT, leading to enhanced migration and invasion. ABI2 is a gene that codes for a protein that interacts with ABL proto-oncogene 1 (ABL1) kinase. Therefore, we investigated whether the change in ABI2 expression affected the activation of ABL1 kinase. The knockdown of ABI2 and PRR16 overexpression increased the phosphorylation of Y412 in ABL1 kinase. Our results suggest that PRR16 may be involved in EMT by binding to ABI2 and interfering with its inhibition of ABL1 kinase. This indicates that ABL1 kinase inhibitors may be potential therapeutic agents for the treatment of PRR16-related breast cancer.