• 대한의생명과학회지
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• 제26권4호
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• pp.310-318
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• 2020

The sciatic nerve is the largest nerve among the peripheral nerves, and the damage to the sciatic nerve is caused by mechanical and physical pressure. This is an important disease that consumes a lot of time and money in the treatment process. Among them, research on relieving nerve pain caused by damage to the peripheral sciatic nerve has been made efforts to prevent and treat this disease through various methods such as drugs, natural products, electrical stimulation, exercise therapy, and massage. Existing treatments are not very effective in neurological pain, and countermeasures are needed. Forsythia Fructus, used in this study, has been used as a therapeutic agent for infectious diseases and a pain reliever for cancer from the past, and in past studies, it has been known to properly control the inflammatory response. In this study, rengyolone, a physiologically active substance of Forsythiae Fructus, was administered to rats that caused chronic left nerve pain to verify the pain relief effect. As a result of the experiment, it was found that mechanical pain and cold stimulation pain were significantly reduced in the rengyolone-treated group compared to the non-administered group. In addition, it was found that nerve growth factor (NGF) mRNA expression was significantly reduced and Cyclin-dependent kinase 2 (Cdc2) expression was increased in the rengyolone administration group. This increase in NGF expression is thought to be related to rengyolone's anti-inflammatory regulatory mechanism. It is expected that the reduced NGF was directly involved in pain relief.

• 수산해양교육연구
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• 제20권2호
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• pp.266-285
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• 2008

This study investigated the relationship between musical understanding and expression, the purpose of music education. It also intended to present the theoretical basis of integrated early childhood music education by examining into the necessity of it as a method to help young children with musical understanding and expression. The results of the study showed that either of the understanding and expression of music should be necessary and there is a mutual promotional relationship between them. It was found out that real musical understanding can be formed not by mechanical skill, but when the relationship between notes is understood with various experiences. Therefore an integrated early childhood music education became necessary as a principle of educational method to help young children with musical understanding and musical expression. Concretely it was found out to be necessary in terms of the characteristics, interest and concern of young children, the use and development of multi intelligence and the translation of the same knowledge into the same level.

• Archives of Pharmacal Research
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• 제27권11호
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• pp.1154-1160
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• 2004

We investigated the neurotoxic effects of capsaicin (CAP) on pain sensitivity and on the expression of capsaicin receptor, the vanilloid receptor (VR1), in rats. High-dose application of CAP has been known to degenerate a large fraction of the sensory neurons. Although the neurotoxic effects of CAP are well documented, the effects of CAP on the vanilloid receptor (VR1) are not yet known. In this paper, we investigated the effects of high-dose application of CAP on the expression of VR1 in rats. Thermal and mechanical pain sensitivity was reduced when neonatal rats were treated with a high dose of CAP. This reduction of pain sensitivity was significantly decreased after initiating carrageenan-induced inflammation. The expression of VR1 in dorsal root ganglia (DRG) isolated from the CAP-treated rats was reduced compared to that from the vehicle-treated rats. Therefore, we can conclude that the neurotoxic effect of CAP is related to the decrease of VR1 expression.

• 대한기계학회논문집A
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• 제29권6호
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• pp.787-794
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• 2005

Nowadays chronic degenerative diseases such as arthritis are increasing rapidly, even though acute infectious diseases are decreasing due to the advance of modern medicine. Although many of remedies are developed for arthritis healing, there is no precise medical prescription, and pathogenesis is not examined exactly. In this study, we confirmed gene expression of BMP 1A, BMP 2B, osteonectin and MGP which are genes related with bone formation in osteoblast by using ultrasonic stimulation. Through this study, we also evaluated the fact that ultrasound could be applied to arthritis healing by making activated osteoblast induce remodeling of cartilage. As a result of this research, BMP 2B and MGP have higher rates of expression in specific ultrasound mode. In conclusion, it is expected that ultrasound could be used efficiently for healing arthritis if we use ultrasounds according to symptoms of arthritis on reasonable terms.

• Nuclear Engineering and Technology
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• 제48권6호
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• pp.1315-1320
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• 2016

The present study aims to predict the heat transfer characteristics around a square cylinder with different corner radii using multivariate adaptive regression splines (MARS). Further, the MARS-generated objective function is optimized by particle swarm optimization. The data for the prediction are taken from the recently published article by the present authors [P. Dey, A. Sarkar, A.K. Das, Development of GEP and ANN model to predict the unsteady forced convection over a cylinder, Neural Comput. Appl. (2015) 1-13]. Further, the MARS model is compared with artificial neural network and gene expression programming. It has been found that the MARS model is very efficient in predicting the heat transfer characteristics. It has also been found that MARS is more efficient than artificial neural network and gene expression programming in predicting the forced convection data, and also particle swarm optimization can efficiently optimize the heat transfer rate.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2003년도 하계학술대회 논문집
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• pp.89-89
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• 2003

• BMB Reports
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• 제43권4호
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• pp.257-262
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• 2010

The aim of work was to investigate changes of 7-ketocholesterol synthesis in alveolar macrophages in the dynamic of lung mechanical ventilation with injurious parameters. The goal of in vitro part of work was to observe influence of 7-ketocholesterol on iNOS and MIP1 $\beta$ production in bronchoalveolar lavage fluid (BALF) cells. We used 17 healthy domestic pigs randomly assigned into two treatment groups: group I with mechanical ventilation with physiological parameters; group II underwent injurious ventilation with high volume tidal (VT) and low positive end expiratory pressure (PEEP). Cells were analyzed for CYP27A1 protein and gene expression levels, 7-ketocholesterol production. In alveolar macrophages of group II, we obtained increase of production of CYP27A1 protein and 7-ketocholesterol, as well as the expression of the CYP27A1 gene at the 2nd hour of ventilation. In the in vitro experiments we show dose-dependent increase of MIP1 $\beta$ and decrease of CYP27A1, iNOS protein production after 7-ketocholesterol treatment.

• Journal of Mechanical Science and Technology
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• 제14권10호
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• pp.1051-1060
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• 2000

Linear cyclic systems (LCS's) are a class of systems whose dynamic behavior changes cyclically. Such cyclic behavior is ubiquitous in systems with fundamentally repetitive motions (e. g. all rotating machinery). Yet, the knowledge of the noise and vibration transmission paths in LCS's is quite limited due to the time-varying nature of their dynamics. The first part of this two-part paper derives a generic expression that describes how the noise and/or vibration are transmitted between two (or multiple) locations in the LCS's. An analysis via the Fourier series and Fourier transform (FT) plays a major role in deriving this expression that turns out to be transfer function dependent upon the cycle position of the system. The cyclic nature of the LCS' transfer functions is shown to generate a series of amplitude modulated input signals whose carrier frequencies are harmonic multiples of the LCS' fundamental frequency. Applicability of signal processing techniques used in the linear time-invariant systems (LTIS's to the general LCSs is also discussed. Then, a criterion is proposed to determine how well a LCS can be approximated as a LTIS. In Part II, experimental validation of the analyses carried out in Part I is provided.

• Computers and Concrete
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• 제28권5호
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• pp.451-463
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• 2021

Inorganic basalt fiber (BF) is a novel sort of commercial concrete fiber which is made with basalt rocks. Previous studies have not sufficiently handled the behavior of self-compacted concrete, at elevated temperature, containing basalt fiber. Present endeavor covers experimental work to examine the characteristics of this material at high temperature considering different fiber content and applied temperature. Different tests were carried out to measure the mechanical properties such as compressive strength (fc), modulus of elasticity (E), Poisson's ratio, splitting tensile strength (fsplit), flexural strength (fflex), and slant shear strength (fslant) of HSC and hybrid concrete. Gene expression programming (GEP) was employed to propose new constitutive relationships depending on experimental data. It was noticed from the testing records that there is no remarkable effect of BF on the Poisson's ratio and modulus of elasticity of self-compacted concrete. The flexural strength of basalt fiber self-compacted concrete was not sensitive to temperature in comparison to other mechanical properties of concrete. Fiber volume fraction of 0.25% was found to be the optimum to some extend according to degradation of strength. The proposed GEP models were in good matching with the experimental results.

• 동의생리병리학회지
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• 제32권1호
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• pp.35-42
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• 2018

TRPA1 and TRPV1 are members of the TRP superfamily of structurally related, nonselective cation channels. TRPA1 and TRPV1 are often co-expressed in sensory neurons and play an important role in mechanical hyperalgesia and allodynia during neuropathic pain. Scutellariae Radix was reported to possess anti-inflammation properties and similar patterns of therapeutic action against different diseases. also Baicalin(a known principal constituent of Scutellaria Radix) was shown to down-regulate the mRNA expression levels of TRPV1. In this study, we observed the effects of Scutellariae Radix extract(SRE) in neuropathic pain induced SD rats via modulation of TRPV1 and TRPA1. Oral administration of a Scutellaria Radix extract(in doses of 300mg/kg, SRE(300)) showed a meaningful increase in the withdrawal threshold of mechanical allodynia and showed a meaningful decrease in the expression of c-fos compared to the control group. SRE(100) and SRE(300) showed a meaningful decrease in the expression of TRPV1 level compared to the control group. These results suggest that Scutellariae Radix extract could decrease mechanical allodynia by down-regulate the TRPV1 on the model of neuropathic pain.