• IMMUNE NETWORK
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• v.8 no.1
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• pp.13-20
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• 2008

Background: Coptis chinensis rhizome has been used as a medicinal herb in traditional Oriental medicine. We investigated the effects of Coptis chinensis extract on inflammatory mediators and delayed type hypersensitivity in mice. Methods: The inhibitory effect of ethanolic extract of Coptis chinensis (CCE) on cell proliferation was evaluated using MTS assay. The lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and the Con A-activated mouse splenocytes were cultured with various concentrations of CCE. Total nitric oxide (NO) production was determined by Griess reaction. The amounts of secreted prostaglandine E2 ($PGE_2$), interleukin (IL)-2 and IFN-${\gamma}$ were measured by ELISA. To investigate the in vivo anti-inflammatory effect of CCE, oxazolone-induced delayed type hypersensitivity (DTH) model was used. Results: The CCE at $100{\mu}g/ml$ significantly blocked the LPS-induced production of pro-inflammatory mediators (NO and PGE) in RAW264.7 macrophages. Also, it significantly inhibited cell proliferation and cytokine (IL-2 and IFN-${\gamma}$) production in splenocytes. Furthermore, when splenocytes from CCE fed mice (200 mg/kg for 2 weeks) were activated with Con A, cell proliferation and cytokine production were significantly inhibited. In addition, CCE decreased in vivo inflammation in oxazolone-induced DTH model mice. Conclusion: We suggest that Coptis chinensis can be used as an anti-inflammatory drug by exerting an inhibitory effect in inflammatory mediator- and cell-mediated inflammation.

• Journal of the Korea Convergence Society
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• v.7 no.4
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• pp.163-172
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• 2016

This research was convergence study conducted to understand the effect that parent-son/daughter communications have on the addiction to smartphones, with stress level, self-control, and self-efficacy as the mediator. The subjects were college students located in J province and K province, and 232 questionnaires were used as the data for analysis. As a result, addiction to smartphones had negative correlations with parent-son/daughter communication, self-control, and self-efficacy and had positive correlations with stress level. In addition, parent-son/daughter communication influenced the degree of addiction to smartphones, with stress level, self-control, and self-efficacy as the mediator. Therefore, in order to reduce college students' addiction to smartphones, programs should be developed specifically and systematically to increase their communication with their parents, and it is necessary to draw up measures to reduce students' stress levels and increase their self-control and self-efficacy levels.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.21 no.2
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• pp.28-38
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• 2008

In traditional oriental medicine, Gentianae Radix has been used clinically for clearing away 'heat', removing dampness and purging fire in the liver and gall bladder. However, there has been a lack of studies regarding the effects of Gentianae Radix on the immunological activities. The present study was conducted to evaluate the effect of Gentianae Radix on the regulatory effects of cytokines and nitric oxide(NO) for the immunological activities in Raw 264.7 cells. After the treatment of Gentianae Radix MeOH extract, cell viability was measured by MTT assay, and NO production was monitored by measuring the nitrite content in culture medium. The expression of COX-2 and iNOS was determined by immunoblot analysis, and the content of levels of cytokines in media was analyzed by ELISA kit. Results provided evidence that Gentianae Radix inhibited the production of nitrite and nitrate (NO), inducible nitric oxide synthase (iNOS), $interleukin-l{\beta}$ $(IL-l{\beta})$ and IL-6, and the activation of phospholylation of inhibitor ${\kappa}B{\alpha}$ ($p-I {\kappa}B{\alpha}$) in Raw 264.7 cells activated with lipopolysaccharide (LPS). These findings suggest that Gentianae Radix can make anti-inflammatory effect, which may playa role in adjunctive therapy.

• The Korea Journal of Herbology
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• v.23 no.3
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• pp.11-18
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• 2008

SunBangHwalMyungEum (SBH) has the effects of subduing swelling, resolving masses and alleviating pain in traditional oriental medicine. Recent studies showed that SunBangHwalMyungEum produced anti-cancer, anti-metastasis and immuno-modulatory effects. However there is lack of studies regarding the effects of SBH on the immunological activities. The present study was conducted to evaluate the effect of SBH on the regulatory mechanism of cytokines and nitric oxide (NO) in Raw 264.7 cells. Methods : After the treatment of SBH, cell viability was measured by MTT assay, NO production was monitored by measuring the nitrite content in culture medium. Inducible nitric oxide synthase (iNOS) was determined by immunoblot analysis, and levels of cytokine were analyzed by sandwich immunoassays. Results : Results provided evidence that SBH inhibited the production of NO, iNOS, $interleukin-1{\beta}$ ($(IL-1{\beta})$), IL-6, and the activation of phospholylation of inhibitor ${\kappa}B{\alpha}$ in Raw 264.7 cells activated with lipopolysaccharide. Conclusions : These findings suggest that SBH can produce anti-inflammatory effect, which may play a role in adjunctive therapy in Gram-negative bacterial infections.

• The Mathematical Education
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• v.58 no.1
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• pp.21-39
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• 2019

This study examines the longitudinal effect of goal perception, mathematics class factors(perceptions about mathematics teachers (PMT), mathematics classroom attitude), and mathematics academic achievement. This study consists of three research models. First, we examined the longitudinal change of goal perception, perceptions about mathematics teachers (PMT), mathematics classroom attitude, and mathematics academic achievement using latent growth curve modeling. Secondly, the slope of PMT is a critical mediator between the slope of goal perception and the slope of mathematics academic achievement. Finally, the slope of mathematics classroom attitude is a critical mediator between the slope of goal perception and the slope of mathematics academic achievement. Data were extracted from Seoul Education Longitudinal Study from 2010 to 2012 (in three waves), and the analysis used by middle school students, measured by 4163 students of the three-wave surveys. Latent growth modeling was applied to verify the research problems. The results of the research are as follows. First, the slope of goal perception had positive and significant effects on the slope of PMT and mathematics classroom attitude, respectively. Second, the slope of PMT and mathematics classroom attitude had positively significant effects on the slope of mathematics academic achievement. Finally, it was confirmed that the slopes of PMT and mathematics classroom attitude are critical mediators between the slope of goal perception and the slope of mathematics academic achievement.

• Journal of Families and Better Life
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• v.29 no.3
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• pp.59-69
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• 2011

The purpose of this study was to investigate the structural relationships among adolescents' internet addiction, self-esteem, self-control, and aggression. The participants were 300 students in their first year of middle school. The questionnaire consisted of measures of internet addiction, self-esteem, self-control, and aggression. The major findings were as follows: 1) self-control had a direct effect on aggression; 2) internet addiction had a direct effect on self-esteem and self-control; 3) self-esteem had a direct effect on self-control; 4) internet addiction had an indirect effect on aggression and self-control; and self-esteem had an indirect effect on aggression. This study implied that self-related variables could mediate the relationship between the possibility of internet addiction and adolescents' aggression. This study also suggested that research on various mediator variables could reduce adolescents' psychosocial problems.

• Culinary science and hospitality research
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• v.22 no.6
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• pp.33-51
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• 2016

The hotel industry needs to make the competitive advantage difficult to be imitated in order to remain sustainable in competitive business circumstances. Front-line employees' service-oriented citizenship behaviors(OCBs) can be such a strength from the perspective of organizational system. With an aim of investigating the antecedents of the hotel front-line employees' service-oriented OCBs, this study proposed a theoretical framework linking authentic leadership to service-oriented OCBs with goal commitment as a mediator. A total of 260 cases without missing values have been used for the final analysis and structural equation modeling (SEM) is employed using the SPSS and AMOS 7. It was first found that self-awareness and relational transparency of authentic leadership made a significant impact on their goal commitment while balanced processing and moral perspective failed to influence them. Second. goal commitment influenced all sub-factors of service-oriented OCBs. Third, moral perspective and relational transparency of authentic leadership significantly influenced service-oriented OCBs while self-awareness and relational transparency failed to make it. Finally, goal commitment significantly makes an intervening effect for the relationship between self-awareness & service-oriented OCBs and relational transparency & service-oriented OCBs but failed to intervene the other relationships. The results provide theoretical and practical implications regarding directions of leadership styles and HR management in the hotel industry and suggestions for the further extended studies.

• Journal of the Korean Society of School Health
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• v.31 no.1
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• pp.29-38
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• 2018

Purpose: The purpose of this study is to investigate the mediator effect of major satisfaction in relation to depression and job-seeking stress of university students according to the majors. Methods: This descriptive study was conducted in three universities randomly chosen from 47 universities in Seoul, Korea. Participants were 241 undergraduate students who were eligible and agreed to participate in the study. Data were collected from October 27 to November 10, 2014. The data were analyzed with descriptive statistics, $x^2$ test, Fisher's exact test, t-test, Kruskal-Wallis test, Pearson correlation coefficients, simple and multiple regression techniques with the PASW/WIN 20.0 program. Results: There were significant negative, negative, and positive correlations between job-seeking stress and major satisfaction, major satisfaction and depression, and job-seeking stress and depression regardless of major field, respectively. Moreover, in the major group in natural science and engineering, the link between job-seeking stress and depression was partially mediated by major satisfaction. Conclusion: The findings of this study contribute to providing basic data for the development of job-seeking stress and depression intervention programs and future study for university students.

• 한국사회복지학회:학술대회논문집
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• 2005.04a
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• pp.677-702
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• 2005

The purpose of this study is to examine the Korean social workers' level of social work values, advocacy attitude and advocacy intervention, and to verify the relations among social work education, social work advocacy and social work values by examining whether social work education influences social work advocacy and social work values, and whether social work values affect social work advocacy. Further, this study wishes to confirm not only the direct effect that social work education has on social work advocacy, but also how social work education indirectly influences social work advocacy through social work values on the social level as a mediator. The research of this study was conducted on 461 social work practitioners who have obtained either social worker licenses or mental health social worker licenses and are currently working in the field. As survey tools, this study utilized social work advocacy attitude, social work advocacy intervention, outcomes of social work education, social work values, self-esteem and locus of control. Collected data were analyzed by using SPSS/PC+ 11.5 for one-way ANOVA and t-test, Pearson's correlation, reliability analysis, exploratory factor analysis and multiple regression. To sum up the results of the study in terms of the research hypothesis, the research hypothesis was established according to the analysis method of the testing mediation of Baron & Kenny (1986) in order to examine whether social work values on the social level intervene between social work education and social work advocacy. The results of the hypothesis test confirm that social work values on the social level serve as a mediator variable.

• Journal of Distribution Science
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• v.18 no.10
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• pp.53-64
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• 2020

Purpose: With the emergence of high technology in China, online shopping distribution of fresh agricultural products have been developing rapidly. This study built a model to investigate how perceived quality of products and logistic services, perceived risk, and perceived cost affect intention to buy fresh agricultural products in an Internet environment. Especially, in the purchasing process, attitude may work as an important mediator. Research design, data and methodology: To achieve the objectives of this study, Chinese respondents were asked to fill in a questionnaire through the China online survey website. With 520 available data, regression analysis was used to test the hypotheses. Results: Results indicate that perceived quality of fresh agriculture products and perceived logistics service quality have a significant positive impact on attitude and purchase intention. Results also reveal that perceived risk and perceived cost affect attitude and purchase intention negatively. Finally, results imply that attitude has a positive effect on purchase intention, which is the unique mediator in the online shopping process. Conclusions: This study suggests that managers in the online shopping distributions of fresh agricultural products should improve the quality of products and logistics services along with the reduction of the perceived risk and cost to compete in the China market.