• Journal of Korean Medical Science
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• v.33 no.43
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• pp.282.1-282.6
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• 2018

Lung transplantation is the only treatment for end-stage lung disease, but the problem of donor shortage is unresolved issue. Herein, we report the first case of living-donor lobar lung transplantation (LDLLT) in Korea. A 19-year-old woman patient with idiopathic pulmonary artery hypertension received her father's right lower lobe and her mother's left lower lobe after pneumonectomy of both lungs in 2017. The patient has recovered well and is enjoying normal social activity. We think that LDLLT could be an alternative approach to deceased donor lung transplantation to overcome the shortage of lung donors.

• Journal of Arbitration Studies
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• v.28 no.4
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• pp.43-59
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• 2018

This study aims to review various efforts required by medical institutions to prevent medical accidents in advance and to suggest the necessity of introducing liability insurance for medical accidents based on cases abroad and compulsory professional indemnity insurance at home. Over the past five years between 2013 and 2017, the number of inquiries regarding medical accidents and medical disputes has increased by 11.1 percent from 36,099 to 54,929, and the number of mediation and arbitration for medical disputes has increased by 14.3 percent from 1,304 to 2,225. Since some medical accidents even cause social problems, a compulsory insurance system for the liability of medical institutions for damages need to be introduced to promptly compensate the victims of medical accidents and to ensure compensation by medical personnel. In Korea, a system is in place to provide compensation for a client who suffers an accidental damage after receiving professional services, regardless of whether or not the professional service provider can provide compensation. In major foreign countries, a medical liability system is in place that is applied either by the principle of liability with fault, or the principle of liability without fault. In this study, the cases of compulsory insurance and semi-compulsory insurance in the US and Japan to which the principle of liability with fault is applied, as well as the case of New Zealand to which the principle of liability without fault is applied, were examined. It is necessary to urgently introduce the compulsory insurance system for the liability of compensation to prevent medical disputes and to compensate for the life and physical damages of the victims of medical accidents in domestic medical institutions. Doing so is expected to ensure fair compensation for the victims of medical malpractice and compensation by medical personnel, thereby improving medical practice.

• Journal of The Korea Institute of Healthcare Architecture
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• v.28 no.1
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• pp.7-21
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• 2022

Purpose: As the pandemic period continues, various attempts are being made to new medical spaces in the medical society. Many hospitals, including existing general hospitals, have been effected by infected patients and are showing limitations in patient care capacity. Mobile-hospitals may be the starting point for the development of new environment in the medical society and healthcare facilities which are not replacing the role of existing hospitals. Mobile-hospitals can possibly respond to situations that require medical services and provide emergency care for various demands in connection with existing healthcare facilities. Methods: Through a total of five investigations/analysis, medical functions that can be inserted into mobile-hospitals based on modular architecture are set. The first is the analysis of domestic legal guidelines, the second is the analysis of previous studies, the analysis of emergency medical facilities and other medical spaces of hospitals to be compared, the fourth is the analysis of medical spaces of actual mobile hospital projects. Results: Through five analyses, medical functions applicable to the modular building platform were finally established. Mobile hospitals can be used not only in disaster sites such as infectious diseases, but also in medical underprivileged areas or general hospitals. Therefore, it is necessary to establish medical functions that meet the specificity of mobile hospitals along with the functions of existing fixed medical facilities. Furthermore, various studies such as use in international aid, use in normal times, and connection with other platform-based medical facilities are considered necessary. Implications: Through 5 strategies of analysis, 41 medical functions which can be applied to UNIT are decided and these functions will be placed where medical services will be required.

• The Journal of Korean Medical History
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• v.36 no.1
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• pp.23-30
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• 2023

Objective : The role of female medical personnel in traditional East Asian societies was limited. It might be said that there are no known female medical practitioners in the history of East Asian medicine. However, in the case of Joseon, there was a system for female medical personnel, Euinyeo(醫女). After the late 19th century, women's social activities in Joseon were expanded by Christian missionaries who entered Joseon In somehow, and efforts to train female medical personnel were also growing. The authors are trying to get the actual operation aspect of Gyeongseong Women's Medical College, established in 1938 after ten years of effort from establishing the Gyeongseong Women's medical school in 1928. Methods : Through the 『Gyeongseong Women's Medical College Catalog(京城女子醫學專門學校一覽)』 in 1941, owned by the Handok Museum, the authors researched the operation aspects of Gyeongseong Women's Medical College from the application for establishment in 1937 and the opening of the school in 1938 to 1941 when the College Catalog was published. Results & Conclusion : In the early 20th century, when various medical institutions were appearing in Joseon, it could be said that the role of Gyeongseong Women's Medical College is noteworthy with the fact that a specialized medical college for women has been established and operated to train female medical personnel separately.

• Journal of Society of Preventive Korean Medicine
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• v.22 no.2
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• pp.13-24
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• 2018

Objectives : According to the data from the 2016 Yearbook of Traditional Korean Medicine, 10 out of 12 medical schools of Korean medicine are offering medical ethics. Medical ethics has become essential in Korean medicine education, but there has been no agreement on the content of education yet, so initial discussions are necessary with respect to the content and methods of education. Methods : In this study, basic data were collected by searching papers, reports, books, and media articles on medical ethics related to Korean medicine education, and by studying the website of medical schools of Korean medicine nationwide. Based on the collected data, the status of medical ethics lectures were determined and compared with the current state of medical ethics lectures by western medical schools. The contents suitable for medical ethics education at medical schools of Korean medicine were discussed. Results : The topics of the medical ethics include: the basic concepts of medical ethics, the ethics of birth, the ethics associated with genetics, the ethics associated with death, and the ethics regarding doctor-patient interaction, the ethics of medical research, medical rationing ethics, ethics between medical staffs, medical law and ethics, philosophical base of medical ethics, ethics of doctor as professional, and moral personality formation of doctor. The contents of medical ethics in traditional Korean medicine reflected views on the human body and life based on "Huangdi's Internal Classic"and medical ethics from the viewpoints of Buddhism and Confucianism. Conclusions : Medical schools of Korean medicine are medical training institutions, and medical ethics education is essential to become a Korean medicine doctor as professional worker, medical practitioner, and biomedical researcher. There is no fundamental difference in the basic principles of medical ethics in both western and Korean medicine, and there are differences in contents depending on the clinical practice. The contents of medical ethics on clinical practice should be modified for Korean medicine doctors, and traditional Korean medicine ethics would be set up upon that. In the national licensing examination, medical ethics needs to be added as one part so that all the ethical problems related to the clinical situation can be solved.

• Journal of Society of Preventive Korean Medicine
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• v.21 no.2
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• pp.45-53
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• 2017

Background and Aim : Lately the age of competition has come among the medical service area. At the same time disputes over the medical practice related to the medical person's territory tend to increase. In part it is due to the increased medical persons but in part it is because the medical practice is not defined clearly in the Medical Service Act for the practice of each medical person. So the legal definition of medical practice will be discussed here. Materials and Method : The cases from the court have been confirmed the difference between the two medical persons regarding the actual events. Legal aspects of medical practice in Korean medicine and the related cases will be reviewed and analysed. Results : The form of medical practice consists of administrating Korean medicine treatment and providing guidance for health based on Korean medicine. For medical doctors the practice includes medical treatment and guidance for health. Circular definition in the Medical Service Act over the medical practice, medical person and medical instruments makes it difficult to understand the whole idea. Therefore, the court has a tendency to decide the medical practice of medical doctor of Korean medicine from the some reliable points which is: 1) it is based on the principle of traditional Korean Medicine, 2) it is practiced by the medical doctor of Korean Medicine, 3) it can do harm to the patient without proper involvement of the medical doctor of Korean Medicine. Now the Act on the promotion of Korean Medicine and Pharmaceuticals makes it include the concept of "scientifically applied and developed" medical practice of Korean Medicine. Conclusions : With the essential change in the Act on the promotion of Korean Medicine and Pharmaceuticals, it is expected that even slight change can be seen in the court cases. However, still the concept of medical practice in the Medical Service Act remains the same. Modernisation of Korean Medicine, enhancement of textbooks and clinical practice training and the effort to amend the law to clearly define the medical practice of Korean Medicine will contribute to the clinical and academic environment. Evidence based Korean Medicine and even the unification of east-west medicine could be considered for the situation.

• Journal of the Korean Society for information Management
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• v.38 no.3
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• pp.239-262
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• 2021

The Korean Medical Journal (1930-1937) is the first Korean medical journal published by The Korean Medical Association, which Korean doctors established to resist Japanese medical organizations during the Japanese colonial period. Using the bibliometric research method for The Korean Medical Journal, this study aimed to analyze the journal as follows. First, the study analyzed the subject trends of medical research by extracting the MeSH terms from the title of the articles. Next, the study identified characteristics of authors, type of language used in the papers, publication year and countries of references included in the papers. Also, this study identified the researchers' interests by analyzing the frequency of keywords appearing in the roundtable titles. As a result of the research, infections, pathological symptoms and diseases of the digestive system were studied most often. Most authors belonged to Severance Union Medical College, and internal medicine and general surgery departments had the most authors. Most of the titles and texts of the papers were written in Korean and Chinese characters in combination. Of the 131 papers, only 40 contained abstracts, 22 of which were English abstracts, the most number. The study analyzed 1,103 references in the papers and found that the authors mainly cited the latest journals published in Japan, Germany, and the United States. The topics discussed the most in the roundtable talks were tuberculosis, neurasthenia, and gonorrhea in order. This research examined the history of the publication of The Korean medical journal. Also, it showed that Korean doctors accumulated their academic medical research results and contributed to improving medical conditions.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2557-2561
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• 2013

Background: Chemoradiation (CRT) using cisplatin-based regimens has become the standard of care in the treatment of squamous cell head and neck cancers (SCHNC). The impact of taxanes as radiosensitizing agents with concurrent CRT regimens is unknown. We therefore retrospectively evaluated the efficacy and tolerability of a weekly cisplatin+docetaxel combination with CRT in locally advanced SCHNC. Methods: Sixty-six patients with locally advanced SCHNC (39.4% stage IV, 53% stage III, and 7.6% stage II) were assessed retrospectively. Total radiation dose to the PTV of gross disease (primary and/or node) was 70 Gy/35 fractions, 5 fractions per week. Minimum doses of 60 Gy and 50 Gy were administered to PTVs of elective high risk and low risk disease, respectively. Chemotherapy (CT) consisted of weekly cisplatin (20 $mg/m^2$)+docetaxel (20 $mg/m^2$) concurrently with RT. Results: The median age of the patients was 58 years (range, 32-77). Objective response rate was 83.3%. The 2-year progression-free survival (PFS) and overall survival (OS) were 75.7% and 78.3%, respectively. The most common grade 3 and 4 toxicities were mucositis (36.4%), nausea and vomiting (12.1%), neutropenia (4.5%). Conclusion: Weekly cisplatin and docetaxel concurrent with RT for locally advanced SCHNC was found tolerable with high efficacy.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6581-6586
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• 2014

Background: The istone deacetylase (HDAC) inhibitor trichostatin A (TSA) is known to mediate the regulation of gene expression and antiproliferation activity in cancer cells. Kr$\ddot{u}$ppel-like factor 4 (klf4) is a zinc finger-containing transcription factor of the SP/KLF family, that is expressed in a variety of tissues and regulates cell proliferation, differentiation, tumorigenesis, and apoptosis. It may either either function as a tumor suppressor or an oncogene depending on genetic context of tumors. Aims: In this study, we tested the possibility that TSA may increase klf4 expression and cancer cell growth inhibition and apoptosis in SKOV-3 and A549 cells. Materials and Methods: The cytotoxicity of TSA was determined using the MTT assay test, while klf4 gene expression was assessed by real time PCR andto ability of TSA to induce apoptosis using a Vybrant Apoptosis Assay kit. Results: Our results showed that TSA exerted dose and time dependent cytotoxicity effect on SKOV-3 and A549 cells. Moreover TSA up-regulated klf4 expression. Flow cytometric analysis demonstrated that apoptosis was increased after TSA treatment. Conclusions: Taken together, this study showed that TSA increased klf4 expression in SKOV3 and A549 cell lines, consequently, klf4 may played a tumor-suppressor role by increasing both cell growth inhibition and apoptosis. This study sheds light on the details of molecular mechanisms of HDACI-induced cell cycle arrest and apoptosis.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4255-4259
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• 2014

Lactobacilli are probiotics shown to have antitumor activities. In addition, they can regulate gene expression through epigenetic mechanisms. In this study, we aimed to assess anti tumor activities of Lactobacillus acidophilus and Lactobacillus crispatus on the MDA-MB-231 breast cancer cell line. The effects of culture supernatants were determined by MTT [3-(4,5-dimethylthiazol-2-y-2,5-diphenyltetrazolium bromide] assay. Changes in expression of 5 cancer-testis antigens (CTAs), namely AKAP4, ODF4, PIWIL2, RHOXF2 and TSGA10, were analyzed by quantitative real time RT-PCR. The culture supernatants of the 2 lactobacilli inhibited MDA-MB-231 cell proliferation. In addition, transcriptional activity of all mentioned CTAs except AKAP4 was significantly decreased after 24 hour treatment with culture supernatants. This study shows that Lactobacillus acidophilus and Lactobacillus crispatus have antiproliferative activity against MDA-MB-231 cells. In addition, these lactobacilli could decrease transcriptional activity of 4 CTAs. Previous studies have shown that expression of CTAs is epigenetically regulated, so it is possible that lactobacilli cause this expression downregulation through epigenetic mechanisms. As expression of CTAs in cancers is usually associated with higher grades and poor prognosis, downregulation of their expression by lactobacilli may have clinical implications.