• Title/Summary/Keyword: miR-144-3p

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Clinical study of Bangpoongtongsungsan on body weight change in subjects with obesity (방풍통성산이 비만인에 미치는 영향에 대한 임상적 연구)

  • Shin, Dae-Hee;Cho, Guk-Hyun;Lee, Hyuck;Moon, Mi-Kyung;Kang, Dae-Gill;Yun, Young-Gab;Park, Do-Shim;Juhng, Seon-Kwan;Lee, Ho-Sub
    • Herbal Formula Science
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    • v.16 no.2
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    • pp.133-144
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    • 2008
  • Recently, people are becoming fatter in most parts of the world. Obesity is regarded as an important risk factor to adversely affect the health of humans, associated with hypertension, hyperlipidemia, diabetes, and cardiovascular diseases. In the present study, therefore, we tested the short time efficiency and safety of Bangpoongtongsungsan as a drug to decrease body weight in subjects with obesity. A total 48 volunteers (24 man, 24 woman) with body mass index (BMI : weight in kg divided by square of height in meters) of $23㎏/m^2$ participated in clinical study for 12 weeks, from 2008, March 01 to 2008, Jun 30. The subjects was received a dietary supplement of 12 pieces hard capsules per day (4 pieces in one, 3 times in a day) during the clinical study. At the end of clinical study, body weight of subjects was significantly decreased from $72.21{\pm}11.44\;kg$ to $70.53{\pm}11.67\;kg$ (p<0.05). Waist circumferences of subjects were reduced $91.58{\pm}6.43\;cm$ to $85.25{\pm}7.70\;cm$ (p<0.05). Also, a BMI of subjects was significantly decreased $26.07{\pm}2.35\;kg/m^2$ to $25.63{\pm}2.63\;kg/m^2$ (p<0.05). Particularly, a decrease in body weight, waist circumferences, and BMI was more significant in woman than man. But, other biochemical levels including lipid and glucose in plasma had no changes at the end of clinical study. In conclusion, administration of Bangpoongtongsungsan in subjects with high body weight fat could inhibit obesity associated with a decrease in body weight, waist circumferences, and BMI.

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Fatty Acid, Amino Acid and Nucleotide-related Compounds of Crossbred Korean Native Chickens (KNC) (교배 조합 토종닭의 지방산, 아미노산 및 핵산 관련 물질 함량)

  • Park, Mi-Na;Hong, Eui-Chul;Kang, Bo-Seok;Kim, Hak-Kyu;Heo, Kang-Nyeong;Han, Jae-Yong;Jo, Cheo-Run;Lee, Jun-Heon;Choo, Hyo-Jun;Suh, Ok-Suk;HwangBo, Jong
    • Korean Journal of Poultry Science
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    • v.38 no.2
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    • pp.137-144
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    • 2011
  • The current work was carried out to investigate the effect of crossbred Korean native chickens (KNC) on fatty acid, amino acid and nucleotide-related compounds contents of chicken meat. A total of 360 male chicks (1d of age) was used in this work and were divided 4 groups as A) (KNC egg-meat type C strains ${\times}$ KNC meat type S strains) ${\times}$ Ross broiler, B) (KNC egg-meat type C strains ${\times}$ KNC meat type H strains) ${\times}$ KNC meat type S strains, C) (KNC native R strains ${\times}$ KNC meat type S strains) ${\times}$ KNC meat type H strains and D(White Semibroiler Chickens) strains for 5 weeks at the flat house. Palmitic acid and vaccenic acid were highest in C strain meat, and myristic acid and linolenic acid were lowest in A strain meat (p<0.05). Saturated fatty acid was lowest in C strain meats (p<0.05). Valine, leucine, phenylalanine and lysine of essential acid were low in A strain meat. Cystine, aspartic acid, glycine, alanine and proline were also low in A strain meat. Hypoxanthin (Hx) was high compared other strains at 5 weeks and low at 10 weeks. IMP was high compared other strains at 5 and 10 weeks. AMP has not significant difference among strains at 5 weeks but B strain was high other strains at 10 weeks. These results showed that C stain was excellent on the fact of nutrients compared to other strains. Consequently, the result of this work gave the basic data that needed to develope the new strains.

Association between Satisfaction with Assistive Technology Devices and Psychosocial Impact among Some Mentally or Physically Disabled Children (뇌병변 및 지체 장애아의 보조공학기기 사용 만족도와 심리사회적 영향의 관련성)

  • Jang, Kyoung-Lae;Ryu, So Yeon;Park, Jong;Han, Mi Ah
    • Journal of agricultural medicine and community health
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    • v.42 no.3
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    • pp.132-144
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    • 2017
  • Objectives: The purpose of this study was to identify the association between satisfaction with assistive technology devices and psychosocial impact among some mentally or physically disabled children. Methods: The study subjects were 120 disabled children and their primary caregivers who were using rental assistive technology devices in Gwangju and Jeollanam-Do. Data were collected by structured questionnaire composed of general characteristics of subjects, characteristics related with using assistive devices. Quebec User Evaluation of Satisfaction with assistive Technology 2.0 (QUEST 2.0) and Psychosocial Impact of Assistive Device Scale (PIADS). The statistical analysis were performed by descriptive statistics, t-test, ANOVA and Pearson's correlational analysis. Results: The total mean score for QUEST 2.0 was $4.08{\pm}0.66$ (satisfaction with devices, $4.01{\pm}0.70$; satisfaction with the assistive devices service, $4.14{\pm}0.90$) and the mean of PIADS was $1.00{\pm}0.75$ (ability, $0.99{\pm}0.78$; adaptability, $1.04{\pm}0.86$; self-respect, $0.99{\pm}0.74$). The scores of PIADS was statistically significant difference according to usage time of assistive devices. The PIADS was significantly positive correlated with QUEST 2.0 Conclusions: The mentally or physically disabled children reported that the higher level of satisfaction and the more positive impact of psychosocial aspect with assistive technology devices. It would be necessary to perform further studies for addressing the effects of assistive technology devices.