• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2987-2990
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• 2013

Background: To explore mRNA expression and clinical significance of ERCC1, BRCA1, RRM1, TYMS and TUBB3 genes in tumor tissue of postoperative patients with non-small cell lung cancer (NSCLC). Materials and Methods: Sixty NSCLC patients undergoing radical operation in our hospital from Nov., 2011 to Jun., 2012 were selected. Plasmid standards of ERCC1, BRCA1, RRM1, TYMS and TUBB3 were established and standard curves were prepared by SYBR fluorescent real-time quantitative PCR analysis. Samples from tumor centers were taken to detect mRNA expression of ERCC1, BRCA1, RRM1, TYMS and TUBB3 genes in cancerous tissue during operation. The total mRNA expression quantities were compared according to different clinical characteristics. Results: The total expression quantities of 5 genotypes from high to low were ERCC1>RRM1>TUBB3>TYMS>BRCA1 in turn. By pairwise comparisons, other differences showed statistical significance (p<0.05 or p<0.01) except for TYMS and TUBB3 (p>0.05); the low expression rates from high to low were ERCC1>TYMS>TUBB3>TUBB3>RRM1>BRCA1 in turn. The expression quantities of BRCA1, RRM1 and TYMS in males, smokers and patients without adenocarcinoma were all significantly higher than that in females, non-smokers and patients with adenocarcinoma, and significant differences were present (p<0.05 or p<0.01). In terms of pathological staging, the expression quantities of BRCA1, RRM1 and TYMS in phases IIa~IIb and IIIa~IIIb had a tendency to be greater than in phases I and IV. Conclusions: Resistance to chemotherapy and sensitivity to targeted therapy differ among patients with NSCLC. Differences in gene expression in different individuals were also revealed. Only according to personalized detection results can individualized therapeutic regimens be worked out, which is a new direction for oncotherapy.

• Journal of Korean Medical classics
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• 제33권3호
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• pp.21-36
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• 2020

Objectives : This paper aims to understand the meaning of '少陰人 心之範圍' and to determine its clinical implication. Methods : First, the meaning of the verb '範圍' was examined in 『IChing·XiCi(周易·繫辭傳)』 from where it originated. Based on the findings, the meaning of '心之範圍' in the context of the nature and emotion[性情] of So-eumin as explained in the 『DongUisusebowon(東醫壽世保元)』 was further investigated. Moreover, the clinical significance of the observation of '心之範圍' in relation to determining prognosis was discussed in regards to 'visceral syncope[藏厥]' and 'exuberating yin separating yang[陰盛隔陽]' which come under the severe symptoms[危證] category in the disease pattern of So-eumin. Results : '範圍' as mentioned in 『IChing·XiCi(周易·繫辭傳)』 refers to the process of creating a framework that takes after the tendencies of the patterns of change of the external world that influences mankind. The objective of this process is to prepare for the excessiveness and insufficiency of the change that happens in the external world so as to ultimately protect all existences. The workings of '範圍' could be assumed on a personal level as well. As the nature and emotion of So-eumin is closely related to the purpose and object of '範圍', Yi Jema suggested that through observing whether the So-eumin exhibits '心之範圍' or not, that it could be determined whether his/her innate nature is being properly exercised or not. Conclusions : Whether one's agitation calms down or not even for a moment is the criteria for determining prognosis of the entire disease, while its calming-down relies on proper functioning of '心之範圍'. The way to determine this is through observation of the manifest attitude of the So-eumin. If the So-eumin displays a poised and autonomous[綽綽卓卓] attitude even for a moment, it could be understood as the '心之範圍' process being properly functioning, indicating the overall direction to be heading towards relief of the sense of instability, allowing for a positive outlook on treatment.

• The Journal of Korean Medicine
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• 제32권4호
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• pp.149-158
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• 2011

Object: Any medication can have the risk of liver damage. To prevent this risk, liver function tests should be monitored carefully during every course of medication. This paper is a psoriasis case report on liver damage related to Scutellaria Radix medication. Shown by this case, herbal medicine has the possibility of liver damage, too. Therefore it should be carefully used under the direction of Oriental Medical Doctors who specialize in it. The purpose of this case report is to suggest this, and that more cases of liver damage related to herbal medicine should be reported. Methods: To monitor the medication's effect on the liver, liver function was evaluated during medications. Reflotron plus was used to evaluate AST and ALT by analyzing peripheral blood. Results: By this test, a case was identified as liver damage caused by a medication including Scutellaria Radix. Conclusion: This case suggests that Scutellaria Radix medication caused liver damage in a certain patient. Therefore, to prevent liver damage related to Scutellaria Radix, doctors should monitor patient's liver function regularly.

• Archives of Plastic Surgery
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• 제41권4호
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• pp.407-413
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• 2014

Background Implant malposition can produce unsatisfactory aesthetic results after breast augmentation. The goal of this article is to identify aspects of the preoperative surgical planning and intraoperative flap fixation that can prevent implant malposition. Methods This study examined 36 patients who underwent primary dual plane breast augmentation through an inframammary incision between September 1, 2012 and January 31, 2013. Before the surgery, preoperative evaluation and design using the Randquist formula were performed. Each patient was evaluated retrospectively for nipple position relative to the breast implant and breast contour, using standardized preoperative and postoperative photographs. The average follow-up period was 10 months. Results Seven of 72 breasts were identified as having implant malposition. These malpositions were divided into two groups. In relation to the new breast mound, six breasts had an inferiorly positioned and one breast had a superiorly positioned nipple-areolar complex. Two of these seven breasts were accompanied with an unsatisfactory breast contour. Conclusions We identified two main causes of implant malposition after inframammary augmentation mammaplasty. One cause was an incorrect preoperatively designed nipple to inframammary fold (N-IMF) distance. The breast skin and parenchyma quality, such as an extremely tight envelope, should be considered. If an extremely tight envelope is found, the preoperatively designed new N-IMF distance should be increased. The other main cause of malposition is failure of the fascial suture from Scarpa's fascia to the perichondrium through an inframammary incision. As well, when this fixation is performed, it should be performed directly downward to the perichondrium, rather than slanted in a cranial or caudal direction.

• The Journal of Korean Medical History
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• 제28권1호
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• pp.111-119
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• 2015

Objectives : The Dongui Bogam in My Hand', which is an output of computerizing Donguibogam (Principles and Practice of Eastern Medicine), is an interim outcome of the research project led by the Korea Institute of Oriental Medicine. This study examined the process in which Donguibogam, a record in Chinese and a classic of Oriental medicine, expanded into a modern content. Methods : This study will classify the modernization of Donguibogam into three 'contents' that form Donguibogam, 'container' that will hold the contents, and 'community' that is the consumer of Donguibogam. Towards the end, this study will sketch out the status of computerizing Chinese records in Korea, and point out the reality faced by computerization of ancient documents on Oriental medicine as well as the direction for the future. Results : 'The Dongui Bogam in My Hand' has been downloaded more than 10,000 times for 4 months since it releases in August 2014, and is used for at least 6,000 times on average every month. This achievement can be due to the two following reasons. First, the application contains high-quality contents such as the original text of Donguibogam as well as Korean and English translations. Second, it satisfied the needs of Donguibogam users with (1) the Browse function that well displays the table of contents, (2) the Search function that separates the title from the main text, and (3) the Personalization function designed to link and share relevant knowledge. Conclusions : Computerization of Chinese records was triggered by the request of the academia, but it was accelerated after being selected as a public laboring project to overcome the IMF crisis. However, computerization of ancient documents is not a simple task but a field of study to modernize classical knowledge. The success or failure of computerization of Chinese records is determined by whether high-quality modern 'contents' are secured, whether the 'container' design adequately implements the search, browse and link functions, and how well it fulfills the needs of the consumer 'community'.

• Korean Institute of Interior Design Journal
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• 제21권5호
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• pp.399-410
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• 2012

Due to development of modern medical services and economics, people raised expectation and demand about medical services from previous disease treatment to comprehensive health care covering prevention and health care. Responses of each medical facility to these social needs and the evolution of concept of medicine rapidly occur. The health examination centers are being operated with the purpose of health examination and this trend is reflected on several aspects such as the size of the facilities, function and configuration of space in health examination centers. Thus, health examination centers consisting of various space systems appear, but this trend and interpretations are lacking. Therefore, the purpose of this study is to draw trends of system through analysis of types and its evolved space systematic analysis and establish it. Analysis targets were classified into small, medium and large groups by sizes based on number of space and a total of 12 health examination centers in four for each category were selected. As research methods, functional relationship of space was examined through analysis of type in which segmentalized type tools were applied in local units. The flow diagram was established based on direction turning point and was classified into sub-flow and main-flow in local units and the systems between local units were derived. Finally, the results of this study can be summarized as the following three results. 1) The space connection system of health examination center showed four systems such as circulation, independence, continuation, and network. 2) Local type indicators and global type indicators which were evolved more from limitation of type analysis tools in existing research were derived so that more systematic analysis could be made. 3) Network system is distributed approach system and space for each function is formed around public space.

• Safety and Health at Work
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• 제12권4호
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• pp.511-516
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• 2021

Background: Difficulties in walking and balance are risk factors for falling. This study aimed to predict dynamic balance based on demographic information and anthropometric dimensions in construction workers. Methods: This descriptive-analytical study was conducted on 114 construction workers in 2020. First, the construction workers were asked to complete the demographic questionnaire determined in order to be included in the study. Then anthropometric dimensions were measured. The dynamic balance of participants was also assessed using the Y Balance test kit. Dynamic balance prediction was performed based on demographic information and anthropometric dimensions using multiple linear regression with SPSS software version 25. Results: The highest average normalized reach distances of YBT were in the anterior direction and were 92.23 ± 12.43% and 92.28 ± 9.26% for right and left foot, respectively. Both maximal and average normalized composite reach in the YBT in each leg were negatively correlated with leg length and navicular drop and positively correlated with the ratio of sitting height to leg length. In addition, multiple linear regressions showed that age, navicular drop, leg length, and foot surface could predict 23% of the variance in YBT average normalized composite reach of the right leg, and age, navicular drop, and leg length could predict 21% of that in the left leg among construction workers. Conclusion: Approximately one-fifth of the variability in the normalized composite reach of dynamic balance reach among construction workers using method YBT can be predicted by variables age, navicular drop, leg length, and foot surface.

• Korean Journal of Clinical Oncology
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• 제14권2호
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• pp.102-107
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• 2018

Purpose: Cardiotoxicity is a serious late complication of breast cancer treatment. Individual treatment risk of specific drugs has been investigated. However, studies on the evaluation of the composite risk of chemotherapeutic agents are limited. Methods: We retrospectively analyzed the medical records of breast cancer patients who received adjuvant treatment and had available serial echocardiography results. Patients were assigned to subgroups based on chemotherapy containing anthracyclines (A), anthracyclines and taxanes (A+T), and radiotherapy (RT). The development of cardiac disease and serial ejection fraction (EF) were reviewed. EF decline up to 10% from baseline was considered grade 1 cardiotoxicity and EF decline >20% or absolute value <50% was considered grade 2 cardiotoxicity. The most recent medical records and echocardiography results over 1 year of chemotherapy completion were also reviewed. Late cardiotoxicity was defined as a lack of recovery of EF decline or aggravated EF decline from baseline. Results: In total, 123 patients were evaluated. A small reduction in EF was observed after chemotherapy in both chemotherapy groups. There were no significant differences between groups A and A+T in EF decline following chemotherapy. We could not find any differences in composite risk between the chemotherapy groups and the RT group during follow-up. Late cardiotoxicity was seen in 15.45% of patients. During follow-up, three patients were diagnosed with dilated cardiomyopathy. Conclusion: There was no significant composite risk elevation following adjuvant treatment of breast cancer. However, late cardiotoxicity was considerable and further research in this direction is necessary.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• 제28권4호
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• pp.331-345
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• 2018

Objective: Shift work including night work is known to be harmful to the health of nurses. This study was conducted in order to systematically review the academic literature on the health effects of working time patterns, including shift work or night work, among Korean nurses and propose a research direction for the future. Methods: We searched online academic databases to find relevant papers in domestic and international journals using the keyword terms 'shift work', 'night work', 'night shift', 'work shift', 'nurse', and 'Korea', and reviewed a total of 36 articles. Results: As a result of this literature review, more than half of the articles were found to investigate the health effects between shiftwork and non-shiftwork nurses. A few studies considered the shift type(n=6), frequency of night shift(n=4), and shiftwork duration(n=3) as working time patterns. These studies focused mainly on mental health(n=18) or sleep(n=15). Conclusions: Based on the review results obtained from this study, it is necessary to assess working time patterns of Korean nurses using a variety of variables including night-work-related factors, and various health outcomes should be examined considering the confounder.

• The korean journal of orthodontics
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• 제52권6호
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• pp.387-398
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• 2022

Objective: Controlling the incisal inclination is fundamental in orthodontics. However, the relationship between the inclination prescription and its clinical outcome is not obvious, and the incisal inclination changes generated by different bracket prescriptions were investigated. Methods: Twenty-eight non-extraction dental Class II patients (15 females, 13 males; mean age = 12.9) were retrospectively analyzed. Patients were treated using passive self-ligating fixed appliances with three inclination prescriptions for maxillary incisors (high, standard, low), and two for mandibular incisors (standard, low). Clinical outcomes were compared among different prescriptions, and regression analysis was used to explain the effects of bracket prescriptions and to understand the prescription selection criteria (α = 0.05). Results: For maxillary central incisors, low and high prescriptions were related to linguoversion (p = 0.046) and labioversion (p = 0.005), respectively, while standard prescription maintained the initial dental inclination. Maxillary lateral incisors did not show significant changes. For mandibular incisors, low prescription led to linguoversion (p = 0.005 for central incisors, p = 0.010 for lateral incisors), while standard prescription led to labioversion (p = 0.045 for central incisors, p = 0.005 for lateral incisors). The factors affecting inclination changes were the imposed change and selected prescription, while prescription selection was influenced by the initial dental inclination and initial intercanine distance. Conclusions: The direction of correction of incisal inclination can be controlled by choosing a certain prescription, but the final inclination may show limited consistency with it. The amount of imposed inclination change was the most relevant predictor of the clinical outcome.