• 대한한의학원전학회지
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• 제24권2호
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• pp.101-107
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• 2011

The Korean Medical Classics[KMC] which established in Sepember 20th, 1983. is a major society in Medical Classics. KMC has studied on classics and related branches such as "Neijing", "Nanjing", "Shanghanlun", "Jinkuiyaolue", "Dongeuibogam", "Dongeuisusebowon", etc. through The Journal of Korean Medical Classics[JKMC] that KMC published. This article is written on 727 articles of JKMC from 1983 to early 2010 and focused on tendency of studies on medical classics in KMC and JKMC.

• BMB Reports
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• 제45권11호
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• pp.641-646
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• 2012

It has been reported that ubiquitin-conjugating enzyme 9 (Ubc9), the unique enzyme2 in the sumoylation pathway, is up-regulated in many cancers. However, the expression and regulation of UBC9 in glioma remains unknown. In this study, we found that Ubc9 was up-regulated in glioma tissues and cell lines compared to a normal control. UBC9 knockdown by small interfering RNA (siRNA) affected cell proliferation and apoptosis in T98G cells. Further experiments revealed that microRNA (miR)-214 directly targeted the 3' untranslated region (UTR) of UBC9 and that there was an inverse relationship between the expression levels of miR-214 and UBC9 protein in glioma tissues and cells. miR-214 overexpression suppressed the endogenous UBC9 protein and affected T98G cell proliferation. These findings suggest that miR-214 reduction facilitates UBC9 expression and is involved in the regulation of glioma cell proliferation.

• 보험의학회지
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• 제18권
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• pp.81-96
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• 1999

• 보험의학회지
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• 제18권
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• pp.103-106
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• 1999

• Korean journal of medical education
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• 제30권4호
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• pp.279-281
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• 2018

• Korean journal of medical education
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• 제30권4호
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• pp.365-368
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• 2018

• BMB Reports
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• 제42권6호
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• pp.361-366
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• 2009

It was reported that high doses of sodium selenite can induce apoptosis of cancer cells, but the molecular mechanisms are poorly understood. Manganese superoxide dismutase (MnSOD) converts superoxide radical to hydrogen peroxide within the mitochondrial matrix and is one of the most important antioxidant enzymes. In this study, we showed that 20 ${\mu}M$ sodium selenite could alter subcellular distribution of MnSOD, namely a decrease in mitochondria and an increase in cytosol. The alteration of subcellular distribution of MnSOD is dependent on the production of superoxide induced by sodium selenite.

• 대한한의학원전학회지
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• 제29권1호
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• pp.55-63
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• 2016

Objectives : Doctors are obviously one of the most interesting subject in medical history. Doctors are who treat patients and disease and the authors for medical records or books. Especially doctors in traditional medicine mostly tried to write medical books for new idea or their esperiences or leave their medical records for treatments, medication, prescription and so on. Therefore, many researchers have explained Korean or Chinese medical history of traditional society through those books or documents rather than doctors themselves. The Annals of the Joseon Dynasty has massive records for history, politics, society, culture, etc. Relating to medical history in traditional Korean medicine, there are ceveral researches about disease of King, disease itself, the methods of treatment and so on, through The Annals of the Joseon Dynasty. However, there are few on activities of many doctors in The Annals of the Joseon Dynasty. Methods : I tried to find out the names who had some roles of medicine in The Annals of King Sejong out of The Annals of the Joseon Dynasty. I could get 35 doctors and browsed 35 doctors in The Annals of the Joseon Dynasty again. Finally, I could have lots of articles from The Annals of the Joseon Dynasty related to 33 doctors(2 dontors had no records about medicine even they were doctors). Results : I categorized 2 ways of those articles; medical activities, non-medical activities. For medical activities, I got subcategories for medical activities; medical maltreatment, treatment for King, royal family, bureaucrat, ambassador. I also got subcategories for non-medical activities; publishing medical books, ambassador as a doctor, medical training, things related to hot spring, food therapist, veterinarian. Conclusions : Medical history of Joseon Dynasty in Korean medical history has somehow been recorded by medical books such as Hyangyakjipseongbang, Euibangyuchwi, Euilimchwalyo, Dongeuibogam, Jejungsinpyeon, Dongeuisusebowon, etc. So I have concerned that there are massive records on doctors activities in The Annals of the Joseon Dynasty and tried to focus on their various activities through this research.

• 대한한의학원전학회지
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• 제25권2호
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• pp.95-105
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• 2012

Objective : This study was conducted to examine the scope and learning objective of Medical classics in the field of the education of Korean Medicine. Method : This study was analyzed and figured out list of classes which was taken by department of medical classics in eleven College of Korean Medicine and one school of Korean Medicine. Results & Conclusions : 1. Now, 14 subjects out of 16 subjects which were taken by whole department of medical classics in Korea can be a proper area of education of medical classics. Now, Hwangjenaekyung and Nangyeong are the only aim of the lessons at the medical classics. Therefore, we present to modify the aims inclusively. 2. The subject of the class have to change as follows. 'Wonjeon' changes into 'Hwangjenaekyung', 'Medical Chinese character' changes into 'Korean medical chinese character', 'medical informatics' changes into 'korean medical informatics'. 3. As we consider the condition that 'Nangyeong' is educating in just four departments of medical classics, we have to discuss about the stature of Nangyeong and to extend education of Nangyeong. 4. In the department of medical classics, we can improve the level of understanding and reading skills by educating the class of 'Sanghanron' and 'Donguibogam'. 5. This study is actively involved in trying to include 'Korean Medical Informatics' and 'Korean medical terminology ' in the education field of the medical classics.

• Journal of Microbiology and Biotechnology
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• 제25권6호
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• pp.936-940
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• 2015

Human papillomavirus (HPV) type 52 is a high-risk HPV responsible for cervical cancer. HPV type 52 is common around the world and is the most common in some Asian regions. The available prophylactic HPV vaccines protect only from HPV types 16 and 18. Supplementing economical vaccines that target HPV type 52 may satisfactorily complement available prophylactic vaccines. A codon-adapted HPV 52 L1 gene was expressed in the methylotrophic yeast Hansenula polymorpha, which is used as an industrial platform for economical hepatitis B surface antigen particle production in China. We found that the recombinant proteins produced in this expression system could form virus-like particles (VLPs) with diameters of approximately 50 nm. This study suggests that the HPV 52 VLPs produced in this platform may satisfactorily complement available prophylactic vaccines in fighting against HPVs prevalent in Asia.