• 제목/요약/키워드: miR-21

검색결과 500건 처리시간 0.037초

노인의 식습관과 구강건강상태에 관한 연구 (The study on the state of the elderly oral health and food habits)

  • 권미영;원영순;김윤신
    • 한국치위생학회지
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    • 제9권2호
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    • pp.13-24
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    • 2009
  • The purpose of this study was to examine the relationship between the dietary habits and oral health of elderly people in an attempt to pave the way for the development of oral health promotion programs geared toward improving the quality of life of the elderly. The subjects in this study were senior citizens who were selected by convenience sampling from Seoul. The findings of the study were as follows: 1. Regarding subjective oral health state, 54.5% of the elderly people, more than the half, considered their mouth to be in good health. The number of their mean remaining permanent teeth was 13.71. 47.5 percent of the senior citizens investigated had no shaking teeth. 2. Those who found themselves to be in good oral health had meals on a regular basis(p=0.022) and ate detergent food often. The gaps between them and the others was significant(p=0.005). In contrast, the elderly people who were in a bad oral health frequently ate cariogenic food(p=0.044). 3. The elderly people who had 21 teeth or more ate detergent food often(p=0.029), and those who owned no teeth had a sweet teeth(p=0.003), ate more cariogenic food(p=0.001) and had a snack frequently(p=0.026). 4. The subjective oral health status had a positive correlation to detergent food intake(r=0.23) and had a slightly negative correlation to preference for sweets(r=-0.14), cariogenic food intake(r=-0.14) and snack intake(r=-0.06). The number of tooth was positively correlated to detergent food intake(r=0.23) and negatively to preference for sweets(r=0.32), cariogenic food intake(r=-0.30) and snack intake(r=-0.21). The presence or absence of shaking teeth had a positive correlation to snack intake(r=0.14). The above-mentioned findings suggested that the dietary habits of the elderly people had a statistically significant relationship to subjective and objective oral health state, which indicated that there was a close relationship between oral health and dietary habits. Therefore how to improve dietary habits as well as oral health should be taken into account when oral health promotion programs are developed for the sake of the elderly. That would contribute to promoting the oral health of elderly people and eventually boosting their quality of life.

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천연 색소 고정화 기술을 활용한 오미자와 자소엽 추출물 함유 음료의 항산화 활성 연구 (Antioxidative Activities of Mixture of Schisandrae Fructus (SF) and Perilae Folium (PF) using Natural Color fixation technic)

  • 신인순;황수정;김성옥;허담;김미려
    • 대한본초학회지
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    • 제26권3호
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    • pp.37-45
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    • 2011
  • Objectives : This study focused on Schisandrae Fructus (SF) and Perilae Folium (PF), traditional medicine herbs and health functional food in Korea, Japan and China. We investigated various pharmacological activities that include a potential source of free radical scavenging, anti-viral, anti-microbial, anti-allergy and anti-inflammatory activities. Methods : We conducted an investigation of total contents of phenolic and flavonoid compounds in these single herbal extraction with/without combined to mixture. We also measured antioxidant activities such as DPPH free radical scavenging, SOD-like scavenging, nitrite scavenging and hydroxyl radical scavenging activities, xanthine oxidase inhibition, linoleic acid peroxidation inhibition, and reducing power. Results : As the results, contents of total phenoilc compounds and flavonoids were higher in those of PF than those of SF. Those of SF+PF mixture showed the synergy effects compared with those of SF and PF single extractions. Activities of DPPH free radical and SOD-like scavenging in 1 mg/mL concentration increased in dose dependent manners. That of SF increased compared with that of PF. That of SF and PF mixture also increased compared with that of BHA as a positive control. The other antioxident activities also showed similar to patten of activity of DPPH free radical scavenging. When combined to SF and PF extractions, there was showed synergic effect compared with those of BHA, excepted activities of xanthine oxidase inhibition and reducing power. Taken together, SF and PF have high phenolic and flavonoid compounds content furthermore, antioxidant activities in SF and PF mixture showed more synergy effect compared with those of BHA. Conclusions : Therefore, these findings suggest that SF and PF mixture may offer functional materials potential for development of functional beverage. But further studies are needed for the identification of the active compounds.

관상동맥질환 위험정도와 혈관탄성의 관계에서 치료지시이행의 매개효과: 경피적 관상동맥 중재술 환자 대상 (Comparison of Vessel Elasticity according to Risk Factors for Coronary Artery Disease, and the Mediating Effects of Treatment Compliance among Patients with Percutaneous Coronary Intervention)

  • 여가람;성경미
    • 동서간호학연구지
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    • 제22권1호
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    • pp.32-40
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    • 2016
  • Purpose: This study aimed to provide basic data for vascular health of patient who underwent percutaneous coronary intervention (PCI) by verifying the mediating effect of compliance in the relationship between risk level of coronary artery disease (CAD) and blood vessel elasticity. Methods: This is a descriptive study with 115 patients, who underwent the PCI a year ago and visited in the cardiology department from January to March, 2015. The risk level of CAD, blood vessel elasticity and the compliance were measured. For data analysis, SPSS/WIN 21.0 and AMOS (IBM) 21.0 were used. Results: There were a positive correlation with blood vessel elasticity score (i.e. inelasticity of the blood vessel wall) (r=.189) and a negative correlation with compliance (r=-.658) in mediating effect of risk level of CAD. There was a negative correlation between compliance and blood vessel elasticity (r=-.482). The direct effect (${\beta}=-.226$), indirect effect (${\beta}=.415$) and total effect (${\beta}=.186$) of mediating effect of risk level of CAD on blood vessel elasticity were significant. Compliance had a partial mediating effect of risk level of CAD on blood vessel elasticity. Conclusion: The results of this study suggest that managing and preventing moderating effect of risk level of CAD on compliance is helpful in restoring blood vessel elasticity.

Imprinted Gene mRNA Expression during Porcine Peri-implantation Development

  • Cha, Byung-Hyun;Kim, Bong-Ki;Hwang, Seongsoo;Yang, Byoung-Chul;Im, Gi-Sun;Park, Mi-Rung;Woo, Jae-Seok;Kim, Myung-Jick;Seong, Hwan-Hoo;Cho, Jae-Hyeon;Ko, Yeoung-Gyu
    • Asian-Australasian Journal of Animal Sciences
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    • 제23권6호
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    • pp.693-699
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    • 2010
  • Imprinted genes are essential for fetal development, growth regulation, and postnatal behavior. However, little is known about imprinted genes in livestock. We hypothesized that certain putatively imprinted genes affected normal peri-implantation development such as embryo elongation, initial placental development, and preparation of implantation. The objective of the present study was to investigate the mRNA expression patterns of several putatively imprinted genes during the porcine peri-implantation stages from day 6 to day 21 of gestation. Imprinted genes were selected both maternally (Dlk1, IGF2, Ndn, and Sgce) and paternally (IGF2r, H19, Gnas and Xist). Here, we report that the maternally imprinted gene IGF2 was expressed from day 6 (Blastocyst stage), but Dlk1, Ndn, and Sgce were not expressed in this stage. These genes were first expressed between days 12 and day 14. All the maternally imprinted genes studied showed significantly high expression patterns from day 18 of embryo development. In contrast, paternally imprinted genes IGF2r, H19, Gnas, and Xist were first expressed from day 6 of embryo development (BL). Our data demonstrated that the expression of H19 and Gnas genes was significantly increased from day 14 of the embryo developmental stage, while IGF2r and Xist only showed high expression after day 21. This study is the first to show that the putatively imprinted genes were stage-specific during porcine embryonic development. These results demonstrate that the genes studied may exert important effects on embryo implantation and fetal development.

Developmental Changes of Gustatory Neurons in Nucleus of Solitary Tract in Rats

  • Kim, Mi-Won;Kim, Won-Jae;Mistretta, Charlotte
    • The Korean Journal of Physiology and Pharmacology
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    • 제4권3호
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    • pp.169-175
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    • 2000
  • To learn the developmental changes in intrinsic electrophysiological properties of the second order taste neurons, whole cell recordings from the developing nucleus of the solitary tract neurons were done in brainstem slices of postnatal rats. Rats aged from postnatal 0 to 21 days (P0-P21) were used, being divided into 3 age groups: postnatal first week (P0-P7 days), second week (P8-P14 days), and third week (P15-P21 days). Slices containing gustatory NTS were cut horizontally in the thickness of $300\;{\mu}m.$ Whole cell recordings were obtained from neurons in response to a series of hyperpolarizing and depolarizing current pulses. The intrinsic electrophysiological properties of the rostral NTS (rNTS) neurons were compared among the age groups. Depolarizing current pulses evoked a train of action potentials in all neurons of all age groups. The resting membrane potential and input resistance of the neurons did not show any significant differences during the postnatal 3 weeks. The time constant, however, decreased during the development. Duration of action potential measured at half maximum amplitude was longer in younger age groups. Both the maximum rate of rise and the maximum rate of fall in the action potential increased during the first 3 weeks postnatal. Electrophysiologically more than half neurons were type III. In summary, it is suggested that developmental changes in electrophysiological properties in rNTS occur during the first three weeks in rats.

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여자대학생의 비만지수와 신체상에 관한 연구 (A Study of the Body Mass Index and Body Image among Female College Students)

  • 정은순
    • 여성건강간호학회지
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    • 제7권4호
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    • pp.622-630
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    • 2001
  • This study aims at examining relationships between body mass index and perceived body shape and image. Using a purposive sampling method, 404 female college students were recruited from three universities located in Busan from April 2000 to June 2000. To classify the levels of obesity, Broca's method was used. Secord & Jourard's Body Cathexis Scale(1953) modified by Kim mi ok(1997) was also used to measure body image. The collected data were analyzed with the percentages, Mean, Standard deviation, T-test, and Pearson correlation Coefficient. The results of this study were as follows. 1. 56.4 % of subjects were under weight, and 42.1% were normal for BMI. 2. 55.9% of subjects were very satisfied with their body shape and 15.1% were satisfied. 3. The mean values of perceived body shape according to the BMI were 3.0 for the overweight group, 2.65 for the normal weight group, and 2.21 for the low weight group, the mean differences among three groups were significantly satisfied (F= 21.42, P= .000). 4. The mean scores of body image according to the BMI was 160.21 for low weight group, 155.57 for the normal weight group, and 140.0 for overweight group. The mean differences among the three groups were not significantly satisfied. 5. The mean scores of body image according to perceived body shape were 17819 for the satisfaction group, 161.08 for the moderate group and 150.82 for dissatisfied group. The mean differences among the three groups were significantly satisfied (F= 35.72, P=. 000). 6. There were high positive correlations between BMI and perceived body shape(r= .317) and between perceived body shape and body image (r=- .415).

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Fabrication of shape-controlled Au nanoparticle arrays for SERS substrates

  • Shin, Seon Mi;Choi, Kyeong Woo;Ye, Seong Ji;Kim, Young Yun;Park, O Ok
    • Advances in materials Research
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    • 제3권3호
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    • pp.139-149
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    • 2014
  • Surface enhanced Raman Scattering (SERS) has attracted attention because the technique enables detection of various chemicals, even down to single molecular scale. Among the diverse candidates for SERS substrates, Au nanoparticles are considered promising due to their fine optical properties, chemical stability and ease of surface modification. Therefore, the fabrication and optical characterization of gold particles on solid supports is highly desirable. Such structures have potential as SERS substrates because the localized surface plasmon resonance of gold nanoparticles is very sensitive to combined molecules and environments. In addition, it is well-known that the properties of Au nanoparticles are strongly dependent on their shape. In this work, arrays of shape-controlled Au nanoparticles were fabricated to exploit their enhanced and reproducible optical properties. First, shape-controlled Au nanoparticles were prepared via seed mediated solution-phase synthesis, including spheres, octahedra, and rhombic dodecahedra. Then, these shape-controlled Au nanoparticles were arranged on a PDMS substrate, which was nanopatterned using soft lithography of poly styrene particles. The Au nanoparticles were selectively located in a pattern of hexagonal spheres. In addition, the shape-controlled Au nanoparticles were arranged in various sizes of PDMS nanopatterns, which can be easily controlled by manipulating the size of polystyrene particles. Finally, the optical properties of the fabricated Au nanoparticle arrays were characterized by measuring surface enhanced Raman spectra with 4-nitrobenezenethiol.

간호대학생의 스트레스 대처행위가 문제해결능력에 미치는 영향 (The Influence of Nursing Students' Stress Coping Styles on Problem Solving Ability)

  • 유미옥
    • 한국산학기술학회논문지
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    • 제19권3호
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    • pp.291-300
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    • 2018
  • 본 연구는 간호대학생의 스트레스 대처행위가 문제해결능력에 미치는 영향을 파악하기 위한 서술적 조사연구이다. 자료 수집은 M지역의 간호학과 학생 142명을 대상으로 2016년 9월 20일부터 11월 30일까지 실시하였으며, 수집된 자료는 SPSS WIN 21.0 프로그램을 이용하여 분석하였다. 본 연구의 결과 대상자의 스트레스 대처행위 정도는 $3.36{\pm}.30$점(5점 척도)이었고, 문제해결능력 정도는 $3.42{\pm}.38$점(5점 척도)이었다. 스트레스 대처행위 중 가장 점수가 높은 하위영역은 문제중심적 대처행위로 $3.60{\pm}.42$점이었고, 문제해결능력 중 가장 점수가 높은 하위영역은 명료화로 $3.50{\pm}.51$점이었다. 간호대학생의 문제해결능력은 스트레스 대처행위와 정적 상관관계(r=.53, p<.001)로 나타났고, 스트레스 대처행위의 하위영역 중 문제중심적 대처행위(r=.66, p<.001), 긍정적 관점(r=.53, p<.001), 사회적지지 탐색(r=.42, p<.001)에 정적 상관관계를 보였다. 또한 간호 대학생의 문제해결능력에 영향을 미치는 요인은 스트레스 대처행위 중 문제중심적 대처행위(${\beta}=.416$, p<.001)와 긍정적 관점(${\beta}=.257$, p=.002)이었으며, 두 요인은 문제해결능력을 54.3% 설명하는 것으로 나타났다. 따라서 학생들이 문제중심적이고 긍정적인 스트레스 대처행위를 통해 문제해결능력을 향상시킬 수 있는 교수-학습법 적용을 제언한다.

근접쌍성 AG Virginis의 분광학적 연구 (A SPECTROSCOPIC STUDY OF THE CLOSE BINARY AG VIRGINIS)

  • 김호일;이충욱;이재우;손미림
    • Journal of Astronomy and Space Sciences
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    • 제22권4호
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    • pp.353-362
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    • 2005
  • 2004년 3월 25일부터 4일 동안 보현산천문대의 1.8m 망원경과 BOES(Bohyunsan Optical Echelle Spectrograph)를 사용하여 AG Vir의 고분산 분광관측을 수행하고, 전위상에 걸쳐 총 59개의 스펙트럼을 얻었다. 쌍성계의 시선속도를 얻기 위하여, 교차상관함수(CCF; Cross-Correlation Function) 와 선폭증가함수(BF; Broadening Function)를 관측된 스펙트럼의 분석에 사용하였다. 이때, 교차상관함수 분석을 통하여 주성의 시선속도만을 얻을수 있었던 반면, 선폭증가함수 분석을 통하여 두 성분별의 시선속도를 모두 구할 수 있었다. 우리는 분광 궤도요소($K_1=90.5km/s$$K_2=258.8km/s$)와 Bell, Rainger, & Hilditch(1990)의 측광학적 해로부터 AG Vir의 절대 물리량을 다음과 같이 산출하였다. 즉, $M_1:1.99M_\bigodot,\;M_2:0.62M_\bigodot,\; R_1=2.21R_\bigodot,\;R_2=1.36R_\bigodot,\;L_1=13.17L_\bigodot$, 그리고 $L_2=3.47L_\bigodot$. 우리가 구한 각 성분별의 질량과 반경은 Bell, Rainger, & Hilditch(1990)의 값보다 더 크고, 광도 또한 더 밝다. 발표된 모든 시선속도곡선을 재분석한 결과, AG Vir의 시스템 속도는 약 ${\pm}8km/s$의 비교적 큰 편차를 나타낸다. 그러나 이 변화가 Qian(2001)이 제안한 제3 천체의 광시간 효과에 의해 일어난다고 단정 지을 수 있는 근거를 찾을 수는 없었다.

서울 경기지역의 공원 연못 및 한강 수계내 조류독소 Microcystin-LR의 분포 (Distribution of Cyanotoxin Microcystin-LR in Han River System and Ecological Park in Seoul and Kyunggi Districts)

  • 서미연;김백호;한명수
    • 생태와환경
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    • 제38권2호통권112호
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    • pp.237-248
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    • 2005
  • 서울 경기지역 공원 연못 및 한강 수계내의 수중 조류독소 Microcystin (MC)의 분포를 파악하기 위하여, 수도권 공원 연못 7개소, 한강수계 4개소, 경안천 1개소, 양수리 육각지 1개소, 대조군 2개소를 포함 총 15개 지점을 대상으로 강우가 적은 저온기 동안, 3차례에 걸쳐 수중내 환경요인, 조류 현존량, 조류 독소량을 조사하였다. 조류독소는 유도체중 가장 독성이 강한 Microcystin-LR (MCLR)만을 대상으로 하였으며 ELISA법으로 분석하였다. 조사기간 동안 수온($0.4\;{\sim}\;21.9^{\circ}C$)을 비롯한 대부분의 환경요인들은 계절성과 지역성이 뚜렷하였다. 조류 현존량은 수온 변화에 민감하였고 (r = 0.307), Microcystis aeruginosa를 포함하여 남조류는 경복궁 경회루, 석촌호수. 양수리 육각지 등에서 우점하였다. 조류독소 MCLR (측정한계 $0.05\;{\mu}g\;L^{-1}$) 는 남조 Microcystis aeruginosa출현이 높았던 지점에서 높게 검출되었으며, 조체성과 용존성을 합한 총 MCLR은 1차조사시 경복궁 경회루 ($1.39\;{\mu}g\;L^{-1}$), 석촌호수($0.55\;{\mu}g\;L^{-1}$), 양수리 육각지 ($0.59\;{\mu}g\;L^{-1}$)에서 각각 높게 나타났으나,2, 3차 조사에서는 양수리 육각지에서만 검출되었다. 남조류 총현존량은 조류 현존량 (r = 0.066)이나 엽록소 a량(r = -0.058)과는 낮은 관계를보였으며, M. aeruginosa 현존량(r = 0.766)과는 매우 높은 관계를 나타냈다. 조류독소 MCLR은 남조 M. aeruginosa 현존량이 높았던 지점에서 높게 검출되었다(조체성: r = 0.526, 용존성: r = 0.433).따라서, 서울, 경기지역 공원 연못이나 한강수계의 조류독소는 주로 정체성 연못에서 남조 Microcystis aeruginosa에 의해 형성되지만, 여가활동이나 상수원 공급에는 위험성이 낮은 것으로 판단되었다.