• Journal of Periodontal and Implant Science
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• v.26 no.1
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• pp.216-229
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• 1996

Interferon(IFN) is a sort of glycoproteins that are produced by activated lymphocyte, monocyte and fibroblast. IFN has anti-viral effects, immuno-defensive mechanism and regulating properties to the several kinds of cells that includes affect on the bone formation and resorption. The effect of IFN on the osteoclast & other tissue cells has been studied in a number of researchers with the limited reports on the osteoblast. The purpose of this study was to evaluate the effects of IFN on the osteoblastic function. The MC3T3/El cell(Mouse osteoblast) was incubated in ${\alpha}-minimum$ essential medium containing 10% FBS. To detect the cytotoxic effect of $IFN-{\gamma}$ on osteoblast, the cells were cultured in 96-well plate to which $IFN-{\gamma}$ of various concentrations were added for 2 days. After staining with trypan blue, total cells and living cells were counted under microscope. To determine the activity of alkaline phosphataset(ALP), various concentrations of $IFN-{\gamma}$ were treated to culture medium, and biochemical assay was performed. $IFN-{\gamma}$ and $IFN-{\gamma}$ plus cycloheximide were added to culture medium separately and then ALP activity were determined. To detect the effect of the $IFN-{\gamma}$ on the bone formation of osteoblast, long-term culture was performed, and calcified nodule formation were observed using von Kossa's staining. After the addition of $IFN-{\gamma}$ with various concentrations to the medium, no cytotoxic effect of $IFN-{\gamma}$ was detected at any concentration. The significant increase in ALP activity of osteoblast were found the concentration of $IFN-{\gamma}$ 500-2500U/ml and the culture time of 24-48 hours respectively. The enhancement of ALP activity by $IFN-{\gamma}$ of osteoblast was decreased significantly by the treatment of cycloheximide. After long-term culture of osteoblast, the nodule formation was found to be increased in number and density by the addition of 500 U/ml $IFN-{\gamma}$. These results suggest that $IFN-{\gamma}$ was affected on the bone formation of osteoblast. Forthemore this kind of study or $IFN-{\gamma}$ to osteoblast will be held continuously.

• The Journal of Information Technology
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• v.8 no.3
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• pp.159-176
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• 2005

The Purpose of this Article is to analyze the special settlement and electronic settlement system in the international trade. First, Factoring is a fast, easy and flexible way to improve a company's cash flow and generate working capital for the company. Factoring can be short-term or part of an ongoing financing program. New companies can benefit as well, since there is no requirement for a long-term credit history. Second, Forfaiting is a method of trade financing that allows exporters to obtain cash and be free of all risks by selling their medium term receivables on a 'without recourse' basis. Forfaiting can be an alternative to export credit or insurance cover, especially for those transactions in which the export credit agency is not open to a particular country and/or bank. Third, The Bolero System is jointly financed by SWIFT(Society for World International Financial Telecommunications) which handles most of the electronic funds transfer for banks, and the Through Transport Mutual Assurance Association(the TT Club), a mutual insurance association most of whose members are drawn from the Multimodal transport industry or transport intermediaries. Fourth, TradeCard is a payment and settlement system that is an alternative to letters of crdeit. That is, TradeCard is a business-to-business e-commerce infrastructure that enables buyers and sellers to conduct and settle international trade transactions securely over the Internet.

• Journal of the Korea Institute of Building Construction
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• v.17 no.2
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• pp.199-209
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• 2017

The measurement of business performance is important to secure the competitiveness of construction companies. Therefore, the purpose of this study is to analyze what is needed to increase the competitiveness of small & medium construction companies. In order to analyze efficiently, this study reconfirms the effectiveness of Key Performance Indicators(KPI) of construction companies selected from previous studies. The empirical analysis to find differences of KPI between small & medium construction companies and big construction companies is performed using the 4,286 construction company samples extracted by 'KIS-Value Data Base'. The results of the empirical analysis show that there are significant differences in characteristics of KPI between small & medium construction companies and big construction companies. Particularly, small & medium construction companies are relatively insufficient to invest for the purpose of preparation for future and long-term growth. Additionally, empirical tests reconfirm that most of the KPIs from previous survey studies are suitable as a performance indicators. The contribution of this study is to analyze empirically small & medium construction company's strong & weak points and the effectiveness of KPIs derived from previous studies.

• International Commerce and Information Review
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• v.16 no.3
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• pp.141-158
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• 2014

This research is intended to improve the performance of "small and medium companies international marketing program" by screening the performance indicators of the program. The program aims to prepare SMEs to penetrate foreign market and become global companies eventually. This research analyzed the current SMEs international marketing programs based on Logic Model to find the current performance measurement lacks in qualitative indicators and process evaluation with focusing on quantitative indicators and short term result evaluation. Therefore, the measurement indicators should be balanced between process and results including mid-term and long term results.

• Environmental and Resource Economics Review
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• v.13 no.3
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• pp.499-518
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• 2004

This study tests four hypotheses on management performance of environment-friendly firms. The hypotheses are that i) environment-friendly firms are lower management performance than general firms, ii) high cost environment-friendly firms are lower management performance than lower cost ones, small and medium environment-friendly firms lower management performance than large ones, and long-term environment-friendly firms higher management performance than short-term ones. The major findings are that the first hypothesis is not supported at the 5% significance level and the second one is also not supported at the 10% significance level. The third one is supported in terms of stability since large firms are more stable small and medium ones at the 5% significance level. The last one is not supported since short-term environment-friendly firms are more stable than long-term ones in the 10% significance level.

• Korean Journal of Community Nutrition
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• v.20 no.6
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• pp.468-478
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• 2015

Objectives: The objective of this study was to evaluate the thermic effects, the macronutrient oxidation rates and the satiety of medium-chain triglycerides (MCT). Methods: The thermic effects of two meals containing MCT or long-chain triglycerides (LCT) were compared in ten healthy men (mean age $24.4{\pm}2.9years$). Energy content of the meal was 30% of resting metabolic rate of each subject. Metabolic rate and macronutrient oxidation rate were measured before the meals and for 6 hours after the meals by indirect calorimetry. Satiety was estimated by using visual analogue scales (VAS) at 8 times (before the meal and for 6 hours after meal). Results: Total thermic effect of MCT meal (42.8 kcal, 8.0% of energy intake) was significantly higher than that (26.8 kcal, 5.1% of energy intake) of the LCT meal. Mean postprandial oxygen consumption was also significantly different between the two types of meals (MCT meal: $0.29{\pm}0.35L/min$, LCT meal: $0.28{\pm}0.27L/min$). There were no significant differences in total postprandial carbohydrate and fat oxidation rates between the two meals. However, from 30 to 120 minutes after consumption of meals, the fat oxidation rate of MCT meal was significantly higher than that of the LCT meal. Comparison of satiety values (hunger, fullness and appetite) between the two meals showed that MCT meal maintained satiety for a longer time than the LCT meal. Conclusions: This study showed the possibility that long-term substitution of MCT for LCT would produce weight loss if energy intake remained constant.

• Asia-Pacific Journal of Business
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• v.11 no.2
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• pp.173-188
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• 2020

Purpose - This study examines the determinants of offer price and short-term and long-term performance of small and medium-sized enterprise(SME) IPO stocks listed on the KOSDAQ during the period from July 2007 to December 2016. Design/methodology/approach - The SME IPO samples are classified into three categories of regular listing, technology-based special listing, and listing by merger with special purpose acquisition company(SPAC), whose results are compared each other and compared to the result for the KOSDAQ listing of large firms. Findings - From the point of SME management which attempts to list its company on the KOSDAQ, the listing by merger with SPAC is the most unfavorable, and the underpricing phenomenon of the technology-based special listing is severe in the second place. By contrast, IPO stock investors can earn the largest abnormal return by purchasing the SPAC which succeeds the merger with unlisted firm, and the next abnormal returns are obtained in the order of the IPO stocks of technology-based special listing, regular listing of SMEs, and regular listing of large firms. However, it is interesting to observe that the net buying ratio of individual investors is relatively large for the IPO stocks of regular listing of SMEs and large firms, which exhibit the long-term under-performance. Research implications or Originality - This result implies that the exceptional listing system such as the technology-based special listing or the listing by merger with SPAC cost the SMEs which bypass the complicated procedure of the regular listing.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.1
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• pp.19-26
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• 2020

Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT propofol is safe in the hyperlipidemic population for long-term use. Free fatty acids (FFAs) were used to establish high-fat stimulation of HepG2 and Huh7 cells. Subsequently, these cells were treated with propofol at the concentration of 0, 4, or 8 ㎍/ml for 24 and 48 h. The results indicated that the cell viability was notably decreased when the cells were stimulated with 2 mmol/L FFAs and treated with 12 ㎍/ml MCT/LCT propofol. Accordingly, we chose 2 mmol/L FFAs along with 4 and 8 ㎍/ml MCT/LCT propofol for the subsequent experiments. Four and 8 ㎍/ml MCT/LCT propofol inhibited FFA-induced lipid accumulation in the cells and significantly reversed acetyl coenzyme A carboxylase (ACC) activity. In addition, MCT/LCT propofol not only significantly promoted the phosphorylation of AMPK and ACC, but also reversed the FFA-induced decreased phosphorylation of AMPK and ACC. In conclusion, MCT/LCT propofol reverses the negative effects caused by FFAs in HepG2 and Huh7 cells, indicating that MCT/LCT propofol might positively regulate lipid metabolism.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.54.4-55
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• 2021

The Seoul National University AGN Monitoring Project (SAMP) is a welldesigned long-term AGN reverberation mapping project. SAMP focuses on the luminous AGNs out to z~0.5 with relative long time lags between AGN continuum and broad emission lines and aims to probe the high-end of the AGN broad line region (BLR) size-luminosity (R-L) relation. The pilot observations started in October 2015 for 100 AGNs to confirm the variability and the H and [O III] emission line strengths. Based on the initial variability test, 48 quasars has been continued spectroscopic monitoring since Feb. 2016 with Lick 3m and MDM 2.4m telescopes with a cadence of ~20 days. Supporting photometric monitoring in B and V band was conducted at multiple facilities including the MDM 1.3m, LOAO, and DOAO telescopes with a cadence of ~10 days. By the time of Feb. 2021, we have obtained five years spectroscopic and photometric data. More than 30 AGNs shows significant variability in five-year baseline and 16 of them show well detected lags between B-band and H. Here, we report some examples of SAMP light curves and lag detections using the first five-year data as well as the location of our 16 targets in the AGN BLR R-L relation. These measurements are consistent with the existing R-L relation and located at the high-end. With the coming data, SAMP are hopefully to report more AGNs with well detected lags. Our results demonstrate the general feasibility and potential of long-term reverberation project with medium cadence for luminous AGNs.

• The Journal of Asian Finance, Economics and Business
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• v.5 no.2
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• pp.5-14
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• 2018

This study is motivated based on concern from some renowned scholars and central bankers whom have raised the issue of the sustainability of the International Monetary System (IMS). Using the panel data set of four major international currencies, USD, JPY, EUR and GBP from 1973 to 2013 with Pooled Mean Group (PMG) estimator, to re-examine whether Triffin dilemma still exists through investigating the relationship between the reserve share, current account balance and real effective exchange rate. The evidence from the result indicates that Triffin dilemma exists only in the long run, and shows that in the long-run, current account balance is proportionate to the increased real effective exchange rate while varies inversely with the reserve shares. However, the estimation for the short-run is not significant to prove the existence of Triffin dilemma. In addition, we investigated the non-dollar panel sample and found that the international monetary system still suffers from Triffin dilemma even without the dollar. To overcome Triffin dilemma, immediate step such as having currency swap mechanism is recommended. In medium term, a multi-polar Monetary System is suggested, and in the longer time, a supranational currency will be used to replace all the currencies in the world.