• Korean Journal of Oriental Medicine
• /
• v.14 no.3
• /
• pp.173-182
• /
• 2008

"EuiBangShinGam" is a classic on oriental medicines written by Han Byung Lyun with the pen name Shin Oh in 1913. It was written under the base of the writer's own experience as well as in the light of 36 other classics on oriental medicines such as "DongEuiBoGam", Introduction to Medicine, and Complete Works of Jingyue. In an attempt to avoid difficult theories and list only the essential informations and formulas for clinical purposes, it attained its own characteristics of not only reorganizing DongEuiBoGam in a pragmatic way but also explaining diseases classified in western medicines in oriental medicines' point of view as well as suggesting medicine formulas regarding such explanations. As a result, it is a complete and efficient medical classic through which one can gain knowledge in both classic oriental medicines and combination of western and oriental medicines. Its special features are making a separate chapter for cholera and phthisis, which is also a contagious disease, and trying in the chapter to explain the disease s in words of oriental medicines; listing details of nine major epidemic and matching them with the diseases known in oriental medicines: and recording a case of enforcing sterilization and preventive injection against contagious diseases. Han Byung Lyun, the writ er of the book, was born in northern province of Ham Gyoung, Woong Bu, and the date of death is unknown. He is one of the eight members who conceived and started the idea of organizing the Organization of Practioners of Oriental Medicines, which was a nationwide organization under the motive of restoring Oriental Medicines against the policy under the colonial government of Japan. Living a era of Japanese Imperialism, he stressed the need to accept western medicines if its beneficial to oriental medicines in order to develop oriental medicines for progressive causes. This reflects that he was a person who tried in various ways to extend oriental medicines to another level by facing up to the reality and coming up with a measure to cope up with it. In fact, he was a oriental medicine doctor who tried to protect oriental medicines by founding academic organizations, publishing academic magazines, and writing himself many papers related to oriental medicines. EuiBangShinGam can he summarized as a classic on traditional korean medicine through which one can find out about realities of Japan Imperialism and the attempts of oriental medicine practitioners under the colonial policies of Japan to make oriental medicines more developed by adding one's own thoughts as well as keeping the old, and adjusting to such situations.

• Journal of Environmental Health Sciences
• /
• v.41 no.1
• /
• pp.30-39
• /
• 2015

Objectives: This study was conducted to determine the heavy metal contents in commercial herbal medicines in Korea. Methods: Monitoring of lead, arsenic, cadmium and mercury was carried out on 116 samples of eleven types of herbal medicines. Among the total samples, 71 samples were domestic and 45 were imported. The samples were digested using the microwave method. The heavy metal contents were measured by inductively coupled plasma atomic emission spectrometry (ICP-AES) and a mercury analyzer. ICP-AES was used to analyze lead, arsenic cadmium. Mercury was analyzed by the amalgamation method. Results: The mean values of the heavy metal contents in the herbal medicines were Pb 0.64mg/kg, As 0.26mg/kg, Cd 0.07mg/kg and Hg 0.004mg/kg. Of the total samples, one violated the MFDS (Ministry of Food and Drug Safety) regulatory guidance on heavy metals in herbal medicines. Lead was detected at more than 5mg/kg in one sample. The measured values of arsenic, cadmium and mercury in the herbal medicines showed levels lower than the recommended levels for herbal medicines in MFDS regulatory guidance. In the comparison of domestic samples with imported herbal medicines, it was found that one domestic sample surpassed the maximum residue limits for lead. Conclusion: These results will be used to establish the regulation and control of heavy metal contents in herbal medicines. In addition, continuous monitoring is needed to ensure confidence in and the safety of these herbal medicines.

• Journal of Preventive Medicine and Public Health
• /
• v.25 no.1 s.37
• /
• pp.64-72
• /
• 1992

To provide the information necessary for the insurance medicine management plan, price discount rates among the insurance medicines were studied. A total of 2,107 items of insurance medicine of which prices were discounted via governmental inspections of real transactional process of insurance medicine were analysed. The conclusions are as follows; 1. Among the variables relevant to the characteristics of manufacturers, price discount rates of insurance medicines were statistically significant with production rankings of manufacturers, incorporation year, existence of investments by foreign corporation, existence of a research institute, and enrollment in the exchange. And among the variables relevant to the properties of medicines, the number of enrolled items which have the same components, classification, the date of new enrollment, the sales of items, and the number of raw materials in the items were statistically significant. 2. Stepwise multiple regression was done to identify the factors which affect the price discount rates of insurance medicines. The number of enrolled items which have the same components, production rankings of manufactures, classification number (medicines for function of tissue cells), incorporation year(1940-1949), existence of investments by foreign corporations, classification number (anti-germ medicines), number of raw materials In the items, the sales of items, and medicines whose major objective is not treatment were significant variables and the $R^2$-value for these variables was 21.2%. Considering all of the above results, for management of insurance medicines, it seems important that the real transactional prices of insurance medicines should be identified systematically, focusing on the properties which affect the price discount rates of insurance medicines.

• Journal of Ginseng Research
• /
• v.44 no.3
• /
• pp.442-452
• /
• 2020

Backgroud: Sleep deprivation (SD) impairs learning and memory by inhibiting hippocampal functioning at molecular and cellular levels. Abnormal autophagy and apoptosis are closely associated with neurodegeneration in the central nervous system. This study is aimed to explore the alleviative effect and the underlying molecular mechanism of stem-leaf saponins of Panax notoginseng (SLSP) on the abnormal neuronal autophagy and apoptosis in hippocampus of mice with impaired learning and memory induced by SD. Methods: Mouse spatial learning and memory were assessed by Morris water maze test. Neuronal morphological changes were observed by Nissl staining. Autophagosome formation was examined by transmission electron microscopy, immunofluorescent staining, acridine orange staining, and transient transfection of the tf-LC3 plasmid. Apoptotic event was analyzed by flow cytometry after PI/annexin V staining. The expression or activation of autophagy and apoptosis-related proteins were detected by Western blotting assay. Results: SLSP was shown to improve the spatial learning and memory of mice after SD for 48 h, accomanied with restrained excessive autophage and apoptosis, whereas enhanced activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in hippocampal neurons. Meanwhile, it improved the aberrant autophagy and apoptosis induced by rapamycin and re-activated phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling transduction in HT-22 cells, a hippocampal neuronal cell line. Conclusion: SLSP could alleviate cognitive impairment induced by SD, which was achieved probably through suppressing the abnormal autophagy and apoptosis of hippocampal neurons. The findings may contribute to the clinical application of SLSP in the prevention or therapy of neurological disorders associated with SD.

• Journal of Oriental Neuropsychiatry
• /
• v.23 no.3
• /
• pp.161-174
• /
• 2012

Objectives : The purpose of this study is to study as reference for practical application in clinics, examine the procedure of historical changes and compare components and their doses of herb medicines, which are recorded in the chapter, Sinmun Jeonkwang of "Donguibogam". Methods : I examined 19 Herb Medicines (Ed note: no need to capitalize the 'h' and 'm') in Chapter Sinmun Jeonkwang of "Donguibogam". Fourteen books, which were noted in Chapter Sinmun Jeonkwang of "Donguibogam" and 16 books in Jeonkwang part of "The Eastern Medical Textbook of neuropsychiatry" and 25 books were mentioned in same part of "Uibujeonrok", were selected as reference. Results and Conclusions : Fourteen documents were referred to the 19 Herb Medicines in Chapter Sinmun Jeonkwang of "Donguibogam". Seventeen Herb Medicines were recorded in the source book but 2 Herb Medicines were not recorded. Fourteen Herb Medicines among 19 were recorded in the source book, which were directly quoted from the firstly appeared books, and 3 Herb Medicines were re-quoted from the other books that succeeded the source books. I suspect that the components and dosages of the Herb Medicines were revised, according to the author's clinical experience and circumstances.

• Journal of Oriental Neuropsychiatry
• /
• v.23 no.3
• /
• pp.175-190
• /
• 2012

Objectives : The purpose of this study is To to study as reference (Ed note: 'study as reference' is awkward and unclear) for practical application in clinics, examine the procedure of historical changes and compare components and their doses of herbal medicines, which are recorded in Chapter Sinmun Jeongan of "Donguibogam". Methods : I examined 23 Herb Medicines in Chapter Sinmun Jeongan of "Donguibogam". Fourteen books, which were noted in Chapter Sinmun Jeongan of "Donguibogam" and 14 books were mentioned in the same part of "Uibujeonrok", which were selected as reference. Results and Conclusions : Fourteen documents were referred to as the 23 Herb Medicines in Chapter Sinmun Jeongan of "Donguibogam". A total of 21 Herb Medicines were recorded in the source book, but 2 Herb Medicines were not recorded. Eleven Herb Medicines among 21 were recorded in the source book, which were directly quoted from the firstly appeared books and 10 Herb Medicines were re-quoted from other books that succeeded the source books. I suspect that the components and dosages of the Herb Medicines were revised, according to the author's clinical experience and circumstances.

• Advances in Traditional Medicine
• /
• v.1 no.1
• /
• pp.1-7
• /
• 2000

Although Oriental medicines have long been used effectively in treating many diseases throughout the world, the pharmacological mechanisms of most Oriental medicines used have not been defined. As part of our continuing search for biologically active antiallergic drugs from natural sources, Oriental medicines were analyzed. Some Oriental medicines have been used against various allergic diseases for generations, and still occupies an important place in traditional medicine in Korea. It is also still unclear how Oriental medicine prevents allergic disease in experimental animal models. Some Korean folk medicines inhibited the mast cell-mediated allergic reaction. This review summarizes the effective folk medicine in experimental effect of allergic reaction. Potential antiallergic folk medicines include: Poncirus trifoliata; Siegesbeckia glabrescence; Solanum lyratum; Aquilaria agallocha; Ulmi radicis; Polygonum tinctorium; Hwanglyun-Haedok-Tang; Rehmannia glutinosa; Kum- Hwag-San; Syzygium aromaticm; Spirulina platensis; Sosiho-Tang; Sinomenium acutum; Schizonepta tenuifolia; Shini-San; Magnoliae flos; Sochungryoung-Tang; Oryza sativa; Cryptotympana atrata; Salviae radix; Rosa davurica; Asiasari radix; Chung-Dae-San; and Cichorium intybus. Understanding the mechanisms of action for these Oriental medicines can permit drug development and laying of the ground-work for evaluating potential synergistic effects by addition and subtraction of prescriptions.

• The Journal of Korean Medical History
• /
• v.28 no.1
• /
• pp.81-92
• /
• 2015

Objectives : The purpose of this study is to analyze and identify the problems of current laws and regulations regarding preparation and processing of herbal medicines at hospitals of Korean Medicine. Possible solutions are proposed in the end Methods : Based on the status of hospitals of Korean Medicine and characteristics of Korean Medicine and Korean Medicine industry, I analyze the laws and regulations in regards to preparation and processing of herbal medicines and propose possible solutions. Results : Regulations for the agents, places, and cautions in respect of preparation and processing of herbal medicines are inadequate. Meanwhile, the definition of drug preparation in the Pharmaceutical Affairs Act does not apply to processing and preparation of herbal Medicines at hospitals of Korean Medicine, since herbal medicines accompanies chemical and physical change. Discussions & Conclusions : New regulations for on-site preparation at hospitals of Korean Medicine are necessary. Also, the definition for herbal medicines preparation, which states possible chemical and physical changes of herbal medicines, should be specified in Pharmaceutical Affairs Act.

• Korean Journal of Clinical Pharmacy
• /
• v.16 no.2
• /
• pp.107-112
• /
• 2006

This study was aimed to investigate the current status and expectations of orphan drugs in Korea. The Korea Orphan Drug Center was established to supply many medicines for the patients with rare diseases. Among the medicines supplied by the Center, the number designated as the orphan drugs by the KFDA is quite few. However, a few of medicines are not under circulation even if the items are designated as the orphan drugs. Neoplasm-related medicines, infectious and parasitic disease-related medicines, endocrine, nutritional and metabolic disease-related medicines are the ones circulated most. There are several unapproved drugs among the medicines supplied by the Center. It's because the director of the Center can import the goods without a process to getting an approval from the KFDA. The Korea Orphan Drug Center has contributed to the selection of the medicines for treating the rare disease. On the contrary, some problems remain in the supply process. The safety and effectiveness of the medicines supplied by the Center are not guaranteed. So far, rare diseases have no specific legal definition, and therefore are only referred to in terms of the population of patients, which prevent from establishing the range of medicines. The introduction of Special Access Program or Access to Unapproved Therapeutic Goods will be the solution of these problems. In addition, it is another solution to keep intimate relations with the Rare and Intractable Disease Center and the Medicine Safety Information Center which will be open soon.

• Herbal Formula Science
• /
• v.21 no.2
• /
• pp.1-12
• /
• 2013

Objectives : Systematize concept of 'Saengsukron(生熟論)', providing theoretical basis for clinical and research purpose. Methods : Herbal medicines listed in 'Tangaekpyeon of Dongeuibogam' were studied in the following order ; (i) Search for herbal medicines that has applied heat. (ii) Choose herbal medicine with reference of change before and after heating. And choose herbal medicine with reference on purpose of heating. (iii) Classify herbal medicines with similar patterns. (iv) Catagorize herbal medicine by its effects, side effects, nature of herbal medicines, tastes of herbal medicines, meridian tropism of the herbal medicines, and others(color of herbal medicines, formation of herbal medicines, storage of herbal medicines) (v) Systematize concept of 'Saengsukron'. Results : We were able to obtain systematized concept of 'Saengsukron(生熟論)'. They are classified by 'Saengsasukbo(生瀉熟補)', 'Saenghwalsukji(生活熟止)', 'Saengmusukyu(生無熟有)', 'Sukjeukhyojeung(熟則效增)', 'Sukjeukhyogam(熟則效減)', 'Sukjeukyudok(熟則有毒)', 'Saengdoksukgam(生毒熟減)', 'Saengjunsukwan(生峻熟緩)', 'Saengchangsukso(生脹熟消)', 'Sukjeukwiseong(熟則爲升)', 'Sukjeukwigang(熟則爲降)', 'Sukjeukwion(熟則爲溫)', 'Sukjeukwiryang(熟則爲凉)', 'Saengjosukgam(生燥熟減)', 'Sukjeukbyeonmi(熟則變味)', 'Sukjeukbyeonchwi(熟則變臭)', 'Sukjeukbui(熟則部異)', 'Sukjeukjongsa(熟則從邪)', 'Sukjeukbyeonsaek(熟則變色)', 'Sukjeukbyeonhyeng(熟則變形)' and 'Sukjeukbojang(熟則保長)'. Conclusions : In this study, heat processing of herbal medicines confirmed that certain regular changes occur. Based on this, concept of 'Saengsukron' could be systematized. Research on 'Saengsukron' will help practitioners and researchers.