• 제목/요약/키워드: memory repair

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3-D Hetero-Integration Technologies for Multifunctional Convergence Systems

  • 이강욱
    • 마이크로전자및패키징학회지
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    • 제22권2호
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    • pp.11-19
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    • 2015
  • Since CMOS device scaling has stalled, three-dimensional (3-D) integration allows extending Moore's law to ever high density, higher functionality, higher performance, and more diversed materials and devices to be integrated with lower cost. 3-D integration has many benefits such as increased multi-functionality, increased performance, increased data bandwidth, reduced power, small form factor, reduced packaging volume, because it vertically stacks multiple materials, technologies, and functional components such as processor, memory, sensors, logic, analog, and power ICs into one stacked chip. Anticipated applications start with memory, handheld devices, and high-performance computers and especially extend to multifunctional convengence systems such as cloud networking for internet of things, exascale computing for big data server, electrical vehicle system for future automotive, radioactivity safety system, energy harvesting system and, wireless implantable medical system by flexible heterogeneous integrations involving CMOS, MEMS, sensors and photonic circuits. However, heterogeneous integration of different functional devices has many technical challenges owing to various types of size, thickness, and substrate of different functional devices, because they were fabricated by different technologies. This paper describes new 3-D heterogeneous integration technologies of chip self-assembling stacking and 3-D heterogeneous opto-electronics integration, backside TSV fabrication developed by Tohoku University for multifunctional convergence systems. The paper introduce a high speed sensing, highly parallel processing image sensor system comprising a 3-D stacked image sensor with extremely fast signal sensing and processing speed and a 3-D stacked microprocessor with a self-test and self-repair function for autonomous driving assist fabricated by 3-D heterogeneous integration technologies.

고집적 메모리의 고장 및 결함 위치검출 가능한 BIST/BICS 회로의 설계 (A design of BIST/BICS circuits for detection of fault and defect and their locations in VLSI memories)

  • 김대익;배성환;전병실
    • 한국통신학회논문지
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    • 제22권10호
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    • pp.2123-2135
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    • 1997
  • 고집적 SRAM을 구성하고 있는 일반적인 메모리 셀을 이용하여 저항성 단락을 MOSFET의 게이트-소오스, 게이트-드레인, 소오스-드레인에 적용시키고, 각 단자에서 발생 가능한 개방 결함을 고려하여 그 영향에 따른 메모리의 자장노드의 전압과 VDD에서의 정전류를 PSPICE 프로그램으로 분석하였다. 해석 결과를 고려하여 메모리의 기능성과 신뢰성을 향상시키기 위해 기능 테스트와 IDDQ 테스트에 동시에 적용할 수 있는 O(N)의 복잡도를 갖는 테스트 알고리즘을 제안하였다. 테스트의 질과 효율을 좀 더 향상시키기 위해 메모리에서 발생되는 고장을 검출하는 BIST 회로와 정전류의 비정상적인 전류의 흐름을 발생시키는 결함을 검출하는 BICS를 설계하였다. 또한 구현한 BIST/BICS 회로는 고장 메모리의 수리를 위해 고장 및 결함의 위치를 검출할 수 있다.

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Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches

  • Johnson, Madeleine A.;Ables, Jessica L.;Eisch, Amelia J.
    • BMB Reports
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    • 제42권5호
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    • pp.245-259
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    • 2009
  • The process by which adult neural stem cells generate new and functionally integrated neurons in the adult mammalian brain has been intensely studied, but much more remains to be discovered. It is known that neural progenitors progress through distinct stages to become mature neurons, and this progression is tightly controlled by cell-cell interactions and signals in the neurogenic niche. However, less is known about the cell-intrinsic signaling required for proper progression through stages of adult neurogenesis. Techniques have recently been developed to manipulate genes specifically in adult neural stem cells and progenitors in vivo, such as the use of inducible transgenic mice and viral-mediated gene transduction. A critical mass of publications utilizing these techniques has been reached, making it timely to review which molecules are now known to play a cell-intrinsic role in regulating adult neurogenesis in vivo. By drawing attention to these isolated molecules (e.g. Notch), we hope to stimulate a broad effort to understand the complex and compelling cascades of intrinsic signaling molecules important to adult neurogenesis. Understanding this process opens the possibility of understanding brain functions subserved by neurogenesis, such as memory, and also of harnessing neural stem cells for repair of the diseased and injured brain.

Pilot study for investigating behavior of recentering frame connection equipped with friction damper

  • Kim, Young Chan;Hu, Jong Wan
    • Steel and Composite Structures
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    • 제44권4호
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    • pp.569-586
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    • 2022
  • This study introduces a novel friction damper as a component of a recentering frame connection, to solve the problem of structural repair costs, caused by stiffness deterioration and brittle fracture of the central brace frame (CBF). The proposed damper consists of shape memory alloy (SMA) bars with pretension applied to them to improve the stability. SMAs reduce the residual displacement by virtue of the properties of the materials themselves; in addition, a pretension can be applied to partially improve their energy dissipation capacity. The damper also consists of a friction device equipped with friction bolts for increased energy dissipation. Therefore, a study was conducted on the effects of the friction device as well as the pretension forces on the friction damper. For performance verification, 12 cases were studied and analyzed using ABAQUS program. In addition, the friction and pretension forces were used as variables in each case, and the results were compared. As a result, when the pretension and friction force are increased, the energy dissipation capacity gradually increases by up to about 94% and the recentering capacity decreases by up to about 55%. Therefore, it has been shown that SMA bars with adequate pretension in combination with bolts with adequate frictional force effectively reduce residual deformation and increase damper capacity. Thus, this study has successfully proposed a novel friction damper with excellent performance in terms of recentering and energy dissipation capacity.

마찰 에너지 소산과 자동 복원력을 활용한 가새 댐퍼 시스템의 최적 설계와 구조적 활용 (Optimum Design and Structural Application of the Bracing Damper System by Utilizing Friction Energy Dissipation and Self-Centering Capability)

  • 허종완;박지웅
    • 대한토목학회논문집
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    • 제34권2호
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    • pp.377-387
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    • 2014
  • 본 연구는 지진에 대한 구조물의 손상을 최소화 하기 위하여 슬립 저항력을 활용한 새로운 형태의 마찰 댐퍼형 가새 시스템의 설계와 개발을 주로 다루고자 한다. 가새 부재 내에서 전단력에 의한 마찰 거동으로 상당량의 에너지를 수동적으로 소산하기 위하여 플레이트 전단 이음부 위에 슬롯 형태의 볼트 구멍을 설치한다. 여기에 전단 마찰 거동으로 인해 발생되는 잔류변형을 줄이고자 상온에서 원형복원이 가능한 초탄성 형상합금 와이어를 꼬아서 만든 연선을 설치하여 댐퍼 시스템 내에 복원성을 증진 시켰다. 기존에 주로 사용된 수동적인 변위 제어 장치와 비교하여 본 연구에서 다루고자 하는 자동복원이 가능한 마찰 댐퍼형 가새 시스템은 중심 가새 프레임 구조물에 손쉽게 설치하여 지진발생 후에 구조물에 발생하는 층간 잔류변위를 최소화하여 유지 보수에 소모되는 비용의 대폭적인 절감을 기대할 수 있다. 본 연구에서는 자동복원이 가능한 마찰 댐퍼형 가새 시스템의 역학적인 거동 메커니즘을 살펴보고 실험값으로 보정되어 신뢰성을 확보한 스프링 모델을 사용하여 해석을 실시하였다. 시스템에 다양한 설계 변수를 적용하여 복원성과 에너지 소산 능력 측면에서 제안된 댐퍼의 성능 동향을 분석을 하고 최적의 설계 방식을 제안하고자 한다. 마지막으로 자동복원이 가능한 마찰 댐퍼를 중심 가새 프레임 구조물에 설치하여 비선형 동적 해석을 실시하고 기존의 시스템과 비교하여 성능적인 우수성을 입증하고자 한다.

Induced neural stem cells from human patient-derived fibroblasts attenuate neurodegeneration in Niemann-Pick type C mice

  • Hong, Saetbyul;Lee, Seung-Eun;Kang, Insung;Yang, Jehoon;Kim, Hunnyun;Kim, Jeyun;Kang, Kyung-Sun
    • Journal of Veterinary Science
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    • 제22권1호
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    • pp.7.1-7.13
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    • 2021
  • Background: Niemann-Pick disease type C (NPC) is caused by the mutation of NPC genes, which leads to the abnormal accumulation of unesterified cholesterol and glycolipids in lysosomes. This autosomal recessive disease is characterized by liver dysfunction, hepatosplenomegaly, and progressive neurodegeneration. Recently, the application of induced neural stem cells (iNSCs), converted from fibroblasts using specific transcription factors, to repair degenerated lesions has been considered a novel therapy. Objectives: The therapeutic effects on NPC by human iNSCs generated by our research group have not yet been studied in vivo; in this study, we investigate those effects. Methods: We used an NPC mouse model to efficiently evaluate the therapeutic effect of iNSCs, because neurodegeneration progress is rapid in NPC. In addition, application of human iNSCs from NPC patient-derived fibroblasts in an NPC model in vivo can give insight into the clinical usefulness of iNSC treatment. The iNSCs, generated from NPC patientderived fibroblasts using the SOX2 and HMGA2 reprogramming factors, were transplanted by intracerebral injection into NPC mice. Results: Transplantation of iNSCs showed positive results in survival and body weight change in vivo. Additionally, iNSC-treated mice showed improved learning and memory in behavior test results. Furthermore, through magnetic resonance imaging and histopathological assessments, we observed delayed neurodegeneration in NPC mouse brains. Conclusions: iNSCs converted from patient-derived fibroblasts can become another choice of treatment for neurodegenerative diseases such as NPC.

AppLock 정보 은닉 앱에 대한 취약점 분석 (Vulnerability analysis for AppLock Application)

  • 홍표길;김도현
    • 정보보호학회논문지
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    • 제32권5호
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    • pp.845-853
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    • 2022
  • 스마트폰의 메모리 용량이 증가하면서 스마트폰에 저장된 개인 정보의 종류와 양도 증가하고 있다. 하지만 최근 악의적인 공격자의 악성 앱이나 수리기사 등의 타인으로 인해 스마트폰의 사진, 동영상 등의 다양한 개인 정보가 유출될 가능성이 증가하고 있기 때문에, 사용자의 이러한 개인 정보를 보호할 수 있는 다양한 정보 은닉 앱이 출시되고 있다. 본 논문은 이러한 정보 은닉 앱의 암호 알고리즘 및 데이터 보호 기능을 분석하여 안전성 및 취약점을 분석 및 연구했다. 이를 위해 우리는 Google Play에 등록된 정보 은닉 앱 중에서 전 세계적으로 가장 많이 다운로드된 AppLock 3.3.2 버전(December 30, 2020)과, 5.3.7 버전(June 13, 2022)을 분석했다. 접근 제어 기능의 경우, 사용자가 입력한 패턴을 암호화하기 위한 값들이 소스 코드에 평문으로 하드코딩 되어있으며 암호 알고리즘이 적용된 패턴 값은 xml 파일에 저장한다는 취약점이 존재했다. 또한 금고 기능의 경우 금고에 저장하기 위한 파일과 로그 파일을 암호화하지 않는 취약점이 존재했다.

원지 디클로로메탄분획이 CT105에 의한 신경세포 상해에 미치는 영향 (The Effects of Polygala Tenuifolia DM Fraction on CT105-injuried Neuronal Cells)

  • 이상원;김상호;김태헌;강형원;류영수
    • 동의생리병리학회지
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    • 제18권2호
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    • pp.507-516
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    • 2004
  • Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the commom disease in public health service. Although a variety of oriental presciptions in study POD(Polygala tenuifolia extracted from dichlorometan) have been traditionally utilized for the treatment of AD, their pharmacological effects and action mechanisms have not yet fully elucidated. It has been widely believed that AP peptide divided from APP causes apoptotic neurotoxicity in AD brain. However, recent evidence suggests that CT105, carboxy terminal 105 aminoacids peptide fragment of APP, may be an important factor causing neurotoxicity in AD. SK-N-SH cells expressed with CT105 exhibited remarkable apoptotic cell damage. Based on morphological observations by phase contrast microscope and NO formation in the culture media, the CT105-induced cell death was significantly inhibited by POD. In addition, AD is one of brain degeneration disease. So We studied on herbal medicine that have a relation of brain degeneration. From old times, In Oriental Medicine, PO water extract has been used for disease in relation to brain degeneration. We were examined by ROS formation, neurite outgrowth assay and DPPH scravage assay. Additionally, we investigated the association between the CT105 and neurite degeneration caused by CT105-induced apoptotic response in neurone cells. We studied on the regeneratory and inhibitory effects of anti-Alzheimer disease in pCT105-induced neuroblastoma cell lines by POD. Findings from our experiments have shown that POD inhibits the synthesis or activities of CT105, which has neurotoxityies and apoptotic activities in cell line. In addition, treatment of POD(>50 ㎍/㎖ for 12 hours) partially prevented CT(105)-induced cytotoxicity in SK-N-SH cell lines, and were inhibited by the treatment with its. POD(>50 ㎍/㎖ for 12 hours) repaired CT105-induced neurite outgrowth when SK-N-SH cell lines was transfected with CT105. As the result of this study, In POD group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of Neuroblastoma cells by CT105 expression is promoted. Decrease of memory induced by injection of scopolamin into rat was also attenuted by POD, based on passive avoidance test. Taken together, POD exhibited inhibition of CT105-induced apoptotic cell death. POD was found to reduce the activity of AchE and induced about the CA1 in rat hippocampus. Base on these findings, POD may be beneficial for the treatment of AD.

Effects of Hypobaric Conditions on Apoptosis Signalling Pathways in HeLa Cells

  • Arican, Gul Ozcan;Khalilia, Walid;Serbes, Ugur;Akman, Gizem;Cetin, Idil;Arican, Ercan
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권12호
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    • pp.5043-5047
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    • 2014
  • Nowadays increasing effectiveness in cancer therapy and investigation of formation of new strategies that enhance antiproliferative activity against target organs has become a subject of interest. Although the molecular mechanisms of apoptosis can not be fully explained, it is known that cell suicide program existing in their memory genetically is activated by pathophysiological conditions and events such as oxidative stress. Low pressure (hypobaric) conditions that create hypoxia promote apoptosis by inhibiting cell cycling. In this study, determination of the effects of fractional hypobaric applications at different times on HeLa cells at cellular and molecular levels were targeted. Experiments were carried out under hypobaric conditions (35.2 kPa) in a specially designed hypobaric cabin including 2% $O_2$ and 98% N. Application of fractional hypobaric conditions was repeated two times for 3 hours with an interval of 24 hours. At the end of the implementation period cells were allowed to incubate for 24 hours for activation of repair mechanisms. Cell kinetic parameters such as growth rate (MTT) and apoptotic index were used in determination of the effect of hypobaric conditions on HeLa cells. Also in our study expression levels of the Bcl-2 gene family that have regulatory roles in apoptosis were determined by the RT-PCR technique to evaluate molecular mechanisms. The results showed that antiproliferative effect of hypobaric conditions on HeLa cells started three hours from the time of application and increased depending on the period of exposure. While there was a significant decrease in growth rate values, there was a significant increase in apoptotic index values (p<0.01). Also molecular studies showed that hypobaric conditions caused a significant increase in expression level of proapoptotic gene Bax and significant decrease in antiapoptotic Bfl-1. Consequently fractional application of hypobaric conditions on HeLa cell cultures increased both antiproliferative and apoptotic effects and these effects were triggered by the Bax gene.

주행시간 기반 실시간 점대점 최단경로 탐색 알고리즘 (A Real-time Point-to-Point Shortest Path Search Algorithm Based on Traveling Time)

  • 이상운
    • 한국인터넷방송통신학회논문지
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    • 제12권4호
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    • pp.131-140
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    • 2012
  • 네비게이션의 최단 경로 탐색 알고리즘은 일반적으로 Dijkstra 알고리즘에 기반을 두고 있으며, 가중치로 단지 길이 (거리) 만을 고려하고 있다. 거리 기반의 Dijkstra 알고리즘은 출발 노드부터 시작하여 그래프의 모든 노드에 대한 최단 경로를 결정하기 때문에 일반적으로 노드의 수 - 1회를 수행해야 하며, 알고리즘 수행에 많은 메모리가 요구된다. 또한, 거리에만 기반하기 때문에 전방에 차량사고로 인해 병목현상이 발생하였을 때 우회도로를 탐색하는 기능이 없어 항상 동일한 경로만을 탐색한다. 이러한 문제점을 해결하고자, 본 논문은 도로 등급 (고속도로, 국도, 지방도 등)을 고려하지 않고, 속도 기준 (원활, 지체 서행, 정체, 사고 통제 등)도 적용하지 않으며, 단지 도로별 주행시간 (주행속도 ${\times}$ 거리)을 고려한다. 이는 사고, 지체, 공사 등으로 인해 동일한 거리의 도로도 다른 시간이 소요되는 현실성을 반영하여 우회도로를 탐색할 수 있는 장점이 있다. 제안된 알고리즘은 특정 도로에서 사고가 발생하였다고 가정한 경우에도 도로의 통행속도를 실시간으로 반영함으로서 돌발지점을 우회하여 목적지 까지 최단시간 내에 도달 할 수 있음을 증명하였다.