• Bulletin of the Korean Chemical Society
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• 제29권7호
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• pp.1303-1310
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• 2008

Inhibitors of farnesyltransferase (FT), a key enzyme in the post-translational modifications of Ras proteins, have been extensively studied as novel anticancer agents in the preclinical stages, some of which are currently in clinical development. Previously, it has been reported that a novel FT inhibitor LB42907 inhibits Ras farnesylation in the nanomolar range in vitro. The aim of this study was to assess the antitumor efficacy of LB42907 in vitro and in vivo. Anchorage-independent growth of various human tumor cell lines was potently inhibited by treatment with LB42907, comparable to other FT inhibitors in clinical development. In the nude mouse, oral administration of LB42907 demonstrated potent antitumor activity in several human tumor xenograft models including bladder, lung and pancreas origin. Interestingly, significant tumor regression in EJ (bladder) and A549 (lung) xenografts was induced by LB42907 treatment. The effectiveness of LB42907 was also investigated in simultaneous combination with paclitaxel, vincristine, cisplatin or gemcitabine against NCI-H460, A549, and HCT116 cells in vitro using median-effect analysis. LB42907 markedly synergized with most anticancer drugs tested in this study in NCI-H460 cell. In contrast, LB42907 displayed antagonism or partial synergism with these drugs in A549 and HCT116 cells, depending on the class of combined drugs and/ or the level of cytotoxicity. Our results demonstrate that LB42907 is an effective antitumor agent in vitro and in vivo and combination of LB42907 with other chemotherapeutic drugs results in synergistic or antagonistic effects mainly in a cell line-dependent manner. Further preclinical study is warranted.

• 성인간호학회지
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• 제26권2호
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• pp.234-243
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• 2014

Purpose: The purpose of this study was to investigate the factors influencing the health-promoting behaviors of the people living with HIV. Methods: Descriptive cross-sectional study design was used. The study participants included 99 people living with HIV recruited via the Korea HIV/AIDS Network of Solidarity from May 15 to August 15, 2012. Self-report questionnaires were used fo data collection measuring perceived stress, depression, self-efficacy, health-promoting behaviors (HPLP-II), and the perceived health status. The analysis was done using SPSS/Win 18.0 program. Descriptive statistics, pearson correlation, t-test, ANOVA and stepwise multiple regressions were used for data analysis. Results: Perceived stress (r=-.21, p=.040), depression (r=-.37, p<.001), self-efficacy (r=.42, p<.001), perceived health status (r=.29, p=.003), and health-promoting behaviors were significantly correlated with each other. The self-efficacy, religion and perceived health status were significant factors, which explained about 26% of the variance of the health-promoting behaviors. Multiple regression analysis showed that a powerful predictor of health-promoting behaviors among people living with HIV was self-efficacy. Conclusion: This study suggested that a focus of nursing intervention program on self-efficacy is necessary in order to increase health-promoting behaviors among people living with HIV.

• 대한한방부인과학회지
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• 제29권3호
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• pp.10-22
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• 2016

Objectives: The aim of the study was to investigate the characteristics of the autonomic innervation of the heart in Precocious Puberty (PP) Girls.Methods: We studied 87 girls visiting Dongshin University Suncheon Oriental Medicine hospital from first Januarty 2013 to 31th December 2015. Among the 87 girls who were selected 14 people under the age of 8. The subjects were categorized in two groups, 2 PP girls and 12 healthy controls. We studied the difference of Heart rate variability (HRV) between two groups by Independent samples T-test using SPSS for windows (version 22.0).Results: The Standard deviation of all normal R-R intervals (SDNN), The spuare root of the sum of the spuare of difference between adjacent normal R-R intervals (RMS-SD) of PP group was non-significantly lower than non-PP group. Total power (TP), Very low frequency power (VLF), High frequency power (HF), Low frequency power (LF) of PP group was non-significantly lower than non-PP group, LF/HF ratio of PP group was significantly higher than non-PP group. Normalized high frequency power (HF norm) of PP group was non-significantly lower than non-PP group. Normalized low frequency power (LF norm) of PP was non-signficantly higher than non-PP group.Conclusion: The results suggest that imbalance of sympathetic and parasympathetic nervous system from girls of precocious puberty can be seen.

• Clinical and Experimental Reproductive Medicine
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• 제29권1호
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• pp.45-56
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• 2002

Objectives: Recently, recombinant FSH (rFSH) has been manufactured using a Chinese hamster ovary cell line transfected with the gene encoding human FSH. Both rFSH and urinary gonadotropin (uFSH) could be used for controlled ovarian hyperstimulation (COH). However, uFSH implies a number of disadvantages, such as batch-to-batch inconsistency, no absolute source control, dependence on large amounts of urine, low specific activity, and low purity. The purpose of this study was to evaluate the efficacy of rFSH in human IVF-ET program. Materials and Methods: A total of 508 infertile women was enrolled in this study. They are classified into rFSH group (n=177) or uFSH group (n=331), and all of them were matched by age and cause of infertility in same period. The $Puregon^{(R)}$ (Organon, Holland) was used as rFSH, and the Metrodin-$HP^{(R)}$ (Serono, Switzeland) and $Humegon^{(R)}$ (Organon, Holland) was used as uFSH. We subdivided the patients into three age groups. The outcomes of IVF-ET program were analyzed using the statistical package for social sciences (SPSS). Results: There was no significant differences in the level of estradiol on hCG injection day, the numbers of retrieved oocytes, matured oocytes, fertilized oocytes, transferred embryos, frozen embryos between the two groups. The total dose (IU) of gonadotropin for COH was significantly lower in the rFSH group compared to uFSH group ($1339{\pm}5491.1$ vs $2527.8{\pm}1075.2$ IU, p<0.001). Clinical pregnancy rate per embryo transfer in the rFSH group showed increasing tendency, compared to the uFSH group, but there was no statistical significance (35.2% vs 29.3%). Our results demonstrated that the relative efficiency of rFSH compared with uFSH is higher in older patients. Conclusions: The ovarian stimulatory effect and clinical outcome of recombinant FSH was similar to that of the urinary gonadotropin. The IVF-ET cycles with significantly lower dose of gonadotropin in rFSH group showed comparable results. Therefore, we suggest that recombinant FSH is more potent and effective than urinary gonadotropin.

• 대한화장품학회지
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• 제49권2호
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• pp.117-125
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• 2023

본 연구에서는 광나무(Ligustrum japonicum) 열매 발효 추출물의 항염 및 항산화 효능을 비발효 추출물과 비교 분석하였다. 광나무 열매의 발효는 제주 자리돔(Chromis notata) 내장에서 분리한 Latilactobacillus curvatus (L. curvatus) 및 Weisella minor (W. minor) 균주를 이용하였으며, 각각의 발효 추출물(LJF-LC 및 LJF-WM)의 수율은 40.5 ~ 46.0%로 비발효 추출물(LJF)의 29.5% 보다 높게 나타났다. Lipopolysaccaride(LPS)로 자극된 RAW 264.7 대식세포를 이용한 nitric oxide (NO) 생성 억제 활성 실험 결과, 발효 추출물인 LJF-WM이 세포 독성 없이 농도 의존적으로 NO의 생성을 저해시키는 효과가 우수함을 확인하였다. 또한 DPPH 및 ABTS⁺ 라디칼 소거 활성 실험 결과, 발효 추출물의 라디칼 소거 활성이 비발효 추출물과 유사하게 나타났으며, 발효 추출물 LJF-WM은 과산화수소(H₂O₂)로 유도된 세포 손상에 대한 세포보호 효과를 보였다. 광나무 열매의 주성분인 salidroside의 함량을 HPLC를 이용하여 분석한 결과, 발효 추출물 LJF-LC에서 15.6 mg/g, LJF-WM에서 13.9 mg/g으로 확인되어 비발효 추출물(12.0 mg/g) 보다 함유량이 높게 분석되었다. 이상의 연구 결과를 바탕으로 광나무 열매 발효 추출물은 항염 및 항산화 효과를 갖는 천연 화장품 소재로써 활용 가능할 것이라 사료된다.

• 간호행정학회지
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• 제13권3호
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• pp.285-292
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• 2007

Purpose: The purpose of this study was to identify the factors influencing the nursing professional values(NPV) of college nursing students. Methods: A convenience sample of 274 subjects was recruited from the department of nursing at a college. The survey was conducted from May 29 to Jun 20 2006. The data was analyzed using descriptive statistics, Pearson correlation coefficients, and stepwise multiple regression with SPSS/WIN 10.1. Results: The average item score of NPV, satisfaction, socialization, self-esteem were 3.60, 3.00, 2.74, and 2.71. The NPV of nursing students showed a significantly positive correlation to speciality satisfaction(r=.28-.46), socialization(r=.13-.46), and self-esteem(r=.12-.15). The significant factors influencing NPV of nursing students were service, curriculum satisfaction, social perception satisfaction, leadership & popularity, and sociability, which explained about 37.5%. Conclusions: Therefore, on the basis of this study's result, when nursing educational programs are developed to make positive NPV, these factors need to be considered.

• 한국안전학회지
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• 제29권5호
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• pp.123-128
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• 2014

This study investigated a posttraumatic stress, social support, and work burden and identified related factors which exerted influence on posttraumatic stress of new firefighters. Data were gathered from total of 144 new firefighters. Also, 22 PTS items, 20 work burden items, and 8 social support items were analyzed by SPSSWIN 21.0 program. Posttraumatic stress according to general characteristics showed significant difference in gender(t=-2.57, p=0.01), experience of self danger(t=3.06, p=0.00), experience of rescuee danger(t=2.41, p=0.02), and experience of colleague danger(t=3.43, p=0.00). High risk group of PTS was 20.1%. Posttraumatic stress, social support, and work burden showed significant difference in the high and low risk group. Posttraumatic stress was correlated with work burden(r=0.34, p=0.00), social support(r=-0.29,p=0.00). Factors influencing PTS were Experience of colleague danger(${\beta}$=1.274, 95% CI=0.08-0.96), social support(${\beta}$=-0.090, 95% CI=0.85-0.98) and work burden(${\beta}$=0.057, 95% CI=1.02-1.10). We need to reduce the work burden caused by influencing variable of traumatic stress and create more preventive discipline of traumatic stress for the new firefighters to improve the social support at work or home. Also, posttraumatic stress has to be managed consistently with support by changing the social attitudes and we need to seek the new system that anybody can get a consultation of a specialist.

• 대한소아치과학회지
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• 제29권3호
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• pp.397-406
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• 2002

본 연구는 한국인의 유치열기 아동, 영구치열기의 구개의 폭, 길이, 구개의 용적, 구개 용적과 구개면적의 상관관계 등을 조사하여 남녀간의 차이, 유치열과 영구치열과의 변화 정도를 파악하고 다양한 구개의 연구를 할 수 있는 기초자료로 삼고자 하였다. 연구대상으로 정상교합의 유치열기 아동(Hellman dental age II A) 100명(남자 50명, 여자 50명)과 영구치열기의 성인(Hellman dental age IV A) 86명(남자 43명, 여자 43명), 총 186명을 대상으로 하여 제작한 상악의 석고모형을 이용하였다. 3차원 laser scanner(DS4060, LDI, U.S.A.), cloud data를 이용하여, polygonization, section curve와 loft surface, 표준평면, 수직평면 등을 얻은 후에 구개용적, 구개의 폭, 구개의 길이 등을 측정하였다(Surfacer 10.0, Imageware, U.S.A). 상수의 결정을 위해 유치열, 영구치열을 남녀별로 구분하여 결과를 구하였으며 남녀간의 차이는 student t-test를 이용하여 검정하여 다음과 같은 결론을 얻었다. 1. 표준평면과 각 치아, 치아 및 구개사이의 측정점들간의 거리는 영구치열에서 더 멀었다. 2. 영구치열에서의 구개용적이 유치열에서 보다 3배이상 컸으며 특히 영구치열에서는 여자에 비해 남자에서 유의성 있게 크게 측정되었다(p<0.05). 3. 구개폭은 유치열과 영구치열에서 남자에서 유의성 있게 크게 나타났지만 구개길이는 영구치열에서만 유의성 있게 컸다(p<0.05). 4. 유치열과 영구치열, 남자와 여자 모두에서 후구개폭과 총구개길이가 이루는 면적 이 구개용적과 가장 큰 상관관계를 보여주었다(r=0.401, r=0.450, r=0.678, r=0.654).

• 한국식품영양학회지
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• 제29권1호
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• pp.27-32
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• 2016

The purpose of this study was to measure concentrations of $K^+$, $Na^+$, $Cl^-$ by ionometer with check salt strip, simple salimeter and Ion-selective electrode (ISE) and compare the results of each mensuration; furthermore, the possibility of inferring the $Na^+$ concentration from $Cl^-$ concentration of urine and the impact of $K^+$ on the concentration of each ion was examined. The results showed that ISE determined $Na^+$ and $Cl^-$ concentrations in the urine are highly interrelated (R=0.9039); in addition, concentrations of $Cl^-$, measured with strip and ISE from urine are highly interrelated (R=0.9338). The concentration of $Na^+$ in urine, inferred by measuring $Cl^-$ concentration with strip, has a high relationship (R=0.8580) with the concentration of $Na^+$ in urine, measured by ISE. The results of our study will increase awareness of $Na^+$ intake and the utility of check salt strip, as well as the possibility of inferred $Na^+$ concentration from measures of $Cl^-$ concentration as a screening test for reducing sodium intake.

• 정신신체의학
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• 제29권2호
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• pp.136-143
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• 2021

연구목적 코로나바이러스 사태로 인해 전세계가 보건 위기와 큰 혼란의 국면을 맞은 가운데, 특히 재난 상황에서 시민의 건강을 위해 노력하는 공공 근로자들의 신체적, 정신적 스트레스가 과중해지고 있다. 본 연구는 공공 근로자들의 정신적 스트레스를 분석하고자 했다. 방 법 본 연구에서는 광명시 정신건강복지센터 홈페이지를 통해 모집한 531명의 공공영역 종사자를 대상으로 한국판 지각된 스트레스 척 도(Perceived Stress Scale, PSS), 한국판 우울증 평가도구(Patient Health Questionnaire-9, PHQ-9), 한국판 사건 충격 척도 수정판(Impact Event Scale-Revised, IES-R-K)을 시행하였다. 결 과 분석 결과에 의하면 코로나 19 관련 종사자들은 중등도 이상의 지각된 스트레스 반응(85.2%), 우울증상(22.2%), 외상 후 스트레스 관련 증 상(38.8%)을 보여, 상당한 스트레스와 우울증상을 경험하는 상태로 나타났다. PSS 총점은 PHQ-9, IES-R 총 점 및 IES-R의 하위 척도별 점수와 유의한 상관관계를 보여, 주관적으로 지각된 스트레스 반응 정도가 우울 증상과 연관되어 있음을 시사하였다. PSS, PHQ-9, IES-R 총점은 각각 모두 연령과 음의 상관관계를 보였다. 즉, 연령이 직무 스트레스 반응과 번아웃에 대한 보호요인으로 작용할 가능성이 있다. 결 론 향후에 공공영역 종사자 들의 정신건강에 관한 추가적인 연구가 필요하겠으며 정신건강 관리 및 적절한 개입이 마련되어야 할 것으로 사료된다.