• Title/Summary/Keyword: miR-27a

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Influence of the Job Stress, Resilience, and Professional Identity on Burnout in Operation Room Nurses (수술실 간호사의 직무스트레스, 회복탄력성, 전문직 정체성이 소진에 미치는 영향)

  • Lim, Eun Jin;Lee, Yun Mi
    • Journal of Korean Critical Care Nursing
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    • v.10 no.1
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    • pp.31-40
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    • 2017
  • Purpose: The purpose of this study was to identify the factors influencing on burnout in operating room nurses. Methods: Using a cross-sectional design, a total of 109 operating room nurses working at 7 general hospitals with 300 beds or more in B city were analyzed. The instruments used for this study assessed job stress, resilience, professional identity, and burnout. Data was analyzed using descriptive statistics, a t-test, an ANOVA, a Pearson's correlation coefficient and a multiple regression analysis. Results: There was a statistically significant correlation between burnout and job stress (r=.53, p<.001), resilience (r=-.59, p<.001), and professional identity (r=-.47, p<.001). The factors influencing burnout include job stress (${\beta}=.27$, p<.001), resilience(${\beta}=-.37$, p<.001), dissatisfaction with the nursing job (${\beta}=.32$, p<.001), and moderate satisfaction with the nursing job (${\beta}=.19$, p=.014), and the explanatory power was 53.0%. Conclusions: The results suggest that intervention to reduce job stress and to improve resilience, which were the factors influencing burnout in operating room nurses, is necessary.

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Identification of Hub Genes in the Pathogenesis of Ischemic Stroke Based on Bioinformatics Analysis

  • Yang, Xitong;Yan, Shanquan;Wang, Pengyu;Wang, Guangming
    • Journal of Korean Neurosurgical Society
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    • v.65 no.5
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    • pp.697-709
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    • 2022
  • Objective : The present study aimed to identify the function of ischemic stroke (IS) patients' peripheral blood and its role in IS, explore the pathogenesis, and provide direction for clinical research progress by comprehensive bioinformatics analysis. Methods : Two datasets, including GSE58294 and GSE22255, were downloaded from Gene Expression Omnibus database. GEO2R was utilized to obtain differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed using the database annotation, visualization and integrated discovery database. The protein-protein interaction (PPI) network of DEGs was constructed by search tool of searching interactive gene and visualized by Cytoscape software, and then the Hub gene was identified by degree analysis. The microRNA (miRNA) and miRNA target genes closely related to the onset of stroke were obtained through the miRNA gene regulatory network. Results : In total, 36 DEGs, containing 27 up-regulated and nine down-regulated DEGs, were identified. GO functional analysis showed that these DEGs were involved in regulation of apoptotic process, cytoplasm, protein binding and other biological processes. KEGG enrichment analysis showed that these DEGs mediated signaling pathways, including human T-cell lymphotropic virus (HTLV)-I infection and microRNAs in cancer. The results of PPI network and cytohubba showed that there was a relationship between DEGs, and five hub genes related to stroke were obtained : SOCS3, KRAS, PTGS2, EGR1, and DUSP1. Combined with the visualization of DEG-miRNAs, hsa-mir-16-5p, hsa-mir-181a-5p and hsa-mir-124-3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene. Conclusion : Thirty-six DEGs, five Hub genes, and three miRNA were obtained from bioinformatics analysis of IS microarray data, which might provide potential targets for diagnosis and treatment of IS.

The Choice of Applicable Law and the Limitations of Party Autonomy - Focusing on International Sports Arbitration - (중재의 준거법 선택과 당사자 자치의 제한 - 국제스포츠중재를 중심으로 -)

  • Yoo, So-Mi
    • Journal of Arbitration Studies
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    • v.31 no.2
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    • pp.23-46
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    • 2021
  • Sports disputes have specific characteristics compared to disputes that arise in the field of commerce. One particularity is the judicial system in which the CAS plays a key role as the International Supreme Court for sports-related matters. The CAS Code applies whenever the parties agree to submit a sports-related dispute to the CAS(Art. R27). Once the parties to the arbitration agreement have decided that the CAS Code should govern their proceedings. The parties' autonomy is, however, limited to the provisions of the CAS Code that provide for such a corresponding autonomy. The application of the mandatory rules contained in the CAS Code cannot be excluded. In CAS appeals arbitration proceedings, the Panel shall decide the dispute according to the applicable sports regulations and, subsidiarily, to the rules of law chosen by the parties(Art. R58). In international sports disputes, the uniform application and interpretation of the relevant regulations are essential. Therefore, Art. R58 should be applied as a mandatory rule without any changes. Regulations of the sports organizations are to be qualified as valid rules of law. CAS panels may also apply the so-called lex sportiva to the merits before considering statutory provisions of national jurisdictions. In this way, the specificities in (international) sports disputes can be taken into account without the need to further examine the application of national legal standards.

Analysis of anterior and posterior corneal spherical aberration with age in the korean (한국 성인의 연령에 따른 각막 전후면 구면수차에 관한 분석)

  • Song, Yun-Young;Jung, Mi-A;Kang, In-San;Choi, Ji-Young
    • Journal of Digital Convergence
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    • v.11 no.1
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    • pp.315-320
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    • 2013
  • We have investigated the variation of spherical aberration of the anterior and posterior surface in a Korean sample population with various age between 20 to 71 years old. We used Pentacam (Oculus Inc., Germany) to measure the corneal radius, asphericity, and spherical aberration of 290 patients with normal cornea. There were negative correlation between corneal anterior radius and spherical aberration(r = -0.22, p<0.0001), and, there were negative correlation between corneal posterior radius and spherical aberration(r=-0.27, p < 0.0001). There were positive correlation between anterior asphericity and spherical aberration(r = 0.24, p < 0.0001), however there were negative correlation between posterior asphericity and spherical aberration(r = -0.17, p=0.00288).The average of anterior spherical aberration and posterior spherical aberration was $0.482{\pm}0.099{\mu}m$ and $-0.098{\pm}0.029{\mu}m$. The average of spherical aberration was $0.385{\pm}0.097{\mu}m$. There were significant positive correlations between anterior spherical aberration and age(r = 0.227, p<0.0001), and there were positive correlations between posterior aberration and age(r = 0.349, p<0.0001). It is considered that this data can be used as basic information for furture studies for improving the quality of vision of modern human and, through the analysis of the spherical aberration of cornea was to provide a better understanding of the optical part of the Korean's eye.

Efficient Multicasting Mechanism for Mobile Computing Environment (물류트랙킹 장비에 활용되는 WCDMA/GSM 이중 대역 안테나 설계 및 성능 검증)

  • Lee, Eun-Kyu;Choi, Sung-Pill;Moon, Young-Sik;Jeon, Mi-Jin;Jo, Jae-Hui;Kim, Jae-Joong;Choi, Hyung-Rim
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2013.10a
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    • pp.896-897
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    • 2013
  • In recent years, logistics tracking Device using GSM & WCDMA to improve logistics efficiency are being extensively researched. The purpose of this paper is to examine the performance development antenna usable cargo container security transport. Antenna developed by study were optimized to match logistics environment apply to GSM & WCDMA dual frequency for monitering system. The measure of antenna have confirmation VSWR is 3:1 measured in return loss -10dB. Reliability of this antenna has been verified about GSM & WCDMA through test-operation between the south korea and Russia.

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Improved cosmetic activity by optimizing the Citrus madurensis (Citrofortunella microcarpa) INEFU extraction process. (둥근금감 (깔라몬딘 오렌지)의 이네푸 추출공정의 최적화를 통한 화장품 기능성 활성 증가 연구)

  • Bae, Kyungseok;Kim, Yu Mi;Moon, Chris
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2019.04a
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    • pp.98-98
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    • 2019
  • This study was expand the use of Citrus madurensis (Citrofortunella microcarpa), which is a good source of skin whitening and antioxidants activation cosmetics. The goal was to provide cosmeceutical activity data about the extraction yield and total phenol of this calamondin orange by optimizing the focused high ultrasound(INEFU) and ultrasound extraction(UE) conditions. Under optimal extraction conditions, which consisted of 1800W for 45min and 500W for 45 min, 21.55 and 13.27 % (w/w) of the highest extractions yield and polyphenol contents were obtained. For the skin whitening activity, tyrosinase inhibitory activity was observed at 69.24 % in the INEFU extracts, which was ca. 18 % higher than that of the UE extracts (58.82 %). To reduce melanin production in Clone M-3 cells, 86.9 % melanin production was observed following the addition of control, WE(water extraction) relative to the control without a sample, and 81.2 and 78.9 % were found in the UE and INEFU conditions. The highest total phenol secretion was conclusively obtained under the optimal conditions and resulted in a significant improvement of the cosmetic activities of Citrus madurensis(Citrofortunella microcarpa) extracts.

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Relationship between occlusion analysis using the T-scan III system and oral behavior checklist according to temporomandibular joint disorder in female college students (여대생의 측두하악장애에 따른 T-scan III System을 이용한 교합분석 및 구강행동유형과의 관련성)

  • Lee, Sun-Mi;Kim, Chang-Hee;Jun, Mi-Kyoung
    • Journal of Korean society of Dental Hygiene
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    • v.19 no.2
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    • pp.317-327
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    • 2019
  • Objectives: This study aimed to evaluate the effects of occlusion patterns using the T-scan $III^{(R)}$ system and oral parafunctional behaviors on temporomandibular joint disorder (TMD) in female college students. Methods: A questionnaire survey assessed TMD symptoms and oral behavioral checklist (OBC) scores in 120 female college students in their early twenties. Occlusion was evaluated using the T-scan $III^{(R)}$ system. Logistic regression analysis was performed to investigate the relationship between occlusion and OBC scores based on patients' symptoms of TMD and to determine whether OBC scores were a predictor of TMD. Results: A total of 101 participants with an average age of 22 (${\pm}2.17$) years were included in the analysis. The reported symptoms of TMD were categorized as moderate (28.8%), slight (27.7%), severe (25.7%), and asymptomatic (17.8%). Occlusion was analyzed using the T-scan $III^{(R)}$ system, and the mean occlusion time was 0.42(${\pm}0.5$) seconds. The results of logistic regression analysis showed that the group that would 'clench or grind teeth' during sleep showed an odds ratio for TMD that was 8.9 times higher than that in the group without this behavior. The group that would 'hold, tighten, or tense muscles without clenching' while awake showed an odds ratio for TMD that was 21.3 times higher than that in the group without this behavior. Conclusions: We confirmed that oral parafunctional behavior affects TMD. Therefore, we would like to continue studying the diagnosis and treatment of TMD by evaluating occlusion patterns and related OBC scores.

Distribution of Functional Feeding and Habitat Trait Groups of Benthic Macroinvertebrates and Biological Evaluation of Water Quality in Gayasan National Park (가야산의 저서성 대형무척추동물 섭식기능군 및 서식습성군 분포와 생물학적 수질평가)

  • Moon, Tae Young;An, Mi Soon;Kim, Hyoung Gon;Yoon, Chun Sik;Cheong, Seon Woo
    • Journal of Environmental Science International
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    • v.27 no.6
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    • pp.383-399
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    • 2018
  • In the present study, the community distribution, functional feeding groups, and habitat groups of the benthic macroinvertebrates from Gayasan National Park were investigated at eight different sites from 2015 to 2016. The correlation between habitat altitude and each group type was analyzed statistically. Biodiversity indices, including dominance, diversity, richness, and evenness indices, were calculated. The results showed a total of 4,216 individual benthic macroinvertebrates were collected, including 4 phyla, 6 classes, 16 orders, 40 families, and 100 species. Gammarus sobaegensis was dominant with 0.141% dominance, and the subdominant species was Epeorus nipponicus with 0.088% dominance. The EPT group(Ephemeroptera, Plecoptera and Tricoptera) accounted for 71.00% of the total species and 67.69% of the total individuals. The number of scraper species was highest, and the number of gathering collector individuals was highest among functional feeding groups. The individual number of scrapers(r=-0.358, p < 0.05) and gathering collectors(r=-0.343, p < 0.05) decreased with increasing altitude. The numbers of species and individuals of clingers and sprawlers were highest among the habitat groups. The individual number of clingers(r=-0.547, p < 0.01) and burrowers(r=-0.331, p < 0.05) significantly decreased with increasing altitude. The diversity and richness indices were higher in St. 3 than in the other sites. The dominance index was highest in St. 2, and the evenness index was highest in St. 7. We evaluated the biological water quality with several known methods, and concluded that ESB(Ecological score of benthic macrovertebrates community) and GPI(Group polution index) were more suitable than KSI(Korean saprobic index) and BMI (Benthic macrovertebrate index) to assess the biological water quality of Gayasan mountain stream water.

The Effect of Natural Mixture Supplementation on Histopathological and Histomorphometrical aspects in High Fat Diet-induced Obese Mice (천연 소재 복합물이 고지방사료로 유도된 비만 생쥐의 조직형태 및 조직병리학적 변화에 미치는 영향)

  • Shin, In-Soon;Choi, Hye-Min;Ku, Sae-Kwang;Kim, Mi-Ryeo
    • The Korea Journal of Herbology
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    • v.27 no.4
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    • pp.53-58
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    • 2012
  • Objective : Obesity is often defined as a condition associated with accumulations of excessive body fats which resulting from disorder of energy balance in term of energy intake and energy expenditure. Methods : The effects of natural mixture (T) for inhibition of lipid metabolism on the liver, epididymal fat pads and pancreatic zymogen granules of high fat diet (HFD) supplied rats were observed by histopathology and histomorphometry. Results : As results of HFD supply, severe steatohepatitis such as increases of mean diameters of hepatocytes and the percentages regions of fatty changes was detected. In addition, hypertrophy of adipocytes (increase of mean diameters of epididymal fat pads) was also detected with dramatic decreases of pancreatic zymogen granules at histopathological and histomorphometrical observations. However, theses steatohepatitis and hypertrophy of adipocytes induced by HFD supply were inhibited by treatment of 5 % and 10 % T (T5, T10), respectively. Well corresponded as the results of adipocyte hypertrophy and steatohepatitis, the decreases of pancreatic zymogen granules were also dose-dependently inhibited by T treatment as compared with HFD control, respectively. Conclusion : In conclusion, based on the results, it is considered that test materials, T5 and T10, will be showed hepatoprotective and anti-obese effects, may be directly and/or indirectly mediated by pancreatic zymogen granules because they dose-dependently inhibited steatohepatitis, hypertrophy of adipocytes and decreases of pancreatic zymogen granules induced by HFD supply, respectively.

Knowledge, Compliance and Quality of Life of Mothers of Children with Atopic Dermatitis (아토피피부염 아동 어머니의 지식, 치료지시이행 및 삶의 질)

  • Kim, Min-Ju;Choi, Mi-Hye
    • Child Health Nursing Research
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    • v.17 no.4
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    • pp.272-280
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    • 2011
  • Purpose: This study was conducted to survey knowledge, compliance, and quality of life of mothers who have children with atopic dermatitis, and to determine whether above mentioned factors influence each other. Methods: The participants in this study were 165 mothers of children with atopic dermatitis recruited from one out-patient clinic in a hospital in Seoul. The data were collected between March 8, and April 16, 2010 using a structured questionnaire. Results: The mean score for participants' knowledge was 4.17/5, for compliance, 4.27/5 and for quality of life, 3.42/5. Among the five domains of quality of life, emotional status had the lowest score (3.20/5). Knowledge was significantly correlated with compliance (r=.215, p<.005). However, quality of life was not correlated with knowledge (r=-.069) and compliance (r=-.077). Conclusion: Accurate knowledge affects compliance of mothers of children with atopic dermatitis. Therefore, to increase the level of compliance, it is necessary to enhance the knowledge of the mothers. Results also suggest that interventions are needed to improve poor quality of life, particularly the emotional condition of mothers of children with atopic dermatitis.