• 한국포장학회지
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• 제26권1호
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• pp.25-31
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• 2020

Recently, applications of biomass-based plastics have increased according to the eco-friendly policy of the reduction of carbon dioxide emissions in domestic and foreign government. In this study, a paper plastic composite was produced by compounding polypropylene and micronized paper powder that was prepared using dry pulverization technology. Subsequently, the specimen of paper plastic was verified with mechanical properties, formability and product safety test to confirm the suitable packaging materials for food packaging. Paper plastics showed slightly lower mechanical properties than currently commercialized PP composites. However, paper plastics are valuable materials as environmentally friendly carbon-reducing material because of high biocarbon content, light weight features and applicability of existing manufacturing machines or system.

• 청정기술
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• 제10권4호
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• pp.215-220
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• 2004

본 연구에서는 초임계 이산화탄소를 역용매로 이용하고, 에탄올을 용매로 하여 마이크로 사이즈의 아세트아미노펜 입자를 제조하였다. 아세트아미노펜/에탄올 용액과 초임계 이산화탄소를 침전조에 주입할 때 이중 노즐을 사용하였다. 반응 온도와 압력, $CO_2$의 유량과 아세트아미노펜/에탄올 용액의 유량의 변화가 입자의 크기와 형상에 미치는 영향에 대해 살펴보았다. 제조된 입자의 크기와 형상은 SEM으로 분석하였다.

• Journal of Pharmaceutical Investigation
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• 제11권1호
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• pp.6-14
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• 1981

Safety, efficacy and reliability are the three basic criteria that define the quality of any well-designed pharmaceutical dosage form. Content uniformity directly bears on each of the three criteria defining the quality of drug product. Effect of manufacturing methods and physicochemical properties of the drug on content uniformity of tablets was investigated. Chlorpheniramine maleate and micronized salicylic acid were used as main ingredients. Three different methods for incorporation of main ingredients with diluents were solvent mixing method, geometric dilution method, and simple mixing method. The solvent mixing method was the best one of the three.

• International Journal of Knowledge Content Development & Technology
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• 제4권1호
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• pp.79-91
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• 2014

Researchers who use science and technology information were found to ask an information service in which they can excerpt the contents they needed, rather than using the information at article level. In this study, we micronized the contents of scholarly articles into text, image, and table and then constructed a micro-content DB to design a new information system prototype based on this micro-content. After designing the prototype, we performed usability test for this prototype so as to confirm the usefulness of the system prototype. We expect that the outcome of this study will fulfill the segmented and diversified information need of researchers.

• Archives of Pharmacal Research
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• 제8권1호
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• pp.7-14
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• 1985

Membrane-coated tablet of isonicotinic acid hydrazide (INAH) which releases INAH at the zero-order kinetics was deveoped. It consisted of a soluble tablet core surrounded by a porous membrane which controls the diffusion rate. Tablet cores were prepared by compressing granules of INAH and polyvinyl chloride (PVC) dissolved in methyl ethyl ketone in which micronized sucrose were suspended. Diffusion rate of INAH from the tablet through the membrane was constant until the loaded INAH in the core was almost released. The rate was independent of pH of the dissolution medium. Water-soluble sucrose particles behaved as a poreproducing material in the water-insoluble PVC film coat. The pH independency of the rate was probably due to the high solubility of INAH in the water of wide pH range. The diffusion rate of INAH could be controlled by chnaging the composition of the membrane or the coat weight. This membrane-coated INAH tablet seemed to be a powerful candidate for the controlled release drug delivery system (DDS) of INAH or other highly watersoluble drugs.

• Journal of the Korean Wood Science and Technology
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• 제44권5호
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• pp.716-725
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• 2016

구리 기반 목재 방부제 중 MCQ를 이용하여, 목재 내 주입량에 따른 부후 특성을 조사하였다. 목재 시편에 주입량을 달리하여 약제를 주입한 후, 갈색부후균인 부후개떡버섯에 의한 방부효력 시험을 진행하였다. 이후, 질량감소율을 측정한 결과 무처리재는 35% 이상의 질량감소율을 보였으며, 실내 부후에 의한 MCQ 약제의 방부 효력을 나타내는 주입량은 $3.99{\pm}0.42kg/m^3$로 나타났다. 광학현미경 및 전자현미경으로 시편의 3단면을 관찰했을 때, 무처리재와 낮은 주입량으로 처리한 처리재에서는 세포벽의 파괴와 함께 전체적으로 부후가 진행됨이 확인 되었고, 많은 수의 균사를 관찰할 수 있었지만, bore hole은 확인할 수 없었다. 본 연구에서 MCQ의 주입량에 따른 질량감소율 및 부후 현상이 크게 차이가 난 점 등을 고려하여, 국내 환경에서 MCQ의 주입량에 관한 적정성 검토가 필요하다고 생각되었다.

• Asian-Australasian Journal of Animal Sciences
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• 제17권7호
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• pp.990-994
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• 2004

Effects of addition of a mycotoxin detoxifier in poultry feed were studied in broilers. Aflatoxins were present in the poultry feed as 28 ppb (normal feed), 78 ppb (contaminated feed) and 170 ppb (highly contaminated feed). The mycotoxin detoxifier was used in 3 concentrations i.e. 1, 3 and 5 kg/ton of feed. Aflatoxins reduced the body weight in broiler chicken and treatment of contaminated feed with low level of detoxifier improved the body weight equivalent to that of normal feed. Higher level of detoxifier proved better than lower level addition in alleviating the effects of highly contaminated feed. Addition of detoxifier also resulted in improvement of FCR to the level of normal feed. Antibody levels against Newcastle disease virus on day 28 of age were significantly lower in chicken fed on contaminated feed. Addition of detoxifier in feed improved the antibody levels in chicken. Mortality was highest in groups given contaminated feed throughout the study period of 7 weeks. Significant mortality was also observed in groups given highly contaminated feed for 2 weeks. Mortality in chicken given detoxifier added contaminated feed was lowest and similar to the group given normal feed. The study shows that mycotoxin detoxifier containing oxyquinol, dichloro-thymol and micronized yeast can effectively neutralize the ill-effects of aflatoxins in poultry feed.

• Preventive Nutrition and Food Science
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• 제9권1호
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• pp.14-20
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• 2004

Bacillus strains capable of producing fibrinolytic enzyme were isolated from traditional fermented Korean soybean paste and Japanese fermented soybean (Natto). Among the 16 strains, a selected Bacillus sp. was identified as bacillus firmus, with 80.7％ homology, by API kit analysis. Seed starter or B. firmus NA-1 was prepared with 5％ soymilk prepared from micronized soybean powder. To produce fibrinolytic enzyme by B. firmus NA-1 the liquid culture was performed with NB broth (pH 7.0) fortified with 1％ galactose, 0.1% tryptone, and 0.5% $K_2$HPO$_4$, by shaking with 180 rpm at 37$^{\circ}C$. Fibrinolytic enzyme activity reached the highest value at 7.8 unit/mL (plasmin unit) after fermentation for 72 hr. The crude fibrinolytic enzyme showed higher relative activity in the range of pH 7.0∼9.0. The activity of crude fibrinolytic enzyme was well maintained even after concentration by the vacuum evaporation at 5$0^{\circ}C$ for 1 hr.

• 한국염색가공학회지
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• 제26권4호
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• pp.290-296
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• 2014

In order to produce black disperse dye which has high heat resistance and depth color for polyester(PET), an orange disperse dye was designed and synthesized with pyridine based derivatives to get high heat resistance. Disperse blue dye adopts heterocycles structure for high molar extinction coefficient and long wavelength absorption. Synthesized disperse dye is micronized to an particle size of $0.7{\mu}m$. The mixing condition for black color using commercial disperse violet 93 is blue dye 30%, red dye 21%, and orange dye 21%, respectively. Dyed PET fabric with synthesized dye has quiet good color fastness to sublimation(grade 3-4) and has excellent rubbing, washing and light fastness grade 4-5.

• Toxicological Research
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• 제35권4호
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• pp.403-410
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• 2019

Curcumin, a hydrophobic polyphenol isolated from the Curcuma longa L. plant, has many pharmacological properties, including antioxidant, anti-inflammatory, and chemo-preventive activities. Curcumin has been shown to have potential in preventing nonalcoholic fatty liver disease (NAFLD). However, the low bioavailability of curcumin has proven to be a major limiting factor in its clinical adoption. Theracurmin, a highly bioavailable curcumin that utilizes micronized technology showed improved biological absorbability in vivo. The aim of this study was to investigate the role of theracurmin in modulating hepatic lipid metabolism in vivo. A fatty liver mouse model was produced by feeding mice a high fat diet (HFD; 60% fat) for 12 weeks. We found that treatment for 12 weeks with theracurmin significantly lowered plasma triacylglycerol (TG) levels and reduced HFD-induced liver fat accumulation. Theracurmin treatment lowered hepatic TG and total cholesterol (T-CHO) levels in HFD-fed mice compared to controls. In addition, theracurmin administration significantly reduced lipid peroxidation and cellular damage caused by reactive oxygen species in HFD-fed mice. Overall, these results suggest that theracurmin has the ability to control lipid metabolism and can potentially serve as an effective therapeutic remedy for the prevention of fatty liver.