• Asian Pacific Journal of Cancer Prevention
• /
• 제17권sup3호
• /
• pp.323-335
• /
• 2016

Breast cancer risk assessment has developed during years and evaluation of genetic factor affecting risk of breast cancer is an important component of this risk assessment. The aim of this meta-analysis was to investigate the role of XRCC1 polymorphisms (Arg194Trp, Arg280His and Arg399Gln) in risk of breast cancer among different population and categories of menopausal status.PubMed, Medline, Web of Science, and PubMed Central were systematically searched to identify studies evaluating association between breast cancer and XRCC1 gene polymorphisms (Arg194Trp, Arg280His and Arg399Gln). Two authors independently extracted required information. Odds Ratios were pooled for four genetic inheritance models using both fixed and the DerSimonian and Laird random-effect models. Egger's test and contour-enhanced funnel plot was used to evaluate publication bias and small study effect. Additional subgroup analysis was performed for menopausal status, ethnicity, and source of controls. After evaluation and applying inclusion criteria on extracted studies, fifty three studies were included in this meta-analysis. For polymorphisms of Arg194Trp and Arg280His, no significant association was observed in all genetic models. Arg194Trp had a protective effect in post-menopausal status only in homozygote model (OR=0.57 [0.37-0.88]). Arg399Gln showed significant association with breast cancer in homozygote (OR=1.21 [1.10-1.34]), dominant (OR=1.09 [1.03-1.15]) and recessive (OR=1.21 [1.09- 1.35]) genetic models. Arg399Gln was associated with higher risk in post-menopausal status for homozygote and heterozygote models. Our findings suggest that XRCC1 gene polymorphisms modify breast cancer risk in different populations and different categories of menopausal status.

• 디지털산업정보학회논문지
• /
• 제17권4호
• /
• pp.1-11
• /
• 2021

In this paper, we explain the purpose of building a mobile app called "ARnetView" that can use the AR(augmented Reality)based calling function and AR based content creation function, and as well as an AR based data center that can share AR based video streaming and AR based contents on smartphones and tablet devices. For the AR(Augmented Reality) based data center implement, we have developed a mobile application and implemented a service system including an AR(augmented Reality) based calling function and AR based content production and AR based video streaming functions for real-time communication to connect a field technician and an expert so that the expert can see and discuss the situation in the field and technician and experts, they can draw digital annotation on mobile screen that accurately stick to 3D physical objects, allowing the expert to guide the technician step by step. In result, it provides a remote technical collaboration environment between field technician and expert. In addition, AR(Augmented Reality) collaboration service Platform was designed and implemented to increase work speed, efficiency, and utilization of advanced technicians, improve continuous productivity of equipment and facilities, maximize equipment and facility utilization, and strengthen industrial competitiveness. Therefore, through this, the AR collaboration service Platform can be applied to the industrial field, the medical field, and the entertainment/education field.

• Korean Journal of Radiology
• /
• 제24권10호
• /
• pp.929-930
• /
• 2023

• Nutrition Research and Practice
• /
• 제11권1호
• /
• pp.76-76
• /
• 2017

• 동의신경정신과학회지
• /
• 제29권2호
• /
• pp.111-119
• /
• 2018

Objectives: To investigate the characteristics of patients diagnosed with dementia or mild cognitive impairment who are treated by means of a blend between Western and Korean medicine. Methods: We searched for outpatients with dementia or mild cognitive impairment by means of a collaboration between Western and Korean medicine from August 1, 2015, to July 31, 2017, through electronic medical records in Wonkwang Hospital. The records were retrospectively analyzed according to the patients' demographic and clinical characteristics, pathway of medical care, diagnostic tests, treatment, and medical expenses. Results: Thirteen patients were included in the analysis. Among them, six patients were diagnosed with mild cognitive impairment, five with dementia, Alzheimer's type, one patient with frontotemporal dementia, and one patient with unspecified dementia. Twelve of the thirteen patients were over 60 years of age. The number of pathways from the Dept. of Neurology to the Dept. of Neuropsychiatry of Korean Medicine was almost the same as the opposite pathway. The most used diagnostic test in Korean medicine was a neuropsychological test such as SNSB, MMSE and GDS. In Western medicine, hematology and neuroimaging were frequently used for patients. Acupuncture in Korean medicine and medication in Western medicine were the most frequently used. In Korean medicine, uncovered service costs were much higher than covered service costs,. whereas, in Western medicine, covered service costs were higher than uncovered service costs. Conclusions: This study describes the basic characteristics of dementia and mild cognitive impairment patients treated by a collaboration between Western and Korean medicine. Based on these results, a clinical pathway of the collaborative practice system between Western and Korean medicine for dementia patients needs to be developed.

• Journal of Acupuncture Research
• /
• 제37권3호
• /
• pp.161-166
• /
• 2020

Background: The purpose of this study was to investigate the characteristics and direction of treatment for peripheral facial palsy (PFP) based on medical collaboration between Western and Korean medicine departments. Methods: There were 195 outpatients with PFP identified retrospectively by examining electronic medical records. These patients were treated with Korean and Western medicine from January 1^st, 2018 to December 31^st, 2018 at the Kyung Hee University hospital. Records were analyzed according to the patients' demographic characteristics and clinical features of the collaborative combined treatment. Results: According to the collaborative treatment pathway, the number of patients consulted from Western medicine departments was more than consulted from Korean department for the first time. The time taken by the Western medicine departments to consult with the patients at the Korean center for the first time was 14.9 days from the onset of symptoms. Acupuncture was the most frequently used Korean medicine treatment. The total treatment period for Korean medicine sessions and intervals were 91.9 days, 23 times and 3.6 days, respectively. When the Korean medicine center consulted with Western medicine departments, the time taken until the first consultation was 8.5 days from the onset of symptoms. Medication was the most used treatment, prescribed after 3.1 days. The most frequently used clinical test was an electromyogram, and this was performed after 20.5 days. The total treatment period, sessions and intervals were 21.2 days, 2.8 times and 5 days, respectively. Conclusion: The clinical status of collaborative treatment for PFP was determined including the timing and interval of consultation according to treatments.

• 의학교육논단
• /
• 제22권1호
• /
• pp.16-27
• /
• 2020

The accreditation process (AccP) is both an opportunity and a burden for medical schools-which one it becomes depends on how medical schools recognize and utilize the AccP. In other words, if a medical school recognizes the AccP only as a formal procedure or as a means for continuing medical education, it will be a burden for the medical school. However, if a medical school recognizes the real and positive value of the AccP, it can be both an opportunity and a tool for developing medical education. The educational value of the AccP is to improve the quality, equity, and efficiency of medical education, along with increasing the options of choice. In order for the AccP to contribute to the development of medical education, accrediting agencies and medical schools must first be recognized as part of an "educational alliance" working together towards common goals. Secondly, clear guidelines on the accreditation standards should be periodically reviewed and shared. Finally, a formative evaluation using self-evaluation as a system that can utilize the AccP as an opportunity to develop medical education must be introduced. This type of evaluation system could be developed through collaboration among medical schools, academic societies for medical education, and the accrediting authority.

• Journal of Trauma and Injury
• /
• 제36권4호
• /
• pp.322-328
• /
• 2023

Purpose: Patients with multiple trauma necessitate assistance from a wide range of departments and professions for their successful reintegration into society. Historically, the primary focus of trauma treatment in Korea has been on reducing mortality rates. This study was conducted with the objective of evaluating the current state of multidisciplinary treatment for patients with severe trauma in Korea. Based on the insights of trauma specialists (i.e., medical professionals), we aim to suggest potential improvements. Methods: An online questionnaire was conducted among 871 surgical specialists who were members of the Korean Society of Traumatology. The questionnaire covered participant demographics, current multidisciplinary practices, perceived challenges in collaboration with rehabilitation, psychiatry, and anesthesiology departments, and the perceived necessity for multidisciplinary treatment. Results: Out of the 41 hospitals with which participants were affiliated, only nine conducted multidisciplinary meetings or rounds with nonsurgical departments. The process of transferring patients to rehabilitation facilities was not widespread, and delays in these transfers were frequently observed. Financial constraints were identified by the respondents as a significant barrier to multidisciplinary collaboration. Despite these hurdles, the majority of respondents acknowledged the importance of multidisciplinary treatment, especially in relation to rehabilitation, psychiatry, and anesthesiology involvement. Conclusions: This survey showed that medical staff specializing in trauma care perceive several issues stemming from the absence of a multidisciplinary system for patient-centered care in Korea. There is a need to develop an effective multidisciplinary treatment system to facilitate the recovery of trauma patients.

• 의학교육논단
• /
• 제26권1호
• /
• pp.55-69
• /
• 2024

Amid the increasing interest in medical humanities education, this study developed a medical humanities course that utilized design thinking to foster creative thinking, problem-solving, and collaboration skills that pre-medical students should possess. The course's efficacy was assessed by evaluating improvements in core design thinking skills. The present study was conducted among 83 first-year medical students after planning and implementing a design thinking course. The reflection journals written by students along the course of the class were examined using the template analysis technique to evaluate the effectiveness of the class. The study's primary findings showed the successful development of step-by-step medical humanities education content utilizing design thinking and its practical implementation in a class. Moreover, the course improved students' core design thinking skills effectively, and in a balanced way. These results illustrate the effective application of design thinking in medical school through a medical humanities course. These findings indicate that a medical humanities course can help medical students showcase their abilities to collaborate and solve problems in the real world. This paper suggests the need for further research to develop a curriculum that integrates design thinking and investigate the relationship between medical students' core competencies and design thinking-based courses.

• 대한핵의학회지
• /
• 제38권5호
• /
• pp.338-343
• /
• 2004

목적: 이 연구의 목적은 두층 섬광결정을 사용하여 PET 기기 시야 외곽에서 발생하는 영상 왜곡현상을 최소화하는 고 민감도, 고 분해능의 소동물 PET 시스템을 개발하는 것이다. 대상 및 방법: GATE (Geant4 Application for Tomographic Emission) 시뮬레이션 프로그램을 사용하여 시스템을 모사하였고 시스템 성능을 예측하였으며 시뮬레이션에서 도출한 파라미터를 기준으로 시스템을 설계 제작 하였다. 두층 섬광결정은 Lutetium Oxyorthosilicate (LSO)와 Lutetium-Yttrium Aluminate-Perovskite (LuYAP)으로 구성하였다. 섬광결정의 각 픽셀크기는 $2mm{\times}2mm{\times}8mm$이며 $8{\times}8$로 배열하여 두층 섬광결정으로 구성하였다. 두층 섬광결정 배열을 위치민감형 광전자증배관(Position Sensitive Photomultiplier Tube: PSPMT)과 결합하여 한 개의 검출기를 구성하였으며, 총 16개 검출기를 지름 10 cm, 유효시야 8 cm인 원형으로 배열하였다. 검출기로부터 출력된 데이터는 소켓, 디코더, ADC, FPGA회로를 거쳐 전 처리 컴퓨터에 입력되고 마스터 컴퓨터에 저장 되도록 하였다. 결과: 시스템 개발의 초기 연구로 한쌍 검출기만 사용하여 단층영상을 획득하고 민감도와 공간분해능을 측정하였다. 점선원을 시야 중앙에 위치했을 때 공간분해능은 2.3 mm FWHM이고, 민감도는 10.9 $cps/{\mu}Ci$이었다. 결론: 구축한 시스템을 사용하여 선원의 위치와 모양변화를 정확하게 측정한 사이노그램과 PET 영상을 획득할 수 있었다. 이 연구는 고 분해능 고 민감도 PET 시스템 개발의 초기연구로, 소형 원형 PET 시스템 개발 가능성을 보여준다.lamate을 이용하여 측정한 사구체 여과율과 통계적으로 유의한 상관 관계를 보이지 않았다. 결론: Gates 방법을 이용한 사구체 여과율 측정에서 배후 방사능 관심 영역은 신장의 상방과 양측 신장사이, 즉 혈액 풀 방사능이 많이 분포하는 부위에 설정하는 것이 I-125-iothalamate을 이용한 사구체 여과율과 가장 높은 상관 관계를 보였고, 신장 깊이가 깊지 않은 2군에서 두 사구체 여과율은 더 높은 상관 관계를 보였다.7%$, 25분일 때 $95{\pm}12%$, 40분일 때 $98{\pm}3%$로 통계학적으로 유의한 차이는 없었다(p>0.05). 항응고제 종류에 따른 결합효율은 헤파린을 사용한 경우 $89{\pm}20%$, CPDA를 사용한 경우 $97{\pm}6%$, ACD를 사용한 경우 $98{\pm}4%$로 CPDA와ACD를 사용한 경우에 유의하게 높은 결합효율을 보였다(p<0.001). 결론: 변형 체내 표지법으로 적혈구를 표지시 우수한 결합효율을 유지하기 위해서는 채취하는 혈액의 양은 3 mL 이상, 배양시간은 10분 이상(10분-40분), 항응고제는 ACD나 CPDA tinning 시간은 20분 이상(20-35분)을 유지하고, 가능한 rotating invertor를 사용하는 것이 좋을 것으로 생각된다.KC $\varepsilon$이 K562(Adr)세포에서 많이 발현되었으나, K562와 K562(Adr)세포에서는 verapamil처리에 따른 PKC 아형의 변화는 없었다. 결론: Verapamil은 암세포의 종류에 따라 MIBI와 TF의 섭취를 감소시켰고, 고용량에는 MDR세포의 섭취도 감소시켰으며 이러한 현상은 세포독성 이나 PKC효소 아형과는 관련이 없었다. 그러므로 MDR의 진단시 verapamil을