• Title/Summary/Keyword: miR-23a

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Relationship between Oriental Obesity Pattern, Life Habitual Factors and Psychological Factors in Korean Obese and Overweight Women (비만 및 과체중 성인 여성에서 한방비만변증과 생활 습관 및 심리적 요인 간의 상관관계)

  • Cho, Yu-Jeong;Lee, A-Ra;Hwang, Mi-Ja;Song, M-Yeon
    • Journal of Korean Medicine for Obesity Research
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    • v.11 no.2
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    • pp.15-24
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    • 2011
  • Objectives: The aim of the study was to investigate the relationship between oriental obesity pattern, life habitual factors(eating attitude, physical activity) and psychological factors(depression, stress, self-esteem) in korean obese and overweight women. Methods: This study was performed in obese and overweight(BMI ${\geq}$ 23 kg/$m^2$) women in Korea (n=56). Simple anthropometry including weight, BMI, waist circumference, BIA(bioelectrical impedance analysis) were done. To assess psychological factors, the Rosenberg self-esteem scale (SES) questionnaire, Beck depression inventory (BDI) questionnaire and stress response inventory (SRI) questionnaire were administered. Regarding diet, Korean eating attitude test(KEAT-26) was done. International physical activity questionnaire(IPAQ) was administered for exercise and physical activity intensity and quantities. All values were verified using correlation analysis. Results: 1. The subjects had stagnation of the liver qi>food accumulation>yang deficiency>blood stasis>spleen vacuity in the order. 2. Stagnation of the liver qi score had significant relationships with self-esteem(r=-0.520, p<0.05) and depression(r=0.688, p<0.01) in stagnation of the liver qi group. There was a relationship between food accumulation score and eating attitude(r=0.784, p<0.01) in food accumulation group. 3. Lean mass had a significant relationship with self-esteem(r=0.434, p<0.05) fat mass had a significant relationship with stress (r=0.633, p<0.01) and in stagnation of the liver qi group. 4. Physical activity had significant relationships with lean mass(r=0.628, p<0.01) and with fat mass(r=-0.478, p<0.05) in group. Conclusions: This study maintained that psychological factors play major roles in obesity with symptoms of stagnation of the liver qi and life habit(dietary factors and physical activity) in food accumulation.

Pathogenesis and prognosis of primary oral squamous cell carcinoma based on microRNAs target genes: a systems biology approach

  • Taherkhani, Amir;Dehto, Shahab Shahmoradi;Jamshidi, Shokoofeh;Shojaei, Setareh
    • Genomics & Informatics
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    • v.20 no.3
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    • pp.27.1-27.13
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    • 2022
  • Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck malignancy, with frequent cervical lymph-node metastasis, leading to a poor prognosis in OSCC patients. The present study aimed to identify potential markers, including microRNAs (miRNAs) and genes, significantly involved in the etiology of early-stage OSCC. Additionally, the main OSCC's dysregulated Gene Ontology annotations and significant signaling pathways were identified. The dataset GSE45238 underwent multivariate statistical analysis in order to distinguish primary OSCC tissues from healthy oral epithelium. Differentially expressed miRNAs (DEMs) with the criteria of p-value < 0.001 and |Log2 fold change| > 1.585 were identified in the two groups, and subsequently, validated targets of DEMs were identified. A protein interaction map was constructed, hub genes were identified, significant modules within the network were illustrated, and significant pathways and biological processes associated with the clusters were demonstrated. Using the GEPI2 database, the hub genes' predictive function was assessed. Compared to the healthy controls, main OSCC had a total of 23 DEMs. In patients with head and neck squamous cell carcinoma (HNSCC), upregulation of CALM1, CYCS, THBS1, MYC, GATA6, and SPRED3 was strongly associated with a poor prognosis. In HNSCC patients, overexpression of PIK3R3, GIGYF1, and BCL2L11 was substantially correlated with a good prognosis. Besides, "proteoglycans in cancer" was the most significant pathway enriched in the primary OSCC. The present study results revealed more possible mechanisms mediating primary OSCC and may be useful in the prognosis of the patients with early-stage OSCC.

Purification and Characterization of Heat-Tolerant Protease Produced by Bacillus polyfermenticus SCD

  • Choi, Gooi Hun;Jo, Mi Na;Kim, Jin-Man;Kim, Cheon-Jei;Kim, Kee-Tae;Paik, Hyun-Dong
    • Journal of Microbiology and Biotechnology
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    • v.23 no.11
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    • pp.1554-1559
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    • 2013
  • A protease produced by Bacillus polyfermenticus SCD was purified and characterized as a new detergent material. The protease was purified from supernatant produced by B. polyfermenticus SCD, by ammonium sulfate precipitation, ion-exchange chromatography on a DEAE-Sephadex A-50, and finally gel filtration chromatography on Sephadex G-50. The molecular mass of this enzyme was 44 kDa based on SDS-PAGE. The optimum temperature and pH were $50^{\circ}C$ and pH 8.0. The ranges of its stability to the pH and temperature were 7.0 to 9.0 and under $40^{\circ}C$, respectively. The enzyme was highly stable in the presence of the surfactants like Triton X-100 (0.1%), showing a 2-fold increase in its proteolytic activity. However, the enzyme was slightly inhibited by the chelating agent EDTA (1 mM). The enzyme has a maximum activity at $50^{\circ}C$ and the activity can be increased by surfactants such as Triton X-100 and Tween 80.

Assessment of Daily Steps, Physical Activity and Activity Coefficient of the Elementary School Children in the Rural Area (농촌지역 초등학생의 1일 평균 보행수, 활동량 및 활동계수 평가)

  • Lee, Hyun-Mi;Kim, Eun-Kyung
    • Korean Journal of Community Nutrition
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    • v.12 no.3
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    • pp.361-371
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    • 2007
  • The purpose of this study was to assess the daily steps, physical activities and activity coefficient of the elementary school children in the rural area. Body weight, height and daily steps were measured and one-day activity diaries were collected by interviewing children. The average age of the subjects was $9.96{\pm}1.02$ years. Average height, weight, obesity index, body fat and muscle of subjects were $136.2{\pm}8.9cm,\;35.2{\pm}8.5kg,\;99.6{\pm}18.8%,\;22.9{\pm}8.5%\;and\;35.8{\pm}6.0%$, respectively. The average daily steps of the subjects was 17,584 and daily steps (19,314) of 3rd grade students was significantly higher than that (15,712) of 5th grade children. But there was no significant difference in daily steps and activity coefficients between boys and girls. Daily steps (23,347) of exercise group showed the significantly higher than that (16,144) of non-exercise group. Gender and grade of subjects did not have significant influence on activity coefficients, but there was a significant difference in activity coefficient on weekdays between the exercise group ($1.82{\pm}0.30$) and non-exercise group ($1.50{\pm}0.21$). Analysis of variance revealed stronger associations between daily steps and body fat (%) than between daily steps and BMI. Daily steps showed significant negative correlation with body fat (%) measured using two methods r=-0.321 and r=-0.365, respectively. Activity coefficient was significantly correlated (r=0.436) with daily steps, thus increasing daily steps cm prevent and treat childhood obesity by increasing the energy expenditure. The higher activity coefficients (weekday 1.56, weekend 1.53) of the subjects was caused by the fact that rural students spent more time outside and enjoyed stronger activities than urban students. The results of this study can be used to estimate energy requirements for Korean children based on exercise levels and living areas.

Relationships among Nursing Students' Recognition, Perceived Usefulness, and Intention to Accept IoT

  • KANG, Ji-Yeon;KONG, Ye-Won;KIM, Eun-Bi;KIM, Eun-Ae;PARK, Sun-Joo;PARK, Jina;SEONG, Ji-Yeon;SON, Chae-Eun;LEE, Bo-Mi;KIM, Yunmi
    • The Korean Journal of Food & Health Convergence
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    • v.7 no.1
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    • pp.1-5
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    • 2021
  • The purpose of this study was to investigate the degree of recognition, perceived usefulness, and intention to accept the Internet of Things (IoT) in healthcare among nursing students, as well as to determine related factors. Through this study, we wanted to develop the basic research for the education related to the IoT in healthcare. In this study, data were collected from 348 nursing students using self-report online questionnaires, Naverform, and analyzed using the independent sample t-test, one-way analysis of variance, and Pearson correlation coefficients in SPSS version 26.0. The results of the study show that recognition of the IoT was correlated with its perceived usefulness (r=0.37; p<.001) and intention to accept the IoT (r=0.23 (p<.001). The strongest correlation was found between perceived usefulness of the IoT and intention to accept (r=0.67; p<.001). In conclusion, recognition of the IoT in healthcare affected its perceived usefulness, and a significant correlation was found between perceived usefulness of the IoT and intention to accept it. This study analyzed how much recognition, perceived usefulness, and intention to accept IoT in healthcare nursing students have. Based on these findings, we suggest that education related to the IoT in healthcare should be incorporated into the nursing curriculum.

Post-traumatic Growth and it's associations with Deliberate Rumination, Self-disclosure, and Social Support among Intensive Care Unit Nurses (중환자실 간호사의 의도적 반추, 자기 노출, 사회적 지지가 외상 후 성장에 미치는 영향)

  • Min, Sae Mi;Kim, Hee Jun;Kim, Chun-Ja;Ahn, Jeong-Ah
    • Journal of Korean Critical Care Nursing
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    • v.15 no.2
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    • pp.50-63
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    • 2022
  • Purpose : This study aimed to identify intensive care units (ICU) nurses' experience of traumatic events, deliberate rumination, self-disclosure, social support, and post-traumatic growth (PTG), and to explore relationships among the variables. Methods : Participants were 157 nurses who have provided direct patient care for six months or more in ICUs at a university hospital. Collected data were analyzed using descriptive statistics, independent t-tests, one-way ANOVAs, Pearson correlations, and multiple linear regressions using the SPSS/WIN version 23.0. Results : The PTG was found to be significantly associated with deliberate rumination (r=0.36, p<.001), self-disclosure (r=0.39, p<.001), and social support (r=0.54, p<.001). Factors that affect PTG significantly were found in the order of social support (𝛽=0.40, p<.001), self-disclosure (𝛽=0.25, p<.001), and deliberate rumination (𝛽=0.24, p<.001). The final regression model explained 40.1% of the variance of PTG (F=26.33, p<.001). Conclusion : The influencing factors identified in this study on PTG, including social support, self-disclosure, and deliberate rumination should be included in programs to promote PTG for ICU nurses who may experience traumatic events repeatedly.

Battery Discharge System Configuration using Photovoltaic Simulator and PCS (태양광 시뮬레이터와 PCS를 이용한 배터리 방전시스템 구성)

  • Jeong, Da-Woom;Park, Sung-Min;Park, Seong-Mi;Park, Sung-Jun;Moon, Seung-Pil
    • Journal of the Korean Society of Industry Convergence
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    • v.23 no.3
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    • pp.491-498
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    • 2020
  • Recently, In the production line of batteries, charge and discharge tests are essential to verify battery characteristics. In this case, the battery charging uses a unidirectional AC/DC converter capable of output voltage and current control, and the discharge uses a resistive load. Since this method consumes energy during discharge, it must be replaced with a bi-directional AC/DC converter system capable of charging and discharging. Although it is difficult to replace the connected inverter part of the bi-directional AC/DC converter system due to the high cost, the spread of the solar-connected inverter rapidly increases as the current solar supply business is activated, and thereby the solar-connected type Inverter prices are plunging. If it can be used as a power converter for battery discharge without program modification of the solar-powered inverter, it will have competition. In this paper, propose a new battery discharge system using a combination of a photovoltaic DC/DC simulator and photovoltaic PCS using a battery to be used as a power converter for battery discharge without program modification of a low-cost photovoltaic inverter. In addition, propose an optimal solar characteristic curve for the stable operation of PCS. The validity of the proposed system was verified using a 500[W] class solar DC/DC simulator and a solar PCS prototype.

The Effects of Life Stress and Stress Coping among Nursing College Students on Health Promotion Behavior (간호대학생의 생활 스트레스, 스트레스 대처가 건강증진행위에 미치는 영향)

  • Choi, Yooun-Sook;Kim, Mi-Young
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.7
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    • pp.109-119
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    • 2020
  • The purpose of this study was to provide basic data for improving health promotion behavior by identifying the effects of life stress and coping with stress among nursing college students on health promotion behavior. The data was collected from 352 nursing students in 6 colleges in B and K city, and the data was analyzed with SPSS/Win 23.0. Factors influencing health promotion behavior were school life satisfaction (F=9.18, p<.001), happiness score (F=20.64, p<.001), health status (F=12.40, p<.001), eating breakfast (t=-3.31, p=.001), unbalanced diet (t=-4.20, p<.001), time spent sleeping (F=2.64, p=.049), and exercise (t=5.20, p<.001). In the correlations, health promotion behavior was negatively correlated with life stress (r=-.289, p<.001), but it was positively correlated with coping with stress (r=.539, p<.001). The factors influencing health promotion behavior were stress coping (β=.439, p<.001), happiness score (β=.251, p<.001), exercise (β=.172, p<.001), unbalanced diet (β=.125, p=.002), life stress (β=-.121, p=.005), and eating breakfast (β=.083, p=.046). The above variables explained 46.0% for the health promotion behavior. Thus, in order to improve the health promotion behavior of nursing college students, integrated nursing interventions need to be developed through improving coping with stress, creating a sense of happiness, reducing life stress, and maintaining exercise and good eating habits.

The Relationship between Emotional Intelligence, Critical Thinking Disposition and Clinical Competence in New Graduate Nurses immediately after Graduation (졸업직후 신규간호사의 감성지능, 비판적 사고능력 및 임상수행능력 간의 관계)

  • Lee, Oi Sun;Kim, Mi Jeoung
    • Journal of Digital Convergence
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    • v.16 no.6
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    • pp.307-315
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    • 2018
  • The purpose of this study is to examine to identify the mediating effects of emotional intelligence in the relation between critical thinking disposition and clinical competence among new graduate nurses immediately after graduation. Subjects were 181 new graduate nurses immediately after graduation. in two general hospitals in C city and K city. Data were collected by self-report questionnaires from February 27 to March 30, 2017. Data were analyzed by descriptive statistics, Independent t-test, ANOVA, Pearson's correlation and Multiple regression and Sobel test to test the significance of a mediation effect using SPSS 23 software. Emotional intelligence were significantly positive correlations with critical thinking disposition(r=.62, p<.001) and clinical competence(r=.60, p<.001) in new graduate nurses immediately after graduation. Emotional intelligence partially mediated the relationship between critical thinking disposition and clinical competence which showed significance in Sobel's test(Z=3.88, p<.001). Theses results indicated that in order to improve the clinical competence of new nurse, it is necessary to develop and test the program for improving not only on the critical thinking disposition but also on the emotional intelligence.

The Factors Influencing Dependence of the Elderly Patients in Medical and Care Hospital (요양병원 입원 노인의 의존성 영향요인)

  • Oh, Mi Suk;Ko, Sung Hee;Lee, Young Hee
    • 한국노년학
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    • v.36 no.4
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    • pp.1177-1189
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    • 2016
  • The dependency is a problem in the aged. The purpose of this study was to investigate depression, urinary incontinence, sleep patterns, and dependence, and to identify affecting factors of dependence on elderly patients in medical and care hospital. The subjects consisted of 209 elderly inpatients in the J city. The variables of dependency, depression, urinary incontinence, sleep were measured using questionnaires. Data analysis was performed using the SPSS 23.0 program, using descriptive statistic, t-test, ANOVA, Pearson correlation coefficient, and multiple regression analysis. Major findings of this study are as follows. The mean score of depression is $6.83{\pm}4.14$(out of 15), urinary incontinence is $6.44{\pm}9.63$(out of 60), sleep hour is $8.09{\pm}1.55$, quality of sleep is $39.37{\pm}6.55$(out of 60), and dependence is $42.68{\pm}8.78$(out of 85). The economic dependence among the subdomain of dependence is the highest dependence score. Dependence was positively correlated with depression(r=.26, p<.001), urinary incontinence(r=.35, p<.001). Factors Influencing dependence were depression (${\beta}.227$, p=.001), urinary incontinence (${\beta}=.259$, p<.001), and explanation of dependence is 11.5%. These results suggest that it is necessary for multidisciplinary approach and nursing intervention for decreasing dependence.