• Title/Summary/Keyword: miR-21

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외국어 교육인가 방해인가? - 한국 외국어 교육관행을 분석하며

  • Park Jin-Gil
    • Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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    • v.4
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    • pp.373-394
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    • 2001
  • Bis jetzt haben wir $haupts\"{a}chlich$ verschiedene Probleme an Ort und Stelle des Fremdsprachunterrichts analysiert, und zwar: (a) den > Spracherwerbsmechanismus < die >SMQ< und den > auf jeweilige (Fremd)sprache fuhrenden Unterrieht<, die drei Lehr- u. Lernfaktoren des Spraeherwerbs, (b) den Lehr- u. $Lemproze\ss$ der Muttersprache, (c) die 5 Fertigkeitsaufgaben und (d) einige Prinzipien und ihre $Ma{\ss}nahmen$ der Sprachlehr- u. -lernmethode Aus diesen Grundlagen werden die folgenden Ergebnisse be- sonders hervorgebracht werden: (d) Das Hauptziel des Fremdspraehunterrichts soll/muss man darin finden, $zun\"{a}chst$ die >SMQ< zu $erf\"{u}llen$, die etwa 1000 $\"{A}u{\ss}erungen/S\"{a}tzen$ entspricht, um perfekt zu sprechen. (e) Alle Menschen kommen ausnahmslos genetisch mit dem >Spracherwerbsmechanismus< zur Welt, der alles Sprachmaterial grammatisch/systematisch aufnimmt. (f) Aus diesem Grund darf man den $Anf\"{a}nger$ keine Gramma -tik lehren, bis er perfekt sprechen kann, weil er als Mensch schon alles grammatisch lernen kann. (g) Stattdessen lohnt es sich, im Unterricht nur auf jeweilige Fremdsprache zu sprechen, zu schreiben und zu $erkl\"{a}ren$, d.h. den auf jeweilige Sprache $f\"{u}hrenden$ Unterricht intensiv zu hal- ten, was auch beim Mutterspracherwerb immer der Fall ist. (h) Es ist sehr ratsam $f\"{u}r$ uns, die Lehr- u. Lernmethode im Fall des Mutterspracherwerbs als Unterrichtsmodell dynamisch anzuwenden, weil sie uns immer den $100\%$ Erfolg geschenkt hat. (i) Im Alltag braucht man $st\"{a}ndig$ den Ansprecher/die -in (z.B. im Fernseh/ durch Internet) nachzuahmen, und zwar die Sprechweise, die Gestik bzw. Mimik usw. (j) Es soll/muss streng verboten werden, im Fremdsprach- unterricht auf Muttersprache zu sprechen, weil es mit der Fremd -sprachausbildung, d.h. mit der $Erf\"{u}llung$ von >SMQ< gar nicht zu tun hat, sondern eine Art Betrug sein $k\"{o}nnte$, soweit das folgende koreanische Sprichwort noch gilt: Der Apfel $f\"{a}llt$ nicht weit vom Stamm. (k) Ohne Reformierung des konventionellen Fremdsprachunter -richts, $100\%\;Mi{\ss}lingen$ hinnehmen zu $m\"{u}ssen$, kann man nichts weiter machen. Denn er $st\"{o}rt$ uns das auf jeweilige Sprache bezo -gene Denken. Z.B. die sinnlose Grammatik, auf Muttersprache zu sprechen, die unmittelbare $\"{U}bersetzung$ usw. sind dessen $R\"{a}delsf\"{u}hrer.\;Alle\;L\"{a}nder\;besch\"{a}ftigen\;sich\;st\"{a}ndig\;damit,\;ihre\;M\"{o}glichkeit$ in der harten Existenzkonkurrenz durch die Bildungsreform auszu -gleichen. Denn die Ausbildung der Hochtechnologie im 21. Jh. braucht notwendig die $Fremdsprachf\"{a}higkeit$ als ihre Grundlage. Ohne Selbstreformierung $k\"{o}nnten$ wir als Fremdsprachlehrer/-pro -fessoren - auf Koreanisch sprechend - weiter den Fremdsprach -unterricht halten?

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A STUDY ON THE RELATIONSHIP BETWEEN THE LEVEL OF CAREER AWARENESS AND SELF-ESTEEM OF CHILDREN IN ELEMENTARY SCHOOLS (초등학교 아동들의 진로인식 수준과 자아존중감과의 관계 연구)

  • Kim, Mi-Ran
    • 한국초등상담교육학회:학술대회논문집
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    • 2004.01a
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    • pp.205-222
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    • 2004
  • Fundamental direction of the seventh education curriculum aims to nurture active and creative Koreans for globalized and information-oriented society of 21 century, and emphasizes the importance of career education identifying its subsections that are practices of student-focused education of aptitude, ability and career. Hence, as a clear targeting of career objective from elementary school through relevant career education enables them to recognize appropriate career for themselves, the basis of self- actualization and social contribution must be settled. This paper seeks to identify the relationship between career awareness and self-esteem by examining and analysing differences of sex, region and level. This study selected 536 samples from 4th and 6th year elementary school students in C city and S town of Chungcheong province. Career awareness test and self-esteem test is used as a measurement, statistical process control (SPC) of career awareness and self-esteem (M, SD, r) is made for each variable, and the significance was tested. The result of this research can be summarized as follows: First, generally there is very significant regional differences of career awareness (F=16.817, p<.001), which contains that urban children has higher career awareness (M=120.22) than that of rural children (M=113.87). In subsections of career awareness, self-esteem of urban children is higher than that of rural children, and the attitude & for career and values of girls is higher than that of boys. In terms of the career planning, urban children and 6th year students are higher than rural children and 4th year students. Second, self-esteem generally has very significant regional difference (F=12.123, p<.01), which contains that the self-esteem of urban children (M=106.50) is higher than that of rural children (M=101.80). In comparison of different forms, a very significant difference is as much as p<.01 level (F=11.046), which contains 4th year students (M=105.63) have higher self-esteem than 6th year students (M=102.05). In subsections of self-esteem, gross self-esteem and social self-esteem of urban children are higher than rural children. In terms of family self-esteem, urban children and 4th year students have higher figure than rural children and 6th year students. In school self-esteem, 4th year students had higher level than the 6th. Third, the career awareness and self-esteem are generally related as r= .50, it was very significant at p<. 001 level. All subsections of career awareness had positive relationships except the school self-esteem. According to the result, rural children had relatively low career awareness and self-esteem. This is presumably due to relatively poor circumstances for rural children, comparing to that of urban children. Therefore rural elementary schools should try to let them have appropriate career awareness by associating with family, school and local society to expand the opportunity of experiences for the self perception of aptitude, nature and interest. In addition, we have to strive for the whole-minded education increasing the self-esteem of rural children and giving them positive thinking through career counselling, personal counselling and group counselling.

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Factors Associated with the Concentrations of Urinary Creatinine in Korean Children and Adolescents (한국 어린이와 청소년의 요중 크레아티닌 농도와 영향요인에 대한 연구)

  • Lee, Jin-Heon;Ahn, Ryeong-Mi;Kang, Hee-Sook;Choi, Suk-Nam;Hong, Chun-Pyo;Kim, Jin-Gyong
    • Journal of Environmental Health Sciences
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    • v.38 no.4
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    • pp.291-299
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    • 2012
  • Creatinine-adjustment is an important process in the urinary monitoring of the environmental exposure of children and adolescents. The purpose of this study was to investigate the concentrations of urinary creatinine and factors associated with them among Korean children and adolescents. We recruited 1,025 persons from 128 extracted schools. They were from three to 18 years old and supplied urine samples for measuring creatinine. The concentrations of urinary creatinine were 98.18 mg/dl (SD, 67.67) in arithmetic mean and 72.05 mg/dl (GSD 2.49) in geometric mean, were significantly higher among male children/adolescents than females in all age groups, and higher values appeared following increasing ages, heights and BMIs. The rates of the number who were below the lowest limit recommended by WHO (<30 mg/dl) were 25.57% among three to four year olds, 21.77% among five to six year olds, 20.0% among seven to eight year olds and 14.69% among nine to ten year olds, respectively. The rates of those above the highest limit (>300 mg/dl) were 0.0% among three to twelve year olds. The coefficient of determination R-square of the fitted regression model for urinary creatinine was 27.4% with general characteristic variables of sex, age, BMI and height. The significant variables among these were height (standardized beta = 0.372) and age (standardized beta = 0.129). Another coefficient of determination R-square was 15.3% with dietary habit variables of smoking, drinking, dining area, number of meals and snacks, and intake of milk food, cup-noodles, canned foods, popcorn, nachos, and hamburgers. In conclusion, the concentration of urinary creatinine was significantly lower in children than in adults, and was very significantly associated with the height of children. Therefore, children need the recommended concentrations for urinary creatinine, as distinguished from adults.

Phenotypic and genetic characteristics of Vibrio ichthyoenteri isolated from the olive flounder, Paralichthys olivaceus of culturing size (미성어 양식 넙치, Paralichthys olivaceus에서 분리한 Vibrio icthyoenteri의 표현형 및 유전형적 특성)

  • Park, Su-Il;Lee, Hua;Kim, Su-Mi
    • Journal of fish pathology
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    • v.19 no.2
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    • pp.127-139
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    • 2006
  • From 2002 to 2004, various vibrios were isolated from the olive flounder, Paralichthys olivaceus of culturing size with disease signs. During this survey, it was known that the high proportion of Vibrio ichthyoenteri was occupied among the isolated vibrios. Generally, V. ichthyoenteri is well known as the pathogen of bacterial enteritis of olive flounder larvae. The aim of the present study was the compare the characteristics of two groups of V. ichthyoenteri, culturing sized olive flounder, and larvae of olive flounder showing the intestinal necrosis. The research was focused on the physiology, biochemistry, genetics in the two bacterial groups. The physiological and biochemical characteristics of the tested strains were very similar. The intergenic spacer (IGS) region between the 16S and 23S rRNA genes of 21 isolated strains and 3 reference strains, V. ichthyoenteri, were investigated by PCR fragment length typing and DNA sequencing. After the isolated strains were identified as V. ichthyoenteri, not only phenotypic characteristics of the isolated and reference strains but also homology of 16S-23S IGS of all isolated strains and reference strains as 99.1~100%. The V. ichthyoenteri showed 4 specific 16S-23S patterns and contained no-tRNA, tRNAGlu(TTC) , tRNAIle(GAT) tRNAAla(TGC) type .

Quality Characteristics of Sulgidduk Containing Different Levels of Dandelion (Taraxacum officinale) Leaves and Roots Powder (민들레 잎과 뿌리 분말을 첨가한 설기떡의 품질 특성)

  • Yoo Kyung-Mi;Kim Sai-Hee;Chang Jeong-Hwa;Hwang In-Kyeong;Kim Kyeong-Im;Kim Sung-Soo;Kim Young-Chan
    • Korean journal of food and cookery science
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    • v.21 no.1 s.85
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    • pp.110-116
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    • 2005
  • In order to develop a dandelion (Taraxacum officinale) with natural food applications, the effects of dandelion leaves and roots powder content on the physical, textural and sensory properties of sulggidduk were examined. Dandelion powders of leaves and roots at 0, 1, 2 and $3\%$ were added to the dandelion sulgidduk. In the dandelion roots powder in sulgidduk, the color intensity of L values and the values and moisture content decreased however, the sensory color intensity, dandelion flavor and overall acceptability increased with increasing the dandelion powder content. The sensory overall acceptability indicated the dandelion roots powder content at 3% had the highest overall and flavor scores. As the dandelion leaves content was increased, the moisture contents, lightness, adhesiveness and cohesiveness of sulggidduk decreased, while the sensory color intensity, sensory hardness, hardness of texture properties and dandelion flavor increased. The addition at $1\%$ of the dandelion leaves powder content with the dandelion sulggidduk and the addition at $3\%$ of the dandelion roots powder content with the dandelion sulggidduk showed the highest overall acceptability.

Identification of Genes Involved in Decolorization of Crystal Violet and Malachite Green in Citrobacter sp. (Citrobacter sp.에서 crystal violet와 malachite green 색소분해에 관여하는 유전자들의 동정)

  • Lee, Young-Mi;Jang, Moon-Sun;Kim, Seok-Jo;Park, Yong-Lark;Cho, Young-Su;Lee, Young-Choon
    • Journal of Life Science
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    • v.14 no.1
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    • pp.21-25
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    • 2004
  • To identify genes involved in the decolorization of both crystal violet and malachite green, we isolated random mutants generated by transposon insertion in triphenylmethane-decolorizing bacterium, Citrobacter sp. The resulting mutant bank yielded 14 mutants with complete defect in color removal capability of both crystal violet and malachite green. Southern hybridization with a Tn5 fragment as a probe showed a single hybridized band in 5 mutants and these mutants appeared to have insertions at different sites of the chromosome. Tn5-inserted genes were isolated and the DNA sequence flanking Tn5 was determined. From comparison with a sequence database, putative protein products encoded by cmg genes were identified as follows. cmg 2 is MaIC protein in maltose transport system; cmg 6 is transcriptional regulator (LysR-type): cmg 12 is a putative oxidoreductase. The sequences deduced from two cmg genes, cmg 8 and cmg 11, showed no significant similarity to any protein with a known function. Therefore, these results indicate that these two cmg genes encode unidentified proteins responsible for decolorization of both crystal violet and malachite green.

fMRI evidence of compensatory mechanisms during a verbal working memory task in individuals with alcohol use disorders (알코올 사용 장애자의 언어 작업 기억과 관련된 뇌의 보상 기전: fMRI 연구)

  • Park, Mi-Suk;Son, Seon-Ju;Park, Ji-Eun;Eum, Yeong-Ji;Kim, Suk-Hui;Yu, In-Gyu;Son, Jin-Hun
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 2009.05a
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    • pp.101-104
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    • 2009
  • This study investigated compensatory mechanisms in the brain during a verbal working memory task among people with Alcohol Use Disorders (AUD). A total of 21 college male students participated in the study: eleven AUD participants and 10 normal controls. Study participants were asked to complete the Korean version of the Wechsler Adult Intelligence Scale-III (K-WAIS-III) prior to the fMRI experiment. Verbal 0-back and 2-back tasks were used to assess brain activities of the participants' verbal working memory. Brain scanning was performed on Siemens SONATA 1.5T Scanner while participants were performing the 0-back and 2-back tasks. Within the AUD group, participants with greater dependency to alcohol (based on DSM-IV criteria) in the past 1 year showed lower mean score on the 'Similarities' of the K-WAIS-III (r=-0.63, p<0.05, N=11). The more participants experienced alcohol withdrawal symptoms in the past 1 year, the lower the score they received on the K-WAIS-III 'Picture Arrangement' (r=-0.69, p<0.05, n=11). The fMRI regression results showed that individuals who present greater degree of alcohol dependency symptoms are likely to show greater brain activation in the bilateral middle frontal gyri (BA 9) during the verbal working memory task. The degree of alcohol withdrawal symptoms were associated with increased brain activation in the left superior and middle frontal gyri (BA8), left precentral gyrus (BA 6), and left inferior parietal lobule (BA 40). The study findings showed that the degree of alcohol abuse/dependence and withdrawal symptoms were associated with decreased cognitive function and increased activations in brain regions particularly important for abstract reasoning (BA 9), central executive (BA 9), or spatial storage (BA 40) during a working memory task. Therefore, these results could support previous studies suggesting that the neural system of people with ADD may adopt a brain compensatory mechanism to maintain normal level of cognitive functions.

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A Study on the Consciousness of Economic Ethics in Nursing Students (간호대학생의 경제의식에 관한 연구)

  • Hong, Yoon-Mi
    • Journal of Korean Academy of Nursing Administration
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    • v.9 no.3
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    • pp.429-445
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    • 2003
  • Purpose : The present study attempted to consider the degree of consciousness of economic ethics in nursing students and the factors affecting these perceptions. Method : A survey was conducted to a total of 874 nursing students from the freshmen and seniors of 11 depts of nursing science nationwide selected by convenience sampling (one for each province, and as for Gangwon-do, two schools were selected from Yeongdong area and Yeongseo area ; 13 male students were excluded). A structured questionnaire was used to collect data on their demographic characteristics and economic ethical perceptions. Collected data were analyzed using the SAS V8.1 statistical package. Result : (1) The score for the economic ethical consciousness of the subjects was $36.76{\pm}10.20$. As for each sub-categories, the score for industry was $7.67{\pm}2.77$; thrift, $7.42{\pm}2.37$; cooperation, $7.41{\pm}2.21$; occupational consciousness, $7.18{\pm}2.20$; and, for consumption, $7.02{\pm}1.90$. The score for the consciousness of consumption was the lowest. (2) Among the demographic characteristics of the subjects, age was found to have a statistically significant positive relation to the consciousness of economic ethics(r=.13, p<.001). The next significant factor was grade: seniors seemed to have a higher economic consciousness in all the sub-categories than freshmen(t=-4.32, p<.001). The number of in-home family has a statistically significant negative correlation with economic attitudes(r=-.15, p<.001). In addition, their economic ethical perceptions were significantly higher with no religion (t=2.14, p<.05); have an unemployed father (t=2.78, p<.05); have credit cards under their own names (t=3.04, p<.05); have ever had overdue card bills (t=4.25, p<.001); have ever had part time job(t=1.74, p<.1) and when they don't live with their parents (t=-2.01, p<.05). 3) A multiple regression analysis was conducted to examine the influential power of the factors affecting the consciousness of economic ethics of the subjects. The factors had more influence on the economic attitudes of the seniors than those of freshmen; in those who having credit cards under their own names than under others; and, in those who have ever experienced credit default than those haven't. Though these factors raised average 3.0 points of economic consciousness, their expository power for the consciousness were low. Conclusion : The nursing students had medium-high consciousness of economic ethics and they seemed to have low consciousness of the proper consumption practices. Their actual life experiences had an influence on their economic attitudes. Therefore, practical programs on economic knowledge should be developed and taught to students systematically at school so that they could have sound consciousness of economic ethics and appropriate knowledge closely related with their real life.

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Comparison of One-Tube Nested-PCR and PCR-Reverse Blot Hybridization Assays for Discrimination of Mycobacterium tuberculosis and Nontuberculous Mycobacterial Infection in FFPE tissues

  • Park, Sung-Bae;Park, Heechul;Bae, Jinyoung;Lee, Jiyoung;Kim, Ji-Hoi;Kang, Mi Ran;Lee, Dongsup;Park, Ji Young;Chang, Hee-Kyung;Kim, Sunghyun
    • Biomedical Science Letters
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    • v.25 no.4
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    • pp.426-430
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    • 2019
  • Currently, molecular diagnostic assays based on nucleic acid amplification tests have been shown to effectively detect mycobacterial infections in various types of specimen, however, variable sensitivity was shown in FFPE samples according to the kind of commercial kit used. The present study therefore used automated PCR-reverse blot hybridization assay (REBA) system, REBA Myco-ID HybREAD 480®, for the rapid identification of Mycobacterium species in various types of human tissue and compared the conventional one-tube nested-PCR assay for detecting Mycobacterium tuberculosis (MTB). In conventional nested-PCR tests, 25 samples (48%) were MTB positive and 27 samples (52%) were negative. In contrast, when conducted PCR-REBA assay, 11 samples (21%) were MTB positive, 20 samples (39%) were NTM positive, 8 samples (15%) were MTB-NTM double positive, and 13 samples (25%) were negative. To determine the accuracy and reliability of the two molecular diagnostic tests, the one-tube nested-PCR and PCR-REBA assays, were compared with histopathological diagnosis in discordant samples. When conducted nested-PCR assay, 10 samples (59%) were MTB positive and seven samples (41%) were negative. In contrast, when conducted PCR-REBA test, three samples (17%) were MTB positive, 10 samples (59%) were NTM positive and four samples (24%) were negative. In conclusion, the automated PCR-REBA system proved useful to identify Mycobacterium species more rapidly and with higher sensitivity and specificity than the conventional molecular assay, one-tube nested-PCR; it might therefore be the most suitable tool for identifying Mycobacterium species in various types of human tissue for precise and accurate diagnosis of mycobacterial infection.

Serum anti-M$\ddot{u}$llerian hormone levels as a predictor of the ovarian response and IVF outcomes

  • Choi, Min-Hye;Yoo, Ji-Hee;Kim, Hye-Ok;Cha, Sun-Hwa;Park, Chan-Woo;Yang, Kwang-Moon;Song, In-Ok;Koong, Mi-Kyoung;Kang, Inn-Soo
    • Clinical and Experimental Reproductive Medicine
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    • v.38 no.3
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    • pp.153-158
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    • 2011
  • Objective: The aim of this study was to investigate whether anti-M$\ddot{u}$llerian hormone (AMH) levels could be predict ovarian poor/hyper response and IVF cycle outcome. Methods: Between May 2010 and January 2011, serum AMH levels were evaluated with retrospective analysis. Three hundred seventy infertile women undergoing 461 IVF cycles between the ages of 20 and 42 were studied. We defined the poor response as the number of oocytes retrieved was equal or less than 3, and the hyper response as more than 25 oocytes retrieved. Serum AMH was measured by commercial enzymelinked immunoassay. Results: The number of oocytes retrieved was more correlated with the serum AMH level (r=0.781, $p$ <0.01) than serum FSH (r=-0.412, $p$ <0.01). The cut-off value of serum AMH levels for poor response was 1.05 ng/mL (receiver operating characteristic [ROC] curves/area under the curve [AUC], $ROC_{AUC}$=0.85, sensitivity 74%, specificity 87%). Hyper response cut-off value was 3.55 ng/mL $ROC_{AUC}$=0.91, sensitivity 94%, specificity 81%). When the study group was divided according to the serum AMH levels (low: <1.05 ng/mL, middle: 1.05 ng/mL - 3.55 ng/mL, high: >3.55 ng/mL), the groups showed no statistical differences in mature oocyte rates (71.6% vs. 76.5% vs. 74.8%) or fertilization rates (76.9% vs. 76.6% vs. 73.8%), but showed significant differences in clinical pregnancy rates (21.7% vs. 24.1% vs. 40.8%, $p$=0.017). Conclusion: The serum AMH level can be used to predict the number of oocytes retrieved in patients, distinguishing poor and high responders.