• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.16 no.6
• /
• pp.1242-1249
• /
• 2012

This paper proposes a metastability-free synchronization method and a mesochronous synchronizer for NoC. It uses the clock transmitted from TX as a strobe and solves the metastability problem by selecting one of rising or falling clock edge depending on the sampling value in RX when the phase difference between clocks is under a metastability window. The logic simulation results show that it works without metastability under $0^{\circ}{\sim}360^{\circ}$ phase difference in the synchronizer that a fault is inserted. The mesochronous synchronizer has a simple control logic and is suitable for NoC.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.9 no.12
• /
• pp.1345-1352
• /
• 2014

Bus architecture of SoC has been replaced by NoC in recent years. Noc uses the multi-clock domains to transmit and receive data between neighbor network interfaces and they have same frequency, but a phase difference because of clock skew. So a synchronizer is used for a mesochronous frequency in interconnection between network interfaces. In this paper the metastability is defined and analyzed in a D latch and a D flip-flop to search the possibilities that data can be lost in the process of sending and receiving data between interconnects when a local frequency and a transmitted frequency have a phase difference. 180nm CMOS model parameter and 1GHz are used to simulate them in HSpice. The simulation results show that the metastability happens in a latch and a flip-flop when input data change near the clock edges and there are intermediate states for a longer time as input data change closer at the clock edge. And the next stage can lose input data depending on environmental conditions such as temperature, processing variations, power supply, etc. The simulation results are very useful to design a mescochronous synchronizer for NoC.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.12 no.2
• /
• pp.273-280
• /
• 2017

As massive integration technology of transistors has been developing, multi-core circuit is fabricated on a silicon chip and a clock frequency is getting faster to meet the system requirement. But increasing the clock frequency can induce some problems to violate the operation of system such as clock synchronization, so it is very import to avoid metastability events to design digital chips. In this paper, metastability windows are measured by bisection method in H-spice depending on temperature, supply voltage, and the size of transmission gate with D-FF designed with 180nm CMOS process. The simulation results show that the metastability window(: MW) is slightly increasing to temperature and supply voltage, but is quadratic to the area of a transmission gate, and the best area ration of P and Ntransitor in transmission gate is P/N=4/2 to get the least MW.

• Proceedings of the Korean Biophysical Society Conference
• /
• 1999.06a
• /
• pp.41-41
• /
• 1999

The native forms of some proteins such as inhibitory serpins (serine protease inhibitors) and viral membrane fusion proteins are metastable, which is critical to their functions. To understand the mechanism of how native metastability regulates the inhibitory function of serpins, we characterized stabilizing mutations of $\alpha$$_1$-antitrypsin, a prototype serpin, in which Gly 117 was replaced by a series of larger hydrophobic residues.(omitted)

• Journal of information and communication convergence engineering
• /
• v.10 no.3
• /
• pp.253-257
• /
• 2012

This paper presents an efficient filtering system for a metastable state-based true random number generator. To output a result with high randomness, we use loop-storage for storing the value of metastability. During the metastable state, the output value is accumulated to the storage. When the non-metastable state arises, the stored metastable value will be used for output instead of the result of the non-metastable state. As a result, we can maintain high entropy together with the original throughput.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.10 no.10
• /
• pp.1123-1130
• /
• 2015

Network on a chip(NoC) is a communication subsystem between intellectual property(IP) cores in a SoC and improves high performance in the scalability and the power efficiency compared with conventional buses and crossbar switches. NoC needs a synchronizer to overcome the metastability problem between data links. This paper presents a new mesochronous synchronizer(MS) which is composed of selection window generator, selection signal generator, and data buffer. A delay line circuit is used to build selection window in selection window generator based on the delayed clock cycle of transmitted clock and the transmitted clock is compared with local clock to generate a selection signal in the SW(selection window). This MS gets rid of the restriction of metastability by choosing a rising edge or a falling edge of local clock according to the value of selection signal. The simulation results show that the proposed MS operates correctly for all phase differences between a transmitted clock and a local clock.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2001.11b
• /
• pp.3-6
• /
• 2001

In common globular proteins, the native form is in its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, and internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of a 1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of a 1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of a 1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• Electrical & Electronic Materials
• /
• v.14 no.12
• /
• pp.3-6
• /
• 2001

In common globular proteins, the native form is n its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, ad internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of $\alpha$1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of $\alpha$1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of $\alpha$1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2001.11a
• /
• pp.3-6
• /
• 2001

In common globular proteins, the native form is in its most stable state. However, the native form of inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins is in a metastable state. Metastability in these Proteins is critical to their biological functions. Our previous studies revealed that unusual interactions, such as side-chain overpacking, buried polar groups, surface hydrophobic pockets, and internal cavities are the structural basis of the native metastability. To understand the mechanism by which these structural defects regulate protein functions, cavity-filling mutations of ${\alpha}$1-antitrypsin, a prototype serpin, were characterized. Increasing conformational stability is correlated with decreasing inhibitory activity. Moreover, the activity loss appears to correlate with the decrease in the rate of the conformational switch during complex formation with a target protease. We also increased the stability of ${\alpha}$1-antitrypsin greatly via combining various stabilizing single amino acid substitutions that were distributed throughout the molecule. The results showed that a substantial increase of stability, over 13 kcal/mol, affected the inhibitory activity with a correlation of 11% activity loss per kcal/mol. The results strongly suggest that the native metastability of proteins is indeed a structural design that regulates protein functions and that the native strain of e 1-antitrypsin distributed throughout the molecule regulates the inhibitory function in a concerted manner.

• Solar Energy
• /
• v.8 no.1
• /
• pp.68-73
• /
• 1988

In the glass/TCO/p-i-n a-Si/Al type of amorphous silicon solar cell, the effects on solar cell efficiency and metastability for the various kinds of TCO analyzed by SAM and ESCA, which was used to measure the diffusion profiles of In and Sn and the Fermi energy shifts in the TCO/p interface respectively. Indium which diffused into a-Si p-layer did not have any significant effects on the Fermi level shift of p-layer when the content of $B_2H_6/SiH_4$ in p-layer was at 1 gas%. The cell fabricated on $SnO_2$ turned out to have the best cell photovoltaic characteristics. ITO fabricated by electron beam deposition system, which was shown to have the greatest rate of diffusion of Indium in ITO/p interface produced the worst metastability among the cells tested.