• Title/Summary/Keyword: miR-21

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The Communication Styles and Nursing Service Satisfaction of Clinical Research Nurses Perceived by Clinical Subjects (임상시험 대상자가 지각한 임상연구 간호사의 의사소통 유형과 간호서비스 만족도)

  • Seo, Mi Seon;Park, Young Im
    • The Journal of Korean Academic Society of Nursing Education
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    • v.22 no.4
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    • pp.559-566
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    • 2016
  • Purpose: This study aimed to examine the communication styles and nursing service satisfaction of clinical research nurses perceived by clinical subjects. Methods: The data were collected with self-administrated questionnaires after receiving consents from 200 clinical trial subjects. The data were analysed with descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients and stepwise multiple regression analysis using SPSS 21.0 statistic program. Result: Clinical subjects perceived that clinical research nurses used the informative, affective, and non-authoritative communication styles. The study identified factors influencing the nursing service satisfaction, and they were the informative communication styles (${\beta}$=.34, p<.001) and affective communication styles (${\beta}$=.35, p<.001, $R^2$=37%) by multiple linear regression. Conclusion: If educational programs on communication are developed to help clinical research nurses use the informative and affective communication styles according to the characteristics of subjects and applied to the field of practice, they will be able to increase the nursing service satisfaction and contribute to the higher quality of clinical trials.

Influence of Interpersonal relation and Job Stress on Nursing Performance of Male Nurses (남자간호사의 대인관계능력과 직무 스트레스가 간호업무성과에 미치는 영향)

  • Cho, Mi-Kyoung;Kim, Chul-Gyu;Mo, Hyeong-Jung
    • Journal of muscle and joint health
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    • v.22 no.3
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    • pp.195-204
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    • 2015
  • Purpose: The purpose of this study was to identify the effect of interpersonal relation and job stress on nursing performance among male nurses. Methods: This study was cross-sectional descriptive one. The data were collected from self-administered questionnaires by 110 male nurses members affiliated with the Korean Man Nurses Association. The data were analyzed using descriptive statistics, independent t-test, one way ANOVA with Duncan test, Pearson correlation, and stepwise multiple regression with the SPSS/WIN 21.0. Results: The average scores of interpersonal relation, job stress, and nursing performance were respectively 3.64, 3.10, 3.63. Nursing performance was high in married, good health condition, manager, and high salary among male nurses. Nursing performance showed significant positive correlation with interpersonal relation (p<.001), and a significant negative correlation with job stress (p=.010). Influencing factors of nursing performance among male nurses were interpersonal relation, health status, total duration of career, position, and the adjusted $R^2$ of the regression model was 42%. Conclusion: The results suggest that we need to develop a training program to improve the nursing performance of the male nurses.

Gas Chromatographic Analysis of Zipeprol in Blood (혈액중 지페프롤의 가스크로마토그래피에 의한 분석)

  • Yoo, Young-Chan;Chung, Hee-Sun;Kim, Eun-Mi
    • YAKHAK HOEJI
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    • v.36 no.3
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    • pp.191-198
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    • 1992
  • The abuse of zipeprol, an antitussive agent, is prevalent among young people. Ten fatal cases of zipeprol concentration in blood after its abuse had caused death are disscussed. GC equipped with TSD was used to quantify the drug in postmortem blood and GC/MS to identify the metabolites in urine after preliminary test. The calibration curve of zipeprol was linear (r = 0.998) and the recoveries of zipeprol 5, 10 and $20\;{\mu}g$ added to 1 ml postmortem blood were $97.2{\pm}3.9$, $92.5{\pm}3.9$ and $86.9{\pm}4.6%$ respectively. The blood zipeprol concentration varied 2.9 to $24.69\;{\mu}g/ml$ in 10 fatal cases. All the deaths were young adults with the age of 16-21. Three metabolites were identified in drug abuser's urine, 2-methoxy-2-phenyl ethylpiperazine, 2-hydroxy-3-methoxy-3-phenyl propylpiperazine and a demethylated zipeprol.

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An Analysis of Factors Influencing Job Satisfaction among Nurses Working in College Health Centers (대학보건소 간호사의 직무만족 영향요인 분석)

  • Cha, Kyu Jung;Song, Mi Ryeong
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.20 no.3
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    • pp.259-268
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    • 2013
  • Purpose: The purpose of this study was to identify factors influencing job satisfaction among nurses working in college health centers in order to enhance their role functions and to increase their work capabilities. Method: In this study a cross-sectional survey was used to collect data from 106 nurses working in college health centers. Collected data were analyzed using frequency, Pearson correlation coefficients, independent t-test, one-way ANOVA and multiple regression with the SPSS 20.0. Results: Mean scores for self-efficacy, job stress and job satisfaction for the participants were 3.86 (5-point scale), 2.51 (5-point scale) and 3.37 (5-point scale) respectively. There was a negative correlation between self-efficacy and job satisfaction (r=-.653, p<.001). Factors influencing job satisfaction were job stress (${\beta}$=-.58, p=<.001), level of perception among the nurses that they were contributing to the health promotion of students (${\beta}$=-.21, p=.005) and marital status (${\beta}$=.17, p=.029). These 3 elements accounted for 47.7% of the variance in job satisfaction. Conclusions: The results indicate that reduction in job stress and increase in the perception that nurses are contributing to the promotion of students' health are important to reinforce the role function of nurses and to increase their work capabilities.

Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer

  • Kim, Youngeun;Jho, Eek-hoon
    • BMB Reports
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    • v.50 no.6
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    • pp.281-282
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    • 2017
  • Advances in the understanding of the Hippo signaling as a key regulatory pathway of proliferation and apoptosis have provided mechanical insights for controlling organ size and tumorigenicity. Recently, much attention has been directed to the regulation of LATS1/2 (large tumor suppressor) kinases that phosphorylate YAP/TAZ, a transcriptional co-activator in the Hippo pathway, and control the level and nuclear localization of YAP/TAZ. In our recent work, we showed that deubiquitinase YOD1 stabilizes ITCH, and facilitates ITCH-mediated LATS1/2 ubiquitination and degradation, resulting in increased YAP/TAZ level. Furthermore, we found that the YOD1-ITCH-LATS1/2-YAP/TAZ signaling axis is controlled by the differential expression of miR-21 in a cell-density-dependent manner. Using a transgenic mouse model, we showed that the inducible expression of YOD1 enhances the proliferation of hepatocytes and leads to hepatomegaly in a YAP/TAZ-activity-dependent manner. Moreover, a strong correlation was observed between YOD1 and YAP expression in liver cancer patients. Overall, our data suggest that YOD1 is a novel regulator of the Hippo pathway, and thereby a potential therapeutic target for liver cancer.

Relationship between Critical Thinking Disposition and Clinical Decision-Making Abilities in Home Health Advanced Practice Nurses (가정전문간호사의 비판적 사고성향과 임상의사결정능력과의 관계)

  • Choi, Seong Mee;Lee, Mi Kyoung
    • Journal of Korean Academic Society of Home Health Care Nursing
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    • v.21 no.2
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    • pp.147-155
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    • 2014
  • Purpose: Clinical decision-making carried out by nurses is a complex process that influences the quality of care provided and various patient outcomes. This study examined the relationship between critical thinking disposition and clinical decision-making abilities in home health advanced practice nurses. Method: The study had a non-experimental correlational design. Data were collected from 100 home health advanced practice nurses in 20 hospitals. Results: The mean critical thinking disposition score was $3.69{\pm}.39$ out of 5 and the mean score for clinical decision-making abilities was $3.48{\pm}.22$ out of 5. In this correlation analysis, a significant positive correlation (r=.58, p<.001) was found between critical thinking disposition and clinical decision-making abilities of home health advanced practice nurses. Conclusion: In order to improve the clinical decision-making ability of home health advanced practice nurses, we need to improve their critical thinking disposition. In order to make this change, appropriate training program are needed to increase the critical thinking disposition and clinical decision-making abilities of home health advanced practice nurses.

Optimizing Steeping Conditions of Waxy Rice Based on the Sensory Properties of Gangjung (a Traditional Korean Oil-Puffed Snack) (강정의 관능적 특성에 의한 찹쌀의 수침조건 최적화)

  • Kim, Haeng-Ran;Kim, Kyung-Mi;Kim, Kwang-Ok
    • Korean Journal of Food Science and Technology
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    • v.41 no.4
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    • pp.464-470
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    • 2009
  • This study was conducted to determine the optimal steeping period and temperature for Gangjung production, using response surface methodology based on the previously reported sensory characteristics. Five sensory attributes ('degree of expansion', 'sourness', 'butyric acid flavor', 'hardness' and 'degree of melting'), which showed high variability explained ($R^2$) and recognized to be important for the quality of Gangjung were selected for optimization. As a result, the optimal steeping temperature and period of waxy rice were determined to be $31.5^{\circ}C$ and 9 days, respectively.

Effect of Fall Prevention Education for Older Patients in Comprehensive Nursing Care Service Ward (간호·간병 통합병동에 입원한 노인환자의 낙상예방교육 효과)

  • Shim, Song-mi;Kim, Eunha
    • Journal of Korean Public Health Nursing
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    • v.33 no.2
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    • pp.200-213
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    • 2019
  • Purpose: This study was conducted to examine the effect of a fall prevention education on the fall related knowledge and fall prevention behavior of the elderly patients in comprehensive nursing care service wards. Method: A quasi experimental study with control group and experimental group was used. A total 62 elderly patients in comprehensive nursing care service wards were randomly divided into the experimental group(n=30) and the control group(n=32). The data collection period was from August to December, 2017. Data were analyzed with $X^2-test$, paired t-test, independent t-test and Pearson's correlation coefficient by using SPSS 25.0. Results: Experimental group reported higher score in fall related knowledge than the control group(t=-10.28, p<.001). Participants who viewed DVD and received the leaflet education reported higher score than those with routine admission education(t=-6.51, p<.001). The experimental group showed significant improvement in fall related knowledge and fall prevention behavior(r=.21, p=.015). Conclusion: The fall prevention program was effective in improving fall-related knowledge and fall prevention behavior among elderly patients. Since the DVD plus leaflet education was effective in improving prevention behaviors, it might be included in routine orientation on admission for the elderly patient in comprehensive nursing care service wards.

Differences in the relationship, learning perception and satisfaction of nursing students before and after clinical practice

  • Lee, Mi-Ok
    • Journal of the Korea Society of Computer and Information
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    • v.24 no.4
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    • pp.145-151
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    • 2019
  • The purpose of this study was to find out whether there was a meaningful change in the learning perception and interpersonal relations of nursing students after completing clinical practice. Participants were 32 nursing students in the third grade. The research data were collected by questionnaire consisting of interpersonal relations and learning perception. The analysis of data was analyzed by SPSS 21 Version. General characteristics were analyzed by descriptive statistics, correlation between variables was analyzed by Pearson's relation, and differences of variables before and after clinical practice were analyzed by paired t-test. The results of the study are as follows. In clinical practice, interpersonal abilities showed a significant correlation with learning outcomes (R =.351, p =.049). The interpersonal abilities of nursing students improved significantly(t =2.264, p =.13) after completion of clinical practice. Nursing college students recognized that their interpersonal abilities had improved after completion of clinical practice, and the improvement of interpersonal abilities was statistically supported. Considering that the interpersonal relationship was an important factor in the clinical practice related stress of the nursing college students, it was meaningful that the interpersonal ability improved after the clinical practice. The positive correlation between interpersonal abilities and learning perceptions in clinical practice of nursing college students suggests future directions for future research. The results of this study will provide basic data on education that will enhance the satisfaction of students' clinical practice and improve their learning outcomes.

Clinical Evaluation of Guided Bone Regeneration Using 3D-titanium Membrane and Advanced Platelet-Rich Fibrin on the Maxillary Anterior Area (상악 전치부 3D-티타늄 차폐막과 혈소판농축섬유소를 적용한 골유도재생술의 임상적 평가)

  • Lee, Na-Yeon;Goh, Mi-Seon;Jung, Yang-Hun;Lee, Jung-Jin;Seo, Jae-Min;Yun, Jeong-Ho
    • Implantology
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    • v.22 no.4
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    • pp.242-254
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    • 2018
  • The aim of the current study was to evaluate the results of horizontal guided bone regeneration (GBR) with xenograf t (deproteinized bovine bone mineral, DBBM), allograf t (irradiated allogenic cancellous bone and marrow), titanium membrane, resorbable collagen membrane, and advanced platelet-rich fibrin (A-PRF) in the anterior maxilla. The titanium membrane was used in this study has a three-dimensional (3D) shape that can cover ridge defects. Case 1. A 32-year-old female patient presented with discomfort due to mobility and pus discharge on tooth #11. Three months after extracting tooth #11, diagnostic software (R2 GATE diagnostic software, Megagen, Daegu, Korea) was used to establish the treatment plan for implant placement. At the first stage of implant surgery, GBR for horizontal augmentation was performed with DBBM ($Bio-Oss^{(R)}$, Geistlich, Wolhusen, Switzerland), irradiated allogenic cancellous bone and marrow (ICB $cancellous^{(R)}$, Rocky Mountain Tissue Bank, Denver, USA), 3D-titanium membrane ($i-Gen^{(R)}$, Megagen, Daegu, Korea), resorbable collagen membrane (Collagen $membrane^{(R)}$, Genoss, Suwon, Korea), and A-PRF because there was approximately 4 mm labial dehiscence after implant placement. Five months after placing the implant, the second stage of implant surgery was performed, and healing abutment was connected after removal of the 3D-titanium membrane. Five months after the second stage of implant surgery was done, the final prosthesis was then delivered. Case 2. A 35-year-old female patient presented with discomfort due to pain and mobility of implant #21. Removal of implant #21 fixture was planned simultaneously with placement of the new implant fixture. At the first stage of implant surgery, GBR for horizontal augmentation was performed with DBBM ($Bio-Oss^{(R)}$), irradiated allogenic cancellous bone and marrow (ICB $cancellous^{(R)}$), 3D-titanium membrane ($i-Gen^{(R)}$), resorbable collagen membrane (Ossix $plus^{(R)}$, Datum, Telrad, Israel), and A-PRF because there was approximately 7 mm labial dehiscence after implant placement. At the second stage of implant surgery six months after implant placement, healing abutment was connected after removing the 3D-titanium membrane. Nine months after the second stage of implant surgery was done, the final prosthesis was then delivered. In these two clinical cases, wound healing of the operation sites was uneventful. All implants were clinically stable without inflammation or additional bone loss, and there was no discomfort to the patient. With the non-resorbable titanium membrane, the ability of bone formation in the space was stably maintained in three dimensions, and A-PRF might influence soft tissue healing. This limited study suggests that aesthetic results can be achieved with GBR using 3D-titanium membrane and A-PRF in the anterior maxilla. However, long-term follow-up evaluation should be performed.