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Toxic Optic Neuropathy Caused by Chlorfenapyr Poisoning (클로르페나피르 음독 후 발생한 독성 시신경병증 1예)

  • Park, Su Jin;Jung, Jae Uk;Kang, Yong Koo;Chun, Bo Young;Son, Byeong Jae
    • Journal of The Korean Ophthalmological Society
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    • v.59 no.11
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    • pp.1097-1102
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    • 2018
  • Purpose: To report a case of toxic optic neuropathy caused by chlorfenapyr ingestion accompanied by central nervous system involvement. Case summary: A 44-year-old female visited our clinic complaining of reduced visual acuity in both eyes for 7 days. She had ingested a mouthful of chlorfenapyr for a suicide attempt 2 weeks prior to the visit. Gastric lavage was performed immediately after ingestion at the other hospital. Her best-corrected visual acuity was finger count 30 cm in the right eye and hand motion in the left eye. Both pupils were dilated by 5.0 mm and the response to light was sluggish in both eyes. A relative afferent pupillary defect was detected in her left eye. Funduscopy revealed optic disc swelling in both eyes. Magnetic resonance imaging of the brain showed a symmetric hyper-intense signal in the white matter tract including the internal capsule, corpus callosum, middle cerebellar peduncle, and brainstem. The patient was diagnosed with toxic optic neuropathy induced by chlorfenapyr ingestion, and underwent high-dose intravenous corticosteroid pulse therapy. Three days later, the best-corrected visual acuity was no light perception in both eyes. Three months later, optic atrophy was observed in both eyes. Optical coherence tomography revealed a reduction in the thicknesses of the retinal nerve fiber layer and ganglion cell and inner plexiform layer in the macular area. Conclusions: Ingestion of even a small amount of chlorfenapyr can cause severe optic nerve damage through the latent period, despite prompt lavage and high-dose steroid treatment.

Character of constructed group for Wooden chamber tomb of the Three kingdoms in Yaksa-dong Bukdong archaeological site, Ulsan (울산 약사동 북동유적 삼국시대 목곽묘 축조집단의 성격)

  • Choi, Soo-Hyeong
    • Korean Journal of Heritage: History & Science
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    • v.48 no.2
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    • pp.4-29
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    • 2015
  • This article considered generally gradational change aspect, character of community for the tombs of the Three kingdoms prepared by some certain homogenous groups. It was completed by tracing the transfering process to grasp character of social structure and organizing System in the community. For this reason, it's analyzed that Wooden chamber tomb was formed in some certain Time-Space of the Yaksadong Buk-dong archaeological site in the Three Kingdom Period. Constructed group was distinguished by the five classes. So perhaps scale of Wooden chamber and sort, material of burial relics, the top layer and the upper layer were established two status those are active the ruling class led the Wooden chamber tomb's society, the general public hold a large majority from the middle class to the lowest class. And it depends on age(nonage-adult) that differed in relation of arrangement, character. It's changed with function or roles, property, purpose etc. of social community in accordance with these individual position, age. Received signification, value of social status were considered with social worth, faith. Members in a community had been conducted under premeditated, organised system for common target, relatedness. Also it seems to attempt organization's own maintenance, persistiveness in norms that given at common law. To do that, relation for combination between members who consisted systems had to be organic. The relation for combination was considered to form relation for the much larger community in based on blood relationship that most vital part. One social structure had established family(house, household) community in based on individual blood relationship, family communities gather up to develop into relative(blood relative, same race) community gradually. Furthermore, relative(blood relative, same race) communities, that focus on the public good gather up to develop into social community in based on regionalism. It's considered to go through the Development Process of family(house, household) community - relative(blood relative, same race) community - social community.

Changes of myelin basic protein in the hippocampus of an animal model of type 2 diabetes

  • Nam, Sung Min;Kwon, Hyun Jung;Kim, Woosuk;Kim, Jong Whi;Hahn, Kyu Ri;Jung, Hyo Young;Kim, Dae Won;Yoo, Dae Young;Seong, Je Kyung;Hwang, In Koo;Yoon, Yeo Sung
    • Laboraroty Animal Research
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    • v.34 no.4
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    • pp.176-184
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    • 2018
  • In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in the hippocampus of Zucker diabetic fatty (ZDF) rats and their control littermates (Zucker lean control; ZLC). In the ZLC group, body weight steadily increased with age; the body weight of the ZDF group, however, peaked at 30 weeks of age, and subsequently decreased. Based on the changes of body weight, animals were divided into the following six groups: early (12-week), middle (30-week), and chronic (52-week) diabetic groups and their controls. MBP immunoreactivity was found in the alveus, strata pyramidale, and lacunosum-moleculare of the CA1 region, strata pyramidale and radiatum of the CA3 region, and subgranular zone, polymorphic layer, and molecular layer of the dentate gyrus. MBP immunoreactivity was lowest in the hippocampus of 12-week-old rats in the ZLC group, and highest in 12-week-old rats in the ZDF group. Diabetes increased MBP levels in the 12-week-old group, while MBP immunoreactivity decreased in the 30-week-old group. In the 52-week-old ZLC and ZDF groups, MBP immunoreactivity was detected in the hippocampus, similar to the 30-week-old ZDF group. Western blot results corroborated with immunohistochemical results. These results suggested that changes in the immunoreactivity and expression of MBP in the hippocampus might be a compensatory response to aging, while the sustained levels of MBP in diabetic animals could be attributed to a loss of compensatory responses in oligodendrocytes.

Compositions and Provenience Studies on Horse Armour Excavated from Changnyeong Gyo-dong and Songhyeon-dong Tumuli (창녕 교동과 송현동 고분군 출토 마구류(馬具類)의 조성 및 원료 산지 추정)

  • Han, Woorim;Park, Jiyeon;Kim, Sojin
    • Korean Journal of Heritage: History & Science
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    • v.54 no.1
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    • pp.4-17
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    • 2021
  • This study analyzed 19 samples of harness fittings and pendants, which were excavated in Tomb No. 15 in Songhyeon-dong, Changnyeong. Harness fittings and pendants are used for ostentation, rather than practicality, and were excavated from ancient tombs in Gaya culture. So, they are considered artifacts that compare the production techniques and raw materials. This study aimed to examine the production techniques and provenience studies of Bihwa Gaya, which is estimated to be from the 5th to 6th centuries. According to the research, harness fittings were made of pure copper and were gilded with Au·Ag alloys on their surfaces. Hg was detected together and plated with a mercury amalgam method. As a result of the pendant (fish scales-pattern, oval and fish-tail shape), analysis showed that Fe in the background metal, Cu in the middle layer, and Au and Ag on the surface were the main components. The method of adhesion between Cu and Au·Ag gilded layers are plated by a mercury amalgamation method. So, it was identified by the gilt-iron·gold·bronze technique. Since the pendant (heart shaped) is found to be the main component of Fe in the background metal and Ag in the surface layer, the metal was made gilt-iron·silver technique. The background metal and gilding were additionally fixed using a rivet. The raw materials of 3 harnesses excavated from Changnyeong are plotted in zone 2 in the southern Korean Peninsula. And 16 harnesses were plotted in Chinese copper ore by Mabuchi Hishao in the Chinese Peninsula.

The Numerical Study on Individual Vacuum Seepage Consolidation Method with Flexible Well Point (연성 Well Point를 적용한 개별진공 침투압밀공법에 관한 해석적 연구)

  • Kim, Byung-Il;Hong, Kang-Han;Kim, Young-Seon;Han, Sang-Jae
    • Journal of the Korean Geosynthetics Society
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    • v.21 no.1
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    • pp.11-21
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    • 2022
  • In this study, the individual vacuum seepage consolidation method, a new soft ground improvement method, was developed to supplement the conventional suction drain method (individual vacuum preloading method) and the geotechnical behavior was predicted through numerical analysis. If the individual vacuum seepage consolidation method applied, the effect of accelerating settlement and increasing the amount of settlement was high when the aquifer was located in the middle or at the bottom of the layer to the target improvement layer. It was found that the pumping amount in the aquifer does not affect the settlement behavior when it exceeds a certain level. Even vacuum pumping wells were installed in various locations, such as inside or outside of the embankment, the difference in settlement and horizontal displacement was insignificant. In addition, it was predicted that the settlement rate was the fastest and the horizontal displacement (inward) was large when both methods were carried out at the same time. Since this method can reach the target settlement amount very quickly, it was confirmed that it is possible to increase the spacing of vertical drain, thereby securing economic feasibility.

Ultrastructures of the Compound Eye in Dragonfly, Crocothemis servilia Drury (고추잠자리 複眼의 電子顯微鏡的 構造)

  • Paik, Kyong Ki;Choi, Choon Keun;Shin, Kil Sang
    • The Korean Journal of Zoology
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    • v.15 no.3
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    • pp.111-131
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    • 1972
  • Fine structures of retina of an ommatidium in dragonfly, having eyes of closed rhabdom type, were studied under light and electron microscopes. The ommatidia consisted of eight retinular cells distributed in a circular pattern and the retinular layer in turn can be divided into three sublayers according to the number of cells in the retina. Each retinular cell has different starting points in the retina and the length of retinular cells is varied greatly; the length of one distal retinular cell shows one half of that of others. In the middle layer, three proximal retinular cells interconnect the adjacent two rhabdoms which are triangular in the appearence of the cross section which in turn consisted of tubular, parallel and lamellated microvilli. The rhabdom is formed by three rhabdomeres, each of which is separated by $120^{\circ}$ between them, but they can be distinguished into two parts according to electron density. Around the outer part of microvilli composing rhabdom, electron density was much less than the inner part of the structure. The microvilli of the inner part appear to be connected to the cytoplasm of retinular cells. Rough endoplsmic reticulum with enlarged cisternae runs through the vacuoles in the outer part of distal retinular cells. Abundant mitochondria concentrated in the vicinity of rhabdom are found at the central part of the retinular cells, while in the area of immediate vicinity of the rhabdom, prominent vacuoles are observed. Above the rhabdom of an ommtidium stands a crystalline cone which is consisted of four cone cells arranged radially along the axis. The crystalline cone is surrounded by cells containing pigment granules. The outermost photoreceptor element of an ommatidium is corneal lens.

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Production of High-Resolution Long-Term Regional Ocean Reanalysis Data and Diagnosis of Ocean Climate Change in the Northwest Pacific (북서태평양 장기 고해상도 지역해양 재분석 자료 생산 및 해양기후변화 진단)

  • Young Ho Kim
    • Journal of the Korean earth science society
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    • v.45 no.3
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    • pp.192-202
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    • 2024
  • Ocean reanalysis data are extensively used in ocean circulation and climate research by integrating observational data with numerical models. This approach overcomes the spatial and temporal limitations of observational data and provides high-resolution gridded information that considers the physical interactions between ocean variables. In this study, I extended the previously produced 12-year (2011-2022) Northwest Pacific regional ocean reanalysis data to create a long-term reanalysis dataset (K-ORA22E) with a horizontal resolution of 1/24° spanning 30 years (1993-2022). These data were analyzed to diagnose long-term ocean climate change in the Korean marginal seas. Analysis of the K-ORA22E data revealed that the axis of the Kuroshio extension has shifted northward by approximately 6 km per year over the past 30 years, with a significant increase in sea surface temperature north of the Kuroshio axis. Among the waters surrounding the Korean Peninsula, the East Sea exhibited the most significant temperature increase. In the East Sea, the temperature increase was more pronounced in the middle layer than in the surface layer, with the East Korea Warm Current showing a rate two to three times higher than the global average. In the central Yellow Sea, where the Yellow Sea Bottom Cold Water appears, temperatures increased over the long-term, but decreased along the west and south coasts of the Korean Peninsula. These spatial differences in long-term temperature changes appear to be closely related to the heat transport pathways of warm water from the Kuroshio Current. High-resolution regional ocean reanalysis data, such as the K-ORA22E produced in this study, are essential foundational data for understanding long-term variability in the Korean marginal seas and analyzing the impacts of climate change.

The Development and Application of New Chromatographic Methods Using Smart Devices (스마트 기기를 활용한 새로운 크로마토그래피 분석법 개발 및 적용)

  • Jae Hwan Lee;Ye Geon Choi;Jae Jeong Ryoo
    • Journal of Science Education
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    • v.48 no.2
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    • pp.91-100
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    • 2024
  • The use of smart devices in science classes has brought about positive changes, such as increased student participation and more self-directed learning. Smart devices are increasingly being used in science classes, creating a need to develop lesson models that can stimulate students' interest and encourage active, self-directed learning in scientific inquiry and experimental activities. In smart education, smart devices and applications play a major role. However, in the "Mixture Separation" section of middle school science, chromatography focuses mainly on paper chromatography, which is not currently used in the field of actual research. This approach is not well-suited for students preparing for a new future society, and it is becoming obsolete due to curriculum revisions. Although chromatography can be used as an activity for career exploration, removing it is not convincing. The advantage of using thin-layer chromatography (TLC), which is employed in actual research, is that it is inexpensive and easy to use in classroom settings. In this study, we have developed a new, faster, and simpler analysis method for TLC that uses smart devices for both qualitative and quantitative analysis. We hope this method will enhance student engagement and facilitate small-scale learning by integrating smart devices into learning activities, making it a practical tool for actual school settings.

Characteristics of Breeding Birds Community in Relation to the Forest Environment in Deogyusan National Park (덕유산국립공원의 산림환경에 따른 번식기 조류군집 특성)

  • Yu, Jae-Pyoung;Jin, Seon-Deok;Kim, Hyoun-Sook;Lee, Joon-Woo;Paek, Woon-Kee;Song, Ho-Kyung
    • Korean Journal of Environment and Ecology
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    • v.25 no.2
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    • pp.132-144
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    • 2011
  • We studied the forest environment and characteristics of bird community between April and September of 2010 on the Hyangjeokbong area(A), Baekryunsa area(B) and Anseong area(C), all in the Deogyusan National Park. Hyangjeokbong area of the high latitude ridge was characterized by the Taxus cuspidata and Abies koreana etc., and deciduous broadleaf forest species, such as the Quercus mongolica, with abundance of subalpine zone coniferous trees, the Hemerocallis fulva and the Rhododendron schlippenbachii, while the areas Baekryunsa and Anseong were primarily characterized by deciduous broadleaf forests, with the valleys showing Fraxinus mandshurica colonies. In terms of the DBH(diameter at breast height) of trees, between 11 and 20cm showed the highest frequencies, while over 30cm was the highest in Baekryunsa area and the lowest in Hyangjeokbong area. Furthermore, in terms of coverage in relation to layers, in Hyangjeokbong area, the coverage volume of the lower layer was very high, in Baekryunsa area, the coverage volume of the middle layer between 8 and 12m was the highest, and in Anseong area, the coverage volume of the upper layer over 18m was the highest. A total of 53 bird species were observed during the study period at the Deogyusan National Park. The numbers of species and density of areas were 25 species and 45.20 Ind./km for Hyangjeokbong area, 50 species and 58.63 Ind./km for Baekryunsa area and 35 species and 66.89 Ind./km for Anseong area, with Baekryunsa area showing the highest number of species and Anseong area showing the highest level of density. In terms of dominant species, in Hyangjeokbong area, Cettia diphone, along with species which inhabit in grassland and shrubs, were the dominant species, and species which live in the canopy layer, including the Aegithalos caudatus, were found to be dominant in Baekryunsa and Anseong areas. For guild structure, bush nesting guild and bush foraging guild species were the highest in all areas, and the hole nesting guild and the air foraging guild species showed the lowest proportion. This seems to be the result of the low number of trees with diameter at breast height of over 30cm, which results in the lack of nesting grounds for hole nesting guild species.

Growth Characteristics and Vegetation Structure of the Pinus densiflora Forest for Sugumagi of Unmun Temple, Cheongdo-gun, Korea (청도군 운문사 입구 수구막이 소나무림 식생구조 및 생육 특성)

  • Kang, Gi Won;Lee, Do-I;Han, Bong-Ho;Kwak, Jeong-In
    • Journal of the Korean Institute of Landscape Architecture
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    • v.48 no.5
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    • pp.1-15
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    • 2020
  • This study was designed to come up with a way of managing a cultural landscape forest by conducting research on the vegetation structure and growth characteristics. This study's target site, which was 45,201㎡ in size, was Pinus densiflora forest for Sugumagi placed at the entrance of Unmun Temple, Sinwon-ri, Unmun-myeon, and Cheongdo-gun in the southernmost part of Gyeongsangbuk-do, Korea. Sugumagi means the water of the valley flows far away, and where no downstream is visible according to feng shui. The historical sources of the Sugumagi Pinus densiflora forest at the entrance of Unmun Temple isn't clear. It waw only found at that location. The Pinus densiflora forest at the entrance of Unmun Temple is located in the waterway in terms of Feng Shui. The present condition of growth was investigated through a grid surveys of 98 trees and Pinus densiflora growth. As a result of the analysis of growth status, Pinus densiflora, Larix leptolepis, Zelkova serrata, Celtis sinensis, and Rhus javanica were distributed in the conopy layer, and 28 species including Ailanthus altissima were grown in the understroy layer, and 92 species, including Ampelopsis brevipedunculata, in the shrub layer. The plant community structure was divided into low, medium and high-density Pinus densiflora forests in the study area, based on the number in the conopy layer and the grade of and the trees analyzed. As a result of the analysis, the Pinus densiflora dominated the low, medium and high-density Pinus densiflora forests, and there were no competitive species. The relative dominance of the low-density Pinus densiflora forests was 46.9% on average, medium-density was 62.6% and 50.2% was found in high-density. The mean species diversity of Shannon in the low-density study was 0.7055, medium-density study was 0.8966 and the average species diversity of Shannon in the high-density study was 0.8317. The analysis of the age and growth of 25 sample trees in the Sugumagi Pinus densiflora forest shows that the distribution of the chest diameter (DBH) of the sample Pinus densiflora is 38 to 77cm with the average chest diameter being 61.1cm. The age was 84-161 years and the average was 114 years. In the Pinus densiflora forest, most(670,659, or 98.3%) of the tree trunk wound was collected for rosins during the Japanese colonia Era, Of the total 670, 659 were Pinus densiflora, 98.3% of the total. 394 were surgically repaired in 2005. For the preservation of the Sugumagi Pinus densiflora forest, dead trees should be replaced with substitute trees appropriate to the middle and south topography. It is demanded that foreign species such as Larix leptolepis in the research area should be removed and Pinus densiflora that underwent surgical operations should be regularly sterilized. It is also emphasized that the management of insecticide is important.