• Journal of the Semiconductor & Display Technology
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• v.23 no.1
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• pp.65-70
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• 2024

Direct cache-to-cache transfer has been studied to reduce the latency and bandwidth consumption related to the shared data in multiprocessor system. Even though these studies lead to meaningful results, they assume that caches consist of SRAM. For example, if the system employs the non-volatile memory, the one of the most important parts to consider is to decrease the number of write operations. This paper proposes a hybrid write avoidance cache coherence protocol that considers the hybrid cache architecture. A new state is added to finely control what is stored in the non-volatile memory area, and experimental results showed that the number of writes was reduced by about 36% compared to the existing schemes.

• Journal of Oriental Neuropsychiatry
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• v.19 no.3
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• pp.85-100
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• 2008

Objective: This experiment was designed to investigate the effect of the KSKH hot water extract & ultra-fine powder on microglia and memory deficit model. Method: The effects of the KSKH hot water extract on expression of IL-1$\beta$, IL-6, TNF-$\alpha$ mRNA and production of IL-1$\beta$, IL-6, TNF-$\alpha$ in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. The effects of the KSKH hot water extract & ultra-fine-fine powder on the behavior of the memory deficit mice induced by scopolamine and AChE in serum of the memory deficit mice induced by scopolamine were investigated. Results: 1. The KSKH hot water extract suppressed the expression of IL-1$\beta$, IL-6, TNF-$\alpha$ mRNA in BV2 microglial cell line treated by LPS. 2. The KSKH hot water extract suppressed the production of IL-1$\beta$, IL-6, TNF-$\alpha$ in 100$\mu g/m\ell$ concentration of BV2 microglial cell line culture supernatant. 3. The KSKH hot water extract & ultra-fine powder decreased AChE activation significantly in the serum of the memory deficit mice induced by scopolamine. 4. The KSKH hot water extract & ultra-fine powder showed significant effect on memory impairment in the stop-through latency type of Morris water maze test. Conclusions: This experiment shows that the KSKH hot water extract & ultra-fine powder might be effective for the prevention and treatment of amnesia and Alzheimer's disease. Investigation into the clinical use of the KSKH hot water extract & ultra-fine powder for amnesia and Alzheimer's disease is suggested for future research.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.2
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• pp.79-89
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• 2012

We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic system and pro-inflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses for 14 days of PA (100 and 200 mg/kg, i.p.) and BER (20 mg/kg, i.p.) 30 min before scopolamine injection (2 mg/kg, i.p.). Daily administration of PA and BER improved memory impairment as measured by the passive avoidance test and reduced the escape latency for finding the platform in the Morris water maze test. Administration of PA and BER significantly alleviated memory-associated decreases in cholinergic immunoreactivity and restored brain-derived neurotrophic factor and cAMP-response element-binding protein mRNA expression in the hippocampus. PA and BER also decreased significantly the expression of proinflammatory cytokines such as interleukin-$1{\beta}$, tumor necrosis factor-${\alpha}$ and cyclooxygenase-2 mRNA in the hippocampus. These results demonstrated that PA and BER had significant neuroprotective effects against neuronal impairment and memory dysfunction caused by scopolamine in rats. These results suggest that PA and BER may be useful as therapeutic agents for improving cognitive functioning by stimulating cholinergic enzyme activity and alleviating inflammatory responses.

• The KIPS Transactions:PartD
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• v.18D no.1
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• pp.1-8
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• 2011

The cache structure, which is designed for assuring fast accesses to frequently accessed data, resides on the various levels of computer system hierarchies. Many studies on this cache structure have been conducted and thus many page-replacement algorithms have been proposed. Most of page-replacement algorithms are designed on the basis of heuristic methods by using their own criteria such as how recently pages are accessed and how often they are accessed. This data-retrieval process in computer systems is analogous to human memory retrieval process since the retrieval process of human memory depends on frequency and recency of the retrieval events as well. A recent study regarding human memory cognition revealed that the possibility of the retrieval success and the retrieval latency have a strong correlation with the frequency and recency of the previous retrieval events. In this paper, we propose a novel page-replacement algorithm by utilizing the knowledge from the recent research regarding human memory cognition. Through a set of experiments, we demonstrated that our new method presents better hit-ratio than the LRFU algorithm which has been known as the best performing page-replacement algorithm for DBMS caches.

• Korean Journal of Pharmacognosy
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• v.51 no.1
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• pp.70-77
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• 2020

Mentha arvensis is used traditional medicine to treat various disorders. In the present study, M. arvensis were extracted by the solid-phase microextraction (SPME) method and analyzed by gas chromatograph-mass spectrometry (GC-MS). We investigated the protective effects and mechanisms of a M. arvensis extract on scopolamine-induced cognitive and memory impairment. Mice were orally pretreated with a M. arvensis extract or normal saline, and then behavior tests were conducted 30 min after scopolamine injection. The antioxidant capacities were analyzed by free radical scavenging (DPPH and ABTS). Acetylcholinesterase (AChE) activity were also measured using Ellman's method ex vivo test. In behavior tests, percent of spontaneous alteration, escape latency and swimming time in target quadrant were improved by the administration of the M. arvensis extract, which suggests that the M. arvensis extract improves memory function in the scopolamine-treated mice model. In addition, M. arvensis extract showed inhibition of the free radical and AChE activity. The results of the present study suggest that the M. arvensis extract ameliorates scopolamine-induced cognitive and memory deficits through the inhibition of free radicals and AChE activity. Therefore, M. arvensis may be a promising neuroprotective agent for management of learning and memory improvements in human dementia patients.

• IEMEK Journal of Embedded Systems and Applications
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• v.12 no.4
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• pp.193-204
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• 2017

Various 3D-stacked DRAMs have been proposed to overcome the memory wall problem. Hybrid Memory Cube (HMC) is a true 3D-stacked DRAM with stacked DRAM layers on top of a logic layer. The logic die is mainly used to implement a memory controller for HMC, and it is connected through a high speed serial link called SerDes with a host that is either a processor or another HMC. In HMC, the serial link is crucial for both performance and power consumption. Therefore, it is important that the link is configured properly so that the required performance should be satisfied while the power consumption is minimized. In this paper, we propose a HMC system model included the high speed serial link to estimate performance accurately. Since the link modeling strictly follows the link flow control mechanism defined in the HMC spec, the actual HMC performance can be estimated accurately with respect to each link configuration. Various simulations are conducted in order to deduce the correlation between the HMC performance and the link configuration with regard to memory utilization. It is confirmed that there is a strong correlation between the achievable maximum performance of HMC and the link configuration in terms of both bandwidth and latency. Therefore, it is possible to find the best link configuration when the required HMC performance is known in advance, and finding the best configuration will lead to significant power saving while the performance requirement is satisfied.

• Journal of Advanced Navigation Technology
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• v.14 no.5
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• pp.767-774
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• 2010

Due to advantages of NAND flash memory such as non-volatility, low access latency, low energy consumption, light weight, small size and shock resistance, it has become a better alternative over traditional magnetic disk drives, and has been widely used. Traditional DBMSs including mobile DBMSs may run on flash memory without any modification by using Flash Translation Layer (FTL), which emulates a random access block device to hide the characteristics of flash memory such as "erase-before-update". However, most existing FTLs are optimized for file systems, not for DBMSs, and traditional DBMSs are not aware of them. Also, traditional DBMSs do not consider the characteristics of flash memory. In this paper, we propose a flash-conscious storage system for DBMSs that utilizes flash memory as a main storage medium, and carefully put the characteristics of flash memory into considerations. The proposed flash-conscious storage system exploits log records to avoid costly update operations. It is shown that the proposed storage system outperforms the state.

• The Korea Journal of Herbology
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• v.35 no.5
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• pp.33-39
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• 2020

Objectives : Increasing evidence supports the biological and pharmacological activities of essential oils on the central nervous system such as pain, anxiety, attention, arousal, relaxation, sedation and learning and memory. The purpose of present work is to investigate the protective effect and molecular mechanism of cypress essential oil (CEO) against scopolamine (SCO)-induced cognitive impairments in C57BL/6 mice. Methods : A series of behavior tests such as Morris water maze, passive avoidance, and fear conditioning tests were conducted to monitor learning and memory functions. Immunoblotting and RT-PCR were also performed in the hippocampal tissue to determine the underlying mechanism of CEO. Results : SCO induced cognitive impairments as assessed by decreased step-through latency in passive avoidance test, relatively low freezing time in fear conditioning test, and increased time spent to find the hidden platform in Morris water maze test. Conversely, CEO inhalation significantly reversed the SCO-induced cognitive impairments in C57BL/6 mice comparable to control levels. To elucidate the molecular mechanisms of memory enhancing effect of CEO we have examined the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. CEO effectively elevated the protein as well as mRNA expression of BDNF via activation of cAMP response element binding protein (CREB). Conclusions : Our findings suggest that CEO inhalation effectively restored the SCO-impaired cognitive functions in C56BL/6 mice. This learning and memory enhancing effect of CEO was partly mediated by up-regulation of BDNF via activation of CREB.

• Archives of Pharmacal Research
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• v.23 no.4
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• pp.413-417
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• 2000

The effect of ischemia/reperfusion-induced neuronal damage on the memory impairment were investigated using active avoidance and Morris water maze tasks in Wistar rats. Focal ischemia was induced by 1 h occlusion of the right middle cerebral artery (MCA) of Wistar male rats. Reperfusion was induced by releasing the occlusion and restoring the blood circulation for 24 h. The acquisition and preservation memory tested by active avoidance showed a significant difference between the sham and ischemia/reperfusion group. The water maze acquisition performance was also significant difference between sham and ischemia/repefusion groups in both latency and moving distance. The infarction volume was increased by the ischemia/reperfusion. Furthermore, the cresyl violet staining of the ischemia/reperfusion brain showed severe neuronal damage (pyramidal cell loss) in the cortex in addition to the striatum lesion of brain. This study shows that pyramidal cell damage in the cortex lesion may be partially related to memorial disturbance in the ischemia/reperfusion brain injury.

• Journal of KIISE:Computer Systems and Theory
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• v.32 no.2
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• pp.85-94
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• 2005

It has been reported and verified in many design experiences that a judicious utilization of the page and burst access modes supported by DRAMs contributes a great reduction in not only the DRAM access latency but also DRAM's energy consumption. Recently, researchers showed that a careful arrangement of data variables in memory directly leads to a maximum utilization of the page and burst access modes for the variable accesses, but unfortunately, found that the problems are not tractable, consequently, resorting to simple (e.g., greedy) heuristic solutions to the problems. In this parer, to improve the quality of existing solutions, we propose 0-1 ILP-based techniques which produce optimal or near-optimal solution depending on the formulation parameters. It is shown that the proposed techniques use on average 32.2%, l5.1% and 3.5% more page accesses, and 84.0%, 113.5% and 10.1% more burst accesses compared to OFU (the order of first use) and the technique in [l, 2] and the technique in [3], respectively.