• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8019-8026
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• 2014

The promyelocytic leukemia (PML) gene is a gene known to be a tumor suppressor, although recent data suggest that it has a dual function in tumorigenesis. It was initially discovered in acute promyelocytic leukemia (APL) in which a t(15; 17) chromosomal translocation fused it to the retinoic acid receptor alpha ($RAR{\alpha}$). It has been shown to be involved in various types of cancer. It has at least 6 nuclear isoforms and a cytoplasmic type with different characteristics. Its multiple functions in growth inhibition, apoptosis induction, replicative senescence, inhibition of oncogenic transformation, and suppression of migration and angiogenesis have made it a therapeutic target for cancer therapy. However, its dual role in the process of tumorigenesis has made this field challenging. In this review, we discuss PML structure, functions and expression in tumors.

• IEMEK Journal of Embedded Systems and Applications
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• v.7 no.6
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• pp.311-321
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• 2012

When developing a CPS, since it is nature of CPS to interact with a physical system, CPS should be verified during its development process by real-time simulation supporting timely interactions between the simulator and existing implemented hardwares. Furthermore, when a part of a simulated system is implemented to real hardwares, i.e., incremental development, the simulator should aware changes of the simulated system and apply it automatically without manual description of the changes for effective development. For this, we suggest a real-time simulation framework including the concept of 'port' which abstracts communication details between the tasks, and a scheduling algorithm for guaranteeing 'real-time correctness' of the simulator.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.11a
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• pp.69-72
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• 2007

Cellulose is a beneficial material that has low cost, lightweight, high compatibility and biodegradability. Recently electroactive paper (EAPap) on cellulose base was discovered as a smart material and actuator through ion migration and piezoelectric effect. Furthermore cellulose has a potentiality to apply the display material, because of its high reflectivity, flexibility and high transmittance. The various shapes and height patterns of the Cellulose acetate (CA) solution, such as circle and honeycomb patterns, were fabricated and observed by field emission scanning electron microscope (FESEM, S4300 Hitachi). The resulting pattern showed uniform size in the large area without defect. After stretching the CA film with saponification process in the sodium methoxide in methanol solution, Most of the compositions become one directional ordered nanofibers below 50nm.

• Journal of the Korean Operations Research and Management Science Society
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• v.24 no.2
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• pp.121-134
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• 1999

In this paper, I propose a hybrid genetic algorithm(HGAM) incorporating a greedy interchange local optimization procedure for the multiobjective vehicle scheduling problems with service due times where three conflicting objectives of the minimization of total vehicle travel time, total weighted tardiness, and fleet size are explicitly treated. The vehicle is allowed to visit a node exceeding its due time with a penalty, but within the latest allowable time. The HGAM applies a mixed farming and migration strategy in the evolution process. The strategy splits the population into sub-populations, all of them evolving independently, and applys a local optimization procedure periodically to some best entities in sub-populations which are then substituted by the newly improved solutions. A solution of the HCAM is represented by a diploid structure. The HGAM uses a molified PMX operator for crossover and new types of mutation operator. The performance of the HGAM is extensively evaluated using the Solomons test problems. The results show that the HGAM attains better solutions than the BC-saving algorithm, but with a much longer computation time.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.26 no.6
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• pp.478-481
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• 2013

Diameter controlled carbon nanotubes (CNTs) were grown using surface modified iron nano-particle catalysts with aminpropyltriethoxysilane (APS). Iron nano-particles were synthesized by thermal decomposition of iron pentacarbonyl-oleic acid complex. Subsequently, APS modification was done using the iron nano-particles synthesized. Agglomeration of the iron nano-particles during the CNT growth process was effectively prevented by the surface modification of nano-particles with the APS. APS plays as a linker material between Fe nano-particles and $SiO_2$ substrate resulting in blocking the migration of nano-particles. APS also formed siliceous material covering the iron nano-particles that prevented the agglomeration of iron nano-particles at the early stages of the CNT growth. Therefore we could obtain the diameter controlled CNTs by blocking agglomeration of the iron nano-particles.

• Journal of Adhesion and Interface
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• v.7 no.4
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• pp.53-59
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• 2006

The paper highlights technical advances and introduces recent innovations such as smart curing laminating adhesives for flexible packaging with low migration rates of aromatic isocyanates and amines. Latent reactive one-part systems on the basis of surface deactivated solid isocyanates open up new dimensions for heat setting adhesives and waterborne PU dispersions. The new generation of Purmelt Micro Emission adhesives contains less than 0.1% of MDI monomer, thereby drastically reducing the emission of hazardous isocyanate vapors during processing and setting a significantly improved technical standard in occupational safety. Once again, polyurethane adhesives have demonstrated their unique ability to adapt to new process, product, safety and environmental requirements.

• Proceedings of the Korean Geotechical Society Conference
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• 2007.09a
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• pp.542-557
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• 2007

Contamination of subsurface results in degradation of geomaterials (i.e., soils and rock mass), in the long run. This is mainly due to the presence of chemical and/or radiological materials in undesirable concentrations and at elevated temperatures. However, as contaminant-geomaterial interaction is an extremely slow and complex process, which primarily depends on their physical, chemical and mineralogical properties, it is quite difficult to study this interaction under laboratory or in situ conditions. In such a situation, accelerated physical modeling, using a geotechnical centrifuge, and finite element/difference based numerical modeling techniques are found to be quite useful. This paper presents details of various modeling techniques developed by the researchers at the Indian Institute of Technology Bombay, Mumbai, India, for studying heat migration, flow and interaction (fate) of reactive and non-reactive contaminants in the geoenvironment, under saturated and unsaturated conditions. In addition, paper presents details of the technique that can be employed for determining susceptibility of a material to undergo physico-chemico-mineralogical alterations due to its interaction with contaminants.

• Proceedings of the IEEK Conference
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• 2008.06a
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• pp.635-636
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• 2008

Due to the rapid development of the hardware divisions, varied and low-price mobile devices were provided to not only end-users but also widespread industry. However, in the software divisions, the characteristics of the software such as closed and differentiation causing restrictions of development. Therefore, it requires high costs and long times in the development process. In this paper, we introduce the Mobile Platform Middleware based on L4 Microkernel which provides linux-like environment and services for other mobile application platforms such as BREW and WIPI to facilitate easily development and migration of applications for mobile devices.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.711-712
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• 2002

A numerical study of a hemodynamical model for the tumor angiogenesis is carried out. The tumor angiogenesis process is comprised of a sequence of events; secretion of tumor angiogenesis factor(TAF) from the solid tumor, degradation of the basement membrane of nearby blood vessels, migration and proliferation of the endothelial cells. The model takes into account the effect of TAF concentration and endothelial cell density, and their conservation equations are represented as a set of one-dimensional initial boundary value problems. These equations are discretized by using a finite difference method in which the second order schemes both in time and in space are used. The effects of the parameters contained in the model are Investigated extensively through the numerical simulation of the discretized model. The result for the typical case compares very well with the known result.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2003.10a
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• pp.15-15
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• 2003

Cutaneous wound healing is a highly orchestrated process comprising a number of well-defined temporally overlapping phase. These include the migration of inflammatory cells to the wound site, and re-establishment of an epithelial barrier (re-epithelization), and the deposition of matrix by fibroblast [1]. We attempt to find out that active ceramic resources has effects on cutaneous wound healing. And furthermore, we investigate its related mechanism and expression of cytokines of cutaneous wound healing which is accelerated by active ceramic resources. (omitted)