• International Journal of Computer Science & Network Security
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• v.21 no.9
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• pp.169-172
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• 2021

The article discusses the results of a quantitative analysis of open educational resources in the field of information technology. Study is based on a study of the content of ten platforms that provide access to open resources (OPs). To achieve this goal, we used the following methods: theoretical analysis and generalization of Internet sources to determine the popularity of educational platforms and resources on them; quantitative data analysis to determine the relative proportion of IT courses in various parameters: the relative weight of courses in the IT field in general and on each platform in particular, the language of instruction, the quantitative content by thematic areas. The following platforms providing access to open educational resources were subjected to quantitative analysis: Coursera, Edx, Udemy, MIT OpenCourseWare, OpenLearn, Intuit, Prometheus, UoPeople, Open Learning Initiative, Maidan Open University.

• Molecules and Cells
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• v.40 no.9
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• pp.655-666
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• 2017

We constructed a large $na{\ddot{i}}ve$ human Fab library ($3{\times}10^{10}$ colonies) from the lymphocytes of 809 human donors, assessed available diversities of the heavy-chain variable (VH) and ${\kappa}$ light-chain variable (VK) domain repertoires, and validated the library by selecting Fabs against 10 therapeutically relevant antigens by phage display. We obtained a database of unique 7,373 VH and 41,804 VK sequences by 454 pyrosequencing, and analyzed the repertoires. The distribution of VH and VK subfamilies and germline genes in our antibody repertoires slightly differed from those in earlier published natural antibody libraries. The frequency of somatic hypermutations (SHMs) in heavy-chain complementarity determining region (HCDR)1 and HCDR2 are higher compared with the natural IgM repertoire. Analysis of position-specific SHMs in CDRs indicates that asparagine, threonine, arginine, aspartate and phenylalanine are the most frequent non-germline residues on the antibody-antigen interface and are converted mostly from the germline residues, which are highly represented in germline SHM hotspots. The amino acid composition and length-dependent changes in amino acid frequencies of HCDR3 are similar to those in previous reports, except that frequencies of aspartate and phenylalanine are a little higher in our repertoire. Taken together, the results show that this antibody library shares common features of natural antibody repertoires and also has unique features. The antibody library will be useful in the generation of human antibodies against diverse antigens, and the information about the diversity of natural antibody repertoires will be valuable in the future design of synthetic human antibody libraries with high functional diversity.

• Journal of the Korean Society for Library and Information Science
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• v.57 no.4
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• pp.5-24
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• 2023

In ancient Egypt, temples were not only religious sanctuaries but also community centers. One of the core spaces created in the temple is the facility where priests and scribes copied and preserved texts on papyrus and other media. Its common designation was 'pr-mḏȝ'(House of Books) and the 'per-(nw)-seshw'(House of Scrolls). The general term used during that time was 'Per Ankh', and the modern term for it is 'temple library'. Therefore, this study first identified the character and identity of the Per Ankh attached to the temple, and then traced whether it is appropriate to designate 'healing place of the souls' depicted on the hypostyle hall(Per Ankh) in the Ramesseum(mortuary temple) built by Ramses II of the New Kingdom as a library. As a result, Per Ankh, a hieroglyph combining the Per(house) and Ankh(life), was revealed to be a multi-purpose complex facility consisting of a learning and research center, a treatment and healing center with medical facilities and sanatoriums, a religious ceremony and a center for the celebration of eternal life, a scriptorium and a library. Therefore, the traditional argument that Per Ankh refers to a library cannot be justified. In the same context, the inscription 'Ψυχῆς ἰατρεῖον' on the doorplate of the hypostyle hall of the Ramesseum, which was first introduced by Greek historian Hecataeus of Miletus in the 4th century BC, was translated into Latin as 'Psychēs Iatreion' by Diodorus Siculus in the 1st century BC and described as the motto of the sacred library. However, Psyche is the goddess of Greek and Roman mythology, and Iatreion means hospital(clinic, healing center) and pharmacy, so Per Ankh in the Ramesseum is a space to heal the soul of the pharaoh (Ka). Therefore, 'Psychēs Iatreion = library' is a distortion and a mistranslation. It is not the motto of the library, but a metaphor for the Per Ankh.

• BMB Reports
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• v.44 no.8
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• pp.517-522
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• 2011

Mitochondrial dynamics not only involves mitochondrial morphology but also mitochondrial biogenesis, mitochondrial distribution, and cell death. To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission. Niclosamide promoted mitochondrial fragmentation but this was blocked by down-regulation of Drp1. Niclosamide treatment resulted in the disruption of mitochondria membrane potential and reduction of ATP levels. Moreover, niclosamide led to apoptotic cell death by caspase-3 activation. Interestingly, niclosamide also increased autophagic activity. Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death.

• Journal of Microbiology
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• v.35 no.4
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• pp.347-353
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• 1997

We have characterized a phage library displaying random 22mer peptides which were produced as N-terminal fusions to the pIII coat protein of M13 filamentous phages. Among the sixty phages randomly picked from the library, 25 phages had the 22mer peptide inserts. The DNA sequence analysis of the 25 inserts showed the following results: first, each nucleotide was represented almost equally at each codon position except that there were some biases toward G bases at the first position of the codons. Secondly, the expected 47 sense codons were represented. The deduced amino acid sequences of the 25 inserts were analyzed to examine its diversity. Glycine and glutamate were the two most overrepresented residues above the expected value, whereas cysteine and threonine residues were underrepresented. The range of dicersity in dipeptide sequences showed that the amino acid residues were randomly distributed along the peptide insert. Acidic, basic, polar, and nonpolar amino acid residues were represented to the extent expected at most positions of the peptide inserts. The predicted isoelectric points and hydropathy indices of the 25 peptides showed that a variety of the peptide were represented in the library. These results indicate that this phage display library could be useful in fiuding ligands for a broad spectrum of receptors by affinity screening.

• Journal of the Korean Society for Library and Information Science
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• v.31 no.1
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• pp.29-52
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• 1997

A questionnaire survey was conducted to investigate the use of SCI and awareness of SCI source journals by fatuity members at Korean medical colleges. 104 out of 180 faculty members randomly chosen from four prestigious medical colleges returned the questionnaires malled to them. Korean medical researchers rarely used SCI as their main source of research Information. They rather used the MEDLINE to seek the research information probably because they are easily available from their local libraries. Furthermore. many respondents mistakenly Identified 'SCI journals ranked by Impact factor' lists found In Journal Citation Reports (JCR) with the SCI Itself. That Is. In Korean medical research community. the virtue of SCI Is not as an Index but as a source of SCI Journal Impact factor Information. It Is because the Interest in impact factor Is highly associated with the pressure to publish In one of those SCI source Journals. The collected data shows that even the medical professors at these prestigious medical colleges suffer from the lack of knowledge and information about SCI. SCI source journals and their Impact factors. Nontheless, core journal titles of a medical specialty selected by Korean medical professors are mostly high-Impact Journals of Its field (1.e.. belong to the upper 1/3) zone ranked by Impact factor). Within each specialty. the Journal ranks assigned to the selected core Journals by the respondents agree with the ranks by SCI Impact factor to a great extent. That Is. the Korean medical scientists awareness on SCI Journals as defined in this study is in good standing. Therefore. a policy of a medical college to require medical professors to publish In SCI Journals to be promoted or a policy to evaluate a researcher's work by the fact that his research papers are published In SCI Journals can be positively pursued.

• The Korean Journal of Health Service Management
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• v.10 no.4
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• pp.25-36
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• 2016

Objectives : This study describes the current state of medical advertisement and quality of advertisement execution according to the different departments based on 2-year case study of actual medical advertisements which were published in newspapers. Additionally, this paper provides data which will help in the efficient planning of medical advertisements. Methods : This study was based on medical advertisements that were in local newspapers, etc. from January 1, 2012 to December 31, 2013. The data were collected from September 20, 2014 to November 2, 2014 (44 days). A total of 4,991 data points were acquired from newspapers supplied by the Busan Public Library directly to the researcher. Results : According to the major findings of this study, the services of clinics had more medical advertisements than that of hospitals. Urology was the most advertised service of clinics while orthopedics and neurosurgery were the most advertised services of hospitals. Conclusions : In the study, the characteristics for the technical advertising factor was evident according to the type of examinations. Some types of examinations showed definite differences compared to other examinations.

• Journal of Korean Medical classics
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• v.35 no.3
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• pp.1-20
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• 2022

Objectives : Translations of Korean Medical Classical texts were analyzed quantitatively to verify their trend. Based on findings, accumulated problems and their solutions were discussed. Methods : A list of translated Classical texts in the field of Korean Medicine from the National Central Library collection was organized. Afterwards, the publication date, field, author information and content of the translated version were analyzed. Results : Of Chinese Medical texts, those from the Ming and Qing periods were most translated, while major texts pre-dating the Song period were left out. In addition, while texts in the fields of Shanghan-Jingui, comprehensive medical texts, scriptures, medical theories that were high in demand in educational and clinical sectors were actively translated, those in secondary fields were insufficiently translated. Of medical texts of Korea, those from the Joseon period were mostly translated, including major texts such as the Donguibogam and various kinds of texts reflecting research demands. Conclusions : In the future, texts that have not been translated need to be prioritized while basic elements need to be identified for better quality translation. To enable quantitative and qualitative expansion of Korean Medical Classical Texts translation, institutional and academic support is crucial.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.2
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• pp.10-25
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• 2023

Objectives : The purpose of this review is to validate the effectiveness of acupuncture treatment on dry eye syndrome. Methods : Through foreign online databases(Pubmed, Cochrane Library) and domestic online databases(Science On, OASIS) we only searched for Randomized controlled trials(RCTs) that performed acupuncture for dry eye syndrome from January 2010 to December 2022. Results : The most commonly used acupoints were 風池(GB20), 贊竹(BL2) and the most commonly used meridian was the gall bladder meridian of foot-shaoyang. The most commonly used evaluation criteria was Tear Break Up Time(TBUT) followed by Schirmer Test and Ocular Surface Disease Index(OSDI). In most of 8 studies, acupuncture treatment showed significant therapeutic effects. Conclusions : According to this study results, acupuncture can be suggested to effective way for treating dry eye syndrome. More clinical studies are needed to prove the effectiveness of the acupuncture on dry eye syndrome.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.14 no.1
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• pp.199-218
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• 2003

The discriminating power of journal evaluation criteria of Korean medical journals were measured. The study used the data of 76 medical journals, collected in the "Korean Medical Journal Evaluation" process conducted by the Korean Association of Medical Journal Editors (KAMJE) between 1997 and 1999. For each evaluation criterion, the distribution of the individual score vs the total score of a journal received was plotted and their correlations were analyzed. It is found that the evaluation criteria with a high discriminating power are the ones associated with the peer review system and the journal editing. The evaluation criteria with a low discriminating power are the journal frequency and how often a chief editor is changed. Some evaluation criteria such as "Journal holding rates of medical libraries" and "year-end index" need modifications in the evaluation methods. Other evaluation criteria such as "Journal self-citation rate","SCI citation rate" and "SCI impact factor" need to modify the score ranges. It is recommended that the new evaluation criteria such as "citation rate by Korean medical journals" and "Access availability of the journal information through major Korean medical abstract databases" should be added.formation through major Korean medical abstract databases" should be added.dded.