• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.645-649
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• 2013

Objective: The prognostic role of vascular endothelial growth factor (VEGF) in bladder cancer remains controversial. This meta-analysis aimed to explore any association between overexpression and survival outcomes. Methods: We systematically searched for studies investigating the relationships between VEGF expression and outcome of bladder cancer patients. Study quality was assessed using the Newcastle-Ottawa Scale. After careful review, survival data were extracted from eligible studies. A meta-analysis was performed to generate combined hazard ratios (HRs) for overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS). Results: A total of 1,285 patients from 11 studies were included in the analysis. Our results showed that tissue VEGF overexpression in patients with bladder cancer was associated with poor prognosis in terms of OS (HR, 1.843; 95% CI, 1.231-2.759; P = 0.003), DFS (HR, 1.498; 95% CI, 1.255-1.787; P = 0.000) and DSS (HR, 1.562; 95% CI, 0.996-1.00; P = 0.052), though the difference for DSS was not statistically significant. In addition, there was no evidence of publication bias as suggested by Begg's and Egger's tests except for DFS (Begg's test, P = 0.221; Egger's test, P = 0.018). Conclusion: The present meta-analysis indicated elevated VEGF expression to be associated with a poor prognosis in patients with bladder cancer.

• 한국콘텐츠학회논문지
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• 제18권1호
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• pp.551-560
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• 2018

본 연구에서는 국내에서 유아를 위한 연극프로그램의 효과성을 보다 체계적이고 통합하여 제시하고 효과적인 유아대상 연극프로그램의 실행방안을 제시하기 위하여, 유아를 위한 연극프로그램의 효과성에 대한 국내연구들을 메타분석하였다. 자료 수집은 2017년 4월까지 국내에서 발표된 유아대상의 연극프로그램 논문을 대상으로 검색하였고 선정기준에 따라서 최종 39편의 논문을 분석하였다. 메타분석을 위하여 메타분석의 통계프로그램인 CMA(Comprehensive Meta-Analysis) software 2.0을 사용하였다. 주요 결과는 다음과 같다. 첫째, 유아를 위한 연극프로그램의 평균효과크기를 살펴보면, 언어표현력은 평균효과크기가 1.922로 가장 강한 효과크기를 나타냈고, 정서지능은 1.898, 창의성은 1.558, 사회성은 1.292로 모두 큰 효과크기를 나타내었다. 둘째, 유아를 위한 연극 프로그램의 효과가 조절변수에 따라 차이가 나는지 살펴본 결과, 언어표현력, 창의성, 사회성에 있어서 '연령', '언어표현력에 있어서 '총시행횟수'가 통계적으로 유의미한 차이를 나타내었다. 즉, 유아를 위한 연극프로그램은 연령이 만 4세보다는 만 5세인 경우에 언어표현력, 창의성, 사회성에서 가장 효과적인 것으로 나타났으며, 언어표현력은 최소한 10회 이상을 시행한 경우에 효과적인 것으로 나타났다. 본 연구결과를 바탕으로 유아를 대상으로 한 연극 프로그램 실행의 함의와 제한점을 제시하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5665-5669
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• 2012

Background: The vascular endothelial growth factor (VEGF) mediates vasculogenesis and angiogenesis through promoting endothelial cell growth, migration and mitosis, and has involvement in cancer pathogenesis, progression and metastasis. However, the prognostic value of VEGF in patients with prostate cancer remains controversial. Objectives: The aim of our study was to evaluate the prognostic value of VEGF in prostate cancer, and summarise the results of related research on VEGF. Methods: In accordance with an established search strategy, 11 studies with 1,529 patients were included in our meta-analysis. The correlation of VEGF-expression with overall survival and progression-free survival was evaluated by hazard ratio, either given or calculated. Results: The studies were categorized by introduction of the author, demographic data in each study, prostate cancer-relatived information, VEGF cut-off value, VEGF subtype, methods of hazard ratio (HR) estimation and its 95% confidence interval (CI). High VEGF-expression in prostate cancer is a poor prognostic factor with statistical significance for OS (HR=2.32, 95%CI: 1.40-3.24). However, high VEGF-expression showed no effect on poor PFS (HR=1.30, 95%CI: 0.88-1.72). Using Begg's, Egger's test and funnel plots, we confirmed lack of publication bias in our analysis. Conclusion: VEGF might be regarded as a prognostic maker for prostate cancer, as supported by our meta-analysis. To achieve a more definitive conclusion enabling the clinical use of VEGF in prostate cancer, we need more high-quality interventional original studies following agreed research approaches or standards.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6761-6766
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• 2014

Background: CD44v6 (CD44 variant exon 6) is the chief CD44 variant isoform regulating tumor invasion, progression, and metastasis. The prognostic value of CD44v6 expression in non small cell lung cancer (NSCLC) has been evaluated in many studies, but the results have remained controversial. Thus, we performed a meta-analysis of currently available studies to investigate the prognostic value of CD44v6 expression in NSCLC patients and the relationship between the expression of CD44v6 and clinicopathological features. Materials and Methods: Two independent reviewers searched the relevant literature in Pubmed, Medline and Embase from 1946 to January 2014. Overall survival (OS) and various clinicopathological features were collected from included studies. This meta-analysis was accomplished using STATA 12.0 and Revman 5.2 software. Pooled hazard ratios (HRs) with 95% confidence intervals (95%CIs) were calculated to estimate the effects. Results: A total of 921 NSCLC patients from ten studies met the inclusion criteria. The results showed that CD44v6 high expression was a prognostic factor for poor survival (HR=1.91, 95%CI=1.12-3.26, p<0.05). With respect to clinicopathological features, CD44v6 high expression was related to histopathologic type (squamous cell carcinoma versus adenocarcinoma: OR=2.72, 95%CI=1.38-5.38, p=0.004), and lymph node metastasis (OR=3.02, 95%CI=1.93-4.72, p<0.00001). Conclusions: Our results suggested CD44v6 high expression as a poor prognostic factor for NSCLC, and CD44v6 expression is associated with lymph node metastasis and histopathologic type. Therefore, CD44v6 expression can be used as a novel prognostic marker in NSCLC cases.

• Journal of Periodontal and Implant Science
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• 제51권1호
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• pp.18-29
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• 2021

Purpose: The aim of this study was to compare the characteristic expression patterns of advanced periodontitis in 2 cohort data sets analyzed using different microarray platforms, and to identify differentially expressed genes (DEGs) through a meta-analysis of both data sets. Methods: Twenty-two patients for cohort 1 and 40 patients for cohort 2 were recruited with the same inclusion criteria. The 2 cohort groups were analyzed using different platforms: Illumina and Agilent. A meta-analysis was performed to increase reliability by removing statistical differences between platforms. An integrative meta-analysis based on an empirical Bayesian methodology (ComBat) was conducted. DEGs for the integrated data sets were identified using the limma package to adjust for age, sex, and platform and compared with the results for cohorts 1 and 2. Clustering and pathway analyses were also performed. Results: This study detected 557 and 246 DEGs in cohorts 1 and 2, respectively, with 146 and 42 significantly enriched gene ontology (GO) terms. Overlapping between cohorts 1 and 2 was present in 59 DEGs and 18 GO terms. However, only 6 genes from the top 30 enriched DEGs overlapped, and there were no overlapping GO terms in the top 30 enriched pathways. The integrative meta-analysis detected 34 DEGs, of which 10 overlapped in all the integrated data sets of cohorts 1 and 2. Conclusions: The characteristic expression pattern differed between periodontitis and the healthy periodontium, but the consistency between the data sets from different cohorts and metadata was too low to suggest specific biomarkers for identifying periodontitis.

• Molecules and Cells
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• 제24권2호
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• pp.200-209
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• 2007

We generated gene expression data from the tissues of 50 gastric cancer patients, and applied meta-analysis and gene set analysis to this data and three other stomach cancer gene expression data sets to define the gene expression changes in gastric tumors. By meta-analysis we identified genes consistently changed in gastric carcinomas, while gene set analysis revealed consistently changed biological themes. Genes and gene sets involved in digestion, fatty acid metabolism, and ion transport were consistently down-regulated in gastric carcinomas, while those involved in cellular proliferation, cell cycle, and DNA replication were consistently up-regulated. We also found significant differences between the genes and gene sets expressed in diffuse and intestinal type gastric carcinoma. By gene set analysis of cytogenetic bands, we identified many chromosomal regions with possible gross chromosomal changes (amplifications or deletions). Similar analysis of transcription factor binding sites (TFBSs), revealed transcription factors that may have caused the observed gene expression changes in gastric carcinomas, and we confirmed the overexpression of one of these, E2F1, in many gastric carcinomas by tissue array and immunohistochemistry. We have incorporated the results of our meta- and gene set analyses into a web accessible database (http://human-genome.kribb.re.kr/stomach/).

• 스마트미디어저널
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• 제13권3호
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• pp.9-17
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• 2024

최근 팬데믹의 영향과 ICT 기술의 발전으로 인해 비대면·무인 시스템의 활용이 확대되고 있으며, 비대면 상황에서 의사소통은 감정을 이해하는 것이 매우 중요하다. 감정을 이해하기 위해서는 다양한 표정에 대한 감정 인식 방법이 필요함에 따라 이미지 데이터에서 표정 감정 인식 개선을 위한 인공지능 기반 연구가 진행되고 있다. 하지만 기존의 표정 감정 인식 연구는 정확도 향상을 위해 대량의 데이터를 활용하기 때문에 높은 컴퓨팅 파워와 많은 학습 시간이 필요하다. 본 논문에서는 이러한 한계점을 개선하기 위해 소량 데이터로도 표정 감정 인식이 가능한 방법으로 이미지 메타 정보인 연령과 성별을 활용한 표정 감정 인식 방법을 제안한다. 표정 감정 인식을 위해 원본 이미지 데이터에서 Yolo Face 모델을 활용하여 얼굴을 검출하였으며, 이미지 메타 정보를 기반으로 VGG 모델을 통해 연령과 성별을 분류한 다음 EfficientNet 모델을 활용하여 7가지 감정을 인식하였다. 메타 정보 기반 데이터 분류 모델과 전체 데이터로 학습한 모델을 비교한 결과 제안하는 데이터 분류 학습 모델의 정확도가 더 높았음을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2903-2908
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• 2012

Background: Matrix metalloproteinase-9 (MMP-9) is associated with disruption of basement membranes of blood vessels and promotion of metastasis through the lymphatics. However, its prognostic value for survival in patients with gastric cancer remains controversial. Method: We therefore conducted a meta-analysis of the published literature in order to clarify the impact of MMP-9. Clinical studies were selected for further analysis if they provided an independent assessment of MMP-9 in gastric cancer and reported analysis of survival data according to MMP-9 expression. Results: A total of 11 studies, covering 1700 patients, were included for meta-analysis. A summary hazard ratio (HR) of all studies and sub-group hazard ratios were calculated. The combined HR suggested that a positive MMP-9 expression had an impact on overall survival: 1.25 (95% confidence interval 1.11-1.40) in all eligible studies; 1.13 (1.06-1.20) in 8 studies detecting MMP-9 by immunohistochemistry; 1.36 (1.12-1.65) in 7 studies from Asia. Only one study for DFS showed a significant impact on disease free survival (HR 1.73, 95%CI 1.27-2.34). Conclusions: Our findings suggested that MMP-9 protein expression might be a factor for a poor prognosis in patients with gastric cancer. However, the association was rather weak, so that more prospective studies should further explore the prognostic impact of MMP-9 mRNA and correlations between MMP-9 and clinicopathological characteristics.

• 아동학회지
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• 제36권2호
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• pp.145-166
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• 2015

The main purpose of this study was to examine the direct and indirect effects of maternal meta-emotion on preschoolers' emotional intelligence through mothers' emotion socialization. A total of 252 preschool-aged children and their mothers residing in the Seoul Metropolitan and Gyeonggi-do areas participated in this study. The mothers completed questionnaires regarding their meta-emotion, emotion socialization and preschoolers' emotional intelligence. The results of the study indicated that maternal meta-emotion did not have a direct effect on preschoolers' emotional intelligence. However, maternal meta-emotion did indeed have an indirect effect on preschoolers' emotional intelligence through emotion socialization styles. That is, mothers who had desirable beliefs about emotions provided supportive reactions to children's negative emotion expression and showed positive emotions more frequently in the family. In addition, the preschoolers of mothers who showed positive emotion socialization styles were reported to be more emotionally intelligent. The findings of this study suggest that maternal meta-emotion and emotion socialization are important in predicting preschoolers' emotional intelligence.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4583-4587
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• 2014

Objective: Beclin-1 has recently been observed as an essential marker of autophagy in several cancers. However, the prognostic role of Beclin-1 in colorectal neoplasia remains controversial. Our study aimed to evaluate the potential association between Beclin-1 expression and the outcome of colorectal cancer patients. Materials and Methods: All related studies were systematically searched in Pubmed, Embase, Springer and Chinese National Knowledge Infrastructure databases (CNKI), and then a meta-analysis was performed to determine the association of Beclin-1 expression with clinical outcomes. Finally, a total of 6 articles were included in our analysis. Results: Our data showed that high Beclin-1 expression in patients with CRC was associated with poor prognosis in terms of tumor distant metastasis (OR=2.090, 95%CI=1.061-4.119, p=0.033) and overall survival (RR=1.422, 95%CI=1.032-1.959, p=0.031). However, we did not found any correlation between Beclin-1 over-expression and tumor differentiation (OR=1.711, 95%CI=0.920-3.183, p=0.090). In addition, there was no evidence of publication bias as suggested by Egger's tests for tumor distant metastasis (p=1.000), differentiation (p=1.000) and OS (p=0.308). Conclusions: Our present meta-analysis indicated that elevated Beclin-1 expression iss associated with tumor metastasis and a poor prognosis in patients with CRC. Beclin-1 might serve as an efficient prognostic indicator in CRC, and could be a new molecular target in CRC therapy.