• Journal of Microbiology and Biotechnology
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• v.15 no.1
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• pp.192-196
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• 2005

Abstract Oligotrophic microbial fuel cells (MFCs) were tested for the continuous monitoring of low biochemical oxygen demand (BOD) by using artificial wastewater, containing glucose and glutamate, as check solution. Ten times diluted trace mineral solution was used to minimize the background current level, which is generated from the oxidation of nitrilotriacetate used as a chelating agent. The feeding rate of 0.53 ml/min could increase the sensitivity from 0.16 to 0.43 ${\mu}$A/(mg BOD/l) at 0.15 ml/min. The dynamic linear range of the calibration curve was between 2.0 and 10.0 mg BOD/l, and the response time to the change of 2 mg BOD/l was about 60 min. The current signal from an oligotroph-type MFCs increased with the increase in salts concentration, and the salt effect could be eliminated by 50 mM phosphate buffer.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2008.04a
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• pp.77-86
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• 2008

It's been known that overexpression of the oncoprotein Her2 (eu/ErbB2), transmembrane receptor protein, occurs in human breast cancer. Her2-positive breast cancer patients who have Her2 overexpression show less therapeutic efficacy with enhanced metathesis and increased resistance to chemotherapy. So far, a humanized monoclonal antibody against Her2 protein called Herceptin is the only drug approved by Food and Drug Administration for treatment of Her2-overexpressing breast tumors. However, antibody therapy of Herceptin may not be ideal method for therapeutic intervention of Her2 protein expression. The therapeutic intervention of Her2 protein expression may be more efficiently achieved by inhibiting the expression of Her2 gene rather than by down-regulating the Her2 protein already overexpressed. Here, we found that the interaction of two proteins of ESX (an epithelial-restricted transcription factor) and DRIP130/CRSP130/Sur2 (a Ras-linked subunit of human mediator complexes) mediates the expression of Her2 gene. The association of ESX with Sur2 is mediated by a small hydrophobic face of 8-amino acid helix in ESX, suggesting that the ESX-Sur2 interaction can be a new novel target for Her2-positive cancer. The process to develop potent ESX-Sur2 interaction inhibitors targeting for Her2-positive cancer therapeutics will be discussed.

• Journal of Korean Academy of Nursing Administration
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• v.19 no.4
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• pp.536-543
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• 2013

Purpose: The purpose of this study was to identify the mediating effect of professionalism in the relationship between clinical competence and field adaptation in newly graduated nurses. Methods: The participants in this study were 213 nurses from four tertiary hospitals who had less than 12 months of nursing experience. Data were collected during January and February, 2013. A structured questionnaire was used for data collection and data were analyzed using descriptive statistics, Pearson correlation coefficients, and path analysis with the SPSS/WIN 21.0 and AMOS 21.0 programs. Results: The mean score for clinical competence was $2.85{\pm}0.25$, for professionalism, $3.10{\pm}0.30$, and for field adaptation, $2.79{\pm}0.37$. There was a significant positive relationship between clinical competence and field adaptation. Also, professionalism was positively correlated with field adaptation. Professionalism showed mediating effects between clinical competence and field adaptation. Improvement of clinical competence increased professionalism and the increased professionalism raised the field adaptation. Conclusion: Based on these findings, orientation programs including strategies to increase professionalism, should be established to promote effective field adaptation in newly graduated nurses. These orientation programs can strengthen professionalism, the mediator between clinical competence and field adaptation in newly graduated nurses.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.37 no.1
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• pp.41-49
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• 2014

The purpose of this study is to examine the green management evaluation criteria and Employee Awareness and analyze their impact on management performance. A survey was conducted using a questionnaire form that was given to companies with fewer than 300 regular workers and less than 30 billion won in sales. The three-step mediated effect analysis proposed by Baran and Kenny was performed to verify the roles of the parameters. The research results are summarized as follows. First, awareness of greenhouse gases and environmental pollution play a mediating role affecting the management performance. Second, awareness of harmful chemical substances play a mediating role affecting the management performance. Lastly, The survey subjects were limited to SMEs in Chungcheong province and thus, this may not be applicable to all companies.

• Journal of health informatics and statistics
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• v.42 no.2
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• pp.192-198
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• 2017

Objectives: This study was designed to construct and test the structural equation model for the alcohol-related problem of alcohol use disorders. Methods: Data were collected by structured self-questionnaires from 229 male subjects who received > 8 (greater than 8) score on Alcohol Use Disorder Identification Test (AUDIT). The Data were analyzed by SPSS 21.0 and AMOS 21.0. Results: The model fit indices for the modified hypothetical model showed Q = 2.50, GFI = 0.90, and CFI = 0.94. As a result, Life position, parent's drinking problem, and alcohol expectancy had significantly direct effect on alcohol-related problem. Alcohol expectancy also had mediator effect between life position and alcohol-related problem. Conclusions: Consequently, the more positive life position, the less alcohol-related problem occurred. It is necessary to change their life position, which is individual factor, to prevent or reduce the alcohol related problem of alcohol use disorders.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.5
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• pp.1055-1063
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• 2021

How to manage a business effectively and successfully is the most important goal of all businesses on their way to expand and develop. Most researchers have confirmed that highly committed employees may perform better than less committed ones. The paper aims to find out what critical factors really affect employee's commitment for success of a business. The findings show that three factors having impacts on organizational commitment are leadership, meeting effectiveness and job satisfaction. Particularly, leadership positively affects meeting effectiveness with weight of 0.838. It is believed that if employees feel satisfied with their job, they become more committed to their organization. In addition, it is evident that meeting effectiveness positively affects organizational commitment with weight of 0.296. Last but not the least, in the relationship between meeting effectiveness and organizational commitment, there is a mediator of job satisfaction with the indirect effect of 0.454 and its bootstrap errors at 0.053. It emphasizes the importance of meetings in workplaces. In order to make subordinates satisfied with their jobs, every conflict or problem needs to be thoroughly resolved in meetings. That's why meeting effectiveness has a significant effect on job satisfaction. Furthermore, whether meetings are effective or not is based on leaders or meeting organizers.

• Human Ecology Research
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• v.59 no.4
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• pp.477-488
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• 2021

This study investigated the association between children's perceptions of autonomy support from mothers and teachers in relation to academic procrastination. It also examined the role of self-efficacy for self-regulated learning in mediating these effects. The sample comprised 372 fifth and sixth grade elementary school students from Seoul, Korea. Each completed a questionnaire regarding mothers' and teachers' autonomy support, children's self-regulated learning efficacy, and academic procrastination. The results indicated that whereas mothers' autonomy support had a direct effect on children's academic procrastination, teachers' support did not. In other words, children who perceived higher levels of autonomy support from mothers tended to exhibit less academic procrastination. Regarding indirect paths, children who perceived higher levels of mothers' and teachers' autonomy support displayed greater efficacy for self-regulated learning, which corresponded to lower levels of academic procrastination. The discussion highlights the vital roles of autonomy support from mothers and teachers in enhancing children's feelings of effective self-regulated learning and encouraging them to complete academic tasks. Furthermore, the present study considered not only outward behavioral factors but also the underlying cognitive and affective aspects of delaying behavior that underpin the effects of self-regulated learning efficacy and autonomy support of mothers and teachers on academic procrastination.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.1
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• pp.53-61
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• 2022

The goal of this research was to find the relationship between the work environment and societal issues that impede women's advancement to senior management positions. The study included 500 women professionals from diverse firms in Pakistan's business sector, of whom 100 were chosen as the sample size using a purposive sampling method. Experts confirmed the validity of the study tool, which was a questionnaire, and Cronbach's alpha coefficient was used to verify its reliability (0.704-0.982). The model's standardized regression coefficients suggested that social factors (0.298) were the most important factors determining women's empowerment in terms of career development and that they were further influenced by factors related to the work environment (0.411). It was concluded that organizational rules for female employees assist them to maintain a balance between work and family, resulting in a less stressful working environment. The role of the social factor as a mediator is also thought to be important in maintaining a healthier work environment in companies. It was also determined that much more work needs to be done on promotional regulations, as well as gender-blind legislation so that women's professional advancement is not limited to middle management.

• The Journal of Internal Korean Medicine
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• v.38 no.4
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• pp.468-478
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• 2017

Objectives: This study investigated the effects of Douchi Hataedock on Th2-skewed conditions to control allergic rhinitis. Methods: NC/Nga mice were divided into three groups: 10 mice were assigned to the control group (CTRL; no treatment), 10 mice to allergic rhinitis-induced (ARE) without treatment group, and 10 mice to the allergic rhinitis-induced (FGT) after Douchi Hataedock treatment group. The 3-week-old mice of the FGT group were given one 10 mg/kg dose of Douchi Hataedock extract and resensitized to allergic antigens at weeks four, five, and six. Allergic rhinitis was induced primarily in mice nasal cavities for five days after one week of final sensitization. The second induction used the same method one week after the first induction was completed. After one week, the nasal mucosal tissues of each group were observed. Immunohistochemical staining for IL-4, STAT6, CD40, $Fc{\varepsilon}RI$, substance P, MMP-9, $NF-{\kappa}B$ p65, p-IkB, and iNOS in the nasal mucosa was also performed. Results: The FGT group had less respiratory epithelial damage and less mucin secretion in goblet cells than the ARE group and showed a 62% decrease in IL-4, 85% decrease in STAT6, 71% decrease in CD40, 69% decrease in $Fc{\varepsilon}RI$, 43% decrease in substance P, 49% decrease in MMP-9, 43% decrease in NF-kB p65, 38% decrease in p-IkB, and 73% decrease in iNOS compared to the ARE group. Conclusions: Douchi Hataedock lessens inflammation in epithelial and goblet cells and reduces inflammatory mediator secretion in a mouse allergic rhinitis model.

• The Journal of the Korea Contents Association
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• v.17 no.9
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• pp.563-574
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• 2017

The predominant concerns of the study consist of: (1) the direct effects of social work students' evaluation toward connivers of exam-cheating on their evaluation toward connivers of corruptio ns in social welfare organizations; (2) the dual mediation effects of their concerning dysfunction of whistle-blowing and needing of protection arrangement for whistle-blowers. The notable findi ngs are as follows: First, the evaluation toward a person conniving at exam-cheating significantl y has an effect on the evaluation toward connivers committing corruptions in social welfare orga nizations($.211^{***}$). Second, the more positive evaluation for connivers of exam-cheating, the more concerning dysfunction of whistle-blowing, the less needing protection arrangement for whistle-blowers($-.191^{^{\prime}***}$). The students, concerning dysfunction of whistle-blowing more, show less neg ative evaluation toward a person, conniving at corruption in social welfare organizations($.245^{***}$). The more needing protection arrangement for whistle-blowers, the less positive evaluation regar ding whistle-blowers in the organizations($-.122^{***}$). Lastly, both mediating effects of the needing protection arrangement for whistle-blowers and concerning about dysfunction of whistle-blowing are significant so dual mediator are proved. Some practical implications are discussed based on the study's findings.