• Journal of the Korean Data and Information Science Society
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• 제20권5호
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• pp.925-931
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• 2009

In this paper we propose a variance function estimation method for replicated data based on averages of squared residuals obtained from estimated mean function by the least squares support vector machine. Newton-Raphson method is used to obtain associated parameter vector for the variance function estimation. Furthermore, the cross validation functions are introduced to select the hyper-parameters which affect the performance of the proposed estimation method. Experimental results are then presented which illustrate the performance of the proposed procedure.

• 약학회지
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• 제46권5호
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• pp.331-336
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• 2002

The purpose of this study is to develop a non-invasive blood glucose measurement method by a portable near infrared (NIR) system which was newly integrated by our lab. The portable NIR system includes a tungsten halogen lamp, a specialized reflectance fiber optic probe and a photo diode array type InGaAs detector; which was developed by a microchip technology based on the lithography. Reflectance NIR spectra of different parts of human body (finger tip, earlobe, and inner lip) were recorded by using a fiber optic probe. The spectra were collected over the spectral range 1100 ∼ 1740 nm. Partial least squares regression (PLSR) was applied for the calibration and validation for the determination of blood glucose. The calibration model from earlobe spectra presented better results, showing good correlation with a glucose oxidase method which is a mostly used standard method. This model predicted the glucose concentration for validation set with a SEP of 33 mg/dL. This study indicated the feasibility for non-invasive monitoring of blood glucose by a portable near infrared system.

• Nuclear Engineering and Technology
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• 제45권5호
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• pp.665-674
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• 2013

This paper presents the development and validation methods of the FUTURE (FUel cycle analysis Tool for nUcleaR Energy) code, which was developed for a dynamic material flow evaluation and economic analysis of the nuclear fuel cycle. This code enables an evaluation of a nuclear material flow and its economy for diverse nuclear fuel cycles based on a predictable scenario. The most notable virtue of this FUTURE code, which was developed using C# and MICROSOFT SQL DBMS, is that a program user can design a nuclear fuel cycle process easily using a standard process on the canvas screen through a drag-and-drop method. From the user's point of view, this code is very easy to use thanks to its high flexibility. In addition, the new code also enables the maintenance of data integrity by constructing a database environment of the results of the nuclear fuel cycle analyses.

• Journal of electromagnetic engineering and science
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• 제8권1호
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• pp.1-5
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• 2008

In this paper, a biconical type antenna is proposed for EMI test site validation above 1 GHz. To achieve broadband and omni-directional radiation patterns required by international standard(CISPR), the proposed antenna consists of general bicones with cylindrical loads and adopts side feeding method to minimize the influence on H-plane pattern due to feeding cable, balun, and connector. The radiation patterns of the fabricated antenna are measured and the results are compared with CISPR criteria and commercial antenna in our interest frequencies. Although the proposed antenna has a few problems in frequency range of 1 GHz to 2 GHz, it has relatively better performance than commercial antenna.

• 한국군사과학기술학회지
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• 제14권5호
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• pp.812-817
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• 2011

In this paper, we propose new data association method called the Highest Probability Data Association with Limited Measurement Numbers(HPDA-LIMN) using a Signal Itensity Ordering method applied to tracking in clutter environment. The performance of HPDA-LIMN algorithm is tested in a series of Monte Carlo simulations runs and is compared with the exiting data association method in cluttered environment.

• 농약과학회지
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• 제9권2호
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• pp.159-165
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• 2005

환경시료 중에 포함되어 있는 미량 산성농약을 분석하기 위하여 유도체화방법으로 TFE/TFAA를 사용하였으며, 물시료 분석에 있어 기존 U.S. EPA 혹은 일본의 SPEED 98 방법보다 시료양은 최대 1/5로 줄이고 검출한계는 최대 10배 이상 증가되는 결과를 얻을 수 있었다. 또한 보다 신뢰도 높은 표준분석법을 만들기 위해서 자체 정도관리 실험과 더불어 외부 연구기관에 의한 정도관리를 수행하였다. 정도관리 실험은 동일 조건에서 시료를 분석함으로써 검량선 작성 및 기지 농도에서의 정밀도와 정확도를 조사하였고, 그 결과 0.1 - 10 ppb 농도 범위에서 직선성 0.99 이상의 검량선을 얻을 수 있었으며, 각 실험실의 내부 정도관리 값은 정확도 $-20.5{\sim}12.2$ bias %와 정밀도는 0.55 - 24.48 %로 나타났으며, 실험실간 정확도는 -6.66 - 0.80 bias %와 정밀도는 1.92 - 13.86 %로 매우 우수한 결과를 나타내었다.

• Journal of the Korean Data and Information Science Society
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• 제28권5호
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• pp.971-980
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• 2017

가변계수 회귀모형은 회귀계수의 동적변화를 모형화함으로써 종속변수와 입력변수의 관계에 대한 쉬운 해석이 가능하고 회귀계수의 변동성도 추정할 수 있는 장점을 지니고 있으므로, 여러 과학 분야에서 많은 주목을 받고 있다. 본 논문에서 입력변수와 출력변수의 오차를 효과적으로 고려한 가변계수 오차모형을 제안한다. 가변계수가 평활변수의 알려지지 않은 형태의 비선형함수이므로 이를 추정하기 위하여 커널 방법을 사용한다. 제안된 모형의 성능에 영향을 미치는 초모수의 최적값을 구하기 위하여 일반화 교차타당성 방법 또한 제안한다. 제안된 방법은 모의자료와 실제자료를 이용한 수치적 연구를 통하여 평가된다.

• Journal of Microbiology and Biotechnology
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• 제32권8호
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• pp.976-981
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• 2022

Phenanthrenes are bioactive phenolic compounds found in genus Dioscorea, in which they are distributed more in peel than in flesh. Recent studies on phenanthrenes from Dioscorea sp. peels have revealed the potential for valuable biomaterials. Herein, an analytical method using high-performance liquid chromatography (HPLC) for quantitation of bioactive phenanthrenes was developed and validated. The calibration curves were obtained using the phenanthrenes (1-3) previously isolated from Dioscorea batatas concentrations in the range of 0.625-20.00 ㎍/ml with a satisfactory coefficient of determination (R²) of 0.999. The limit of detection (LOD) and the limit of quantification (LOQ) values of the isolated phenanthrenes ranged from 0.78-0.89 and 2.38-2.71 ㎍/ml, respectively. The intraday and interday precision ranged from 0.25-7.58%. The recoveries of the isolated phenanthrenes were from 95 to 100% at concentrations of 1.25, 2.5, and 5.0 ㎍/ml. Additionally, phenanthrenes (1-3) were found in all investigated peel extracts. Hence, the developed method was encouraging for the quantitative analysis of phenanthrenes in genus Dioscorea.

• 분석과학
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• 제35권2호
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• pp.60-68
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• 2022

In this study, we developed and validated a sensitive analytical method to quantify baphicacanthin A in mouse plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The standard calibration curves for baphicacanthin A ranged from 0.5 to 200 ng/mL and were linear, with an r² of 0.985. The inter- and intra-day accuracy and precision and the stability fell within the acceptance criteria. Besides, we investigated the pharmacokinetics of baphicacanthin A following its intravenous (5 mg/kg) and oral administration (30 mg/kg). Intravenously injected baphicacanthin A showed biphasic elimination kinetics with high clearance and volume of distribution values. Furthermore, baphicacanthin A showed a rapid absorption but low aqueous solubility (182.51±0.20 mg/mL), resulting in low plasma concentrations and low oral bioavailability (2.49 %). Thus, we successfully documented the pharmacokinetic properties of baphicacanthin A using this newly developed sensitive LC-MS/MS quantification method, which could be used in future lead optimization and biopharmaceutic studies.

• 대기
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• 제17권2호
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• pp.125-133
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• 2007

Cloud amount calculation algorithm was developed using MTSAT-1R satellite data. The cloud amount is retrieved at 5 km ${\times}$ 5 km over the Korean Peninsula and adjacent sea area. The algorithm consists of three steps that are cloud detection, cloud type classification, and cloud amount calculation. At the first step, dynamic thresholds method was applied for detecting cloud pixels. For using objective thresholds in the algorithm, sensitivity test was performed for TBB and Albedo variation with temporal and spatial change. Detected cloud cover was classified into 3 cloud types (low-level cloud, cirrus or uncertain cloud, and cumulonimbus type high-level cloud) in second step. Finally, cloud amount was calculated by the integration method of the steradian angle of each cloud pixel over $3^{\circ}$ elevation. Calculated cloud amount was compared with measured cloud amount with eye at surface observatory for the validation. Bias, RMSE, and correlation coefficient were 0.4, 1.8, and 0.8, respectively. Validation results indicated that calculated cloud amount was a little higher than measured cloud amount but correlation was considerably high. Since calculated cloud amount has 5km ${\times}$ 5km resolution over Korean Peninsula and adjacent sea area, the satellite-driven cloud amount could show the possibility which overcomes the temporal and spatial limitation of measured cloud amount with eye at surface observatory.