• 한국직업건강간호학회지
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• 제25권2호
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• pp.96-107
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• 2016

Purpose: The purpose of this study was to investigate the effects of shift work and hours of sleep on metabolic syndrome in Korean workers. Methods: This study used the Korean National Health and Nutrition Examination Survey data of 2014. The study included 1,579 Korean workers aged over 20. $x^2$ test, t-test, and hierarchical multiple logistic regression were used for statistical analysis of data. Results: From the univariate analysis, hours of sleep, regular work, occupational group, sex, age, marital status, education, smoking, and self-rated health were significantly related to metabolic syndrome. After adjusting demographic, occupational, and health-related variables, workers with under 6 hours/day of sleep showed higher risk for metabolic syndrome (AOR: 1.56, 95% CI: 1.01~2.44), and shift work was not significantly related to metabolic syndrome. Male laborers and workers aged 40 or older also showed higher risk for metabolic syndrome. Conclusion: Results of this study suggest that workers with under 6 hours of sleep, male laborers and workers aged 40 or older are the risk groups of metabolic syndrome. Therefore, prevention and management program for metabolic syndrome should be implemented for this population.

• Safety and Health at Work
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• 제14권1호
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• pp.59-65
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• 2023

Objectives: Epidemiological evidence linking long working hours and shift work to metabolic syndrome remains inadequate. We sought to evaluate the impact of reducing working hours on metabolic syndrome. Methods: We compared the prevalence of metabolic syndrome among male manual workers in a manufacturing company (N = 371) before and after the introduction of policy to reduce daily work hours from 10 to 8 hours. Components of metabolic syndrome were measured in periodic health examinations before the intervention, 6-9 months after, and 1.5-2 years after the intervention. Generalized estimating equation models were used to estimate changes in the prevalence of metabolic syndrome. Analyses were stratified by day work versus shift work. Results: The results showed a significantly decreased prevalence of metabolic syndrome 6-9 months following the intervention in day workers (risk ratio = 0.68, 95% confidence interval 0.52-0.88), but the benefit disappeared after 1.5-2 years. Shift workers showed a decreased prevalence of metabolic syndrome for the whole follow-up duration after the intervention, although the change was not statistically significant. Conclusion: Reducing working hours was associated with short-term improvement in metabolic syndrome in male manual workers.

• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 2005년도 2005 Annual Meeting & International Symposium
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• pp.233-244
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• 2005

Guanosine fermentation process can be well predicted and analyzed by the proposed state equations describing the dynamic change of a bioreactor. Pyruvate and alanine were found to be characteristically accumulated along with the decline of the guanosine formation rate during the mid-late phase of the process. The enzymological study of the main pathways in glucose catabolism and the quantitative stoichiometric calculation of metabolic flux distribution revealed that it was entirely attributed to the shift of metabolic flux from hexose monophosphate (HMP) pathway to glycolysis pathway. The process optimization by focusing on the restore of the shift of metabolic flux was conducted and the overcoming the decrease of oxygen uptake rate (OUR) was taken as the relevant factor of the trans-scale operation. As a result, the production of guanosinewas increased from 17 g/L to over 34 g/I.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2003년도 제27회 추계학술대회
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• pp.72-72
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• 2003

Purpose: To prove feasibility of proton chemical shift imaging (lH CSI) during stereotactic procedure, authors performed IH CSI in combination with a stereotactic headframe and selected targets according to local metabolic information, evaluated the pathologic results. Methods: The 1H CSI directed stereotactic biopsy was performed in five patients. 1H CSI was performed before conventional stereotactic MRI with gadolinium enhancement for stereotactic coordinates. The metabolite images expressed as integral ratios, Cho/Cr and Lac/Cr, were displayed in different colors. The stereotactic target coordinates were correlated with the coordinates from the 1H CSI images. Results: The final pathologic results obtained were concordant with the local metabolic information from 1H CSI. We believe that 1H CSI-directed stereotatic biopsy has the potential to significantly improve the accuracy of stereotactic biopsy targeting. Conclusions : Metabolic signals derived from 1H CSI could give us more direct clues for stereotactic target selection during the subsequent conventional stereotactic MR imaging. 1H CSI was feasible with the stereotatic headframe in place. The final pathologic results obtained were concordant with the local metabolic information from 1H CSI. Acknowledgement: This study was supported by a grant of the Center for Functional and Metabolic Imaging Technology, Ministry of Health & Welfare, Republic of Korea (02-PJ3-PG6-EV07-0002).

• Journal of Microbiology and Biotechnology
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• 제14권5호
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• pp.919-923
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• 2004

The sk10 isolated from kimchi was identified as W. kimchii on the basis of l6s-rDNA sequencing. Studies were made to analyze the metabolic flux shift of the sk10 on glucose under aerobic growth conditions. The sk10 produced 38.2 mM acetate, 16.3 mM ethanol, and 33.2 mM lactate under aerobic conditions, but 2.4 mM acetate, 48.0 mM ethanol, and 44.1 mM lactate under anaerobic conditions. The NADH peroxidase (NADH-dependent hydrogen peroxidase) activity of sk10 grown under aerobic conditions was 11 times higher than that under anaerobic conditions. Under the low ratio of $NADH/NAD^+$, the metabolic flux toward lactate and ethanol was shifted to the flux through acetate kinase without NADH oxidation. The kinds of enzymes and metabolites of sk10 were close to those in the pathway of Leuconostoc sp., but the metabolites produced under aerobic growth conditions were different from those of Leuconostoc sp. The stoichiometric balance calculated using the concentrations of metabolites and substrate was about 97%, coincident with the theoretical values under both aerobic and anaerobic conditions. From these results, it was concluded that the metabolic flux of W. kimchii sk10 was partially shifted from lactate and ethanol to acetate under aerobic conditions only.

• 한국식생활문화학회지
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• 제34권4호
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• pp.486-494
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• 2019

There are an increasing number of reports that job related factors are associated with hypertension, sleep deprivation, obesity and diabetes. This study analyzed the relationship of working type, working hours and the prevalence of metabolic syndrome. The study's subjects were 2,777 employees (1,446 males and 1,331 females) over 19 years old and their data was from the Korea National Health and Nutrition Survey (2015). The type of work was divided into day work and shift work. The working hours were divided into less than 40 hours, 40 to 49 hours, 50 to 59 hours and 60 hours or more per week. As a result of this study, the prevalence of metabolic syndrome was 26.4% of the males and 19.1% of the females. Generally there was no relationship between metabolic syndrome and type of work (day work and shift work). As a result of analysis of working hours and metabolic syndrome, the workers who worked 40-49 hr were associated with a decreased prevalence of metabolic syndrome as compared to that of workers who worked less than 40 hr (odds ratio: 0.47, 95% confidence interval: 0.24-0.95, p<0.05). Further, positive relationships were found between the number of work hours and the prevalence metabolic syndrome for specific females who worked over 40 hr/wk. It can be concluded from the results that it is important to help workers avoid metabolic syndrome through setting appropriate work hours.

• Journal of Nutrition and Health
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• 제51권6호
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• pp.567-579
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• 2018

본 연구는 국민건강영양조사 자료를 이용하여 교대 근무자의 근무시간이 대사증후군의 유병률에 영향을 미치는 요인을 파악하는데 대사증후군의 위험군으로 식습관, 영양섭취상태, 일상생활 관련 특성의 관점에서 관리하는 데 도움을 주고자 진행되었다. 본 연구의 분석결과는 다음과 같다. 첫째, 교대 근무자의 근무시간과 식습관 관계는 직접관계 (direct causality)가 있지 않으나 일상생활과는 직접관계를 갖는 것으로 나타났다. 또한, 식습관과 영영 상태, 대사증후군과는 직접관계가 있지 않은 것으로 나타났고 영양섭취상태와 대사증후군과는 직접관계가 없으나 일상생활과는 직접 인과관계가 있는 것으로 나타났다. 둘째, 교대 근무자의 근무시간과 대사증후군 관계에서 각각 식습관, 일상생활의 개별 매개 효과 (specific mediator effect)는 통계적으로 유의한 것으로 나타났으나, 식습관과 영양섭취상태의 다중매개효과 (multiple mediator effect), 그리고 식습관, 영양섭취상태, 일상생활의 다중매개 효과는 통계적으로 유의하지 않는 것으로 나타났다. 셋째, 교대 근무자의 근무시간이 배제된 상태에서 영양섭취상태, 일상생활 그리고 대사증후군 간의 관계에서 영양섭취상태와 일상생활 그리고 일상생활과 대사증후군과는 직접 인과관계는 없으나 일상생활에 의한 매개 효과는 통계적으로 유의한 것으로 나타났다. 넷째, 교대 근무자의 근무시간과 식습관은 대사증후군에 대해 전체 총 효과 (total effect)를 가진 것으로 나타났으나 영양섭취상태와 일상생활은 대사증후군에 대해 총 효과를 갖고 있지 않은 것으로 나타났다. 결론적으로, 구조방정식 모델을 사용하여 교대 근무자의 교대시간은 그들의 일상생활 또는 식습관에 영향을 주고 대사증후군 유병률과 관련성이 있음을 밝혔다.

• KSBB Journal
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• 제20권6호
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• pp.464-469
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• 2005

가정쓰레기 매립지 토양에서 분리된 Enterobacter sp. SNU-1453은 Enteric bacteria에 속하는 종(species)으로서 혐기 발효 시 효과적으로 수소를 생산하였다. 이러한 fermentative bacteria는 여러 가지 외부 요인에 의해 다른 metabolism을 나타내어 수소생산량에 영향을 준다. 혐기 발효가 진행됨에 따라 배지의 pH가 급격히 감소하여 미생물 성장과 수소생산에 영향을 미치므로, pH에 따른 metabolism변화를 관찰함으로써 수소생산을 극대화하기 위한 최적 pH 조건을 선정하여 제어할 필요가 있다. 본 연구에서는 수소생산에 대한 pH의 효과 및 pH 제어에 따른 metabolic flux를 분석하였다. 실험 결과 이 분리 균주는 매우 넓은 영역의 pH(4-7.5)에서도 수소를 생산하였으며, pH 7에서 가장 높은 수소생산량을 나타내었다. pH 7로의 제어는 butanediol pathway로부터 수소 생산에 더 유리한 mixed acid fermentation pathway로 metabolic flux를 변화시킴을 알 수 있었다.

• Annals of Occupational and Environmental Medicine
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• 제35권
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• pp.22.1-22.9
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• 2023

Background: Shift work increases the risk of chronic diseases, including metabolic diseases. However, studies on the relationship between shift work and renal function are limited. The aim of this study was to investigate the association between shift work and a decreased glomerular filtration rate (GFR). Methods: Data were evaluated for 1,324,930 workers who visited the Korean Medical Institute from January 1, 2016 to December 31, 2020 and underwent a health checkup. Daytime workers were randomly extracted at a ratio of 1:4 after matching for age and sex. In total, 18,190 workers aged over 40 years were included in the analyses; these included 3,638 shift workers and 14,552 daytime workers. Participants were categorized into the shift work group when they underwent a specific health checkup for night shift work or indicated that they were shift workers in the questionnaire. The odds ratio was calculated using a conditional logistic regression to investigate the relevance of shift work for changes in GFR. Results: 35 workers in the shift group and 54 in the daytime group exhibited an estimated GFR (eGFR) value of < 60 mL/min/1.73m² (p < 0.01). The difference in eGFR values between two checkups differed significantly depending on the type of work (p < 0.01); the difference in the shift work group (-9.64 mL/min/1.73 m²) was larger than that in the daytime work group (-7.45 mL/min/1.73 m²). The odds ratio for eGFR reduction to < 60 mL/min/1.73 m² in the shift group versus the daytime group was 4.07 (95% confidence interval: 2.54-6.52), which was statistically significant. Conclusions: The results of this study suggest that eGFR decreases by a significantly larger value in shift workers than in daytime workers; thus, shift work could be a contributing factor for chronic kidney disease (CKD). Further prospective studies are necessary to validate this finding and identify measures to prevent CKD in shift workers.

• 한국직업건강간호학회지
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• 제14권2호
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• pp.138-152
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• 2005

Purposes: The purposes of this study are to investigate the definition, components, prevalence, and associated factors of metabolic syndrome and suggest the management strategies for workers. Method: This study was conducted by literature review. Results: Metabolic syndrome by the NCEP-ATP III is the clustering of three or more of five conditions: abdominal obesity, high triglycerides, low levels of HDL cholesterol, high blood pressure, and high glucose(blood sugar). The prevalence of the metabolic syndrome by modified NCEP-ATP III in South Korean workers was about 20 to 25%. Metabolic syndrome is caused by many associated factors, namely, age, family history, socioeconomic status, job strain, shift work, psychosocial distress, bad health behaviprs and so on. Conclusions: To prevent metabolic syndrome at worksites, multifactorial risk factor assessments and preventive approaches are required. Socioeconomic factors such as education, working status should be nationally importantly considered for the health inequality of workers. Occupational health nurse, at first, can start weight control, smoking cessation program. stress management, the improvement of work environment. Next stage, early diagnosis and treatment for metabolic risk group can be performed.