• Korean Journal of Food Science and Technology
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• v.45 no.5
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• pp.661-665
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• 2013

The aim of this study was to investigate the anti-amnesic effect of daebo (Castanea crenata) extract on trimethyltin chloride (TMT)-induced learning and memory impairment, in vivo. The inner skin of daebo was extracted using distilled water under reflux conditions. At the end of the adaptation period, ICR mice were divided into a control group, a TMT injection group (negative control), and a sample group (C5: 5 mg/kg body weight; C10: 10 mg/kg body weight; and C20: 20 mg/kg body weight), and were tested with learning and memory tests. The ethylacetate fraction of the daebo inner skin extract was found to increase TMT-induced memory deficit in the Y-maze and passive avoidance test. Brain tissue analysis showed that the ethylacetate fraction of daebo extract lowered the acetylcholine esterase (AChE) activity and malondialdehyde (MDA) content of neuronal cells, both of which are indicative of lipid peroxidation.

• Korean Journal of Food Science and Technology
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• v.47 no.6
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• pp.779-784
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• 2015

This study was conducted to investigate the effect of herbs on memory improvement by focusing on their cholinergic functions in Tg2576 mice. Seven herbs were used to obtain extracts by using alcohol and water. In screening test for cholinergic activities of the extracts, acetylcholinesterase (AChE) activity was highly inhibited in Oenanthe javanica alcohol extract (OJAE, 18.76%) as compared with the others. The OJAE-treated Tg2576 (Tg-OJAE) groups showed the statistically significant increases of latency time in passive avoidance test. Also, it was found that the concentration of $A{\beta}1-42$ was significantly reduced in Tg-OJAE groups compared to non-treated Tg2576 groups. In the additional enzyme test, it was found that $IC_{50}$ of OJAE was $991.77{\mu}g/mL$ and OJAE acted as an uncompetitive inhibitor of AChE. Therefore, it seemed that OJAE can be used for the development of processed foods for memory improvement.

• Korean Journal of Medicinal Crop Science
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• v.19 no.6
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• pp.456-463
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• 2011

The present study examined the effects of Korean white ginseng (WG, Panax ginseng C. A. Meyer) on the learning and memory function and the neural activity in rats with trimethyltin (TMT)-induced memory deficits. The rats were administered with saline or WG (WG 100 or 300 mg/kg, p.o.) daily for 21 days. The cognitive improving efficacy of WG on the amnesic rats, which was induced by TMT, was investigated by assessing the Morris water maze test and by performing immunohistochemistries on choline acetyltransferase (ChAT), acetylcholinesterase (AchE), cAMP responsive element binding protein (CREB) and brain derived neurotrophic factor (BDNF). The rats treated with TMT injection (control group) showed impaired learning and memory of the tasks, but the rats treated with TMT injection and WG administration produced significant improvement of the escape latency to find the platform in the Morris water maze at the 2nd and 4th days compared to that of the control group. In the retention test, the WG 100 and WG 300 groups showed significantly increased crossing number around the platform compared to that of the control group (p < 0.001). Consistently with the behavioral data, result of immunohistochemistry analysis showed that WG 100 mg/kg significantly alleviated the loss of BDNF-ir neurons in the hippocampus compared to that of the control group (p < 0.01). Also, treatment with WG has a trend to be increased the cholinergic neurons in the hippocampal CA1 and CA3 areas as compared to that of the control group. These results suggest that WG may be useful for improving the cognitive function via regulation of neurotrophic activity.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.3
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• pp.337-345
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• 2014

The present study examined the effects of soybean-derived phosphatidylserine (SB-PS) on the learning and memory function and the neural activity in rats with trimethyltin (TMT)-induced memory deficits. The cognitive improving efficacy of SB-PS on the amnesic rats, which was induced by TMT, was investigated by assessing the Morris water maze test and by performing cholineacetyl transferase (ChAT), acetylcholinesterase (AChE) and cAMP responsive element binding protein (CREB) immunohistochemistry. A positron emission tomography (PET) scanning the rat brain was by performed administer 18F-Fluorodeoxy-glucose (18F-FDG). The rats with TMT injection showed impaired learning and memory of the tasks and treatment with SB-PS produced a significant improvement of the escape latency to find the platform in the Morris water maze at the 2nd day compared to that of the MCT group. In the retention test, the SB-PS group showed increased time spent around the platform compared to that of the MCT group. Consistent with the behavioral data, SB-PS 50 group significantly alleviated the loss of acetyl cholinergic neurons in the hippocampus compared to that of the MCT group. Treatment with SB-PS significantly increased the CREB positive neurons in the hippocampus as compared to that of the MCT group. In addition, SB-PS groups increased the glucose uptake in the hippocampus and SB-PS 50 group increased the glucose uptake in the frontal lobe, as compared to that of the MCT group. These results suggest that SB-PS may be useful for improving the cognitive function via regulation of cholinergic marker enzyme activity and neural activity.

• Science of Emotion and Sensibility
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• v.14 no.3
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• pp.425-434
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• 2011

In the present study was to examine the influence of cold stress conditions on memory function in relation with 5-hydroxytryptamine(serotonin, 5-HT), trptophanhydroxylase(TPH) expression and cell proliferation in the hippocampus. For this study, male Sprague-Dawley rats weighing $250{\pm}10g$ (7 weeks in age) were used. The rats were randomly divided into three groups(n = 10 in each group): the $22^{\circ}C$-control group, the $4^{\circ}C$-3 days group, the $4^{\circ}C$-5 weeks group. The environmental temperature at $22^{\circ}C$ set as the normal conditions, $4^{\circ}C$ was as the cold stress conditions. The present results showed that cold stress conditions shorten latency, representing cold stress disturbed memory function. 5-HT and TPH expressions in the dorsal raphe were increased cold stress. Neurogenesis in the dentate gyrus was increased under cold conditions. The present study revealed that cold stress exerted deteriorative memory function. However, through increasing of 5-HT, TPH and BrdU expression under cold stress conditions did not show memory enhancing effect.

• The KIPS Transactions:PartA
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• v.18A no.4
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• pp.135-142
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• 2011

This research is to design an effective buffer structure and its management for flash memory based high performance SSDs (Solid State Disks). Specifically conventional SSDs tend to show asymmetrical performance in read and /write operations, in addition to a limited number of erase operations. To minimize the number of erase operations and write latency, the degree of interleaving levels over multiple flash memory chips should be maximized. Thus, to increase the interleaving effect, an effective buffer structure is proposed for the SSD with a hybrid address mapping scheme and super-block management. The proposed buffer operation is designed to provide performance improvement and enhanced flash memory life cycle. Also its management is based on a new selection scheme to determine random and sequential accesses, depending on execution characteristics, and a method to enhance the size of sequential access unit by aggressive merging. Experiments show that a newly developed mapping table under the MBA is more efficient than the basic simple management in terms of maintenance and performance. The overall performance is increased by around 35% in comparison with the basic simple management.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.3
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• pp.59-67
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• 2013

Reed-Solomon (RS) codes are powerful error-correcting codes used in diverse applications. Recently, algebraic soft-decision decoding algorithm for RS codes that can correct the errors beyond the error correcting bound has been proposed. The algorithm requires very intensive computations for interpolation, therefore an efficient VLSI architecture, which is realizable in hardware with a moderate hardware complexity, is mandatory for various applications. In this paper, we propose an efficient architecture with low hardware complexity for interpolation in soft-decision list decoding of Reed-Solomon codes. The proposed architecture processes the candidate polynomial in such a way that the terms of X degrees are processed in serial and the terms of Y degrees are processed in parallel. The processing order of candidate polynomials adaptively changes to increase the efficiency of memory access for coefficients; this minimizes the internal registers and the number of memory accesses and simplifies the memory structure by combining and storing data in memory. Also, the proposed architecture shows high hardware efficiency, since each module is balanced in terms of latency and the modules are maximally overlapped in schedule. The proposed interpolation architecture for the (255, 239) RS list decoder is designed and synthesized using the DongbuHitek $0.18{\mu}m$ standard cell library, the number of gate counts is 25.1K and the maximum operating frequency is 200 MHz.

• Science of Emotion and Sensibility
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• v.18 no.2
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• pp.85-100
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• 2015

This study aimed at examining if the original memory remains after a misinformation is presented, using Event-Related Potential based Concealed Information Test (ERP-based CIT). In the first stage of the study, the participant was presented with either the original information or a misleading information after experiencing an event (Post-information). The second stage was to measure brain wave and reaction time on the original, misleading, and irrelevant information (CIT-Stimulus). P300 amplitude, P300 area, P300 latency, and reaction time were used as dependant variables. In the result, a significant Post-information ${\times}$ CIT-Stimulus interaction effect was found on the P300 area measured at Cz, Pz, and Oz area. This interaction effect implied the possibility that the original information could be partially impaired in memory by misleading information presented afterward. P300 amplitude at Pz area did not differ between the accurate and the misleading stimuli in the condition in which a misleading information was presented. This result can be explained by source monitoring error. In discussion, the limitations of this study and directions of future studies were discussed.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.11
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• pp.1031-1040
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• 2010

Hash join is one of the core algorithms in databases management systems. If a hash join cannot complete in one-pass because the available memory is insufficient (i.e., hash table overflow), however, it may incur a few sequential writes and excessive random reads. With harddisk as the tempoary storage for hash joins, the I/O time would be dominated by slow random reads in its probing phase. Meanwhile, flash memory based SSDs (flash SSDs) are becoming popular, and we will witness in the foreseeable future that flash SSDs replace harddisks in enterprise databases. In contrast to harddisk, flash SSD without any mechanical component has fast latency in random reads, and thus it can boost hash join performance. In this paper, we investigate several important and practical issues when flash SSD is used as tempoary storage for hash join. First, we reveal the va patterns of hash join in detail and explain why flash SSD can outperform harddisk by more than an order of magnitude. Second, we present and analyze the impact of cluster size (i.e., va unit in hash join) on performance. Finally, we emperically demonstrate that, while a commerical query optimizer is error-prone in predicting the execution time with harddisk as temporary storage, it can precisely estimate the execution time with flash SSD. In summary, we show that, when used as temporary storage for hash join, flash SSD will provide more reliable cost estimation as well as fast performance.

• Journal of Life Science
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• v.26 no.7
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• pp.812-818
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• 2016

The aim of this study was to investigate the anti-amnesic effect of Stachys sieboldii MIQ. according to the mixing ratio of calcium on scopolamine-induced learning and memory impairment, in vivo. At the end of the adaptation period, SD rats were divided into a normal group (N), a control group (C: scopolamine), a positive control group (PC: scopolamine + tacrine), and a sample group (S: scopolamine + Stachys sieboldii MIQ., 1CS: scopolamine + low calcium-mixed Stachys sieboldii MIQ., 5CS: scopolamine + high calcium-mixed Stachys sieboldii MIQ.), and were tested with learning and memory tests. The C and CS groups were found to have a decreased scopolamine-induced memory deficit in the Y-maze and water maze tests. Brain tissue analysis showed that the CS group decreased acetylcholinesterase (AChE) activity and increased acetylcholine (Ach) content, both of which are indicative of neuronal cell activity. From a light microscopy study, the nucleus of neurons in the hippocampus of the brain was more shrunken or condensed in the C group compared to the CS group. In the CS group, the damage to the neurons in the hippocampus of the brain was suppressed. These results suggest that Stachys sieboldii MIQ. according to the mixing ratio of calcium provides a significant anti-amnesic effect against scopolamine-induced cholinergic system deficits and cognitive impairment.