• Archives of Pharmacal Research
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• v.14 no.4
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• pp.319-324
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• 1991

2,6-Dimethyl-4-(3'-nitrophenyl)-3-methoxylaminocarbonyl-1,4-dihydropyridine-5-carboxylic acid methylester, 3b reacted with 2-cyanoethanol or benzylalcohol to give the corresponding cyanoethylurethane compound 6c in 40.6% yield and benzylurethane compound 6d in 32% yield. The cyanoethylurethane 6c was hydrolized in ethanolic NaOH to give 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3-amino-5-carboxylic acid 5-methyl ester. HCl 8 in 64.8% yield. Another acid hydrolysis of benzylurethane 6d gave 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3-amino-5-carboxylic acid 5-methylester. HBr 11 in 54.7% yield.

• Proceedings of the Membrane Society of Korea Conference
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• 2003.07a
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• pp.65-68
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• 2003

The paper discusses the use of stable emulsion, prepared by membrane emulsification technology, to improve the enantiocatalytic performance of immobilised lipase in multiphasic membrane reactors. The production of optical pure (S)-naproxen from racemic naproxen methyl ester has been used as model reaction system. The enzyme was immobilised in the sponge layer (shell side) of capillary polyamide membrane with 50 kDa cut-off, The O/W emulsion, containing the substrate in the organic dispersed phase, was fed to the enzyme membrane reactor from shell-to-lumen. The results evidenced that lipase maintained stable activity during all the operation time (more than 250 hours), showing an enantiomeric excess (96 $\pm$2%) comparable to the free enzyme (98 $\pm$ 1%) and much higher compared to similar lipase-loaded membrane reactors used in two-separate phase systems (90%). The study showed that immobilised enzymes can achieve high stability as well as high catalytic activity and enantioselectivity.

• Korean Journal of Pharmacognosy
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• v.24 no.3
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• pp.247-250
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• 1993

From the Paeoniae Radix, gallic acid methyl ester, (+)-catechin, paconiflorin, albiflorin, paeonol, ${\beta}-sitosterol$ and campesterol, benzoic acid, oleanolic acid, hederagenin and ${\beta}-sitosterol$ 3-O-glucoside were isolated and characterized by means of spectral data. Oleanolic acid and hederagenin have been isolated for the first time from the genus Paeonia.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2009.10a
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• pp.152-152
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• 2009

유기태양전지 Solvent인 1-2-Dichlorobenzene(DCB)에 1-Bromonaphtalene(BN)을 첨가하여 Air분위기에서 ZnO film을 이용한 유/무기 복합 태양전지를 만들었다. 셀의 구조는 ITO/ZnO nanofilm/Poly(3-hexylthiophene(P3HT):[6,6]-Phenyl C60-Butyric acid methyl ester(PCBM)/PEDOT:PSS/Ag로 제작했다. 두께 70nm ZnO film은 전기화학적 방법으로 ITO위에 전착하였다. AM1.5조건에서 Solar simulator로 측정한 결과 BN을 첨가한 셀에서 Jsc값이 증가되었다. Jsc값의 증가는 BN이 결정화를 향상시켜 효율이 증가됨을 확인하였다.

• Proceedings of the Korean Biophysical Society Conference
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• 1997.07a
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• pp.28-28
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• 1997

Stimulation of $\alpha$$_1$-adrenergic receptor ($\alpha$$_1$-AR) by phenylephrine produced a decrease in intracellular N $a^{＋}$ activity ( $a_{Na}$ $^{i}$ ) in multicellular preparations of cardiac tissues. The role of protein kinase C (PKC) in $\alpha$$_1$-adrenergic regulation of $a_{Na}$ $^{i}$ was studied in single ventricular myocyte isolated from guinea pig hearts. $a_{Na}$ $^{i}$ and membrane potential were measured with N $a^{+}$ indicator, sodium-binding benzofuran isophthalate tetraacetoxy methyl ester (SBFI/AM) and microelectrodes respectively when ventricular myocyte was stimulated at 0.3 Hz.(omitted)d)

• Journal of the Semiconductor & Display Technology
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• v.16 no.2
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• pp.15-18
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• 2017

In this study, we have studied the characteristics of the organic photodiode varying due to the blending conditions of the quantum dots (QDs). The active layer of the photodiode was formed with poly (3-hexylthiophene) and phenyl-C61-butyric acid methyl ester, and CdSe QDs with and without ZnS shell were blended in the active layer. The photodiode with CdSe/ZnS QDs showed the highest power conversion efficiency (PCE) and short-circuit current (Jsc). The performance change of the organic photodiode by X-ray irradiation was also measured. Regardless of X-ray irradiation conditions, the photodiode with CdSe/ZnS QDs showed better stability than other cases.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.67.2-67.2
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• 2003

Four new lanostane-type triterpenes were isolated from CH$_2$Cl$_2$ fraction of Ganoderma applanatum (Polyporaceae). There structures were determined as (20S)-3${\beta}$, 7${\beta}$, 20,23ζ-tetrahydroxy-1l,15-dioxolanosta-8-en-26-oic acid, (20S)-7${\beta}$,20,23ζ- trihydroxy-3,1l,15-trioxolanosta-8-en-26-oic acid, 7${\beta}$,23ζ-dihydroxy-3,11,15- trioxolanosta-8,20E(22)-dien-26-oic acid, and 7${\beta}$-hydroxy-3, 11,15,23-tetraoxolanosta-8,20E(22)-dien-26-oic acid methyl ester on the basis of spectral data.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.265.1-265.1
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• 2002

In the previous study. we isolated kalopanaxsaponin A and pictoside A from the EtOAc fraction of Kalopanax pictus extract. In the present study, the BuOH fraction of K pictus extract was hydrolyzed by alkali and antirheumatic effect of the fraction was evaluated. It was found that the hydrolysate of the BuOH fraction showed inhibition of adjuvant-induced arthritis in rats. Of the EtOAc and BuOH fractions of the hydrolysate, only the former exhibited anti-arthritic activity. (omitted)

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.60-60
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• 1995

새로운 혈소판 활성화인자 (PAF) 수용체 결합 저해활성 유효성분인 pinusolide ($IC_{50}$/=2.5$\times$$10^{-7}$M)와 arctigenin($IC_{50}$/=5.2$\times$$10^{-6}$M)을 측백엽(Biota orientalis)과 우방자(Arctium lappa)로부터 분리하여 이미 보고한 바 있다. PAF 수용체에 대한 구조활성 상관관계를 규명하고자 또한 용해도가 우수한 강력한 PAF 길항제를 개발하고자 이 길항제들의 유도체들을 다양한 유기화학반응을 이용하여 합성하였고 in vitro PAF receptor binding assay로 그 활성의 강도를 비교 검토하였다. 그 결과, lactone ring 부분은 unsaturated lactone이 saturated lactone보다 활성이 강하였고 ring이 개열되면 활성이 현저히 감소하였다. pinusolide 경우 exocylclic double bond 부분은 sp$^2$구조의 hydrophobic한 유도체가 활성이 강하였으며, methyl ester 부분은 hydrophobic한 유도체가 활성이 강하였다. Arctigenin의 경우 aromatic unit가 hydrophobic할수록 활성이 강하였다.

• Natural Product Sciences
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• v.3 no.2
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• pp.89-99
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• 1997

Aminolysis, hydrazinolysis and alkylation of 4-methoxy and 4,9-dimethoxy-6-cyano-7-thione-5-methyl-7H furo [3,2-g] [1] benzopyridine (1 a-b) yielded 7N-substituted furobenzopyridine derivatives (2 a-e or the possible isomers 3 a-e and 4 a-b), (5 a,b and 6 a,b) and the ester (8 a,b). Hydrolysis of (la) with acetic acid gave the corresponding pyridone derivatives (7). Furobenzopyridinyl-7-thioacetyl hydrazide (9 a,b) have been prepared via alkylation of furobenzopyridine thione (1 a-b) with ethyl chloroacetate followed by condensation with hydrazine hydrate. Schiff base (11) was prepared by reacting (9a) with p. N,N-dimethyl aminobenzaldehyde in boiling ethanol. Treatment of (8a) with anthranilic acid gave the corresponding 7-substituted-4H-3,1-benzoxazine-4-one (10). We found that compound (11) increased bleeding, coagulating time, the total count of white blood cells, blood glucose level (cause hyperglycemia), enzymes (GOT, GPT) activities, concentration of urea and creatinine. On the other hand it decreased red blood cells number, haemoglobin content and haematocrite value.