• Computers and Concrete
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• 제5권2호
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• pp.101-116
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• 2008

The microscopic determination of air void characteristics in hardened concrete, defined in EN 480-11 as the linear-traverse method, is an extremely time-consuming and tedious task. Over past decades, several researchers have proposed relatively expensive mechanical automated systems which could replace the human operator in this procedure. Recently, the appearance of new high-resolution flatbed scanners has made it possible for the procedure to be automated in a fully-computerized and thus cost-effective way. The results of our work indicate the high sensitivity of such image analysis automated systems firstly to the quality of sample surface preparation, secondly to the selection of the air void threshold value, and finally to the selection of the probe system. However, it can be concluded that in case of careful validation and the use of the approach which is proposed in the paper, such automated systems can give very good estimate of the air void system parameters, defined in EN 480-11. The amount of time saved by using such a procedure is immense, and there is also the possibility of using alternative stereological methods to assess other, perhaps also important, characteristics of air void system in hardened concrete.

• The Journal of Asian Finance, Economics and Business
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• 제8권5호
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• pp.987-1000
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• 2021

The concept of 'Employer branding' (EB) - one effective and sustainable strategy to attract and retain talent - has received a lot of attention from researchers and business managers. This concept becomes more meaningful when the 'war of talent' takes place in an extremely fierce manner in Vietnam as well as around the world. However, this concept is rather new; as a result, many points related to 'EB' scales should be improved, especially in Vietnamese context. Therefore, this study focuses on developing and confirming the EB scale in the context of Vietnam. Based on EB theory, this research applies the mixed research method: qualitative methods (expert interview and group discussion) and quantitative method (questionnaire survey of 937 respondents). EB is demonstrated to be a quadratic concept, consisting of the following 10 dimensions: Corporate social responsibility (CSR), Promotion (PRO), Work-Life Balance Satisfaction (WLSA), Education (EDU), Behavior-based Family interference with work (WLBE), Travel opportunities (TRA), Time-based work interference with family (WLTI), Teamwork (GRO), Supporting (SUP), and Strain-based family interference with work (WLST) with 58 observed variables. Based on the survey towards the employees in enterprises and organizations in Vietnam, the analysis results affirm that this scale ensures efficiency, reliability, unidirectionality and convergent values.

• Journal of Platform Technology
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• 제6권4호
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• pp.26-33
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• 2018

In this paper, we propose an image retrieval algorithm for real-time processing and design it as hardware. The proposed method is based on the classification of BoWs(Bag of Words) algorithm and proposes an image search algorithm using bit stream. K-fold cross validation is used for the verification of the algorithm. Data is classified into seven classes, each class has seven images and a total of 49 images are tested. The test has two kinds of accuracy measurement and speed measurement. The accuracy of the image classification was 86.2% for the BoWs algorithm and 83.7% the proposed hardware-accelerated software implementation algorithm, and the BoWs algorithm was 2.5% higher. The image retrieval processing speed of BoWs is 7.89s and our algorithm is 1.55s. Our algorithm is 5.09 times faster than BoWs algorithm. The algorithm is largely divided into software and hardware parts. In the software structure, C-language is used. The Scale Invariant Feature Transform algorithm is used to extract feature points that are invariant to size and rotation from the image. Bit streams are generated from the extracted feature point. In the hardware architecture, the proposed image retrieval algorithm is written in Verilog HDL and designed and verified by FPGA and Design Compiler. The generated bit streams are stored, the clustering step is performed, and a searcher image databases or an input image databases are generated and matched. Using the proposed algorithm, we can improve convenience and satisfaction of the user in terms of speed if we search using database matching method which represents each object.

• Geomechanics and Engineering
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• 제16권5호
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• pp.495-501
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• 2018

Geogrid application that has proved to be an effective and economic method of reinforcing particles, is widely used in geotechnical engineering. The discrete element method (DEM) has been used to investigate the micro mechanics of the geogrid deformation and also the interlocking mechanism that cannot be easily studies in laboratory tests. Two types of realistically shaped geogrid models with square and triangle apertures were developed using parallel bonds in PFC3D. The calibration test simulations have demonstrated that the precisely shaped triangular geogrid model is also able to reproduce the deformation and strength characteristics of geogrids. Moreover, the square and triangular geogrid models were also used in DEM pull-out test simulations with idealized shape particle models for validation. The simulation results have been shown to provide good predictions of pullout force as a function of displacement especially for the initial 30 mm displacement. For the granular material of size 40 mm, both the experimental and DEM results demonstrate that the triangular geogrid of size 75 mm outperforms the square geogrid of size 65 mm. Besides, the simulations have given valuable insight into the interaction between particle and geogrid and also revealed similar deformation behavior of geogrids during pullout. Therefore, the DEM provides a tool which enable to model other possible prototype geogrid and investigate their performance before manufacture.

• Steel and Composite Structures
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• 제38권5호
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• pp.547-562
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• 2021

This paper aims to explore the mechanical behavior and moment-rotation model of blind bolted joints between concrete-filled double skin steel tubular columns and steel-concrete composite beams. For this type of joint, the inner tube and sandwiched concrete were additionally identified as basic components compared with CFST blind bolted joint. A modified moment-rotation model for this type of connection was developed, of which the compatibility condition and mechanical equilibrium were employed to determine the internal forces of basic components and neutral axis. Following this, load transfer mechanism among the inner tube, sandwiched concrete and outer tube was discussed to assert the action area of the components. Subsequently, assembly processes of basic coefficients in terms of their stiffness and resistances based on the component method by simplifying them as assemblages of springs in series or in parallel. Finally, an experimental investigation on four substructure joints with CFDST columns for validation purposes was carried out to capture the connection details. The predicted results derived from the mechanical models coincided well with the experimental results. It is demonstrated that the proposed mechanical model is capable of evaluating the complete moment-rotation relationships of blind bolted CFDST column composite connections.

• Steel and Composite Structures
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• 제44권5호
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• pp.691-705
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• 2022

Shear failure in reinforced concrete (RC) structures is very hazardous. This failure is rarely predicted and may occur without any prior signs. Accurate shear strength prediction of the RC members is challenging, and traditional methods have difficulty solving it. This study develops a JAYA-GBRT model based on the JAYA algorithm and the gradient boosting regression tree (GBRT) to predict the shear strength of RC slender beams without stirrups. Firstly, 484 tests are carefully collected and divided into training and test sets. Then, the hyperparameters of the GBRT model are determined using the JAYA algorithm and 10-fold cross-validation. The performance of the JAYA-GBRT model is compared with five well-known empirical models. The comparative results show that the JAYA-GBRT model (R² = 0.982, RMSE = 9.466 kN, MAE = 6.299 kN, µ = 1.018, and Cov = 0.116) outperforms the other models. Moreover, the predictions of the JAYA-GBRT model are globally and locally explained using the Shapley Additive exPlanation (SHAP) method. The effective depth is determined as the most crucial parameter influencing the shear strength through the SHAP method. Finally, a Graphic User Interface (GUI) tool and a web application (WA) are developed to apply the JAYA-GBRT model for rapidly predicting the shear strength of RC slender beams without stirrups.

• Journal of Pharmaceutical Investigation
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• 제37권4호
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• pp.223-227
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• 2007

A rapid, simple and sensitive LC/MS/MS method for the determination of lercanidipine in human serum was validated and applied to the pharmacokinetic study of lercanidipine. Lercanidipine and internal standard, amlodipine, were extracted from human serum by liquid-liquid extraction with hexan-isoamyl alcohol (100: 1, v/v) and analyzed on a $Symmetry^{(R)}$ MS $C_{18}$ column with the mobile phase of acetonitrile-0.2% aqueous formic acid (70: 30, v/v). Using MS/MS with multiple reaction monitoring (MRM) mode, lercanidipine and amlodipine were detected without severe interferences from human serum matrix. Lercanidipine produced a protonated precursor ion ($[M+H]^+$) at m/z 612.3 and a corresponding product ion at m/z 280.0. Internal standard produced a protonated precursor ion ($[M+H]^+$]) at m/z 409.0 and a corresponding product ion at m/z 238.0. The ruggedness of this method was investigated using quality control (QC) samples. This method showed linear response over the concentration range of 0.05-20 ng/mL with correlation coefficient greater than 0.999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ng/mL, which was sensitive enough for pharmacokinetic studies. The overall accuracy of the developed method ranged from 85.51 to 112.2% for lercanidipine with overall precision (% C.V.) being 3.56-13.1%. This method showed good ruggedness (within 15% C.V.) and was successfully applied for the analysis of lercanidipine in human serum samples for the pharmacokinetic studies, demonstrating the suitability of the method.

• 한국환경농학회지
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• 제39권2호
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• pp.130-137
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• 2020

BACKGROUND: Mefentrifluconazole and triticonazole are the triazole fungicides. The maximum residue levels for agricultural products need to be set up. Therefore, development of the official analytical method for determination of mefentrifluconazole and triticonazole residues from agricultural crops was necessary due to safety management, and then a simultaneous analytical method was developed for the determination of mefentrifluconazole and triticonazole in agricultural crops. METHODS AND RESULTS: Samples were extracted using acetonitrile and purified using dispersive solid phase extraction, and then detected with liquid chromatograph-tandem mass spectrometry (LC-MS/MS). Matrix-matched calibration curves (0.0025-0.25 ㎍/mL) were linear into a sample extract with r²>0.99. For validation, the recovery test was carried out at three fortification levels (LOQ, 10 LOQ and 50 LOQ) from agricultural samples. The results for mefentrifluconazole and triticonazole ranged between 92.3 to 115.3% and 91.4 to 108.5%, respectively and RSD (relative standard deviation) values were also below 6.0%. Furthermore, inter-laboratory was conducted to validate the method. CONCLUSION: All values were corresponded with the criteria ranges requested by both the CODEX (CAC/GL 40-1993, 2003) and MFDS guidelines (2016). Therefore, the proposed method can be used as an official analytical method for determination of mefentrifluconazole and triticonazole (triazole fungicides) in the Republic of Korea.

• 약학회지
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• 제49권3호
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• pp.212-216
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• 2005

A rapid, sensitive and selective electrospray tandem mass spectrometric (ESI-LC/MS/MS) method for the quantitation of gliquidone in human plasma was developed. A bioavailability study of gliquidone tablet (30 mg gliquidone, Boehringer Ingelheim Korea Co.) was performed using the validated ESI-LC/MS/MS method. The dose of 30 mg of gliquidone (1 tablet) was orally administered to 9 healthy Korean subjects. After administration, blood was taken at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 7, 9, 12, 24, and 33 hour. The validation data were as follows; the standard curve was linear ($r^2$=0.999) over the concentration range of $10\~1000 ng/ml$. The coefficient of variation for intra- and inter-day assay were $8.30\~18.86$, and $2.19\~12.92\%$, respectively. The lower limit of quantification for gliquidone was 10 ng/ml. The pharmacokinetic parameters obtained were as follows; $AUC_t$ was 3861.17$\pm$1328.61 ng-hr/ml, $C_{max}$ was 831.02$\pm$227.99 ng/ml, $T_{max}$ was $2.94{\pm}0.77 hr,\;K_e$, was 0.19$\pm$0.06 1/hr, and $t_{l/2}$ was 4.47$\pm$3.52 hr. Based on the validated analytical method and pharmacokinetic parameters, a standard guideline of the bioavailability test of gliquidone dosage forms was prepared successfully and could be used for the bioequivalence test of gliquidone preparation.

• 분석과학
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• 제34권5호
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• pp.212-224
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• 2021

The intent of the present work was to develop a simple, sensitive, accurate, precise, rapid and economical UV- spectrophotometric and reverse phase high pressure liquid chromatographic method for the simultaneous estimation of Spironolactone and Furosemide in bulk and combined tablet dosage forms. UV-Spectrophotometry was carried out by simultaneous equation method using 0.02 M potassium dihydrogen phosphate buffer pH 3.5: Acetonitrile (50:50) v/v as a solvent. The linearity range was 2-14 ㎍ mL^-1 for Spironolactone and Furosemide with a correlation coefficient > 0.99. The chromatographic separation was achieved on 250 mm × 4.6 mm, hypersil BDS C18 column with particle size 5 ㎛, by using an isocratic mixture of 0.02 M potassium dihydrogen phosphate buffer pH 3.5: Acetonitrile: tert butyl methyl ether (49:50:1) v/v/v as a solvent at a flow rate of 1 mL min^-1 and UV detection was carried out at 254 nm. The retention time were observed to be 3.666 and 6.661 minutes for Furosemide and Spironolactone respectively. The two developed methods were validated according to the ICH guidelines for accuracy, precision, linearity, LOD, LOQ and were found to be within the limits. It can be concluded that these two methods could be successfully used for the simultaneous estimation of Spironolactone and Furosemide in bulk and combined tablet dosage forms.