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Changes of Depression and Fatigue Level According to Sasang Constitution in Early Postpartum Women (초기산욕기 산모의 사상체질에 따른 우울과 피로수준의 변화)

  • Lee, Ah-Young;Park, Ga-Young;Lee, Eun-Hee
    • The Journal of Korean Obstetrics and Gynecology
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    • v.26 no.2
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    • pp.33-45
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    • 2013
  • Objectives: The purpose of this study was to identify the tendency toward depression and fatigue in early postpartum women and to determine the relationship between the symptoms of these conditions, according to the women's Sasang constitutions. Methods: In this study, 73 healthy postpartum women were analyzed according to Sasang constitution: 33 Taeeumin, 22 Soyangin, and 18 Soeumin. Symptoms of depression and fatigue were assessed using the Edinburgh Postnatal Depression Scale-K(EPDS-K) and the Fatigue Continuum Form(FCF), respectively, on the fourth(time 1), seventh(time 2), and fifteenth(time 3) days postpartum. Sasang constitutional types were determined by a medical specialist, using results from the Two Step Questionnaire for Sasang Constitution Diagnosis(TS-QSCD). Results: 1. The overall depressive symptoms and fatigue scores decreased significantly over time in early postpartum women. 2. The mean scores for the EPDS and FCF were higher in the Soeumin group than in other groups. The scores for EPDS and FCF dropped sharply in comparison to a former level in the Soyangin group. And the mean EPDS score was lower in the Soyangin group than in other groups. The EPDS and FCF scores in the Taeeumin group changed slightly over time. However, these results were not statistically significant according to Sasang constitution. 3. The relationship between postpartum depression and fatigue showed a significant positive correlation. Conclusions: These results suggest that, in early postpartum women, depressive symptoms and fatigue differ according to Sasang constitution.

Opportunistic Screening for Cervical Cancer in a Tertiary Hospital in Karnataka, India

  • Kulkarni, Padmaja Ramesh;Rani, Hephzibah;Vimalambike, Manjunath Gubbanna;Ravishankar, Sunila
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.9
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    • pp.5101-5105
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    • 2013
  • The incidence and mortality of cervical cancer remains high in India even after sixty years of introduction of the Pap smear (cervical cytology) which is an effective means of identifying preinvasive lesions of carcinoma cervix. The morbidity and mortality due to cervical cancer has come down drastically in countries with well established screening programmes at national level. This study aims at screening women for cervical cancer opportunistically during their visit to hospital and to study various types of neoplastic and non-neoplastic lesions of the cervix by cervical smear study (Pap smear study). In the present study, a total of 350 cervical smears were studied. The age of patients ranged from 19 years to 80 years with mean age being 37.5 years. Out of 350 cases, the diagnosis of neoplasia was given in 43 cases and 258 cases were diagnosed as inflammatory smears. Forty-cases were normal and 9 cases were inadequate to evaluate. Forty-three patients who were found to have neoplastic lesions on cytology were referred for further investigations like colposcopy and biopsy to confirm the diagnosis and avail proper treatment. Limitation of the present study was small sample size as all female patients aged between 20 and 60 years visiting hospital were not included in the screening, other screening tests like VIA (visual inspection with acetic acid test) and HPV DNA (human papilloma virus) tests were not done. Until the time centrally organised screening programmes for cervical cancer are established in India, arrangements should be made for hospital based opportunistic screening for all women attending hospital. The cost effectiveness of different screening tests for cervical cancer should be evaluated.

Characteristics of patients who visit the dental emergency room in a dental college hospital

  • Kim, Chihun;Choi, Eunhye;Park, Kyeong-Mee;Kwak, Eun-Jung;Huh, Jisun;Park, Wonse
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.19 no.1
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    • pp.21-27
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    • 2019
  • Background: Emergencies in dentistry can be classified as medical and dental. Medical emergencies occur mainly during dental treatment in patients with a systemic disease. Dental emergency departments are largely divided into dental emergency rooms located in dental college hospitals and medical emergency rooms located in medical institutions. This study aimed to analyze the characteristics of and provide help to dental emergency patients in a dental hospital. Methods: Overall, 1806 patients admitted to a dental emergency room at Yonsei University Dental Hospital for 1 year were included. The data collection period was from October 1, 2014 to September 30, 2015. An investigator reviewed medical records from the electronic medical record (EMR) system and radiographs. Results: The patients were 1,070 men and 736 women. The sex ratio was 1.45:1. The commonest age group was of 0-9 years, including 451 (25.0%) patients, followed by 20-29 years, including 353 (19.5%) patients, and 30-39 years, including 277 (15.3%) patients. Of the 108 patients transferred to the Severance emergency department, 81 had trauma, 19 were in pain, 4 were bleeding, and 4 had other complaints. Among chief complaints, 1,079 patients (60.3%) had trauma, 564 (31.5%) had pain, and 75 (4.2%) had bleeding. Twenty-three cases (1.3%) were caused by temporomandibular disorder (TMD). Conclusion: Dentists should be able to adequately assess patients in a dental emergency room and treat trauma, pain, and bleeding.

Efficacy and Safety of Fractionated Stereotactic Radiosurgery for Large Brain Metastases

  • Jeong, Won Joo;Park, Jae Hong;Lee, Eun Jung;Kim, Jeong Hoon;Kim, Chang Jin;Cho, Young Hyun
    • Journal of Korean Neurosurgical Society
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    • v.58 no.3
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    • pp.217-224
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    • 2015
  • Objective : To investigate the efficacy and safety of fractionated stereotactic radiosurgery for large brain metastases (BMs). Methods : Between June 2011 and December 2013, a total of 38 large BMs >3.0 cm in 37 patients were treated with fractionated Cyberknife radiosurgery. These patients comprised 16 men (43.2%) and 21 women, with a median age of 60 years (range, 38-75 years). BMs originated from the lung (n=19, 51.4%), the gastrointestinal tract (n=10, 27.0%), the breast (n=5, 13.5%), and other tissues (n=3, 8.1%). The median tumor volume was 17.6 cc (range, 9.4-49.6 cc). For Cyberknife treatment, a median peripheral dose of 35 Gy (range, 30-41 Gy) was delivered in 3 to 5 fractions. Results : With a median follow-up of 10 months (range, 1-37 months), the crude local tumor control (LTC) rate was 86.8% and the estimated LTC rates at 12 and 24 months were 87.0% and 65.2%, respectively. The median overall survival (OS) and progression-free survival (PFS) rates were 16 and 11 months, respectively. The estimated OS and PFS rates at 6, 12, and 18 months were 81.1% and 65.5%, 56.8% and 44.9%, and 40.7% and 25.7%, respectively. Patient performance status and preoperative focal neurologic deficits improved in 20 of 35 (57.1%) and 12 of 17 patients (70.6%), respectively. Radiation necrosis with a toxicity grade of 2 or 3 occurred in 6 lesions (15.8%). Conclusion : These results suggest a promising role of fractionated stereotactic radiosurgery in treating large BMs in terms of both efficacy and safety.

Comparative Differences in Cardiovascular-metabolic risk and Mental health according to Physical activity in Postmenopausal women (폐경기 여성의 신체활동에 따른 심혈관대사 및 정신건강의 차이 비교)

  • Dae-In Jung;Dae-Sik Ko
    • Journal of the Health Care and Life Science
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    • v.9 no.2
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    • pp.309-316
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    • 2021
  • This study was conducted to compare the cardiovascular-metabolic risk and mental health according to physical activity in postmenopausal women, in order to present basic data for health promotion of postmenopausal women. 4,453 postmenopausal women among the raw data of the 7th period (2017-2019) of the National Health and Nutrition Examination Survey were used for the final analysis. Cardiovascular-metabolic was measured by waist circumference, systolic blood pressure, diastolic blood pressure, HDL -cholesterol, fasting blood sugar and triglycerides, and mental health was measured by depression and stress perception. As a result of the study, it was found that Korean postmenopausal women were more physically active as their waist circumference was smaller, systolic blood pressure was lower, diastolic blood pressure and HDL-cholesterol were higher. However, there was no difference in depression and stress perception. Consequently, it is considered that waist circumference, blood pressure, and HDL-cholesterol management are necessary to improve cardiovascular and metabolic functions in postmenopausal women.

Feature Selection and Hyper-Parameter Tuning for Optimizing Decision Tree Algorithm on Heart Disease Classification

  • Tsehay Admassu Assegie;Sushma S.J;Bhavya B.G;Padmashree S
    • International Journal of Computer Science & Network Security
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    • v.24 no.2
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    • pp.150-154
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    • 2024
  • In recent years, there are extensive researches on the applications of machine learning to the automation and decision support for medical experts during disease detection. However, the performance of machine learning still needs improvement so that machine learning model produces result that is more accurate and reliable for disease detection. Selecting the hyper-parameter that could produce the possible maximum classification accuracy on medical dataset is the most challenging task in developing decision support systems with machine learning algorithms for medical dataset classification. Moreover, selecting the features that best characterizes a disease is another challenge in developing machine-learning model with better classification accuracy. In this study, we have proposed an optimized decision tree model for heart disease classification by using heart disease dataset collected from kaggle data repository. The proposed model is evaluated and experimental test reveals that the performance of decision tree improves when an optimal number of features are used for training. Overall, the accuracy of the proposed decision tree model is 98.2% for heart disease classification.

The Effects of Evodia Rutaecarpa and Ephedra Sinica on the Resting Metabolic Rate and Body Composition of Obese Women on a Low-Calorie Diet: A Double-blinded Randomized Controlled Clinical Trial (오수유와 마황이 저열량식이요법을 병행한 비만여성환자의 체구성성분 및 휴식대사량에 미치는 영향)

  • Park Jung-Mi;Kim Ho-Jun;Kim Jin-Ah;Kim Su-Jin;Ko Byeong-Pyo
    • The Journal of Korean Medicine
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    • v.26 no.3 s.63
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    • pp.249-262
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    • 2005
  • Backgrounds : As obesity prevails as an epidemic. diet programs including low-calorie diets are developed continuously. It is generally believed that a low-calorie diet is commonly followed by resting metabolic rate decrease and ultimate weight regain. Ephedra and Evodia are known to have sympathomimetic and anti-obesity effect. Objectives : This study was a prospective, double-blinded, randomized md placebo-controlled clinical trial to evaluate the effects of Ephedra sinica and Evodia rutaecarpa on resting metabolic rate (RMR), weight, body composition, and short-term safety in obese women on low-calorie diet. Methods : 125 otherwise healthy obese women (body mass Index ${\geq}\;25kg/m^2$) were recruited and randomly assigned to three groups: Ephedra group (n=41), Evodia group (n =45), and placebo group (n=39). Subjects were administered Ephedra extract in capsules (pseudo-ephedrine 31.52mg) or Evodia extract in capsules (evodiamine 6.75mg, rutaecarpine 0.66mg) or placebo capsules as well as participating in a low-calorie diet for 8 weeks, Resting metabolic rate and body composition were measured at baseline,4 and 8 weeks. Basic serum exams were performed to evaluate the short-term safety of the herbs and changes of lipid variables. Results : All three groups showed significant BMI decreases probably due to low-calorie diet. Among them, the Ephedra group manifested most prominent BMI-reducing effect and towered total cholesterol and triglycerides significantly. The RMR was not changed during the 8-week diet in all groups. No significant difference among the groups was found in RMR, either. Stbject with higher RMR than the mean at the baseline showed a tendency to keep their RMR more stable during the diet program. Conclusions : Ephedra with a low-calorie diet was effective in reducing BMI. RMR change was not compensated by herbal medicines. RMR change seemed to be affected rather by constitution and body composition than medicine. Ephedra and Evodia were proven to be safe for sort-term use in herbal form. Especially, Ephedra was effective in lowering total cholesterol and triglycerides during the 8 weeks.

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Effects of an Epithelial Growth Factor Receptor-Tyrosine Kinase Inhibitor Add-on in Stereotactic Radiosurgery for Brain Metastases Originating from Non-Small-Cell Lung Cancer

  • Kim, Hyun Jung;Kim, Woo Sung;Kwon, Do Hoon;Cho, Young Hyun;Choi, Chang-Min
    • Journal of Korean Neurosurgical Society
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    • v.58 no.3
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    • pp.205-210
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    • 2015
  • Objective : This study was aimed at optimizing the treatment of non-small-cell lung cancer (NSCLC) patients who are candidates for stereotactic radiosurgery (SRS) for brain metastases and harbor activating epithelial growth factor receptor (EGFR) mutations. Methods : We retrospectively reviewed the medical records from 2005 to 2010 of NSCLC patients with brain metastases harboring an activating EGFR mutation. Patients who received a combination therapy of SRS and EGFR-tyrosine kinase inhibitor (TKI) for brain metastases and those who received SRS without EGFR-TKI were compared. The primary endpoint was progression-free survival (PFS) of the brain metastases. Results : Thirty-one patients were eligible for enrolment in this study (SRS with TKI, 18; SRS without TKI, 13). Twenty-two patients (71.0%) were women and the median overall age was 56.0 years. PFS of brain lesions was not significantly prolonged in SRS with TKI treatment group than in SRS without TKI group (17.0 months vs. 9.0 months, p=0.45). Local tumor control rate was 83.3% in the combination therapy group, and 61.5% in the SRS monotherapy group (p=0.23). There were no severe adverse events related with treatment in both groups. Conclusions : Therapeutic outcome of concurrent SRS and TKI treatment was not superior to SRS monotherapy, however, there was no additive adverse events related with combined treatment.

The Relationship between the Urinary Arsenic and 8-Hydroxydeoxyguanosine Levels in Women of Abandoned Mine Area (일부 폐금속광산 지역 거주 여성의 요중 비소와 8-hydroxydeoxyguanosine 농도 사이의 관련성)

  • Choi, Young-Sook;Eom, Sang-Yong;Choi, Byoung-Sun;Park, Jung-Duk;Kim, Yong-Dae;Kim, Heon
    • Journal of Life Science
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    • v.20 no.4
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    • pp.618-622
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    • 2010
  • This study examines the relationship between urinary arsenic concentration and urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations, an index of oxidative DNA damage, among women who live near abandoned metal mines. The sample consisted of 165 residents living near two abandoned metal mines located in Chungbuk Province. Demographic characteristics as well as environmental factors relevant to arsenic exposure were collected through interviews, and urinary arsenic concentrations and urinary 8-OHdG concentrations of the research subjects were measured. The collected data were subsequently analyzed using the statistics program SPSS 12.0. The geometric average of urinary arsenic concentrations among the research subjects was $5.65\;{\mu}g/g$ creatinine. In a correlation analysis between urinary arsenic and 8-OHdG concentrations, the correlation coefficient was significant (p<0.001) at 0.399. This study suggests that urinary 8-OHdG concentrations may be a DNA damage marker for chronic arsenic exposure in women.

Association between dental amalgam restoration and urine mercury concentrations among young women: a cross-sectional study

  • Su-Bin Park;Eun-Kyong Kim;Joon Sakong;Eun Young Park
    • Journal of Yeungnam Medical Science
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    • v.40 no.4
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    • pp.373-380
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    • 2023
  • Background: The association between dental amalgam fillings and urine mercury concentrations was investigated in this study to assess the health risks associated with dental amalgams. Methods: This cross-sectional study included 99 women in their 20s who visited the dental clinic in Daegu, Korea. The 99 participants were composed of 68 subjects who had dental amalgam fillings (exposure group) and 31 subjects who did not have dental amalgam fillings (nonexposure group). Oral examinations were conducted by a single dental hygienist, sociodemographic features were investigated as confounding variables, and urine mercury concentrations were measured using an automatic mercury analyzer. Results: The mean±standard deviation of the urine mercury concentrations of the exposure and nonexposure groups were 1.50±1.78 ㎍/g creatinine and 0.53±0.63 ㎍/g creatinine, respectively. The exposure group showed significantly higher levels than the nonexposure group (p<0.01). The urine mercury concentration significantly increased with an increase in the number of teeth filled with amalgam, cavity surfaces involved, and number of defective amalgam fillings, and according to the latest exposure time (p<0.001). In the multiple regression analysis of amalgam-related factors and urine mercury concentrations after correction for confounding factors, the urine mercury concentration in the group with six or more amalgam-filled teeth, 11 or more cavity surfaces, and two or more defective amalgams was significantly higher than that in the nonexposure group (p<0.001). Conclusion: According to this study, exposure to dental amalgams was confirmed to significantly affect urine mercury concentrations.